*  Institute of Cancer Research Repository - Gain of 1q is associated with adverse outcome in favorable histology Wilms' tumors.
Gain of 1q is associated with adverse outcome in favorable histology Wilms' tumors. Feb 158 (2): Although several genes/genetic loci involved in the etiolgy of wilms' tumor have been identified, little is known of the molecular changes associated with relapse. We therfore undertook an analysis by comparative genomic hybridization (CGH) of 58 tumor samples of favorable histology Wilms' tumor taken at inital diagnosis and/or relapse. The results suggest that 1q gain at diagnosis could be used to identify patients with favorable histology Wilms' tumor at increased risk of relapse who might benefit from early treatment intensification.. ...
  http://publications.icr.ac.uk/715/
*  Nwts - National Wilms` Tumor Studies in Medical & Science by AcronymsAndSlang.com
What does Medical & Science Nwts stand for? Hop on to get the meaning of Nwts. The Medical & Science Acronym /Abbreviation/Slang Nwts means National Wilms` Tumor Studies. by AcronymAndSlang.com
  http://acronymsandslang.com/definition/5860516/Nwts-meaning.html
*  Vincristine, Dactinomycin, and Doxorubicin With or Without Radiation Therapy or Observation Only in Treating Younger Patients...
PRIMARY OBJECTIVES:. I. Evaluate the overall and event-free survival of younger patients with newly diagnosed stage I favorable histology Wilms' tumor (, 2 years of age and , 550gms) treated with nephrectomy only (very low risk), or with newly diagnosed stage III favorable histology Wilms tumor with possible nephrectomy followed by vincristine, dactinomycin, doxorubicin hydrochloride, and radiotherapy (standard risk).. SECONDARY OBJECTIVES:. I. Determine the effects of adding doxorubicin hydrochloride to the regimen for patients with stage I or II favorable histology found to have a high-risk biological marker.. II. Determine whether the omission of adjuvant therapy increases the incidence of contralateral kidney lesions in patients with very low-risk disease treated by nephrectomy and observation only.. III. Determine whether the omission of adjuvant therapy increases the incidence of renal failure in patients with very low-risk disease who ...
  https://clinicaltrials.gov/ct2/show/NCT00352534
*  Vincristine, Dactinomycin, and Doxorubicin With or Without Radiation Therapy or Observation Only in Treating Younger Patients...
PRIMARY OBJECTIVES:. I. Evaluate the overall and event-free survival of younger patients with newly diagnosed stage I favorable histology Wilms' tumor (, 2 years of age and , 550gms) treated with nephrectomy only (very low risk), or with newly diagnosed stage III favorable histology Wilms tumor with possible nephrectomy followed by vincristine, dactinomycin, doxorubicin hydrochloride, and radiotherapy (standard risk).. SECONDARY OBJECTIVES:. I. Determine the effects of adding doxorubicin hydrochloride to the regimen for patients with stage I or II favorable histology found to have a high-risk biological marker.. II. Determine whether the omission of adjuvant therapy increases the incidence of contralateral kidney lesions in patients with very low-risk disease treated by nephrectomy and observation only.. III. Determine whether the omission of adjuvant therapy increases the incidence of renal failure in patients with very low-risk disease who ...
  https://clinicaltrials.gov/ct2/show/NCT00352534?term=Isaac
*  Vincristine, Dactinomycin, and Doxorubicin With or Without Radiation Therapy or Observation Only in Treating Younger Patients...
PRIMARY OBJECTIVES:. I. Evaluate the overall and event-free survival of younger patients with newly diagnosed stage I favorable histology Wilms' tumor (, 2 years of age and , 550gms) treated with nephrectomy only (very low risk), or with newly diagnosed stage III favorable histology Wilms tumor with possible nephrectomy followed by vincristine, dactinomycin, doxorubicin hydrochloride, and radiotherapy (standard risk).. SECONDARY OBJECTIVES:. I. Determine the effects of adding doxorubicin hydrochloride to the regimen for patients with stage I or II favorable histology found to have a high-risk biological marker.. II. Determine whether the omission of adjuvant therapy increases the incidence of contralateral kidney lesions in patients with very low-risk disease treated by nephrectomy and observation only.. III. Determine whether the omission of adjuvant therapy increases the incidence of renal failure in patients with very low-risk disease who ...
  https://clinicaltrials.gov/show/NCT00352534
*  Wilms Tumor Staging :: Wilms-tumor
After making a diagnosis of Wilms tumor, doctors need to assess how advanced the tumor is, including how large it is, how far it has spread, and whether it has invaded other tissues. This is called "staging" the tumor. Staging allows the cancer care team to Identify the best treatment approach using a combination of chemotherapy, surgery and radiation therapy. It will also provide information about the outlook for cure.. The staging system used to describe the extent of spread of Wilms tumors was developed by the National Wilms Tumor Study Group (NWTS). The NWTS system describes Wilms tumor stages using Roman numerals I through V (1 to 5).. Stage I. ...
