... a new cell adhesion molecule in metastasizing human melanoma cell lines, is identical to ALCAM (activated leukocyte cell ... a new cell adhesion molecule in metastasizing human melanoma cell lines, is identical to ALCAM (activated leukocyte cell ... 2003). "Human blastocysts and endometrial epithelial cells express activated leukocyte cell adhesion molecule (ALCAM/CD166)". J ... "Entrez Gene: ALCAM activated leukocyte cell adhesion molecule". Degen WG, van Kempen LC, Gijzen EG, et al. (1998). "MEMD, ...

... and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand". J. Exp. Med. 181 (6): 2213-20. doi: ... domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of ... "The membrane-proximal scavenger receptor cysteine-rich domain of CD6 contains the activated leukocyte cell adhesion molecule ... "The accessory molecules CD5 and CD6 associate on the membrane of lymphoid T cells". J. Biol. Chem. 278 (10): 8564-71. doi: ...

A wild-type activated leukocyte cell adhesion molecule (ALCAM) is also required to activate MMP-2. Mutations in the MMP2 gene ... allowing them to bind with cell receptors and influence cell signaling. Furthermore, many MMPs also activate other proMMPs ... Massagué J (July 2008). "TGFbeta in Cancer". Cell. 134 (2): 215-30. doi:10.1016/j.cell.2008.07.001. PMC 3512574. PMID 18662538 ... "Human endometrial epithelial cells modulate the activation of gelatinase a by stromal cells". Gynecol. Obstet. Invest. 53 (2): ...

Proteomic identification of desmoglein 2 and activated leukocyte cell adhesion molecule as substrates of ADAM17 and ADAM10 by ... These bioactive molecules play roles in coagulation, complement activation, DNA replication, cell-cycle control, cellular ... Placing a reactive group and a recognizable tag feature on the same molecule using a linker moiety gives an ABP molecule its ... Cell Proteomics 3(6):565-76 (2004). Bredemeyer A.J., Lewis R.M., Malone J.P., Davis A.E., Gross J., Townsend R.R., Ley T.J. A ...

... one of these adhesion proteins involved is ALCAM (Activated Leukocyte Cell Adhesion Molecule, also called CD166), and is under ... Apart from that, activated T-Cells can cross a healthy BBB when they express adhesion proteins. (Adhesion molecules could also ... because activated T-Cells can cross a healthy BBB when they express adhesion proteins. ... produced by CD8+ T-cells or CD20+ B-cells), creates a toxic environment that activates microglia. MRI-abnormal areas with ...

... or leukocyte-endothelial cell adhesion molecule 2 (LECAM2), is a selectin cell adhesion molecule expressed only on endothelial ... "E-selectin and intercellular adhesion molecule-1 are released by activated human endothelial cells in vitro". Immunology. 77 (4 ... In endothelial cells, various cell-adhesion molecules including E-selectin, are shown to be upregulated upon exposure to ... E-selectin, also known as CD62 antigen-like family member E (CD62E), endothelial-leukocyte adhesion molecule 1 (ELAM-1), ...

... cell adhesion molecules, neuron-glia MeSH D12.776.395.550.200.250.150.050 - activated-leukocyte cell adhesion molecule MeSH ... neural cell adhesion molecules MeSH D12.776.395.550.200.250.520.156 - antigens, cd56 MeSH D12.776.395.550.200.250.520.578 - ... vascular cell adhesion molecule-1 MeSH D12.776.395.550.550.500 - lysosomal-associated membrane protein 1 MeSH D12.776.395.550. ... neural cell adhesion molecule l1 MeSH D12.776.395.550.200.275 - integrin alphaxbeta2 MeSH D12.776.395.550.200.450 - ...

... cell adhesion molecules, neuron-glia MeSH D23.050.301.350.250.150.050 - activated-leukocyte cell adhesion molecule MeSH D23.050 ... activated-leukocyte cell adhesion molecule MeSH D23.101.100.110.101 - antigens, cd1 MeSH D23.101.100.110.102 - antigens, cd2 ... activated-leukocyte cell adhesion molecule MeSH D23.050.301.264.035.101 - antigens, cd1 MeSH D23.050.301.264.035.102 - antigens ... neural cell adhesion molecules MeSH D23.050.301.350.250.520.156 - antigens, cd56 MeSH D23.050.301.350.250.520.578 - neural cell ...

... cell adhesion molecules, neuron-glia MeSH D12.776.543.550.200.250.150.050 - activated-leukocyte cell adhesion molecule MeSH ... neural cell adhesion molecules MeSH D12.776.543.550.200.250.520.156 - antigens, cd56 MeSH D12.776.543.550.200.250.520.578 - ... vascular cell adhesion molecule-1 MeSH D12.776.543.550.425.150 - calcium channels MeSH D12.776.543.550.425.150.400 - calcium ... neural cell adhesion molecule l1 MeSH D12.776.543.550.200.275 - integrin alphaxbeta2 MeSH D12.776.543.550.200.450 - ...

