*  USFDA approves Zelboraf (vemurafenib) for Erdheim-Chester disease | PharmaTutor
... has approved Zelboraf® (vemurafenib) for Erdheim-Chester disease (ECD) with BRAF V600 mutation. ... Home » USFDA approves Zelboraf (vemurafenib) for Erdheim-Chester disease. USFDA approves Zelboraf (vemurafenib) for Erdheim- ... Roche announced that the US Food and Drug Administration (FDA) has approved Zelboraf® (vemurafenib) for Erdheim-Chester disease ... "This FDA decision means people living with Erdheim-Chester disease will now, for the first time, have an FDA-approved treatment ...
  http://www.pharmatutor.org/pharma-news/2017/usfda-approves-zelboraf-vemurafenib-for-erdheim-chester-disease
*  FDA Grants Priority Review and Breakthrough Therapy Designation for Zelboraf (vemurafenib) in Erdheim-Chester Disease with BRAF...
About Erdheim-Chester Disease Erdheim-Chester disease (ECD) is an extremely rare non-Langerhans cell histiocytosis. The exact ... in Erdheim-Chester Disease with BRAF V600 Mutation - There are currently no FDA-approved treatments for Erdheim-Chester disease ... diseases and hope to see Zelboraf approved for Erdheim-Chester disease as soon as possible." ... granted Priority Review for Zelboraf® (vemurafenib) for Erdheim-Chester disease (ECD) with BRAF V600 mutation. ECD is a rare, ...
  https://www.enhancedonlinenews.com/news/eon/20170807005359/en
*  FDA approves first treatment Zelboraf (vemurafenib)for certain patients with Erdheim-Chester Disease, a rare blood cancer « New...
... to include the treatment of certain adult patients with Erdheim-Chester Disease (ECD), a rare cancer of the blood. Zelboraf is ... Food and Drug Administration today expanded the approval of Zelboraf (vemurafenib) ... FDA approves first treatment for certain patients with Erdheim-Chester Disease, a rare blood cancer The U.S. ... Tags: Erdheim-Chester Disease, FDA 2017, vemurafenib, Zelboraf. By DR ANTHONY MELVIN CRASTO Ph.D in FDA 2017 on November 7, ...
  https://newdrugapprovals.org/2017/11/07/fda-approves-first-treatment-zelboraf-vemurafenibfor-certain-patients-with-erdheim-chester-disease-a-rare-blood-cancer/
*  Most Popular | Managed Care magazine
FDA Approves Zelboraf for Erdheim-Chester Disease The FDA has approved vemurafenib (Zelboraf, Genentech) for Erdheim-Chester ... ECD is a rare, serious blood disease characterized by the abnormal multiplication of white blood cells called histiocytes, ... Acorda Therapeutics, Inc., is discontinuing clinical development of its Parkinson's disease treatment tozadenant after five ... of Alzheimer's disease. The study was supported by the National… ...
  http://www.managedcaremag.com/popular/all?page=9&%3Bdestination=popular%2Fall%3Fpage%3D5
*  Most Popular | Managed Care magazine
FDA Approves Zelboraf for Erdheim-Chester Disease The FDA has approved vemurafenib (Zelboraf, Genentech) for Erdheim-Chester ... ECD is a rare, serious blood disease characterized by the abnormal multiplication of white blood cells called histiocytes, ... of Alzheimer's disease. The study was supported by the National… ...
  http://managedcaremag.com/popular/today?page=9&%3Bamp%3Bdestination=popular%2Ftoday%3Fpage%3D3
*  Medical Xpress - kinases
Diseases, Conditions, Syndromes Zelboraf approved for use in Erdheim-Chester disease. (HealthDay)-Zelboraf (vemurafenib) has ... Food and Drug Administration as the first drug to treat certain adults patients with Erdheim-Chester disease (ECD). ... New therapeutic approach for advanced lung disease. Researchers have demonstrated the potential of a new class of drugs for the ... treatment of refractory chronic obstructive pulmonary disease (COPD). Incurable to date, the disease is one of the most ...
