*  Nav1.9 - Wikipedia
... voltage-gated, type XI, alpha subunit also known as SCN11A or Nav1.9 is a voltage-gated sodium ion channel protein which is ... Voltage-gated sodium channels are membrane protein complexes that play a fundamental role in the rising phase of the action ... Alpha subunits, such as SCN11A, mediate voltage-dependent gating and conductance, while auxiliary beta subunits regulate the ... "Entrez Gene: Sodium channel, voltage-gated, type XI, alpha subunit". Catterall WA, Perez-Reyes E, Snutch TP, Striessnig J ( ...
  https://en.wikipedia.org/wiki/Nav1.9
*  Switch to Europe/Worldwide website
Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma ... The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into ... BKbeta2, Hbeta2, Hbeta3, K(VCA)beta-2, Slo-beta-2, Calcium-activated potassium channel subunit beta-2, BK channel subunit beta- ... Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma ...
  https://www.acris-antibodies.com/target/kcnmb2-antibody.htm?ab_ag_presentation=Aff+-+Purified
*  Plus it
Oh Y, Waxman SG. Novel splice variants of the voltage-sensitive sodium channel alpha subunit. Neuroreport 9: 1267-1272, 1998. ... Functional expression of Drosophila para sodium channels. Modulation by the membrane protein TipE and toxin pharmacology. J Gen ... Diss JK, Archer SN, Hirano J, Fraser SP, Djamgoz MB. Expression profiles of voltage-gated Na(+) channel alpha-subunit genes in ... Charron F, Tessier-Lavigne M. The Hedgehog, TGF-beta/BMP and Wnt families of morphogens in axon guidance. Adv Exp Med Biol 621 ...
  http://jn.physiology.org/content/102/3/1994
*  Sodium Channel NaV1.5 Expression is Enhanced in Cultured Adult Rat Skeletal Muscle Fibers, The Journal of Membrane Biology | 10...
The Journal of Membrane Biology" on DeepDyve, the largest online rental service for scholarly research with thousands of ... "Sodium Channel NaV1.5 Expression is Enhanced in Cultured Adult Rat Skeletal Muscle Fibers, ... Rapid protein kinase C-dependent reduction of rat skeletal muscle voltage-gated sodium channels by ciliary neurotrophic factor ... Differential modulation of sodium channel gating and persistent sodium currents by the beta1, beta2, and beta3 subunits ...
  https://www.deepdyve.com/lp/springer_journal/sodium-channel-nav1-5-expression-is-enhanced-in-cultured-adult-rat-lAZWCBiJ8J
*  Neosaxitoxin - Wikipedia
"Voltage gated", also called "voltage sensitive" and "voltage dependant" sodium channel also known as "VGSCs" or "Nav channel" ... proteins in the mammalian brain are composed of an association that include one alpha subunit and one or more auxiliary beta ... of some voltage gated sodium channels in a very powerful and reversible manner, without affection of other ion channels. " ... This large integral membrane protein plays an essential role in the initiation and propagation of action potentials in neurons ...
  https://en.wikipedia.org/wiki/Neosaxitoxin
*  Anesthetic sensitivity of the Gloeobacter violaceus proton-gated ion channel
Among these are voltage-gated Na+ channels from bacteria (36) and two-pore domain K+ channels from yeast (37). The sensitivity ... Solute modulation of conformational equilibria in intrinsic membrane proteins: apparent "cooperativity" without binding. ... effects of TM2 mutations in the alpha and beta subunits. Anesthesiology. 2003;99:678-84. [PubMed] ... Ouyang W, Jih TY, Zhang TT, Correa AM, Hemmings HC., Jr Isoflurane Inhibits NaChBac, a Prokaryotic Voltage-Gated Sodium Channel ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2897236/?lang=en-ca
*  Voltage-gated calcium channel - Wikipedia
The intracellular β subunit (55 kDa) is an intracellular MAGUK-like protein (Membrane-Associated Guanylate Kinase) containing a ... Zakon, H. H. (2012). "Adaptive evolution of voltage-gated sodium channels: The first 800 million years". Proceedings of the ... "The I-II loop of the Ca2+ channel α1 subunit contains an endoplasmic reticulum retention signal antagonized by the beta subunit ... Voltage-gated calcium channels (VGCCs), also known as voltage-dependent calcium channels (VDCCs), are a group of voltage-gated ...