... genes that encode endothelial cell adhesion molecules, causing decreased lymphocyte and leukocyte activation and hence ... T-cells are activated and more prone to apoptosis without KLF2, suggesting that KLF2 regulates T-cell quiescence and survival. ... This activates mechanosensitive channels, which in turn activates two pathways; the MEK5/ERK5 pathway, which activates MEF2, a ... but it is also expressed temporally during embryogenesis in erythroid cells, endothelium, lymphoid cells, the spleen, and white ...

These substances cause increased expression of cell adhesion molecules by the endothelium of the post capillary venules, ... Mast cells also have the ability to behave as antigen presenting cells, activating T cells and maintaining the duration of the ... "Human leucocyte antigen class II associations in chronic idiopathic urticaria". British Journal of Dermatology. Oxford ... These autoantibodies were found to be capable of activating mast cells and basophils, the key effector cells in urticaria, ...

... adhesion molecules, and other inflammatory mediators. They also reduce synthesis of histamine, stabilize cell membranes, and ... After it binds to the GR in the cytoplasm, the activated corticosteroid-GR complex migrates to the nucleus, where it ... and migration of leukocytes. Neither loteprednol etabonate nor its inactive metabolites Δ1-cortienic acid and Δ1-cortienic acid ... inhibit degranulation of mast cells. Recent work suggests that the activated corticosteroid-GR complex also elicits nongenomic ...

APC affects endothelial cells by inhibiting inflammatory mediator release and down-regulating vascular adhesion molecules. This ... Activated leukocytes release these inflammatory mediators during inflammation, inhibiting the creation of both thrombomodulin ... and it is these cells and leukocytes (white blood cells) that APC affects.: 34 : 3162 Because of the crucial role that protein ... The activated form plays an important role in regulating anticoagulation, inflammation, and cell death and maintaining the ...

... intercellular adhesion molecule continuously present in low concentrations in the membranes of leukocytes and endothelial cells ... ICAM-1 is a ligand for LFA-1 (integrin), a receptor found on leukocytes. When activated, leukocytes bind to endothelial cells ... Frijns CJ, Kappelle LJ (Aug 2002). "Inflammatory cell adhesion molecules in ischemic cerebrovascular disease". Stroke: A ... With the roles of ICAM-1 in cell-cell adhesion, extravasation, and infection more fully understood, a potential role for ICAM-1 ...

... cells SGEF was recruited to the intracellular domain of the transmembrane adhesion molecule ICAM-1 upon leukocyte adhesion to ... that function to activate small G proteins. In their resting state G proteins are bound to guanosine diphosphate (GDP) and ... SGEF is also expressed in endothelial cells of the vasculature. Several widely used cell lines express this protein, these ... Cell. 15 (7): 3309-19. doi:10.1091/mbc.E04-02-0146. PMC 452585. PMID 15133129. Samson et al 2013 "The Guanine-Nucleotide ...

... vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1(ICAM-1), and E-selectin). PARs contribute to the ... For example PAR4 induces leukocyte migration and PAR2 helps macrophages to produce cytokines such as interleukin-8 (IL-8). ... Protease-activated receptor 1 Protease-activated receptor 2 Protease-activated receptor 3 Macfarlane SR, Seatter MJ, Kanke T, ... These findings suggest that TFF3 activates intestinal epithelial cells through G-protein-coupled PAR-2, and could actively ...

2002). "Carcinoembryonic antigen-related cell adhesion molecule 1 expression and signaling in human, mouse, and rat leukocytes ... Skubitz KM, Campbell KD, Skubitz AP (2002). "Synthetic peptides from the N-domains of CEACAMs activate neutrophils". J. Pept. ... Carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) (CEACAM6) also known as CD66c ( ... "Entrez Gene: CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)". Oikawa S ...

Concomitantly they induce local expression of adhesive molecules. Together they increase leukocytes adhesion and extravasation ... Kinin increase vascular permeability by acting on vascular endothelial cells to cause cell contraction. ... Kallikreins activate kinins when stimulated. It is a component of the kinin-kallikrein system. Their precursors are kininogens ... cell differentiation and plant development". Bioactive Natural Products (Part N). Studies in Natural Products Chemistry. Vol. ...

CD11b, as an integrin molecule on the surface of leukocytes, plays an important role in cell migration, adhesion, and ... Once activated, CD11b can bind its ligands with high affinity, e.g., binding of ICAM-1 or ICAM-2 molecules on endothelium and ... and natural killer cells and subsets of T and B cells. It mediates inflammation by regulating leukocyte adhesion and migration ... Stewart M, Thiel M, Hogg N (October 1995). "Leukocyte integrins". Current Opinion in Cell Biology. 7 (5): 690-696. doi:10.1016/ ...

