Activin type 2 receptors
A ligand binds to a type 2 receptor, which recruits and trans-phosphorylates a type I receptor. The type I receptor recruits a ... The activin type 2 receptors belong to a larger TGF-beta receptor family and modulate signals for transforming growth factor ... inhibin/activin betaA and betaB and the activin type II and inhibin beta-glycan receptors in the developing human testis". ... There are two activin type two receptors: ACVR2A and ACVR2B. Despite the large amount of processes that these ligands regulate ...
Activin type 1 receptors
A ligand binds to a Type two receptor, which recruits and trans-phosphorylate a type I receptor. The type I receptor recruits a ... There are three type I Activin receptors: ACVR1, ACVR1B, and ACVR1C. Each bind to a specific type II receptor-ligand complex. ... The Activin type I receptors transduce signals for a variety of members of the Transforming growth factor beta superfamily of ... This family of cytokines and hormones include activin, Anti-müllerian hormone (AMH), bone morphogenetic proteins (BMPs), and ...
Activin receptor
An Activin receptor is a receptor which binds activin. These proteins are receptor-type kinases of Ser/Thr type, which have a ... Types include: Activin type 1 receptors Activin type 2 receptors ACVR1; ACVR1B; ACVR1C; ACVR2A; ACVR2B; ACVRL1; BMPR1A; BMPR1B ... Activin+receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from ... Wrana JL, Attisano L, Wieser R, Ventura F, Massague J (1994). "Mechanism of activation of the TGF-beta receptor". Nature. 370 ( ...
Bimagrumab
It binds to and inhibits activin receptor type-2B. On August 20, 2013, it was announced that bimagrumab had received a ... an activin receptor type II inhibitor, on pituitary neurohormonal axes". Clinical Endocrinology. 88 (6): 908-919. doi:10.1111/ ... is safe and effective for treating excess adiposity and metabolic disturbances of adult patients with obesity and type 2 ...
ACVR2B
Activin receptor type-2B is a protein that in humans is encoded by the ACVR2B gene. ACVR2B is an activin type 2 receptor. ... and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a ... This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type ... resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively ...
ACVR2A
... is an activin type 2 receptor. This gene encodes activin A type II receptor. Activins are dimeric growth and ... and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a ... resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively ... "Truncated activin type II receptors inhibit bioactivity by the formation of heteromeric complexes with activin type I. ...
BMPR1B
"Characterization of type I receptors for transforming growth factor-beta and activin". Science. 264 (5155): 101-4. Bibcode: ... kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in ... the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors ... Bone morphogenetic protein receptor type-1B also known as CDw293 (cluster of differentiation w293) is a protein that in humans ...
ACVRL1
"Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors". ... It is also known as activin receptor-like kinase 1, or ALK1. This gene encodes a type I cell-surface receptor for the TGF-beta ... "Entrez Gene: ACVRL1 activin A receptor type II-like 1". Olivieri C, Mira E, Delù G, Pagella F, Zambelli A, Malvezzi L, ... "Mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2". Nature Genetics. 13 (2 ...
ACVR1
... resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which ... and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a ... Activin A receptor, type I (ACVR1) is a protein which in humans is encoded by the ACVR1 gene; also known as ALK-2 (activin ... Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two ...
Myostatin
2020 scientists reported that suppressing activin type 2 receptors-signalling proteins myostatin and activin A via activin A/ ... A two-week treatment of normal mice with soluble activin type IIB receptor, a molecule that is normally attached to cells and ... Myostatin binds to the activin type II receptor, resulting in a recruitment of either coreceptor Alk-3 or Alk-4. This ... Treating progeric mice with soluble activin receptor type IIB before the onset of premature ageing signs appear to protects ...