  http://wilms-tumor.webnode.com/wilms-tumor/wilms-tumor-staging/
*  Combination Chemotherapy and Surgery in Treating Young Patients With Wilms Tumor - Full Text View - ClinicalTrials.gov
It is often difficult to distinguish Wilms tumors from nephrogenic rests based on imaging studies and percutaneous biopsies. The AREN0534 study uses the guideline that Wilms tumor with a single lesion 1 cm or greater in the contralateral kidney or multiple lesions (of any size) in the contralateral kidney should be treated on the synchronous bilateral Wilms tumor stratum; patients with an isolated lesion less than 1 cm in the contralateral kidney should be treated on the appropriate study for unilateral Wilms tumor OR on the unilateral Wilms tumor/contralateral nephrogenic rest stratum of this study if they have not undergone nephrectomy and are under one year of age ...
  https://clinicaltrials.gov/ct2/show/NCT00945009?recr=Open&cond=%22Wilms+Tumor%22&rank=9
*  Combination Chemotherapy and Surgery in Treating Young Patients With Wilms Tumor - Full Text View - ClinicalTrials.gov
It is often difficult to distinguish Wilms tumors from nephrogenic rests based on imaging studies and percutaneous biopsies. The AREN0534 study uses the guideline that Wilms tumor with a single lesion 1 cm or greater in the contralateral kidney or multiple lesions (of any size) in the contralateral kidney should be treated on the synchronous bilateral Wilms tumor stratum; patients with an isolated lesion less than 1 cm in the contralateral kidney should be treated on the appropriate study for unilateral Wilms tumor OR on the unilateral Wilms tumor/contralateral nephrogenic rest stratum of this study if they have not undergone nephrectomy and are under one year of age ...
  https://clinicaltrials.gov/ct2/show/NCT00945009?term=cancer&recr=Open&locn=wake+forest&rank=15
*  Nephropathy, Wilms tumour and genital anomalies | definition of nephropathy, Wilms tumour and genital anomalies by Medical...
Looking for online definition of nephropathy, Wilms tumour and genital anomalies in the Medical Dictionary? nephropathy, Wilms tumour and genital anomalies explanation free. What is nephropathy, Wilms tumour and genital anomalies? Meaning of nephropathy, Wilms tumour and genital anomalies medical term. What does nephropathy, Wilms tumour and genital anomalies mean?
  http://medical-dictionary.thefreedictionary.com/nephropathy%2C+Wilms+tumour+and+genital+anomalies
*  Wilms Tumor (Nephroblastoma), Pipeline Review, H2 2016: Ken Research
Executive Summary. Wilms' Tumor (Nephroblastoma)-Pipeline Review, H2 2016. Summary. Global Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Wilms' Tumor (Nephroblastoma)-Pipeline Review, H2 2016, provides an overview of the Wilms' Tumor (Nephroblastoma) (Oncology) pipeline landscape.. Wilms' tumor or nephroblastoma is cancer of the kidneys that typically occurs in children, rarely in adults. Its common name is an eponym.Wilms' tumor is a rare kidney cancer that primarily affects children.Wilms' tumor most often occurs in just one kidney, though it can sometimes be found in both kidneys at the same time. Typical symptoms are: an abnormally large abdomen, abdominal pain, fever, nausea and vomiting, blood in the urine (in about 20% of cases) and high blood pressure in some cases.. ...
  https://www.kenresearch.com/healthcare/pharmaceuticals/wilms-tumor-nephroblastoma-pipeline/78644-91.html
*  Plus it
The frequency of molecular cytogenetic abnormalities in the present series of medulloblastomas conforms to data from previous studies (17 , 22 , 26 , 35 , 36) , some of which have also suggested associations between pathological variant and genetic abnormalities. Our results show an association between diploid status and desmoplastic phenotype. This finding has been reported before (37) , and the lack of correlation between ploidy status and outcome in our study at least reflects the conflicting data in the literature on this issue (36 , 38 , 39) .. Mutations of the PTCH gene on 9q22 and loss at this locus have been linked with the desmoplastic phenotype in studies of genetic abnormalities in medulloblastoma (29 , 31) . We supplemented desmoplastic medulloblastomas from patients in the International Society of Pediatric Oncology/United Kingdom Children's Cancer Study Group PNET3 with desmoplastic tumors from other United Kingdom Children's Cancer Study Group trial patients to assess whether ...
  http://clincancerres.aacrjournals.org/content/10/16/5482
*  Institute of Cancer Research Repository - A new familial cancer syndrome including predisposition to Wilms tumor and...
