Loading...
*  Proliferating cell nuclear antigen
Sunspot, a link between Wingless signaling and endoreplication in Drosophila. The Wingless (Wg)/Wnt signaling pathway is highly ... Upon activation of the Wg/Wnt signaling pathway, Armadillo (Arm)/beta-catenin is stabilized and interacts with the TCF family ... To explore the possibility that Ssp is related to the Wg signal transduction pathway, the effect of Wg on the distribution of ... In addition, Ssp was found not to be involved in the signaling pathway mediated by Arm associated with dTCF. These findings ...
  http://www.sdbonline.org/sites/fly/polycomb/pcna3.htm
*  Beta-catenin (IPR013284) | InterPro | EMBL-EBI
... of the Wnt signalling pathway (wingless phenotype) [PMID: 10679188, PMID: 1397690]. The beta-catenin structure has been ... Regulation of beta-catenin signaling in the Wnt pathway.. Biochem. Biophys. Res. Commun. 268 243-8 2000 ... which are implicated in cell adhesion and Wnt signalling [PMID: 9425166]. Originally identified as downstream elements ( ... Signaling and adhesion activities of mammalian beta-catenin and plakoglobin in Drosophila.. J. Cell Biol. 140 183-95 1998 ...
  http://www.ebi.ac.uk/interpro/entry/IPR013284
*  Kaykas A[au] - PubMed - NCBI
Functional genomic analysis of the Wnt-wingless signaling pathway.. DasGupta R, Kaykas A, Moon RT, Perrimon N. ... Bili inhibits Wnt/beta-catenin signaling by regulating the recruitment of axin to LRP6. ... Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements. ... CD40 and LMP-1 both signal from lipid rafts but LMP-1 assembles a distinct, more efficient signaling complex. ...
  https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Kaykas+A%5Bau%5D&dispmax=50
*  New strategy against childhood cancer | News | News | Karolinska Institutet
One potential treatment strategy is to use a drug to target deviant molecular signalling caused by changes in genes. ... The Wingless (Wnt) signalling pathway is important in the development of nerve cells. One current study has shown that ... the so-called Rho/Rac signalling pathway.. "Our results indicate that the signalling molecule Rho and the enzyme Rho kinase, ... approximately one in four neuroblastoma patients have at least one gene change in the part of the Wnt signalling pathway that ...
  https://ki.se/en/news/new-strategy-against-childhood-cancer
*  A combinatorial code of maternal GATA, Ets and β-catenin-TCF transcription factors specifies and patterns the early ascidian...
Functional genomic analysis of the Wnt-wingless signaling pathway. Science 308,826 -833. ... Hudson, C., Darras, S., Caillol, D., Yasuo, H. and Lemaire, P. (2003). A conserved role for the MEK signalling pathway in ... 4A), prior to the activation of FGF signaling in the embryo, and suggesting that it was FGF signaling independent. Consistently ... they converge at the level of the activation of nodal signaling, which is the major pathway inducing both mesoderm and endoderm ...
  http://dev.biologists.org/content/134/22/4023
*  Identification and Characterization of Wnt Signaling Pathway in Keloid Pathogenesis [Abstract]
Numerous studies have shown that the Wingless type (Wnt) signaling pathways play key roles in various cellular functions ... The aim of this study was to clarify the role of Wnt signaling pathway in keloid pathogenesis. Primary fibroblast cultures and ... Identification and Characterization of Wnt Signaling Pathway in Keloid Pathogenesis Shinichi Igota1,2, Mamiko Tosa1,3, Masahiro ... Our findings highlight a potential role for a Wnt/β-catenin canonical signaling pathway triggered by Wnt5a in keloid ...
  http://www.medsci.org/v10p0344
*  Protocols and Video Articles Authored by Douglas R. Mackay (Translated to Dutch)
... as an additional nuclear component of the canonical Wingless(Wg)/Wnt signaling pathway. In this study, we describe the ... a transducer of wnt signaling. Collectively, our findings suggest that movo1 is a developmental target of wnt signaling during ... Consistent with the demonstrated role of the Wnt-beta-catenin-LEF/TCF signaling pathway in mammalian skin development, mpygo2 ... transcription factors and includes members that reside downstream of key developmental signaling pathways such as Wg/Wnt and ...
  https://www.jove.com/author/Douglas+R._Mackay?language=Dutch
*  Protocols and Video Articles Authored by Douglas R. Mackay (Translated to German)
... as an additional nuclear component of the canonical Wingless(Wg)/Wnt signaling pathway. In this study, we describe the ... a transducer of wnt signaling. Collectively, our findings suggest that movo1 is a developmental target of wnt signaling during ... Consistent with the demonstrated role of the Wnt-beta-catenin-LEF/TCF signaling pathway in mammalian skin development, mpygo2 ... and that the wg/wnt-ovo link in epidermal appendage regulatory pathways has been conserved between mice and flies. ...