C19orf18
Activin A receptor type 2A (ACVR2A) is a transmembrane receptor that is involved in ligand-binding and mediates the functions ... "ACVR2A activin A receptor type 2A [Homo sapiens (human)] - Gene - NCBI". Gene. Bock, J B; Klumperman, J; Davanger, S; Scheller ... Bone morphogenetic protein receptor type 1A(BMPR1A) is expressed almost exclusively in skeletal muscle and is a transcriptional ... Fibroblast growth factor receptor 2 (FGFR2) plays an essential role in the regulation of osteoblast differentiation, ...
Fibrodysplasia ossificans progressiva
Normally, the ACVR1 gene encodes the activin receptor type-1 transmembrane kinase that bind BMP receptors (Type I BMPR and Type ... ACVR1 encodes activin receptor type-1, a BMP type-1 receptor. The mutation causes substitution of codon 206 from arginine to ... Lin, Shuxian; Svoboda, Kathy K. H.; Feng, Jian Q.; Jiang, Xinquan (5 April 2016). "The biological function of type I receptors ... Fibro/adipogenic progenitors (FAPs) may be the disease-causing cell type responsible for activin A dependent ectopic bone ...
MAGI2
"Identification and characterization of a PDZ protein that interacts with activin type II receptors". J Biol Chem. 275 (8): 5485 ... 2003). "PKC regulates the delta2 glutamate receptor interaction with S-SCAM/MAGI-2 protein". Biochem. Biophys. Res. Commun. 301 ... 2001). "beta 1-adrenergic receptor association with the synaptic scaffolding protein membrane-associated guanylate kinase ... inverted-2 (MAGI-2). Differential regulation of receptor internalization by MAGI-2 and PSD-95". J. Biol. Chem. 276 (44): 41310- ...
ACVR1C
2004). "Activin isoforms signal through type I receptor serine/threonine kinase ALK7". Mol. Cell. Endocrinol. 220 (1-2): 59-65 ... 2001). "The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate ... "SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase ... The activin A receptor also known as ACVR1C or ALK-7 is a protein that in humans is encoded by the ACVR1C gene. ACVR1C is a ...
Mir-24 microRNA precursor family
January 2008). "MicroRNA miR-24 inhibits erythropoiesis by targeting activin type I receptor ALK4". Blood. 111 (2): 588-95. doi ...
BMPR1A
... and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. ... kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in ... the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors ... "Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs". Mol. Cell ...
TGF beta 1
"Determination of type I receptor specificity by the type II receptors for TGF-beta or activin". Science. 262 (5135): 900-2. ... Oh SP, Seki T, Goss KA, Imamura T, Yi Y, Donahoe PK, Li L, Miyazono K, ten Dijke P, Kim S, Li E (March 2000). "Activin receptor ... Choy L, Derynck R (November 1998). "The type II transforming growth factor (TGF)-beta receptor-interacting protein TRIP-1 acts ... It can also decrease the expression levels of cytokine receptors, such as the IL-2 receptor to down-regulate the activity of ...
TGF beta receptor 1
... activin A receptor type II-like kinase, 53kDa) is a membrane-bound TGF beta receptor protein of the TGF-beta receptor family ... "Determination of type I receptor specificity by the type II receptors for TGF-beta or activin". Science. 262 (5135): 900-2. ... "Entrez Gene: TGFBR1 transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa)". Razani B, ... a novel type II serine/threonine kinase receptor through interaction with the type I transforming growth factor-beta receptor ...
ACVR1B
... resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type IB receptor, composed ... and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a ... "Truncated activin type II receptors inhibit bioactivity by the formation of heteromeric complexes with activin type I. ... "Truncated activin type II receptors inhibit bioactivity by the formation of heteromeric complexes with activin type I. ...
Three-finger protein
... such as the activin type 2 receptor; and bone morphogenetic protein receptor, type IA. Other LU domain proteins are small ... "Three-finger toxin fold for the extracellular ligand-binding domain of the type II activin receptor serine kinase". Nature ... Ploug M, Ellis V (August 1994). "Structure-function relationships in the receptor for urokinase-type plasminogen activator. ... Other receptors with LU domains include members of the transforming growth factor beta receptor (TGF-beta) superfamily, ...
