*  Frontiers | Unusual Fusion Proteins of HIV-1 | Microbiology
... the regulatory genes rev and tat and the accessory genes vpu, nef, vpr and vif enables assembly of the viral particle, ... Expression of the structural genes gag, pol and env, the regulatory genes rev and tat and the accessory genes vpu, nef, vpr and ... vif enables assembly of the viral particle, regulates viral gene transcription and equips the virus to evade or counteract host ... Expression of the structural genes gag, pol and env, ... and a Rev1-Vpu fusion protein is expressed due to a nucleotide ...
  https://www.frontiersin.org/articles/10.3389/fmicb.2016.02152/full
*  US20110142818A1 - Combination enzyme replacement and small molecule therapy for treatment of lysosomal storage diseases ...
This invention provides various combinations of enzyme replacement therapy, gene therapy, and small molecule therapy for the ... For example, lentiviruses may have additional genes including vit, vpr, tat, rev, vpu, net and vpx. The higher complexity ... further enabling disclosure for gene therapy, enzyme replacement therapy, and small molecule therapy components of a ... when a gene therapy vector immune response precludes further immediate gene therapy, or when a gene therapy vector is ...
  https://patents.google.com/patent/US20110142818A1/en
*  Human Immunodeficiency Virus (HIV) - wikidoc
tat, rev, nef, vif, vpr, vpu: Each of these genes codes for a single protein with the same names; see Tat, Rev, Nef, Vif, Vpr, ... env (for "envelope"): Codes for the precursor to gp120 and gp41, proteins embedded in the viral envelope which enable the virus ... Vpu.. * tev: This gene is only present in a few HIV-1 isolates. It is a fusion of parts of the tat, env, and rev genes, and ... Vpu. * Stands for "Viral Protein U". Vpu is involved in viral budding, enhancing virion release from the cell. ...
  https://www.wikidoc.org/index.php/HIV
*  Antievolution.org - Antievolution.org Discussion Board -Topic::Bragging Rights
Other highlights might be showing FtK that her understanding of anti-freeze and globin genes in icefish was a tad flawed, but ... But my personal highlight might be the discovery that Behe had inadvertently left comments enabled on one of his Amazon blog ... I posted the first comment, asking about Abbie's points re Vpu and new functions of mutated proteins, and the floodgates opened ... Other highlights might be showing FtK that her understanding of anti-freeze and globin genes in icefish was a tad flawed, but ...
  http://www.antievolution.org/cgi-bin/ikonboard/ikonboard.cgi?s=50a3939b9b1e291f
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Transmitted viruses encoded intact canonical genes (gag-pol-vif-vpr-tat-rev-vpu-env-nef) and replicated efficiently in primary ... The model enables an assessment of the expected sequence diversity in new HIV-1 infections originating from a single ... For example, sites that tend to evolve rapidly across multiple early-infection patients could be involved in enabling escape ... consistent with enabling a common pathway for immune escape during chronic infection. Its recurrent loss in early infection ...
  https://www.jove.com/visualize?author=Tanmoy+Bhattacharya
*  "What Is The Symptoms Of Chlamydia |Chlamydia Symptoms Males" - HIV AIDS Symptoms Treatment...
The six remaining genes, tat, rev, nef, vif, vpr, and vpu (or vpx in the case of HIV-2), are regulatory genes for proteins that ... Tat is a potent transcriptional regulator, which functions as an elongation factor that enables the transcription of viral RNA ... vpu, and sometimes a tenth tev, which is a fusion of tat, env and rev), encoding 19 proteins. Three of these genes, gag, pol, ... The RNA genome consists of at least seven structural landmarks (LTR, TAR, RRE, PE, SLIP, CRS, and INS), and nine genes (gag, ...
