It and 2-quinolone are the two most important parent (meaning simplified) quinolones. 4-Quinolone exists in equilibrium with a ... The hydroxyquinolines tautomerize to the quinolones. Andriole, VT The Quinolones. Academic Press, 1989. Shi, Pengfei; Wang, ... The chemical synthesis of quinolones often involves ring-closing reactions. Such reactions often install a hydroxyl group (an - ... Lili; Chen, Kehao; Wang, Jie; Zhu, Jin (2017). "Co(III)-Catalyzed Enaminone-Directed C-H Amidation for Quinolone Synthesis". ...
... at Curlie Healthcare-associated Infections (HAIs)- Quinolones and the Clinical Laboratory CDC Information ... Although not formally a quinolone, nalidixic acid is considered the first quinolone drug. It was introduced in 1962 for ... Quinolones should also not be given to people with a known hypersensitivity to the drug class. The basic pharmacophore, or ... Quinolones are associated with a small risk of tendonitis and tendon rupture; a 2013 review found the incidence of tendon ...
... is an organic compound related structurally to quinoline. It is the majority tautomer in equilibrium with 2- ... Media related to 2-Quinolone at Wikimedia Commons (Use dmy dates from December 2021, Articles without InChI source, ECHA ... The isomer 4-quinolone is the parent of a large class of quinolone antibiotics. One example is Ravesilone. Tashima, Toshihiko ( ...
Committee on Safety of Medicines; Medicines and Healthcare products Regulatory Agency (2008). "Quinolones". United Kingdom: ... 178 (4): 317-24. doi:10.1192/bjp.178.4.317. PMID 11282810. De Gier, N.; Gorgels, W.; Lucassen, P.; Oude Voshaar, R.; Mulder, J ... 158 (4): 511-6. doi:10.1192/bjp.158.4.511. PMID 1675901. S2CID 10998674. Curran, H. V.; Bond, A.; O'Sullivan, G.; Bruce, M.; ... The consensus is to reduce dosage gradually over several weeks, e.g. 4 or more weeks for diazepam doses over 30 mg/day, with ...
... may refer to: 2-Quinolone 4-Quinolone Quinolone antibiotics This set index article lists chemical compounds articles ...
Some quinolones exert an inhibitory effect on the cytochrome P-450 system, thereby reducing theophylline clearance and ... Quinolones, including norfloxacin, may enhance the effects of oral anticoagulants, including warfarin or its derivatives or ... The toxicity of drugs that are metabolised by the cytochrome P450 system is enhanced by concomitant use of some quinolones. ... The first members of the quinolone antibacterial class were relatively low potency drugs such as nalidixic acid, used mainly in ...
... is a quinolone antibiotic used to treat bacterial infections. Pefloxacin has not been approved for use in the United ... Casparian JM, Luchi M, Moffat RE, Hinthorn D (May 2000). "Quinolones and tendon ruptures". South. Med. J. 93 (5): 488-91. doi: ... Drlica K, Zhao X (1 September 1997). "DNA gyrase, topoisomerase IV, and the 4-quinolones". Microbiol Mol Biol Rev. 61 (3): 377- ... 4-di-hydro-7-(1-piperazinyl)-4-oxo-3-quinolinecarboxylic acids, Fluoroquinolone antibiotics, Piperazines). ...
Quinolones Alksne L (February 2003). "Balofloxacin Choongwae". Current Opinion in Investigational Drugs. 4 (2): 224-9. PMID ...
Appelbaum PC (1999). "Quinolone activity against anaerobes". Drugs. 58 Suppl 2: 60-4. doi:10.2165/00003495-199958002-00012. ... Rubinstein E (2001). "History of quinolones and their side effects". Chemotherapy. 47 Suppl 3 (3): 3-8, discussion 44-8. doi: ... Nord CE (1999). "Use of newer quinolones for the treatment of intraabdominal infections: focus on clinafloxacin". Infection. 27 ...