LU domain
... such as the activin type 2 receptor; and bone morphogenetic protein receptor, type IA. Other LU domain proteins are small ... "Three-finger toxin fold for the extracellular ligand-binding domain of the type II activin receptor serine kinase". Nature ... Besides uPAR, other receptors with LU domains include members of the transforming growth factor beta receptor (TGF-beta) ... "Localization of the disulfide bonds in the NH2-terminal domain of the cellular receptor for human urokinase-type plasminogen ...
RALBP1
"Regulation of endocytosis of activin type II receptors by a novel PDZ protein through Ral/Ral-binding protein 1-dependent ... involvement of the Ral pathway in receptor endocytosis" (PDF). J. Cell Sci. 113 (16): 2837-44. doi:10.1242/jcs.113.16.2837. ...
SYNJ2BP
"Regulation of endocytosis of activin type II receptors by a novel PDZ protein through Ral/Ral-binding protein 1-dependent ... "Novel factors in regulation of activin signaling". Molecular and Cellular Endocrinology. 225 (1-2): 1-8. doi:10.1016/j.mce. ... "Novel factors in regulation of activin signaling". Molecular and Cellular Endocrinology. 225 (1-2): 1-8. doi:10.1016/j.mce. ... "Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse ...
REPS2
"Regulation of endocytosis of activin type II receptors by a novel PDZ protein through Ral/Ral-binding protein 1-dependent ... The product of this gene is part of a protein complex that regulates the endocytosis of growth factor receptors. The encoded ... Its expression can negatively affect receptor internalization and inhibit growth factor signaling. Multiple transcript variants ... "Epsin binds to the EH domain of POB1 and regulates receptor-mediated endocytosis". Oncogene. 18 (43): 5915-22. doi:10.1038/sj. ...
Eileen Shore
The cause of the disease was traced to a single mutation in the activin A receptor, type I gene. Once the cause of the disease ... "A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva". ... "A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva". ... "A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva". ...
Mothers against decapentaplegic homolog 2
This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. ... Lebrun JJ, Takabe K, Chen Y, Vale W (January 1999). "Roles of pathway-specific and inhibitory Smads in activin receptor ... This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA ... O'Neill TJ, Zhu Y, Gustafson TA (April 1997). "Interaction of MAD2 with the carboxyl terminus of the insulin receptor but not ...
Frederick Kaplan
The cause of the disease was traced to a single mutation in the activin A receptor, type I gene. After the discovery, Kaplan ... "A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva". ... "A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva". ...
Follistatin
... activin complex reveals antagonism of both type I and type II receptor binding". Developmental Cell. 9 (4): 535-543. doi: ... Walsh S, Metter EJ, Ferrucci L, Roth SM (June 2007). "Activin-type II receptor B (ACVR2B) and follistatin haplotype ... Lambert-Messerlian G, Eklund E, Pinar H, Tantravahi U, Schneyer AL (2007). "Activin subunit and receptor expression in normal ... In the blood, activin and follistatin are both known to be involved in the inflammatory response following tissue injury or ...
Acceleron Pharma
ACE-011 was a chimeric protein, created by fusing the binding portion of the activin type 2 receptors to part of an antibody; ... a protein therapeutic that was an activin type 2 receptor antagonist intended to treat bone loss. ... the resulting protein binds to activin and prevents it from acting. Knopf took over as CEO in 2007. He became known for showing ...
Mothers against decapentaplegic homolog 7
It is a TGFβ type 1 receptor antagonist. It blocks TGFβ1 and activin associating with the receptor, blocking access to SMAD2. ... By occupying type I receptors for Activin and bone morphogenetic protein (BMP), it also plays a role in negative feedback of ... "Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation". J. Biol ... Lebrun JJ, Takabe K, Chen Y, Vale W (January 1999). "Roles of pathway-specific and inhibitory Smads in activin receptor ...