  http://penetratearticles.info/english/what-is-the-symptoms-of-chlamydia-chlamydia-symptoms-males/
*  METHODS AND COMPOSITIONS RELATING TO IMPROVED LENTIVIRAL VECTORS AND THEIR APPLICATIONS - Patent application
... genes, such as vpr, vif, vpu, nef, tat, such as where these genes have been removed or otherwise inactivated. In fact, it is ... contain other genes with regulatory or structural function. The higher complexity enables the virus to modulate its life cycle ... a multidrug resistance gene, gp91phox, gp 47, an antiviral gene, a gene coding for blood coagulation factor VIII, a gene coding ... pol and rev genes will preferably be HIV genes and more preferably HIV-1 genes. However, the gag, pol and rev genes and LTR ...
  http://www.patentsencyclopedia.com/app/20130115692
*  Structure and genome of HIV - Wikipedia
tev: This gene is only present in a few HIV-1 isolates. It is a fusion of parts of the tat, env, and rev genes, and codes for a ... vpu (Virus protein U) - Vpu is specific to HIV-1. It is a class I oligomeric integral membrane phosphoprotein with numerous ... This arrest activates the host DNA repair machinery which may enable integration of the viral DNA. HIV-2 and SIV encode an ... genes unique to HIV. The HIV genome contains three major genes, 5'gag-pol-env-3', encoding major structural proteins as well as ...
  https://en.wikipedia.org/wiki/Structure_and_genome_of_HIV
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
All the genes encoding the accessory proteins, including Vif, Vpr, Vpu, and Nef are excluded in the packaging system. The ... A Toolkit to Enable Hydrocarbon Conversion in Aqueous Environments. Authors: Eva K. Brinkman, Kira Schipper, Nadine Bongaerts, ... Each gene deletion construct in S. sanguinis genome is designed to comprise 1-kb upstream of the targeted gene, the aphA-3 gene ... 2,048 mutants with single-gene deletion were ultimately obtained from the 2,270 genes in S. sanguinis excluding four gene ORFs ...
  https://www.jove.com/visualize/abstract/24594763/analysis-of-the-promoters-involved-in-enterocin-as-48-expression
*  Retroviral vectors and transposons for stable gene therapy: advances, current challenges and perspectives | Journal of...
Enabling integration in the genome in a sequence-based fashion opens the possibility for new genes to be integrated in safe ... and vpu (theterin degradation). All the required genes for the lentivirus cycle are depicted in Fig. 1a. Reverse transcription ... Gene therapy. Gene therapy is defined as a set of strategies that modify the expression of an individual's genes or to correct ... Such tools may allow approaches such as add back of gene function, site-directed gene corrections and gene replacements, ...
  https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-016-1047-x
*  Production of engineered long-life and male sterile Pelargonium plants
However, gene transfer via Agrobacterium tumefaciens could be a helpful tool to further improve Pelargonium by enabling the ... se.vpu.ctb@adenipb; Edelín Roque: se.vpu.pcmbi@euqorde; Teresa Antón: se.vpu.rotcod@2ramnaam; Alejandro Atarés: se.vpu.pcmbi@ ... serataa; Marisé Borja: moc.esnopsertnalp@ajrob.esiram; José Pío Beltrán: se.vpu.pcmbi@nartlebj; Vicente Moreno: se.vpu.pcmbi@ ... Keywords: Pelargonium zonale, Pelargonium peltatum, pSAG12 promoter, ipt gene, Engineered long-lived plants, Delayed senescence ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3492168/?report=abstract
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
All the genes encoding the accessory proteins, including Vif, Vpr, Vpu, and Nef are excluded in the packaging system. The ... Thus, this method enables manipulation of CD4 T cell differentiation from its very beginning. It ensures that ectopic gene ... Gene delivery system for the hair follicle using viral vectors or liposomes for gene targeting to the various cell types in the ... Efficient gene delivery in the central nervous system (CNS) is important in studying gene functions, modeling neurological ...
  https://www.jove.com/visualize/abstract/23342159/lentiviral-moloney-retroviral-expression-green-fluorescent-protein
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
All the genes encoding the accessory proteins, including Vif, Vpr, Vpu, and Nef are excluded in the packaging system. The ... Thus, this method enables manipulation of CD4 T cell differentiation from its very beginning. It ensures that ectopic gene ... Efficient gene delivery in the central nervous system (CNS) is important in studying gene functions, modeling neurological ... Adenovirus (Ad) derived vectors have been widely used for short or long-term gene transfer, both for gene therapy and vaccine ...
