AU-rich elements Pillars link to original 1986 Cell publication discovering AU-rich elements mRNA Translational blockade by AU- ... rich elements Brief introduction to mRNA regulatory elements ARED: AU-rich element database Transterm page for AU-Rich Element ... Adenylate-uridylate-rich elements (AU-rich elements; AREs) are found in the 3' untranslated region (UTR) of many messenger RNAs ... The best characterised adenylate uridylate (AU)-rich Elements have a core sequence of AUUUA within U-rich sequences (for ...
... is a database of AU-rich elements (ARE) in vertebrate mRNA 3'-untranslated regions (UTRs). AU-rich elements are ... AU, GU, and U-rich elements). AU-rich elements Gruber, Andreas R; Fallmann Jörg; Kratochvill Franz; Kovarik Pavel; Hofacker Ivo ... a database for the comprehensive investigation of AU-rich elements". Nucleic Acids Res. England. 39 (Database issue): D66-69. ... an enhanced database for the comprehensive investigation of AU/GU/U-rich elements". Nucleic Acids Research. 44 (Database issue ...
The presence of AU-rich elements in some mammalian mRNAs tends to destabilize those transcripts through the action of cellular ... Rapid mRNA degradation via AU-rich elements is a critical mechanism for preventing the overproduction of potent cytokines such ... Chen CY, Shyu AB (November 1995). "AU-rich elements: characterization and importance in mRNA degradation". Trends in ... AU-rich elements also regulate the biosynthesis of proto-oncogenic transcription factors like c-Jun and c-Fos. Eukaryotic ...
One group of elements in the 3′-UTR that can help destabilize an mRNA transcript are the AU-rich elements (AREs). These ... UTR contains many alternative AU-rich elements and polyadenylation signals. These cis- and trans-acting elements, along with ... The element that controls this process is called the CPE which is AU-rich and located in the 3′-UTR as well. The CPE generally ... In addition to containing MREs, the 3′-UTR also often contains AU-rich elements (AREs), which are 50 to 150 bp in length and ...
For example, miR16 contains a sequence complementary to the AU-rich element found in the 3'UTR of many unstable mRNAs, such as ... "Involvement of microRNA in AU-rich element-mediated mRNA instability". Cell. 120 (5): 623-34. doi:10.1016/j.cell.2004.12.038. ... Some of the G-rich pre-miRNAs can potentially adopt the G-quadruplex structure as an alternative to the canonical stem-loop ... 87% of the cases are ischemic strokes, which results from blockage in the artery of the brain that carries oxygen-rich blood. ...
MicroRNA-223 selectively targets distinct populations of transcripts harboring AU-rich elements. More specifically, it was ...
CCCH and CCHC zinc fingers bind to an AU-rich RNA element. Different from CCHH zinc figure, the shape of the protein is the ...
A number of such elements have been called AU-rich elements (AREs). It is now known that AREs are binding sites for RNA-binding ... "Functional characterization of a non-AUUUA AU-rich element from the c-jun proto-oncogene mRNA: evidence for a novel class of AU ... Bakheet T, Frevel M, Williams BR, Greer W, Khabar KS (January 2001). "ARED: human AU-rich element-containing mRNA database ... "Protein expression is increased by a class III AU-rich element and tethered CUG-BP1". Biochem. Biophys. Res. Commun. 347 (3): ...
2007). "Human and yeast zeta-crystallins bind AU-rich elements in RNA". Cell. Mol. Life Sci. 64 (11): 1419-27. doi:10.1007/ ...
In the cytoplasm, the exosome interacts with AU-rich element (ARE) binding proteins (e.g. KRSP and TTP), which can promote or ... Several proteins that stabilize or destabilize mRNA molecules through binding to AU-rich elements in the 3' untranslated region ... Lin, WJ; Duffy, A; Chen, CY (2007). "Localization of AU-rich element-containing mRNA in cytoplasmic granules containing exosome ... 2001). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs". Cell. 107 (4): 451-64. doi:10.1016/S0092-8674 ...
HuD is expressed only in neurons and it binds to AU-rich element-containing mRNAs. As a result of this interaction the half- ... Wang X, Tanaka Hall TM (2001). "Structural basis for recognition of AU-rich element RNA by the HuD protein". Nat. Struct. Biol ... 2000). "HuD RNA recognition motifs play distinct roles in the formation of a stable complex with AU-rich RNA". Mol. Cell. Biol ... Lukong, Kiven E.; Chang, Kai-wei; Khandjian, Edouard W.; Richard, Stéphane (2008-08-01). "RNA-binding proteins in human genetic ...
This encoded protein contains 3 RNA-binding domains and binds cis-acting AU-rich elements. One of its best-known functions is ... Chen CY, Xu N, Shyu AB (2002). "Highly selective actions of HuR in antagonizing AU-rich element-mediated mRNA destabilization ... 2000). "HuD RNA recognition motifs play distinct roles in the formation of a stable complex with AU-rich RNA". Mol. Cell. Biol ... 2002). "Novel binding of HuR and poly(C)-binding protein to a conserved UC-rich motif within the 3'-untranslated region of the ...
Mammalian mRNAs contain AU-rich elements (AREs) within their three prime untranslated regions. In yeast, 3-prime-to-5-prime ... Chen CY, Gherzi R, Ong SE, Chan EL, Raijmakers R, Pruijn GJ, Stoecklin G, Moroni C, Mann M, Karin M (November 2001). "AU ... 2002). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs". Cell. 107 (4): 451-64. doi:10.1016/S0092-8674 ...
