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*  Mannose Binding Lectins
The collectins are a family of proteins whose individual chains consist of a C-type lectin domain, attached to a collagen ... Mannose-binding Lectin Deficiency. Serum mannose-binding protein (MBP) or mannose-binding lectin initiates the lectin branch of ... The lectin route of mannose-binding lectin (MBL) activates complements and [from the phylogenetic and functional points of view ... of human serum mannose-binding lectin (MBL) and pulmonary surfactant protein D (SP-D) have distinctive monosaccharide- binding ...
  https://www.4rhealthproducts.com/Mannose-Binding-Lectins-s/1872.htm
*  Untitled Document
Five collectins are known in mammals: Mannose binding lectins (MBL), lung surfactant proteins sp-A and sp-D, conglutinins, and ... Deficiency of MBL in humans lessens complement binding to microbes (Lu, 2002; Gadieva, 2001). Children without MBL suffer ... LECTINS. Lectins are a diverse group of proteins which bind carbohydrates and other ligands such as proteins, lipid, and ... The complement pathway can also be activated by the serum mannose binding lectin (MBL, a C-type lectin) to the carbohydrates of ...
  http://bio.sunyorange.edu/updated2/GENETICS/4%20LECTINS.htm
*  Mannan-binding lectin - Wikipedia
Online Mendelian Inheritance in Man (OMIM) mannose-binding protein deficiency -614372 Colley KJ, Baenziger JU (1987). " ... MBL belongs to the class of collectins in the C-type lectin superfamily, whose function appears to be pattern recognition in ... It is produced in the liver as a response to infection, and is part of many other factors termed acute phase proteins. ... Mannose-binding lectin (MBL), also called mannose-binding protein or mannan-binding protein (MBP), is a lectin that is ...
  https://en.wikipedia.org/wiki/Mannan-binding_lectin
*  Innate immune mechanisms in the resolution of inflammation | Springer for Research & Development
Ogden CA, deCathelineau A, Hoffmann PR, Bratton D, Ghebrehiwet B, Fadok VA, Henson PM (2001) C1q and mannose binding lectin ... Sano H, Chiba H, Iwaki D, Sohma H, Voelker DR, Kuroki Y (2000) Surfactant proteins A and D bind CD14 by different mechanisms. J ... van de Wetering JK, van Golde LM, Batenburg JJ (2004) Collectins: Players of the innate immune system. Eur J Biochem 271: 1229- ... Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies. Nat Genet 19: 56-59PubMed ...
  https://rd.springer.com/chapter/10.1007/978-3-7643-7506-5_3
*  SP-D counteracts GM-CSF-mediated increase of granuloma formation by alveolar macrophages in lysinuric protein intolerance |...
... immune pattern recognition collectins surfactant proteins A and D and mannose-binding lectin. J Biol Chem. 2004, 279: 32728- ... Since GM-CSF [2, 3, 22, 23, 57-62] and SP-D deficiency [24-26, 42] cause a PAP-like phenotype, we examined their potential ... SP-D deficiency results in the accumulation of apoptotic cells, in vivo [30], and PAP airways contain increased number of dead ... Consistent with our hypothesis, we found that SP-D and GM-CSF increase the uptake of proteins and dying cells by LPI AMs. ...
  https://ojrd.biomedcentral.com/articles/10.1186/1750-1172-4-29
*  David A. Stevens | Stanford Medicine Profiles
Collectins and fungal pathogens: roles of surfactant proteins and mannose binding lectin in host resistance MEDICAL MYCOLOGY ... Mannan binding lectin (MBL) deficiency has been associated with increased susceptibility to vaginitis in humans due to Candida ... and the serum collectins, mannose binding lectins; the binding of these collectins to pathogen associated molecular patterns or ... Collectins, collagenous carbohydrate-binding proteins (C-type lectins), are recognized as important factors in non-specific ...
  https://med.stanford.edu/profiles/david-stevens
*  NAVER Academic | Role of ficolin in innate immunity and its molecular basis
They are similar but with some differences in the expression site, location site, ligand-binding specificity and ability to ... form complexes with MBL-associated serine proteases (MASPs). Like MBL, some ficolins are serum lectins and can form a complex ... The structure is similar to mannose-binding lectin (MBL) and complement C1q owing to the collagen-like stalk. Accumulating data ... Deficiency of mannose-binding lectin and burden of infection in children with malignancy: a prospective study (2001) Neth Olaf ...
  https://academic.naver.com/article.naver?doc_id=65285902
*  ASMscience | Interactions of Capsule
Binding of antibody to the capsule edge to produce the annular rim could be due to localization of epitopes only at the capsule ... Incubation of acapsular cryptococci in adsorbed serum leads to deposition of C3 onto the cell wall, but C3 binding occurs via ... the consequences of antibody and complement binding for modification of the capsular matrix. Differential interference contrast ... the mechanisms for interaction of the capsule with proteins of the complement system, (iii) the nexus of the anticapsular ...
  http://www.asmscience.org/content/book/10.1128/9781555816858.ch29
*  Frontiers | NET balancing: a problem in inflammatory lung diseases | Immunology
In many inflammatory lung diseases, bronchoalveolar SP-D levels are altered and its deficiency results in the accumulation of ... In many inflammatory lung diseases, bronchoalveolar SP-D levels are altered and its deficiency results in the accumulation of ... Innate immune collectins such as pulmonary surfactant protein D (SP-D) binds NETs, and enhances the clearance of dying cells ... Innate immune collectins such as pulmonary surfactant protein D (SP-D) binds NETs, and enhances the clearance of dying cells ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2013.00001/full
*  MBL2 gene - Genetics Home Reference
Several common mutations of the MBL2 gene can lead to a condition called mannose-binding lectin deficiency. People with this ... This binding turns on (activates) the complement system, which is a group of immune system proteins that work together to ... amino acid in the mannose-binding lectin subunit eliminates its ability to assemble into the functional mannose-binding lectin ... Inherited mannose-binding lectin deficiency as evidenced by genetic and immunologic analyses: association with severe recurrent ...