  https://www.jove.com/visualize/abstract/25347556/protective-effect-different-anti-rabies-virus-vhh-constructs-against
*  What Happened in the Stock Market Today -- The Motley Fool
... and Sangamo Therapeutics announced results from the first in vivo gene-editing trial in humans. ... Sangamo falls after reporting on landmark gene-editing trial. Gene-editing biotech pioneer Sangamo Therapeutics made history ... What Happened in the Stock Market Today @themotleyfool #stocks $GME, $SGMO, $^GSPC, $PNQI, $VPU, $^DJI ... enabling them to start producing the IDS enzyme. ... Patients with MPS II have a gene mutation that causes a ...
  https://www.fool.com/investing/2018/09/05/what-happened-in-the-stock-market-today.aspx?source=djc&utm_campaign=article&utm_medium=feed&utm_source=djc
*  Interplay between HIV-1 and Host Genetic Variation: A Snapshot into Its Impact on AIDS and Therapy Response
P. An and C. A. Winkler, "Host genes associated with HIV/AIDS: advances in gene discovery," Trends in Genetics, vol. 26, no. 3 ... 90] demonstrated that while Vpu of both group M and N HIV-1 viruses had activity against human tetherin, Vpu and Nef from group ... might enable achieving UNAIDS mission of "zero new HIV infections, zero discrimination and zero AIDS-related deaths" earlier. ... S. J. O'Brien and G. W. Nelson, "Human genes that limit AIDS," Nature Genetics, vol. 36, no. 6, pp. 565-574, 2004. View at ...
  https://www.hindawi.com/journals/av/2012/508967/
*  Frontiers | The Argus-II Retinal Prosthesis Implantation; From the Global to Local Successful Experience | Neuroscience
Compared to gene therapy; Argus II is less costly with a demonstrated favorable outcome, though the vision is yet artificial. ... Compared to gene therapy; Argus II is less costly with a demonstrated favorable outcome, though the vision is yet artificial. ... and gene therapy have obtained FDA approval in treating blindness resulting from retinitis pigmentosa. ... and gene therapy have obtained FDA approval in treating blindness resulting from retinitis pigmentosa. ...
  https://www.frontiersin.org/articles/10.3389/fnins.2018.00584/full
*  Éric A. Cohen - Wikipedia
Cohen has investigated the role and function of Vpu in HIV pathogenesis. His laboratory demonstrated that Vpu enables the ... Göttlinger, H. and Cohen, E.A. The Vpu gene product of HIV. HIV: a practical approach. Volume 2. Biochemistry, Molecular ... HIV Nef and Vpu protect HIV-infected CD4+ T cells from antibody-mediated cell lysis through down-modulation of CD4 and BST2. ... Cohen's work also showed that Vpu plays a key part in the negative regulation of the CD4 receptor observed during HIV infection ...
  https://en.wikipedia.org/wiki/%C3%89ric_A._Cohen
*  CRM1-dependent, but not ARE-mediated, nuclear export of IFN-α1 mRNA | Journal of Cell Science
HnRNP L binds a cis-acting RNA sequence element that enables intron-dependent gene expression. Genes Dev. 9, 1766-1780. ... Vpu liberates Golgi-targeted gp160 from CD4-dependent retention in the endoplasmic reticulum. J. Biochem. 115, 1010-1020. ... Close kinship of human 20alphahydroxysteroid dehydrogenase gene with three aldo-keto reductase genes. Genes Cells 5, 111-125. ... α1 gene lacking the 3′ UTR. The expression plasmid for the 3′ UTR-truncated IFN-α1 gene was co-transfected into HeLa cells with ...