  https://medicalxpress.com/tags/kinases/
*  ZELBORAF (Vemurafenib) dosage, indication, interactions, side effects | EMPR - The Clinical Advisor
ZELBORAF (Vemurafenib) drug information & product resources from MPR including dosage information, educational materials, & ... Indications for ZELBORAF:. Erdheim-Chester Disease (ECD) with BRAF V600 mutation. Adult:. Swallow whole. ≥18yrs: 960mg every ... Indications for ZELBORAF:. Treatment of unresectable or metastatic melanoma with BRAF V600E mutation as detected by an FDA- ... 18yrs: 960mg every 12hrs; continue until disease progression or unacceptable toxicity. Concomitant strong CYP3A4 inducer: avoid ...
  http://www.clinicaladvisor.com/zelboraf/drug/4106/
*  Drugs and Devices
... to treat certain adult patients with Erdheim-Chester Disease. Read more via Fda.gov . . . ... 6, the U.S. Food and Drug Administration (FDA) expanded approval of Zelboraf (vemurafenib) ...
  https://www.americannursetoday.com/article-type/drugs-and-devices/
*  Roche gets FDA OKs for Alecensa and Zelboraf - PMLiVE
Meanwhile, Roche's Zelboraf has become the first drug ever to be approved for Erdheim-Chester disease (ECD), a rare and deadly ... Zelboraf has been on the market since 2011 to treat melanoma patients with the BRAF V600 mutation, but Roche's efforts to ... Roche gets FDA OKs for Alecensa and Zelboraf. Gains US licences for first-line use in lung cancer and a rare blood cancer ... The US FDA has approved BRAF inhibitor Zelboraf (vemurafenib) for patients with ECD whose cancerous cells carry the BRAF V600 ...
  http://www.pmlive.com/pharma_news/roche_gets_fda_oks_for_alecensa_and_zelboraf_1210753
*  Kidney Failure News, Research
... to include the treatment of certain adult patients with Erdheim-Chester Disease (ECD), a rare cancer of the blood. ... The U.S. Food and Drug Administration today expanded the approval of Zelboraf (vemurafenib) ... Metabolites significantly affected in chronic kidney disease, study finds Chronic kidney disease (CKD) affects 1 in 7 people in ... Report: Overall burden of kidney disease remains high in the U.S. According to an annual data report from the United State ...
  https://www.news-medical.net/?tag=/Kidney+Failure
*  The Leukemia & Lymphoma Society® (LLS) Funds $46 Million in New Research to Find Cures | Markets Insider
Earlier this month, the FDA approved a therapy for a very rare blood cancer called Erdheim-Chester disease (ECD). The therapy, ... vemurafenib (Zelboraf), previously approved to treat a type of melanoma, works by targeting a mutation of the BRAF gene, which ... Multiple new therapies have been approved in myeloma for the past few years, but the disease remains incurable. And after a 40- ... The LLS mission: Cure leukemia, lymphoma, Hodgkin's disease and myeloma, and improve the quality of life of patients and their ...
  http://markets.businessinsider.com/news/stocks/the-leukemia-lymphoma-society-lls-funds-46-million-in-new-research-to-find-cures-1008840325
*  FDA Drug Approvals: ZELBORAF, ALECENSA, PREVYMIS, ADCETRIS, MEPSEVII - Drug and Device Digest
INDICATION: Treatment of patients with Erdheim-Chester Disease (ECD) with BRAF V600 mutation ADDRESSING UNMET NEED: ECD is slow ... ZELBORAF (vemurafenib) Tablet Hoffmann-La Roche, Inc./Genentech, Inc. ... ZELBORAF (vemurafenib) Tablet. Hoffmann-La Roche, Inc./Genentech, Inc.. INDICATION: Treatment of patients with Erdheim-Chester ... FDA Drug Approvals: ZELBORAF, ALECENSA, PREVYMIS, ADCETRIS, MEPSEVII. ...