  https://ghr.nlm.nih.gov/gene/MBL2
*  ASMscience | Interplay between Myeloid Cells and Humoral Innate Immunity
Fluid-phase pattern recognition molecules (PRMs), which include collectins, ficolins, and pentraxins, are key components of the ... Human mannose-binding lectin and L-ficolin function as specific pattern recognition proteins in the lectin activation pathway ... Role of collectins in innate immunity against aspergillosis. Med Mycol 43(Suppl 1):S155-S163. [PubMed]. ... Long pentraxin PTX3 deficiency worsens LPS-induced acute lung injury. Intensive Care Med 37:334-342. [PubMed]. ...
  http://www.asmscience.org/content/journal/microbiolspec/10.1128/microbiolspec.MCHD-0051-2016
*  Properdin Binds to Late Apoptotic and Necrotic Cells Independently of C3b and Regulates Alternative Pathway Complement...
... immune pattern recognition collectins surfactant proteins A and D and mannose-binding lectin. J. Biol. Chem. 279: 32728-32736. ... Genetic deficiencies of the complement system and association with disease: early components. Int. Rev. Immunol. 10: 17-36. ... and lectin pathway (via mannose-binding lectin (MBL) and ficolin) (10, 11, 12, 13, 14). It has been suggested that the main ... and lectin pathway (via mannose-binding lectin and ficolin). Herein we report that the only known naturally occurring positive ...
  http://www.jimmunol.org/content/180/11/7613?ijkey=4c7ecf4340af5dabcca70ddb98a75f3703f2602d&keytype2=tf_ipsecsha
*  NE1334: Genetic Bases for Resistance and Immunity to Avian Diseases - NIMSS
Further, part of the mannose-binding-lectin (MBL) promoter was cloned and sequenced to identify polymorphism in two inbred and ... This research also led to the discovery that only few of the MHC-YF class I proteins are expressed in chickens and that at ... Vitamin A deficiency during development diminished B lymphocyte maturation and the breadth of the antibody repertoire. The ... and search for new genetic disease markers in the group of collectins (Ficolin). AR will develop key indices of cellular and ...
  https://www.nimss.org/projects/view/mrp/outline/15096
*  Pentraxin 3(PTX 3): An Endogenous Modulator of the Inflammatory Response
PTX3 interacts also with components of the lectin pathway. The mannose binding lectin (MBL) binds PTX3 via its collagen-like ... The classical short pentraxins C-reactive protein (CRP) and serum amyloid P component (SAP) are acute-phase proteins in humans ... G. D. Norata, P. Marchesi, V. K. Pulakazhi Venu et al., "Deficiency of the long pentraxin ptx3 promotes vascular inflammation ... This heterogeneous group of molecules consists of three clearly defined subgroups, that is, the collectins, the ficolins, and ...
  https://www.hindawi.com/journals/mi/2012/920517/
*  Frontiers | Comparative Evaluation of Heterologous Production Systems for Recombinant Pulmonary Surfactant Protein D |...
... are less effective when pulmonary diseases involve inflammatory complications because two hydrophilic surfactant proteins (A ... These products contain lipids and the hydrophobic surfactant proteins B and C, which help to lower the surface tension in the ... These products contain lipids and the hydrophobic surfactant proteins B and C, which help to lower the surface tension in the ... are less effective when pulmonary diseases involve inflammatory complications because two hydrophilic surfactant proteins (A ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2014.00623/full
*  Early ficolin-1 is a sensitive prognostic marker for functional outcome in ischemic stroke | Journal of Neuroinflammation |...
Mannose-binding lectin serine proteases and associated proteins of the lectin pathway of complement: two genes, five proteins ... Genetically-defined deficiency of mannose-binding lectin is associated with protection after experimental stroke in mice and ... mannose-binding lectin (MBL) and the recently identified collectins: collectin-10 (CL-L1 or CL-10) and collectin-11 (CL-K1 or ... Mannose-binding lectin deficiency is associated with smaller infarction size and favorable outcome in ischemic stroke patients ...
  https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-016-0481-2
*  ASMscience | Recognition and Removal
... immune pattern recognition collectins surfactant proteins A and D and mannose-binding lectin. J. Biol. Chem. 279:32728-32736.. ... Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies. Nat. Genet. 19:56-59.. ... Stuart, L. M.,, K. Takahashi,, L. Shi,, J. Savill, and, R. A. Ezekowitz. 2005. Mannose-binding lectin-deficient mice display ... C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of ...
  http://www.asmscience.org/content/book/10.1128/9781555816650.ch21
*  US5854214A - Therapeutic uses of bactericidal/permeability increasing protein products - Google Patents
Collectins: collagenous C-type lectins of the innate immune defense system. Marra et al. 1992. The role of bactericidal/ ... Human mannose-binding protein US5447913A (en) 1995-09-05. Therapeutic uses of bactericidal/permeability-increasing protein ... the cationic/hydrophobic motif of LPS binding/bactericidal molecules and the consensus sequences of heparin binding proteins. ... Tuftsin deficiency: a new syndrome with defective phagocytosis. US5112946A (en) 1992-05-12. Modified pf4 compositions and ...
  https://patents.google.com/patent/US5854214A/en