2',3'-Cyclic-nucleotide 3'-phosphodiesterase
Nov 2003). "Structural evidence that brain cyclic nucleotide phosphodiesterase is a member of the 2H phosphodiesterase ... selectively activates the calcium-calmodulin sensitive isoform of cyclic nucleotide phosphodiesterase from human myometrium". ... "Purification to homogeneity and general properties of a novel phosphodiesterase hydrolyzing cyclic CMP and cyclic AMP". The ... "A homogeneous cyclic CMP phosphodiesterase hydrolyzes both pyrimidine and purine cyclic 2':3'- and 3':5'-nucleotides". The ...
2',3'-cyclic-nucleotide 2'-phosphodiesterase
... cyclic nucleotide phosphodiesterase:3'-nucleotidase. This enzyme participates in purine metabolism and pyrimidine metabolism. ... Anraku Y (1964). "A new cyclic phosphodiesterase having a 3′-nucleotidase activity from Escherichia coli B. I. purification and ... Anraku Y (1964). "A new cyclic phosphodiesterase having a 3′-nucleotidase activity from Escherichia coli B. II. Further studies ... Center MS, Behal FJ (1968). "A cyclic phosphodiesterase with 3′-nucleotidase activity from Proteus mirabilis". J. Biol. Chem. ...
Phosphodiesterase 2
"Biologic regulation through opposing influences of cyclic GMP and cyclic AMP: the Yin Yang hypothesis". Adv Cyclic Nucleotide ... June 1997). "cGMP-stimulated cyclic nucleotide phosphodiesterase regulates the basal calcium current in human atrial myocytes ... Bender AT, Beavo JA (September 2006). "Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use". Pharmacol. ... cyclic nucleotide phosphodiesterase (PDE2) on guinea pig left atria in eu- and hyperthyroidism" (PDF). Gen Physiol Biophys. 22 ...
3',5'-cyclic-AMP phosphodiesterase
Johner A, Kunz S, Linder M, Shakur Y, Seebeck T (March 2006). "Cyclic nucleotide specific phosphodiesterases of Leishmania ... "Characterization of cyclic nucleotide phosphodiesterase isoforms associated to isolated cardiac nuclei". Biochimica et ... cyclic-AMP phosphodiesterase (EC 3.1.4.53, cAMP-specific phosphodiesterase, cAMP-specific PDE, PDE1, PDE2A, PDE2B, PDE4, PDE7, ... cyclic-AMP+phosphodiesterase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (Articles ...
Paraxanthine
Essayan DM (November 2001). "Cyclic nucleotide phosphodiesterases". The Journal of Allergy and Clinical Immunology. 108 (5): ... Paraxanthine is a selective inhibitor of cGMP-preferring phosphodiesterase (PDE9) activity and is hypothesized to increase ... Paraxanthine is a competitive nonselective phosphodiesterase inhibitor which raises intracellular cAMP, activates PKA, inhibits ... Paraxanthine is a phosphodiesterase type 9 (PDE9) inhibitor and it is sold as a research molecule for this same purpose. ...
Cyclic guanosine monophosphate
Numerous cyclic nucleotide phosphodiesterases (PDE) can degrade cGMP by hydrolyzing cGMP into 5'-GMP. PDE 5, -6 and -9 are cGMP ... Cyclic guanosine monophosphate (cGMP) is a cyclic nucleotide derived from guanosine triphosphate (GTP). cGMP acts as a second ... cyclic monophosphate (8-Br-cGMP) Francis SH, Corbin JD (August 1999). "Cyclic nucleotide-dependent protein kinases: ... Brown RL, Strassmaier T, Brady JD, Karpen JW (2006). "The pharmacology of cyclic nucleotide-gated channels: emerging from the ...
Cyclic nucleotide
cAMP's role in this process terminates upon hydrolysis to AMP by phosphodiesterase. Cyclic nucleotides are well-suited to act ... The two most well-studied cyclic nucleotides are cyclic AMP (cAMP) and cyclic GMP (cGMP), while cyclic CMP (cCMP) and cyclic ... A cyclic nucleotide (cNMP) is a single-phosphate nucleotide with a cyclic bond arrangement between the sugar and phosphate ... Finally, cyclic nucleotides can be distinguished from non-cyclic nucleotides because they are smaller and less polar. The ...
EHNA
"Isozyme selective inhibition of cGMP-stimulated cyclic nucleotide phosphodiesterases by erythro-9-(2-hydroxy-3-nonyl) adenine ... adenine inhibits cyclic GMP-stimulated phosphodiesterase in isolated cardiac myocytes". Molecular Pharmacology. 48 (1): 121-30 ... which also acts as a phosphodiesterase inhibitor that selectively inhibits phosphodiesterase type 2 (PDE2). "Sigma Aldrich". ... EHNA (erythro-9-(2-hydroxy-3-nonly)adenine) is a potent adenosine deaminase inhibitor, ...