Wilms tumor and neuroblastoma are childhood tumors of the kidney and undifferentiated neural crest cells, respectively. Both disorders are primarily sporadic, but familial Wilms tumor pedigrees and familial neuroblastoma pedigrees are each well recognized and account for approximately 1-3% of each tumor type. Families with Wilms tumor and neuroblastoma in the same, or related individuals, have not been reported. Here, we present nine families with two or more individuals with Wilms tumor and/or neuroblastoma. The affected individuals were otherwise well, without syndromic features. Although this co-occurrence might be due to chance in some families, the coexistence of two rare embryonal tumors in related individuals of multiple families suggests an underlying genetic susceptibility to both tumors. We ...
  http://publications.icr.ac.uk/9884/
*  Pregnancy outcomes after abdominal irradiation that included or excluded the pelvis in childhood Wilms tumor survivors: a...
PURPOSE: This report describes the pregnancy outcomes among 7 survivors of childhood Wilms tumor, who were treated on one of the National Wilms Tumor Studies (NWTS) with radiation therapy (RT) portals that extended beyond the flank. METHODS AND MATER
  http://www.biomedsearch.com/nih/Pregnancy-outcomes-after-abdominal-irradiation/15050311.html
*  Treatment by Type and Stages of Wilms Tumor :: Wilms-tumor
The usual treatment for these children is surgery to remove the recurrent cancer (if possible), radiation therapy, and chemotherapy, often with drugs different from those used during first treatment.. Recurrent Wilms tumors that do not have the features listed above are much harder to treat. These children are usually treated with aggressive chemotherapy, such as the ICE regimen (ifosfamide, carboplatin, and etoposide) or others being studied in clinical trials. Very high-dose chemotherapy followed by a stem cell transplant (sometimes called a bone marrow transplant) may also be an option in this situation.. Thus, The treatment of Wilms tumor depends on the size and location of the tumor, whether the cancer has spread, and the child's overall health. The main treatments for Wilms tumor are surgery, chemotherapy, and radiation therapy. Descriptions of these treatment options are listed ...
  http://wilms-tumor.webnode.com/wilms-tumor/treatment-by-type-and-stages-of-wilms-tumor/
*  National Wilms Tumor Late Effects Study | Nemours
The purpose of this research is to learn more about the possible causes of Wilms tumor and the effects of successful treatment for Wilms tumor.
  https://www.nemours.org/pediatric-research/clinicaltrials/cog-cancer-POG9442.html
*  What`s new in Wilms tumor research and treatment? :: Wilms-tumor
Clinical trials continue to study ways to improve treatment for children with Wilms tumors. Earlier studies identified treatments that were very effective in curing Wilms tumors with the most favorable histology. Current clinical trials are studying ways to treat these cancers successfully while reducing side effects as much as possible. For example, studies are looking at whether young children with very favorable outlooks need any treatment other than surgery.. Many studies are looking to improve upon current chemotherapy treatments. For example, recent studies from Europe suggest that in some cases chemotherapy may not need to be continued as long as previously thought.. The outlook for patients with Wilms tumors with unfavorable histology is not as good, and the Children's Oncology Group is continuing to study more intensive and more effective treatments for these children. Newer chemotherapy drugs such ...
  http://wilms-tumor.webnode.com/what-s-new-in-wilms-tumor-research-and-treatment-/
*  Diagnostic and prognostic role of basic fibroblast growth factor in Wilms' tumor patients. | Clinical Cancer Research
Basic fibroblast growth factor (bFGF) is a potent angiogenic peptide implicated in the growth and metastasis of solid tumors. Elevated concentrations of bFGF have been found in the urine of patients with bladder, prostate, and renal tumors. Furthermore, urinary bFGF levels have been shown to correlate with extent of disease. In order to test the utility of urinary bFGF as a Wilms' tumor marker, we measured bFGF levels in preoperative and postoperative urine samples from 97 patients with Wilms' tumor. Preoperative urine samples (n = 97), early postoperative samples obtained from 1 to 3 weeks after surgery (n = 43), and late postoperative samples obtained from 1 to 6 months after surgery (n = 66) were collected from Wilms' tumor patients at 30 institutions between 1989 and 1993. Urine samples from age-matched controls (n = 17) were also obtained. The bFGF levels were ...
  http://clincancerres.aacrjournals.org/content/1/3/327.long
*  An X Chromosome Gene, WTX, Is Commonly Inactivated in Wilms Tumor | Science
Wilms tumor is a pediatric kidney cancer associated with inactivation of the WT1 tumor-suppressor gene in 5 to 10% of cases. Using a high-resolution screen for DNA copy-number alterations in Wilms tumor, we identified somatic deletions targeting a previously uncharacterized gene on the X chromosome. This gene, which we call WTX, is inactivated in approximately one-third of Wilms tumors (15 of 51 tumors). Tumors with mutations in WTX lack WT1 mutations, and both genes share a restricted temporal and spatial expression pattern in normal renal precursors. In contrast to biallelic inactivation of autosomal tumor-suppressor genes, WTX is inactivated by a monoallelic "single-hit" event targeting the single X chromosome in tumors from males and the active X chromosome in tumors from females.. ...
  http://science.sciencemag.org/content/315/5812/642
*  Wilms tumor in a 37-year-old.