  https://www.jove.com/author/Douglas+R._Mackay?language=German
*  Vinicio de Jesus Perez MD | Stanford Medicine Profiles
We hypothesized that BMPRII supports normal PAEC function by recruiting Wingless (Wnt) signaling pathways to promote ... Wnt signaling pathways preserve pulmonary vascular homeostasis, and dysregulation of this pathway could contribute to limited ... Wnt)-β-catenin (βC) and Wnt-planar cell polarity (PCP) signaling pathways to facilitate vascular smooth muscle motility while ... Targeting the Wnt signaling pathways in pulmonary arterial hypertension. Drug discovery today de Jesus Perez, V., Yuan, K., ...
  https://med.stanford.edu/profiles/vinicio-de-jesus-perez
*  Targeted Screen for Novel Chemical Modulators of Wnt/Beta-Cat Signaling Pathway. - Brian Dynlacht
... pathway is an evolutionarily conserved cell-signaling pathway that regulates many aspects of metazoan development. ... The Wnt/wingless (wg) pathway is an evolutionarily conserved cell-signaling pathway that regulates many aspects of metazoan ... Targeted Screen for Novel Chemical Modulators of Wnt/Beta-Cat Signaling Pathway. Dynlacht, Brian D. Dasgupta, Ramanuj New York ... 2013) HIV's Nef interacts with β-catenin of the Wnt signaling pathway in HEK293 cells. PLoS One 8:e77865 ...
  http://grantome.com/grant/NIH/R01-CA155125-04
*  Interactive Fly, Drosophila
... of other Wingless signaling molecules downstream from Shaggy demonstrates that components of the Wnt signaling pathway modulate ... The signalling pathway that mediates Wnt6 activity have been analyzed. The experiments suggest that the Wnt receptor molecule ... GSK3ß is a serine/threonine kinase and is a component of the Wnt/wingless signaling cascade. GSK3ß is able to bind and ... is a central component of the cadherin cell adhesion complex and plays an essential role in the Wingless/Wnt signaling pathway ...
  http://www.sdbonline.org/sites/fly/segment/shaggy2c.htm
*  Case report: whole exome sequencing of primary cardiac angiosarcoma highlights potential for targeted therapies | BMC Cancer |...
... which acts is an activator of the Wingless-Int (Wnt) signaling pathway [46]. It also contains the GATA Binding Protein 4 (GATA4 ... Weihrauch M, Markwarth A, Lehnert G, Wittekind C, Wrbitzky R, Tannapfel A. Abnormalities of the ARF-p53 pathway in primary ... To date, various studies investigated specific genes and pathways altered in angiosarcoma. V-Myc Avian Myelocytomatosis Viral ... a signal transducer of tyrosine kinase activators [31]. In the current study, we used custom-designed expanded exome capture to ...
  https://bmccancer.biomedcentral.com/articles/10.1186/s12885-016-3000-z
*  AXIN1 gene - Genetics Home Reference - NIH
... but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway (PubMed:12192039). In Wnt signaling, probably ... This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling ... down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, ... and modulating Wnt-signaling (PubMed:12192039, PubMed:27098453). Controls dorsoventral patterning via two opposing effects; ...
  https://ghr.nlm.nih.gov/gene/AXIN1
*  AXIN1 Gene - GeneCards | AXIN1 Protein | AXIN1 Antibody
... pathways, orthologs, and expression. GeneCards - The Human Gene Compendium ... but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway (PubMed:12192039). In Wnt signaling, probably ... This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling ... but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway (PubMed:12192039). In Wnt signaling, probably ...
  https://www.genecards.org/cgi-bin/carddisp.pl?gene=AXIN1
*  WNT Signaling Pathway Inhibitors Therapeutics Pipeline Analysis 2017: Key Players are Samumed, Can-Fite BioPharma & Tactical...
Wnt Signaling Pathway Inhibitors Therapeutics Pipeline Analysis, 2017' report has been added to Research and... ... The signaling pathway was earlier named as Wingless (Wng) in Drosophila and Int1 in the mouse. Wnt proteins consist of several ... since Wnt signaling pathway has been recognized in the development of cancer cells.. The positive clinical results of Wnt ... The 'Wnt Signaling Pathway Inhibitors Therapeutics Pipeline Analysis, 2017' report has been added to Research and Markets' ...
  https://www.prnewswire.com/news-releases/wnt-signaling-pathway-inhibitors-therapeutics-pipeline-analysis-2017-key-players-are-samumed-can-fite-biopharma--tactical-therapeutics-300570832.html
*  Plus it
Genes in the Wnt/wingless signaling pathway play critical roles in differentiation and morphogenesis during embryogenesis. ... Our results indicate that FGF18 is activated in colon cancers as a direct downstream target of the Wnt signaling pathway and ... which plays a pivotal role in cell-to-cell adhesion and signal transduction. In the absence of Wnt signaling, β-catenin is ... Wnt signals control some of the FGFs involved in limb initiation and tooth organogenesis (12 , 13) . Apart from a crucial role ...