Tubulin alpha-1A chain
Cyclic nucleotide 3'-phosphodiesterase: a membrane-bound, microtubule-associated protein and membrane anchor for tubulin". ... 3 (10): 1738-1739, 1742. doi:10.1128/mcb.3.10.1738. PMC 370035. PMID 6646120. Mill, F. D.; Naus, C. C.; Durand, M.; Bloom, F. E ... 3.0.CO;2-L. PMID 9722999. Oakley BR (December 2000). "An abundance of tubulins". Trends in Cell Biology. 10 (12): 537-42. doi: ... 105 (6 Pt 2): 3065-73. doi:10.1083/jcb.105.6.3065. PMC 2114727. PMID 3693406. Cowan NJ, Dobner PR, Fuchs EV, Cleveland DW ( ...
PDE1A
Lefièvre L, de Lamirande E, Gagnon C (2003). "Presence of cyclic nucleotide phosphodiesterases PDE1A, existing as a stable ... cyclic nucleotide phosphodiesterase 1A is an enzyme that in humans is encoded by the PDE1A gene. GRCh38: Ensembl release 89: ... cyclic nucleotide phosphodiesterases". J Biol Chem. 271 (2): 796-806. doi:10.1074/jbc.271.2.796. PMID 8557689. Michibata H, ... "Entrez Gene: PDE1A phosphodiesterase 1A, calmodulin-dependent". Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and ...
PDE1C
2007). "Cyclic nucleotide phosphodiesterase PDE1C1 in human cardiac myocytes". J. Biol. Chem. 282 (45): 32749-57. doi:10.1074/ ... Rybalkin SD, Rybalkina I, Beavo JA, Bornfeldt KE (2002). "Cyclic nucleotide phosphodiesterase 1C promotes human arterial smooth ... cyclic nucleotide phosphodiesterase 1C is an enzyme that in humans is encoded by the PDE1C gene. GRCh38: Ensembl release 89: ... cyclic nucleotide phosphodiesterases". J Biol Chem. 271 (2): 796-806. doi:10.1074/jbc.271.2.796. PMID 8557689. "Entrez Gene: ...
GAL3ST1
... cyclic nucleotide 3'-phosphodiesterase, and myelin proteins in rat forebrain subfractions during development". Neurochem. Res. ... 119 (3): 421-7. doi:10.1093/oxfordjournals.jbchem.a021258. PMID 8830034. Tsuda M, Egashira M, Niikawa N, et al. (2000). "Cancer ... 264 (2): 1252-9. doi:10.1016/S0021-9258(19)85079-2. PMID 2562955. Fleischer B, Zambrano F (1973). "Localization of cerebroside- ... 52 (3): 951-8. doi:10.1016/0006-291X(73)91029-2. PMID 4710574. Farrell DF, McKhann GM (1971). "Characterization of cerebroside ...
Phosphodiesterase
"Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling". ... Usually, phosphodiesterase refers to cyclic nucleotide phosphodiesterases, which have great clinical significance and are ... "Differential activation and inhibition of the multiple forms of cyclic nucleotide phosphodiesterase". Advances in Cyclic ... as well as numerous less-well-characterized small-molecule phosphodiesterases. The cyclic nucleotide phosphodiesterases ...
David Fell (biochemist)
Fell, David A. (1980). "Theoretical analyses of the functioning of the high- and low-Km cyclic nucleotide phosphodiesterases in ... and low-Km cyclic nucleotide phosphodiesterases on the regulation of adenosine 3',5'-cyclic monophosphate (cAMP) From the early ... cyclic monophosphate in animal cells". Journal of Theoretical Biology. 84 (2): 361-385. doi:10.1016/s0022-5193(80)80011-7. ISSN ... El-Yassin, D I; Fell, D A; Lloyd, B B; Fisher, R B (1979). "The breakdown of 2,3-bis(phospho)-D-glycerate by Fe(III)- ...
List of MeSH codes (D08)
... cyclic-nucleotide phosphodiesterase MeSH D08.811.277.352.640.160 - 2',3'-cyclic-nucleotide phosphodiesterases MeSH D08.811. ... cyclic nucleotide-regulated protein kinases MeSH D08.811.913.696.620.682.700.150.125 - cyclic amp-dependent protein kinases ... cyclic-GMP phosphodiesterase MeSH D08.811.277.352.640.150 - 3',5'- ... cyclic gmp-dependent protein kinases MeSH D08.811.913.696.620.682.700.150.575 - protamine kinase MeSH D08.811.913.696.620.682. ...