Commonly referred to as the first generation quinolones. This first generation also included other quinolone drugs such as ... Cinoxacin is a quinolone antibiotic that has been discontinued in the U.K. as well the United States, both as a branded drug or ... Cinoxacin was an older synthetic antimicrobial related to the quinolone class of antibiotics with activity similar to oxolinic ... Przybilla B, Georgii A, Bergner T, Ring J (1990). "Demonstration of quinolone phototoxicity in vitro". Dermatologica. 181 (2): ...
... and the 4-quinolones". Microbiol. Mol. Biol. Rev. 61 (3): 377-92. doi:10.1128/mmbr.61.3.377-392.1997. PMC 232616. PMID 9293187 ...
Peterson U (2006). "Quinolone Antibiotics: The Development of Moxifloxacin". In Fischer J, Ganellin CR (eds.). Analogue-based ... Ziv A, Masarwa R, Perlman A, Ziv D, Matok I (March 2018). "Pregnancy Outcomes Following Exposure to Quinolone Antibiotics - a ... Exposure of the developing fetus to quinolones, including levofloxacin, during the first-trimester is not associated with an ... any member of the quinolone class of antimicrobial agents, or any of the product components." Though not stated as such within ...
... is a quinolone antibiotic useful for the treatment of a number of bacterial infections. When taken by mouth or ... quinolones for community-acquired pneumonia: meta-analysis of randomized controlled trials". Clinical Microbiology and ... Atarashi S. "Research and Development of Quinolones in Daiichi Sankyo Co., Ltd" (PDF). Daiichi. Archived from the original (PDF ... Simultaneous use of corticosteroids is present in almost one-third of quinolone-associated tendon rupture. Tendon damage may ...
Although quinolones are highly toxic to mammalian cells in culture, its mechanism of cytotoxic action is not known. Quinolone ... Flumequine is the first quinolone compound with a fluorine atom at the C6-position of the related quinolone basic molecular ... Significant and harmful residues of quinolones have been found in animals treated with quinolones and later slaughtered and ... The quinolones (Third Edition 2000) By Vincent T. Andriole Chapter I History and overview By Dr. Peter Ball (page 5) King DE, ...
Like all quinolones, it functions by inhibiting the DNA gyrase and topoisomerase IV, two bacterial type IIA topoisomerases. ... Exposure to quinolones, including levofloxacin, during the first-trimester is not associated with an increased risk of ... Ziv A, Masarwa R, Perlman A, Ziv D, Matok I (March 2018). "Pregnancy Outcomes Following Exposure to Quinolone Antibiotics - a ... Atarashi S. "Research and Development of Quinolones in Daiichi Sankyo Co" (PDF). Archived from the original (PDF) on 12 October ...
Ruiz J, Pons MJ, Gomes C (September 2012). "Transferable mechanisms of quinolone resistance". International Journal of ... 72 (4): 387-98. doi:10.5935/0305-7518.20010054. PMID 11826475. Rosengarten R, Citti C, Glew M, Lischewski A, Droesse M, Much P ... 55 (4): 301-11. doi:10.1007/s11427-012-4310-2. PMID 22566086. Clarke JT, Lloyd GT, Friedman M (October 2016). "Little evidence ... 4 (2): e4603. Bibcode:2009PLoSO...4.4603X. doi:10.1371/journal.pone.0004603. PMC 2643483. PMID 19240804. Knowles DG, McLysaght ...
QnrA was the first known plasmid-mediated gene associated in quinolone resistance.Quinolone resistance genes are frequently ... Poirel L, Rodriguez-Martinez JM, Mammeri H, Liard A, Nordmann P (August 2005). "Origin of plasmid-mediated quinolone resistance ... 18 June 2019). "Distribution of quinolone resistance gene (qnr) in ESBL-producing Escherichia coli and Klebsiella spp. in Lomé ... Strahilevitz J, Jacoby GA, Hooper DC, Robicsek A (October 2009). "Plasmid-mediated quinolone resistance: a multifaceted threat ...