Abstract Wilms tumor is rare in adults. Though the approach to diagnosis and treatment of adult Wilms tumor (AWT) is closely modeled on recommendations for childhood Wilms tumor, v..
  https://www.omicsonline.org/references/wilms-tumor-in-a-37yearold-219500.html
*  Analyzing the gene expression profile of anaplastic histology Wilms' tumor with real-time polymerase chain reaction arrays |...
The genetics of Wilms' tumor (WT), a pediatric malignancy of the kidney, is complex. This disease is named after Dr. Max Wilms, a German surgeon (1867-1918) who firstly described this disease [1,2]. WT is a malignant tumor containing metanephric blastema, epithelial derivatives and stromal. Characteristic of this tumor is the presence of glomeruli and abortive tubules surrounded by a spindle cell stroma . The stroma consists of striated muscle, cartilage, bone, adipose tissue, fibrous tissue composition [1-3]. Clinically, the tumor compresses the kidney parenchyma, inhibiting normal function. In most children, the causes of WT are unknown. Very rarely, children that develop WT have other specific conditions present at birth, mainly congenital malformations. Moreover, mutations in WT1 on chromosome 11p13 are observed in about 20% of WTs [4]. At least 50% of the wilm tumor patients with WT1 ...
  https://cancerci.biomedcentral.com/articles/10.1186/s12935-015-0197-x
*  Post-treatment surveillance abdominopelvic computed tomography in children with Wilms tumour: Is it worth the risk?
Introduction. Wilms tumour (nephroblastoma) is the second most common intra-abdominal tumour presenting during childhood, with approximately 80% of cases diagnosed before the age of 5 years.1 Advances in treatment have greatly improved the prognosis for children with this condition. Where survival rates were once less than 30%, they are currently quoted at 90%, making it one of the success stories of modern medicine.2. Nephroblastomas metastasise predominantly to the lungs (58%) and liver (29%), and only rarely to other sites such as the skeleton, mediastinum and brain. Most relapses (90%) occur within 4 years of diagnosis.3 The practice of post-treatment surveillance imaging is aimed at the early detection of tumour recurrence, thereby enabling early salvage therapy. Long-term survival following salvage therapy has reportedly increased from below 30% in the mid-1980s, to the current range of 50% - 60%.4. Recommendations for post-treatment surveillance imaging of patients with ...
  http://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S2078-67782015000100005&lang=en
*  Combination Chemotherapy With or Without Radiation Therapy in Treating Young Patients With Newly Diagnosed Stage III or Stage...
This phase III trial is studying how well combination chemotherapy with or without radiation therapy works in treating young patients with newly diagnosed stage III or stage IV Favorable Histology Wilms' tumor. Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. Giving more than one drug (combination chemotherapy) with or without radiation therapy may kill more tumor cells ...
  https://clinicaltrials.gov/show/NCT00379340
*  Exploring Wilms tumor race disparity | Vanderbilt News | Vanderbilt University
Wilms tumor (WT) - the most common childhood kidney cancer worldwide - varies in incidence and severity according to race. Children of black African ancestry appear to have a heritable predisposition to develop WT, but the biologic basis for this cancer health disparity is not clear.. Harold Lovvorn III, M.D., and colleagues used mass spectrometry proteomics tools to probe WT specimens provided by the Children's Oncology Group and by the Kenyan Wilms Tumor Consortium. They determined peptide profiles for WT specimens from North American white and black children and from Kenyan children. The peptide profiles - "molecular fingerprints" - distinguished WT specimens according to race group and disease characteristics (such as treatment failure and stage). Significant peptides were used to sequence proteins, which revealed cellular signaling pathways important in WT.. The findings, reported in the April issue of the Journal of the American ...
  https://news.vanderbilt.edu/2014/05/29/exploring-wilms-tumor-race-disparity/
*  Wilms' Tumor (Nephroblastoma) - Pipeline Review, H2 2016
... Summary Global Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide - Market research report and industry analysis - 10561165
  https://www.marketresearch.com/Global-Markets-Direct-v3480/Wilms-Tumor-Nephroblastoma-Pipeline-Review-10561165/