IL18BP
... cyclic nucleotide phosphodiesterases". J. Biol. Chem. 271 (2): 796-806. doi:10.1074/jbc.271.2.796. PMID 8557689. Aizawa Y, ... 2001). "Human Ca2+/calmodulin-dependent phosphodiesterase PDE1A: novel splice variants, their specific expression, genomic ... 60 Suppl 3 (Suppl 3): iii18-24. doi:10.1136/ard.60.90003.iii18. PMC 1766679. PMID 11890646. Loughney K, Martins TJ, Harris EA, ... 1517 (2): 278-87. doi:10.1016/s0167-4781(00)00293-1. PMID 11342109. Paulukat J, Bosmann M, Nold M, et al. (2001). "Expression ...
PDE4D
"Myomegalin is a novel protein of the golgi/centrosome that interacts with a cyclic nucleotide phosphodiesterase". The Journal ... "Myomegalin is a novel protein of the golgi/centrosome that interacts with a cyclic nucleotide phosphodiesterase". The Journal ... Zhang HT (2009). "Cyclic AMP-specific phosphodiesterase-4 as a target for the development of antidepressant drugs". Current ... Némoz G, Zhang R, Sette C, Conti M (Apr 1996). "Identification of cyclic AMP-phosphodiesterase variants from the PDE4D gene ...
CNP
Cyclic-nucleotide 3'-phosphodiesterase, a myelin-associated enzyme that makes up 4% of total CNS myelin protein Chronic ... a proposed class of living organisms smaller than the accepted lower limit size for life 2',3'- ...
P19 cell
Cyclic-nucleotide 3'-phosphodiesterase. Moreover, oligodendrocytes also developed and migrated into fiber bundles in mice when ... 560 (1-3): 192-8. doi:10.1016/S0014-5793(04)00086-9. PMID 14988021. Tan, Y; Xie, Z; Ding, M; Wang, Z; Yu, Q; Meng, L; Zhu, H; ... 137 (2): 740-5. PMC 218351. PMID 370098. van der Heyden, MA; Defize, LH (2003-05-01). "Twenty one years of P19 cells: what an ... 3 (12): 2271-9. doi:10.1128/mcb.3.12.2271. PMC 370098. PMID 6656766. McBurney, MW; Reuhl, KR; Ally, AI; Nasipuri, S; Bell, JC; ...
Oligodendrocyte
Cyclic-nucleotide 3'-phosphodiesterase (CNPase) List of distinct cell types in the adult human body List of human cell types ... 115 (2): 535-51. doi:10.1242/dev.115.2.535. PMID 1425339. Yokoo H, Nobusawa S, Takebayashi H, Ikenaka K, Isoda K, Kamiya M, ... 5 (3): 180-9. doi:10.1016/s1071-9091(98)80033-8. PMID 9777676. Káradóttir et al., 2007 Tkachev D, Mimmack ML, Ryan MM, et al. ( ... 81 (2): 871-927. doi:10.1152/physrev.2001.81.2.871. ISSN 0031-9333. PMID 11274346. Richardson, WD; Kessaris, N; Pringle, N (Jan ...
List of EC numbers (EC 3)
... cyclic-nucleotide phosphodiesterase EC 3.1.4.18: Now EC 3.1.16.1, spleen exonuclease EC 3.1.4.19: Now EC 3.1.13.3, ... phosphodiesterase * EC 3.1.4.59: cyclic-di-AMP phosphodiesterase * EC 3.1.4.60: pApA phosphodiesterase * EC 3.1.4.61: cyclic 2, ... glucose-1-phospho-D-mannosylglycoprotein phosphodiesterase EC 3.1.4.52: cyclic-guanylate-specific phosphodiesterase EC 3.1.4.53 ... cyclic-GMP phosphodiesterase EC 3.1.4.36: Now with EC 3.1.4.43 EC 3.1.4.37: 2′,3′-cyclic-nucleotide 3'-phosphodiesterase EC 3.1 ...
Myelin basic protein
... cyclic-nucleotide 3'-phosphodiesterase and multiple molecules of the immune system. GRCh38: Ensembl release 89: ENSG00000197971 ... 3 (3): 96-9. doi:10.4024/18SH03R.jbpc.03.03. Media related to Myelin basic proteins at Wikimedia Commons Overview of all the ... 53 (2): 189-197. doi:10.1002/ana.10425. PMID 12557285. S2CID 43317994. Namer IJ, Steibel J, Poulet P, Armspach JP, Mohr M, ... The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that ...