  http://cancerres.aacrjournals.org/content/63/19/6116
*  Ligand receptor interactions in the Wnt signaling pathway in Drosophila. | The Nusse Lab @ Stanford University
In the genome of Drosophila, seven Wnt genes (including wingless; wg), and five frizzled genes have been identified. Relatively ... Secreted Wnt proteins have numerous signaling functions during development, mediated by Frizzled molecules that act as Wnt ... are also necessary for Wnt signal transduction and have been postulated to act as co-receptors. We have therefore examined ... Most Wnt proteins can bind to multiple Frizzleds and vice versa, suggesting redundancy in vivo. In an extension of these ...
  http://web.stanford.edu/group/nusselab/cgi-bin/lab/node/125
*  Products released in August 2015
Small-molecule inhibitor of the Wnt/wingless signaling pathway; CRT inhibitor €135.00 ... Inhibitor of TNIK that attenuates TGF-β1-mediated Wnt and Smad signaling €125.00 ...
  https://www.axonmedchem.com/date/2015/08/
*  Extracellular - Matrix - Proteins - Products
Specific inhibitor of Wnt/β-catenin signaling pathway €115.00 2135 iCRT14 Small-molecule inhibitor of the Wnt/wingless ... Wnt agonist 1 Wnt/β-catenin signaling pathway agonist or activator €90.00 ... Wnt/β-catenin signaling pathway agonist or activator €90.00 2481 SMT C1100 Orally active, non-toxic upregulator of utrophin ... Inhibitor of TCF-dependent transcription of genes of Wnt signaling pathway €60.00 ...
  https://www.axonmedchem.com/products/proteins/matrix/extracellular
*  Genistein and Cancer: Current Status, Challenges, and Future Directions
Wingless and integration 1 β-catenin (Wnt/β-catenin), and phosphoinositide 3 kinase/Akt (PI3K/Akt) signaling pathways may act ... Wnt) signaling pathway (147). In particular, genistein enhanced gene expression of the Wnt signaling pathway antagonist, ... Zhang Y, Chen H Genistein attenuates WNT signaling by up-regulating sFRP2 in a human colon cancer cell line. Exp Biol Med ( ... Gong L, Li Y, Nedeljkovic-Kurepa A, Sarkar FH Inactivation of NF-kappaB by genistein is mediated via Akt signaling pathway in ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC4496735/
*  AXIN1 - ddPCR Primer Pair - EvaGreen - Digital PCR | PrimePCR | Bio-Rad
This protein functions as a negative regulator of the wingless-type MMTV integration site family member 1 (WNT) signaling ... pathway and can induce apoptosis. The crystal structure of a portion of this protein alone and in a complex with other proteins ... This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and ...
  http://www.bio-rad.com/en-us/prime-pcr-assays/assay/dhsaeg5016864-primepcr-ddpcr-expression-evagreen-assay-axin1-human
*  WNT Signaling and Colorectal Cancer | SpringerLink
The WNT signaling pathway is a critical mediator of tissue homeostasis and repair, and frequently co-opted during tumor ... An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway. Proc ... The WNT signaling pathway is a critical mediator of tissue homeostasis and repair, and frequently co-opted during tumor ... Acute Wnt pathway activation positively regulates leptin gene expression in mature adipocytes. Cell Signal. 2015;27(3):587-97. ...
  https://link.springer.com/article/10.1007/s11888-017-0354-9
*  Adenomatous Polyposis Coli Tumor Suppressor Protein Has Signaling Activity in Xenopus laevis Embryos Resulting in the Induction...
... β-catenin seems to be part of a Wnt signaling pathway, which was first identified as the Wingless pathway in Drosophila (21, 36 ... The Wingless/Wnt pathway has been remarkably well conserved in vertebrates, as evident in early Xenopus embryogenesis. Wnt, ... This signaling activity is shared by several components of the Wnt signaling pathway, including Wnts themselves and a kinase- ... 1994) β-catenin: a common target for the regulation of cell adhesion by Wnt-1 and Src signaling pathways. Trends Biochem Sci 19 ...
  http://jcb.rupress.org/content/136/2/411
*  Plus it
Most mammalian genomes contain 19 WNT genes with distinct signaling pathways and downstream effects. WNT signaling can be ... A key signaling pathway for maintaining precursor cells uncommitted and undifferentiated is the wingless-type mouse mammary ... WNT signaling, adipogenesis, and insulin action. Secreted ligand proteins of the WNT-signaling family regulate several ... Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors. J Biol Chem 2006;281:22429-22433pmid: ...
  http://diabetes.diabetesjournals.org/content/62/9/2997
*  Mir-92 microRNA precursor family - Wikipedia
... a member of the wingless (WNT signalling pathway). But only Gorlin syndrome and the SHH pathway is thought to incorporate the ... PTCH is the receptor for Sonic hedgehog (SHH). This SHH signalling pathway is crucial during early development and SSH is the ... The expression of mir-235 is regulated by the insulin/insulin-like growth factor (IGF) signalling (IIS) pathway in respond to ... As discussed, the mir-17-92 cluster has been proposed to have a functional relationship with Patched signalling. An abnormal ...
  https://en.wikipedia.org/wiki/Mir-92_microRNA_precursor_family