6). Quinolone antibacterial compounds were first developed in the 1960s and have been in clinical use since the 1980s. FQ ... Maxwell A, Bush NG, Germe T, McKie SJ (2018). "Non-quinolone topoisomerase inhibitors". In Fong IW, Drlica K (eds.). ... Bush NG, Diez-Santos I, Abbott LR, Maxwell A (December 2020). "Quinolones: Mechanism, Lethality and Their Contributions to ... 4: 5-20. Fuller FB (April 1971). "The writhing number of a space curve". Proceedings of the National Academy of Sciences of the ...
Quinolones are effective if the organism is sensitive, but high rates of quinolone use in livestock mean that quinolones are ... Fàbrega A, Sánchez-Céspedes J, Soto S, Vila J (2008). "Quinolone resistance in the food chain". Int J Antimicrob Agents. 31 (4 ... 4 (9): e1000203. doi:10.1371/journal.pgen.1000203. PMC 2538567. PMID 18818764. "Campylobacter". Health Topics A TO Z. Retrieved ... Retrieved 4 February 2019. Mitchell, Charlie (13 March 2020). "Schools, hospital among providers of drinking water that's not ...
As quinolones are known to induce arthropathy in juvenile animals, administration of the drug to breast-feeding women cannot be ... Fleroxacin is a quinolone antibiotic. It is sold under the brand names Quinodis and Megalocin. Fleroxacin is a bactericidal ... Like other quinolones and fluoroquinolones the compound eradicates bacteria by interfering with DNA replication (bacterial DNA ... Yoshida H, Nakamura M, Bogaki M, Ito H, Kojima T, Hattori H, Nakamura S (April 1993). "Mechanism of action of quinolones ...
The quinolone is also active against Gram-negative bacteria After oral administration enoxacin is rapidly and well absorbed ... Yoshida H, Nakamura M, Bogaki M, Ito H, Kojima T, Hattori H, Nakamura S (April 1993). "Mechanism of action of quinolones ... De Sarro A, Zappalá M, Chimirri A, Grasso S, De Sarro GB (July 1993). "Quinolones potentiate cefazolin-induced seizures in DBA/ ... Quinolones and fluoroquinolones are bactericidal drugs, eradicating bacteria by interfering with DNA replication. Like other ...
Allocation of metabolic pathways to isoforms and inhibitory effects of quinolones". Toxicology. 82 (1-3): 169-89. doi:10.1016/ ... 74 (4): 980-9. doi:10.1124/mol.108.048207. PMID 18621927. S2CID 14842240. Graham TE, Rush JW, van Soeren MH (June 1994). " ...
... (COR-167) is a drug which acts as a potent and selective cannabinoid CB2 receptor agonist, based on a quinolone-3- ... August 2008). "Investigations on the 4-quinolone-3-carboxylic acid motif. 2. Synthesis and structure-activity relationship of ... August 2010). "Investigations on the 4-quinolone-3-carboxylic acid motif. 3. Synthesis, structure-affinity relationships, and ... 4-Quinolones, Carboxamides, Enones, All stub articles, Cannabinoid stubs). ...
Brook I, Ledney D (1992). "Quinolone therapy in the management of infection after irradiation". Crit Rev Microbiol. 18 (4): ... Empirical regimens contain antibiotics broadly active against Gram-negative aerobic bacteria (quinolones: i.e., ciprofloxacin, ... 37 (2-4). ISBN 978-0-7020-3048-2. Archived from the original on 16 November 2012. Retrieved 17 May 2012. The Effects of Nuclear ... Vomiting in this time-frame is a marker for whole body exposures that are in the fatal range above 4 grays (400 rad). Without ...