Etazolate
... nucleotide phosphodiesterases". Biochemical Pharmacology. 21 (18): 2443-50. doi:10.1016/0006-2952(72)90414-5. PMID 4345859. ... a potent new inhibitor of cyclic 3',5'- ... and as a phosphodiesterase inhibitor selective for the PDE4 ... and characterization of human cAMP-specific phosphodiesterase (PDE4) subtypes A, B, C, and D". Biochemical and Biophysical ... ISBN 3-540-66127-1. Progress in Drug Research / Volume 31 (Progress in Drug Research). Boston: Birkhauser. 1987. p. 526. ISBN 3 ...
Rajendra Kumar Sharma
"Differential regulation of bovine brain calmodulin dependent cyclic nucleotide phosphodiesterase isozyme by cyclic AMP- ... Sharma, RK; Wirch, E; Wang, JH (May 25, 1978). "Inhibition of Ca2+-activated cyclic nucleotide phosphodiesterase reaction by a ... "Mechanism of activation of cyclic nucleotide phosphodiesterase: requirement of the binding of four Ca2+ to calmodulin for ... "Demonstration of bovine brain calmodulin dependent cyclic nucleotide phosphodiesterase isozymes by monoclonal antibodies". J ...
PDE2A
... cyclic nucleotide phosphodiesterase". Gene. 191 (1): 89-95. doi:10.1016/S0378-1119(97)00046-2. PMID 9210593. "Entrez Gene: ... Sadhu K, Hensley K, Florio VA, Wolda SL (1999). "Differential expression of the cyclic GMP-stimulated phosphodiesterase PDE2A ... cyclic phosphodiesterase is an enzyme that in humans is encoded by the PDE2A gene. GRCh38: Ensembl release 89: ENSG00000186642 ... PDE2A phosphodiesterase 2A, cGMP-stimulated". Witzenrath M, Gutbier B, Schmeck B, et al. (2005). "Phosphodiesterase 2 ...
Nidovirales
... phosphate phosphatase activities and cyclic nucleotide phosphodiesterase.[citation needed] The order Nidovirales can be divided ... Nidoviruses are named for the Latin nidus, meaning nest, as all viruses in this order produce a 3' co-terminal nested set of ... The structural proteins are encoded at the 3' region of the genome and are expressed from a set of subgenomic mRNAs.[citation ... Gulyaeva, Anastasia A.; Gorbalenya, Alexander E. (January 2021). "A nidovirus perspective on SARS-CoV-2". Biochemical and ...
Emoxypine
Modulates the activity of membrane-bound enzymes: phosphodiesterase, cyclic nucleotides, adenylate cyclase, aldoreductase, ... Emoxypine (2-ethyl-6-methyl-3-hydroxypyridine), also known as Mexidol or Mexifin when used as the succinate salt, is an ... 3: 100121. doi:10.1016/j.crphar.2022.100121. PMC 9389226. PMID 35992374. Dumayev KM, Voronina TA, Smirnov LD (1995). ... Gruber W (1953). "Synthesis of 3-Hydroxy-2-alkylpyridines". Canadian Journal of Chemistry. 31 (6): 564-568. doi:10.1139/v53-079 ...
Phosphodiesterase 3
September 2003). "Cyclic nucleotide phosphodiesterase activity, expression, and targeting in cells of the cardiovascular system ... Lugnier C (March 2006). "Cyclic nucleotide phosphodiesterase (PDE) superfamily: a new target for the development of specific ... WO 03012030, Movsesian M, "Isoform-Selective Inhibitors and Activators of PDE3 Cyclic Nucleotide Phosphodiesterases", published ... Oocyte maturation inhibitor Bender AT, Beavo JA (September 2006). "Cyclic nucleotide phosphodiesterases: molecular regulation ...
PDE11A
Yuasa K, Ohgaru T, Asahina M, Omori K (2001). "Identification of rat cyclic nucleotide phosphodiesterase 11A (PDE11A): ... Beavo JA, Conti M, Heaslip RJ (1994). "Multiple cyclic nucleotide phosphodiesterases". Mol. Pharmacol. 46 (3): 399-405. PMID ... cyclic nucleotide phosphodiesterase 11A: localization in human tissues". Int. J. Impot. Res. 17 (4): 320-5. doi:10.1038/sj.ijir ... cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and ...
Theobromine
Compared with caffeine, theobromine is weaker in both its inhibition of cyclic nucleotide phosphodiesterases and its antagonism ... Essayan DM (November 2001). "Cyclic nucleotide phosphodiesterases". The Journal of Allergy and Clinical Immunology. 108 (5): ... The potential phosphodiesterase inhibitory effect of theobromine is seen only at amounts much higher than what people normally ... Its effect as a phosphodiesterase inhibitor is thought to be small. Theobromine has no significant stimulant effect on the ...