... and changes in the avidity of cell adhesion molecules called integrins. Chemokines and their receptors play a crucial role in ... The subunit called Gα activates an enzyme known as Phospholipase C (PLC) that is associated with the cell membrane. PLC cleaves ... This role of chemokine is strikingly similar to their normal function of localizing leukocytes to an inflammatory site. Human ... This causes cell responses, including the onset of a process known as chemotaxis that traffics the cell to a desired location ...

... and upregulation of cell surface adhesion molecules on epithelial cells to induce leukocyte extravasation. Neutrophils are ... Along with dendritic cells, macrophages help activate natural killer (NK) cells through secretion of type I interferons (IFN-α ... II molecules on their cell surface for T helper cells. Macrophages are not primary activators of naïve T helper cells that have ... TH2 cells secrete IL-4 and IL-13, which activate macrophages to become M2 macrophages, also known as alternatively activated ...

... binding to the intercellular adhesion molecule-1 (ICAM-1). CR3 causes phagocytosis and destruction of cells opsonized with iC3b ... A fully activated neutrophil may express on its membrane 200,000 or more CR3 molecules. Absence of CR3 results in reduced ... polymorphonuclear leukocytes (mostly neutrophils), NK cells, and mononuclear phagocytes like macrophages. CR3 is a pattern ... phagocytosis and other cell-cell interactions in a variety of cells and circumstances. Upregulation of Mac-1 in the presence of ...

Naïve T cells express CCR7 receptor and adhesion molecules L-selectin and LFA-1. As naïve T cells move through the circulation ... T cells need to be activated. T cells become activated by recognising foreign antigens bound to antigen presenting cells (APC ... consisting of a cuboidal morphology and with various receptors to interact with leukocytes (express specialized ligands for ... HEV cells express addressins, which are specific adhesion molecules that attach to the L-selectins on lymphocytes and anchor ...

Selectins are adhesion molecules that facilitate the capture of circulating leukocytes. Sulfatide is also expressed on the ... Type 2 Natural killer T cells are able to recognize sulfatide/ CD1d tetramers, and as a result, they are activated by different ... Macrophages Dendritic cells Hepatocytes B cells Tumour cells Thymocytes Each of these different cell types are expressed in ... There are two types of cell subtypes that interact with CD1d cells: Type 1 Natural killer T cells and Type 2 Natural killer T ...

... cells as well as inducing the production of costimulatory molecules that allow the cell to bind to and activate T cells more ... leading to increased expression of adhesion molecules that recruit leukocytes to infected regions. This causes inflammation in ... and can activate up to 100% of T cells). The large number of activated T-cells generates a massive immune response which is not ... of the body's T-cells are activated, these SAgs are capable of activating up to 20% of the body's T-cells. Furthermore, Anti- ...

... and leukocytes: The inflamed blood vessels specifically express certain receptors, functioning as cell adhesion molecules, like ... Thrombosis and thrombolysis: Activated platelets are major components of blood clots (thrombi). Microbubbles can be conjugated ... Leukocytes possess high adhesion efficiencies, partly due to a dual-ligand selectin-integrin cell arrest system. One ligand: ... and biomimicry of the leukocyte's selectin-integrin cell arrest system, having shown an increased adhesion efficiency, but yet ...

β2 integrins on rolling leukocytes bind endothelial cellular adhesion molecules, arresting cell movement. LFA-1 is found on ... Activated endothelial cells initially express P-selectin molecules, but within two hours after activation E-selectin expression ... Leukocyte extravasation (also commonly known as leukocyte adhesion cascade or diapedesis - the passage of cells through the ... white blood cells). The binding of PSGL-1 on the leukocyte to P-selectin on the endothelial cell allows for the leukocyte to ...

White blood cells are activated by upregulation of integrin avidity, the lipoxygenase pathway and arachidonic acid metabolism. ... C5a is an anaphylatoxin, causing increased expression of adhesion molecules on endothelium, contraction of smooth muscle, and ... C5a also modulates the balance between activating versus inhibitory IgG Fc receptors on leukocytes, thereby enhancing the ... Both C5a and C5a des-Arg can trigger mast cell degranulation, releasing proinflammatory molecules histamine and TNF-α. C5a is ...

It has also been demonstrated that resistin upregulates intercellular adhesion molecule-1 (ICAM1) vascular cell-adhesion ... Inflammation is the first innate immune response to infection or irritation resulting from leukocyte (neutrophils, mast cells, ... nuclear factor kappa-light-chain-enhancer of activated B cells-mediated) fashion. ... In primates, pigs, and dogs, resistin is secreted by immune and epithelial cells, while, in rodents, it is secreted by adipose ...

... and their presentation to specific cell-surface receptors. The binding of versican with leukocyte adhesion molecules L-selectin ... "Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis". Nature. 457 (7225): 102-6. Bibcode: ... large family of cell adhesion molecules) with their cell surface receptors is sterically hindered. Expression of versican is ... Different tenascin domains interact with a wide range of cellular receptors, including integrins, cell adhesion molecules and ...