Quinolones and fluoroquinolones are bactericidal drugs, eradicating bacteria by interfering with DNA replication. Quinolones ... "As with other quinolones, exposure to the sun or ultra-violet rays may cause phototoxicity reactions in patients treated with ... Quinolones inhibit the bacterial DNA gyrase or the topoisomerase IV enzyme, thereby inhibiting DNA replication and ... Quinolone Nelson JM, Chiller TM, Powers JH, Angulo FJ (2007). "Food Safety: Fluoroquinolone‐Resistant Campylobacter Species and ...
Because of the similarity of these to the reagents in the Friedlander quinolone synthesis, a benzaldehyde with an aldehyde or ... quinolones and their annulation reactions". Tetrahedron Letters. 42 (13): 2553-2555. doi:10.1016/S0040-4039(01)00231-3.{{cite ... 40 (4): 4285-4294. doi:10.1002/cber.19070400444. Hartz, pp. 376-384 Manske, R. H. (1942). "The Chemistry of Quinolines". Chem. ... 5 (4): 145-193. doi:10.1080/00304947309355565. Rosini, M.; Anontello, A.; Cavalli, A.; Bolognesi, M.; Minarini, A.; Marucci, G ...
In medicine, the most interesting are quinolones, already a class of widely used antibiotics. Some plant metabolites are also ... 30 (4): 463-470. doi:10.1111/sum.12142. S2CID 97961385. Marsh KL, Sims GK, Mulvaney RL (November 2005). "Availability of urea ... doi:10.1016/S0010-8545(99)00093-4. Benini S, Rypniewski WR, Wilson KS, Miletti S, Ciurli S, Mangani S (31 January 1999). "A new ... 13 (4): 250-7. PMID 2517764. Prakash O, Bhushan G (January 1997). "Isolation, purification and partial characterisation of ...
Poisons of type II topoisomerases include doxorubicin, etoposide, novobiocin, quinolones (including ciprofloxacin), and ... that renders quinolones ineffective.[citation needed] Recent structural studies have led to the discovery of a compound that no ... 14 (4): 860-71. doi:10.1128/JVI.14.4.860-871.1974. PMC 355592. PMID 4609406. Hyman P (August 1993). "The genetics of the Luria- ... 106 (4): 963-81. doi:10.1016/0022-2836(76)90346-6. PMID 789903. Mufti S, Bernstein H (October 1974). "The DNA-delay mutants of ...
68 (4): 500-4. doi:10.1139/y90-071. PMID 2328452. Schmidt NO, Ziu M, Cargioli T, Westphal M, Giese A, Black PM, Carroll RS ( ... 74 (4): 455-9. doi:10.1002/jps.2600740417. PMID 4039755. Wynalda MA, Liggett WF, Fitzpatrick FA (August 1983). "Sodium 5-(3'- ... Lager E, Nilsson J, Østergaard Nielsen E, Nielsen M, Liljefors T, Sterner O (July 2008). "Affinity of 3-acyl substituted 4- ... quinolones at the benzodiazepine site of GABA(A) receptors". Bioorganic & Medicinal Chemistry. 16 (14): 6936-48. doi:10.1016/j. ...
140 (4): 403-405. doi:10.1007/s10517-005-0503-z. PMID 16671565. S2CID 13179025. He Y, Benz A, Fu T, Wang M, Covey DF, Zorumski ... 26 (4): 760-774. doi:10.1016/j.jmgm.2007.04.012. PMID 17544304. Miller PS, Aricescu AR (August 2014). "Crystal structure of a ... 67 (4): 310-318. doi:10.1016/j.brainresbull.2005.07.004. PMID 16182939. S2CID 6433030. Yarom M, Tang XW, Wu E, Carlson RG, ... 4 (5): 759-765. doi:10.1016/0896-6273(90)90202-Q. PMID 2160838. S2CID 12626366.; (j) Majewska MD, Harrison NL, Schwartz RD, ...