"The Herpesvirus saimiri small nuclear RNAs recruit AU-rich element-binding proteins but do not alter host AU-rich element- ... "The Herpesvirus saimiri small nuclear RNAs recruit AU-rich element-binding proteins but do not alter host AU-rich element- ... Fan XC, Myer VE, Steitz JA (October 1997). "AU-rich elements target small nuclear RNAs as well as mRNAs for rapid degradation ...
Pioli PA, Hamilton BJ, Connolly JE, Brewer G, Rigby WF (September 2002). "Lactate dehydrogenase is an AU-rich element-binding ... Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD) also known as AU-rich element RNA-binding protein 1 (AUF1) is a protein ... "Entrez Gene: HNRPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)". Mazan-Mamczarz K ... AU-rich element mRNA binding protein (AUF1) and Hu antigen R (HuR), in neoplastic lung tissue". Mol. Carcinog. 28 (2): 76-83. ...
This protein binds to AU rich elements in FOS and IL3/interleukin-3 mRNAs. Microarray analysis of GEO profiles were conducted ...
Pioli PA, Hamilton BJ, Connolly JE, Brewer G, Rigby WF (September 2002). "Lactate dehydrogenase is an AU-rich element-binding ...
... is an RNA binding protein that interacts with AU-rich elements of Bcl-2. Upon binding, MEX3D has a negative regulatory ... a new evolutionarily conserved BCL-2 AU-rich element RNA-binding protein". J. Biol. Chem. 279 (19): 20154-66. doi:10.1074/jbc. ...
... of TNF contains an AU-rich element (ARE). TNF is primarily produced as a 233-amino acid-long type II transmembrane protein ... Rick J, Kuster B, Superti-Furga G (February 2004). "A physical and functional map of the human TNF alpha/NF-kappa B signal ...
Binding of tristetraprolin-related zinc finger proteins to Au-rich elements and destabilization of mRNA". J. Biol. Chem. 275 ( ... TTP binds to AU-rich elements (AREs) in the 3'-untranslated regions (UTRs) of the mRNAs of some cytokines and promotes their ... non-binding tristetraprolin mutants exert an inhibitory effect on degradation of AU-rich element-containing mRNAs". J. Biol. ... Lai WS, Stumpo DJ, Blackshear PJ (1990). "Rapid insulin-stimulated accumulation of an mRNA encoding a proline-rich protein". J ...
"Tristetraprolin and its family members can promote the cell-free deadenylation of AU-rich element-containing mRNAs by poly(A) ... "A novel mRNA-decapping activity in HeLa cytoplasmic extracts is regulated by AU-rich elements". The EMBO Journal. 20 (5): 1134- ... Chen CY, Gherzi R, Ong SE, Chan EL, Raijmakers R, Pruijn GJ, Stoecklin G, Moroni C, Mann M, Karin M (November 2001). "AU ...
2002). "The mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements". EMBO J. 21 (1-2): 165 ... 2002). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs". Cell. 107 (4): 451-64. doi:10.1016/S0092-8674 ...
2006). "Tethering KSRP, a decay-promoting AU-rich element-binding protein, to mRNAs elicits mRNA decay". Mol. Cell. Biol. 26 ( ... Far upstream element-binding protein 2 is a protein that in humans is encoded by the KHSRP gene. GRCh38: Ensembl release 89: ... 2002). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs". Cell. 107 (4): 451-64. doi:10.1016/S0092-8674 ... Davis-Smyth T, Duncan RC, Zheng T, Michelotti G, Levens D (Jan 1997). "The far upstream element-binding proteins comprise an ...
He G, Sun D, Ou Z, Ding A (July 2012). "The protein Zfand5 binds and stabilizes mRNAs with AU-rich elements in their 3'- ...
These mRNAs are GM-CSF, Pth, and TGFβ and each of them have AREs, or AU-rich cis-elements. The ARE binding protein KSRP has a ... Follis, Ariele Viacava; Llambi, Fabien; Merritt, Parker; Chipuk, Jerry E.; Green, Douglas R.; Kriwacki, Richard W. (August 2015 ... Richard (2012-09-01). "Serine phosphorylation and proline isomerization in RNAP II CTD control recruitment of Nrd1". Genes & ...
... functions in AU-rich element-mediated mRNA decay". Molecular and Cellular Biology. 28 (17): 5223-37. doi:10.1128/MCB.00431-08. ...
January 2014). "The favorable IFNL3 genotype escapes mRNA decay mediated by AU-rich elements and hepatitis C virus-induced ... especially in populations of African ancestry in which linkage disequilibrium between these variants is weaker than in other ...
Alcoser SY, Hara M, Bell GI, Ehrmann DA (2004). "Association of the (AU)AT-rich element polymorphism in PPP1R3 with hormonal ...
Lee YS, Choi SL, Jun H, Yim SJ, Lee JA, Kim HF, Lee SH, Shim J, Lee K, Jang DJ, Kaang BK (2012). "AU-rich element-binding ... Lee JA, Kim H, Lee YS, Kaang BK (2003). "Overexpression and RNA interference of Ap-cyclic AMP-response element binding protein- ... he found that multiple pulses of serotonin stimulate gene expression that is mediated by the cAMP-response element (CRE). He ... that serotonin-induced transcription requires the protein kinase-A-mediated phosphorylation of the cAMP-response element- ...
The mammalian exosome is required for rapid degradation of AU rich element-containing RNAs but not for poly(A) shortening. The ... Chen CY, Gherzi R, Ong SE, Chan EL, Raijmakers R, Pruijn GJ, Stoecklin G, Moroni C, Mann M, Karin M (Nov 2001). "AU binding ...