  http://jcs.biologists.org/content/117/11/2259
*  Evil under the Sun*: 2008
Tweaking one developmental gene in a fruit fly can lead to an extra set of wings. Unfortunately, those wings don't have muscles ... Although minor changes within HIV have enabled it to resist certain drugs, nothing fundamentally new has emerged. [S. 62]. ... Quelle: 'Illustrated Guide to vpu]. Zwei generelle Reviews zu Behes Buch: von Quintessence of Dust, von Nick Matzke auf The ... Biologists have found that mutations in developmental genes often lead to death and deformity. Evo-devo experts work a lot with ...
  http://evilunderthesun.blogspot.com/2008/
*  Discovery and analysis of the first endogenous lentivirus | PNAS
1 and 2). The tat gene is located immediately downstream of pol, partially overlapping the env gene, whereas rev is located ... Furthermore, the identification of lentiviral genomic fossils enables us to provide the first estimates for the minimum age of ... Purifying selection on the env gene is indicative of extracellular reinfection because this gene is necessary only for movement ... such as the presence of tat and rev genes, thus also indicating an ancient origin for the complex regulation of lentivirus gene ...
  http://www.pnas.org/content/104/15/6261
*  Slashdot: News for nerds, stuff that matters
... enabling them to continue to hold the patent over the so-called breast cancer gene BRCA1. The same patent is also being ... VPU) and an implanted artificial retina. The VPU transforms images from the video camera into electronic data that is ... Australian Federal Court Rules For Patent Over Breast Cancer Gene 160 Posted by samzenpus on Friday February 15, 2013 @05:31AM ... in a decision that has devastated cancer victims.The decision is the first in Australia to rule on whether isolated genes can ...
  https://science.slashdot.org/index2.pl?fhfilter=science&startdate=20130211&issue=20130215&index=1
*  Slashdot: News for nerds, stuff that matters
... enabling them to continue to hold the patent over the so-called breast cancer gene BRCA1. The same patent is also being ... VPU) and an implanted artificial retina. The VPU transforms images from the video camera into electronic data that is ... A contest to write software to analyze immune-system genes garnered more than 100 entries, including many that vastly ... Australian Federal Court Rules For Patent Over Breast Cancer Gene 160 Posted by samzenpus on Friday February 15, 2013 @05:31AM ...
  https://science.slashdot.org/index2.pl?startdate=20130212&issue=20130216&index=1
*  HIV vaccine research in Canada | AIDS Research and Therapy | Full Text
The vaccine preparation was genetically modified by deleting the nef and vpu genes and fully inactivated by aldrithiol-2 and γ- ... This combined approach would incorporate vaccine elements that enable elicitation of antibodies that effectively block ...
  https://aidsrestherapy.biomedcentral.com/articles/10.1186/s12981-017-0181-8
*  JCI - Enhanced antagonism of BST-2 by a neurovirulent SIV envelope
The dogma for accessory genes antagonizing BST-2 has been that HIV-1 utilizes Vpu (30, 31), HIV-2 utilizes Env (40), and SIV ... Although it may not directly reflect the disease progression in HIV-1-infected individuals, nonhuman primate models enable ... Vpu augments the initial burst phase of HIV-1 propagation and downregulates BST2 and CD4 in humanized mice. J Virol. 2012;86(9 ... For instance, Vpu+ SIVs such as SIV from greater spot-nosed monkeys (SIVgsn) can utilize their Nef protein to antagonize BST-2 ...
  https://www.jci.org/articles/view/83725
*  HIV type I envelope determinants for use of the CCR2b, CCR3, STRL33, and APJ coreceptors | PNAS
The SHIV env genes analyzed in this study were derived from SHIV-4, which contains tat, rev, vpu, and env genes from the HXBc2 ... However, these changes did not enable the Env protein to use CCR5. Amino acid changes also were observed in V1/V2, V4, and V5. ... vpu, and env genes of the HXBc2 strain of HIV-1 in a genetic background of SIVmac239. The Env from the parental virus as well ... The first SHIV-4 passaged env gene analyzed in this study was derived from the spleen tissue from macaque PPc (41), which died ...
  http://www.pnas.org/content/95/19/11360