  https://druganddevicedigest.com/2017/11/16/fda-drug-approvals-zelboraf-alecensa-prevymis-adcetris-mepsevii/
*  Zelboraf Approved for Rare Blood Cancer - Health
Erdheim-Chester Disease is a slow-growing cancer that originates in bone marrow, causing a spike in a type of white blood cell ... Food and Drug Administration as the first drug to treat Erdheim-Chester Disease, a rare but deadly blood cancer. The approval ... Zelboraf is a kinase inhibitor that's designed to inhibit enzymes that spur cancer cell growth. The most common side effects ... 6, 2017 (HealthDay News) -- Zelboraf (vemurafenib) has been approved by the U.S. ...
  http://www.health.com/healthday/zelboraf-approved-rare-blood-cancer
*  vemurafenib - WellSpan Health Library
Vemurafenib is also used to treat Erdheim-Chester Disease (a rare blood cancer)... ... Vemurafenib is also used to treat Erdheim-Chester Disease (a rare blood cancer). ... Brand: Zelboraf. What is the most important information I should know about vemurafenib?. Vemurafenib is used to treat melanoma ...
  https://www.wellspan.org/health-library/Document.aspx?id=d07798a1
*  Accepting and Enduring Chronic Pain - National Pain Report
FDA Grants Priority Review and Breakthrough Therapy Designation for Zelboraf in Erdheim-Chester Disease ... You do not forget you have a disease such as chronic pain or Parkinson's disease: that is the practice of non-resistance and ... He has accepted his diagnosis with Parkinson's disease and although his disease is always there, he has found a way through: ... I do not know how I got here and how I accepted pain as this disease stole so much of my life but I know I did it. I also know ...
  http://nationalpainreport.com/accepting-and-enduring-chronic-pain-8829712.html
*  The Pain Patient Says Our Government Isn't Listening - National Pain Report
FDA Grants Priority Review and Breakthrough Therapy Designation for Zelboraf in Erdheim-Chester Disease ... I'm not as most people in chronic pain a patient of 1 disease/disorder but multiple one's making my pain severe. PT & exercise ... How foolish the think that someone with any disease requiring daily medication is an addict to the life improving or life ... If someone has an organic disease, demonstrated by images and diagnostic tests, has not committed a drug related crime or ...
  http://nationalpainreport.com/the-pain-patient-says-our-government-isnt-listening-8830160.html
*  CDC Opioid Guidelines Released - National Pain Report
FDA Grants Priority Review and Breakthrough Therapy Designation for Zelboraf in Erdheim-Chester Disease ... Talk to people with this disease and see what they go through. Not to say that cancer pain is not painful, but people with ... The Centers for Disease Control released its anticipated guideline for prescribing opioids for chronic pain. The guideline is ... Let's focus on putting out those fires and leave the doctors alone to do their jobs which is to provide care, treat diseases ...
  http://nationalpainreport.com/cdc-opioid-guidelines-released-8829808.html
*  king5.com | On Rare Disease Day, experts say 'Don't give up'
You have Erdheim-Chester Disease,'" said Bonnie.. Erdheim-Chester Disease (ECD) is one of 7,000 rare diseases and disorders ... treated with a combination of drugs including the first ever FDA-approved treatment for certain ECD patients called Zelboraf ( ... Get involved, donate, volunteer, don't give up," said Kathy Brewer, president of the Erdheim-Chester Disease Global Alliance. " ... On Rare Disease Day, experts say 'Don't give up'. Rare Disease Day raises awareness of disorders that affect very few of us. A ...
  http://www.king5.com/article/news/health/on-rare-disease-day-experts-say-dont-give-up/281-524316342
*  BRAF (gene) - Wikipedia
... brain tumors including glioblastoma and pilocytic astrocytomas as well as inflammatory diseases like erdheim-chester disease. ... "FDA Approves Zelboraf (Vemurafenib) and Companion Diagnostic for BRAF Mutation-Positive Metastatic Melanoma, a Deadly Form of ... Mutations in the BRAF gene can cause disease in two ways. First, mutations can be inherited and cause birth defects. Second, ... Vemurafenib (RG7204 or PLX4032) was licensed by the US Food and Drug Administration as Zelboraf for the treatment of metastatic ...
  https://en.wikipedia.org/wiki/BRAF_(gene)