  https://en.wikipedia.org/wiki/Voltage-gated_calcium_channel
*  Voltage-gated potassium channel - Wikipedia
Proteins minK and MiRP1 are putative hERG beta subunits. The voltage-gated K+ channels that provide the outward currents of ... "Voltage-gated potassium channel database (VKCDB)" at ualberta.ca UMich Orientation of Proteins in Membranes families/ ... The position of these arginines, known as gating arginines, are highly conserved in all voltage-gated potassium, sodium, or ... Voltage-gated potassium channels (VGKCs) are transmembrane channels specific for potassium and sensitive to voltage changes in ...
  https://en.wikipedia.org/wiki/Voltage-gated_potassium_channel
*  Sodium channel - Wikipedia
Voltage-gated sodium channels normally consist of an alpha subunit that forms the ion conduction pore and one to two beta ... Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's plasma ... In addition to regulating channel gating, sodium channel beta subunits also modulate channel expression and form links to the ... "Voltage-gated", "voltage-sensitive", or "voltage-dependent" sodium channel also called "VGSCs" or "Nav channel") or a binding ...
  https://en.wikipedia.org/wiki/Sodium_channel
*  SCN8A - Wikipedia
Sodium channel, voltage gated, type VIII, alpha subunit also known as SCN8A or Nav1.6 is a membrane protein encoded by the ... Nav1.6 is one sodium channel isoform and is the primary voltage-gated sodium channel at the nodes of Ranvier. The channels are ... "Resurgent current and voltage sensor trapping enhanced activation by a beta-scorpion toxin solely in Nav1.6 channel. ... The voltage gated sodium channel is composed of 1980 residues. Like other sodium channels, Nav1.6 is a monomer composed of four ...
  https://en.wikipedia.org/wiki/SCN8A
*  Voltage-gated ion channel - Wikipedia
Phylogenetic studies of proteins expressed in bacteria revealed the existence of a superfamily of voltage-gated sodium channels ... between the sides of the cell membrane. Voltage-gated ion channels are generally composed of several subunits arranged in such ... ISBN 978-0-7167-3136-8. Gulbis JM, Mann S, MacKinnon R (June 1999). "Structure of a voltage-dependent K+ channel beta subunit ... DB Voltage-gated ion channel subunits The IUPHAR Compendium of Voltage-gated Ion Channels 2005 Voltage-Dependent Anion Channels ...
  https://en.wikipedia.org/wiki/Voltage-gated_ion_channel
*  Potassium channel, voltage-dependent, EAG/ELK/ERG (IPR003938) | InterPro | EMBL-EBI
We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their ... InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites ... Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (IPR030173). Description. Potassium channels are ... or hetero-associations of alpha subunits or association with auxiliary cytoplasmic beta subunits. K+ channel subunits ...
  http://www.ebi.ac.uk/interpro/entry/IPR003938
*  Long QT syndrome - Wikipedia
... subunit of the voltage-gated sodium channel of the heart. The mutation leads to a positive shift in inactivation of the sodium ... LQT9 This newly discovered variant is caused by mutations in the membrane structural protein, caveolin-3. Caveolins form ... Mexiletine, a sodium channel blocker: In LQT3, the sodium channel does not close properly. Mexiletine closes these channels and ... It involves mutations in the gene KCNE1, which encodes for the potassium channel beta subunit MinK. In its rare homozygous ...
  https://en.wikipedia.org/wiki/Long_QT_syndrome
*  Spectrin mutations that cause spinocerebellar ataxia type 5 impair axonal transport and induce neurodegeneration in Drosophila ...
Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje ... Beta III spectrin binds to the Arp1 subunit of dynactin. J. Biol. Chem. 276:36598-36605. doi:10.1074/jbc.M104838200. ... Kinesin superfamily KIF5 proteins bind to beta-III spectrin. Korean J. Physiol. Pharmacol. 8:167-172. ... β]IV-spectrin regulates sodium channel clustering through ankyrin-G at axon initial segments and nodes of Ranvier. J. Cell Biol ...
  http://jcb.rupress.org/content/189/1/143.long
*  Gene Report for G00001826 - Genes2Cognition Neuroscience Research Programme
Voltage-gated sodium channels are composed of a pore-forming alpha subunit and at least one auxiliary beta subunit. Both beta1 ... proteins also known to be localized in these specialized membrane domains include the voltage-dependent sodium channel, the ... Ankyrin G and voltage gated sodium channels colocalize in human neuroma--key proteins of membrane remodeling after axonal ... Ankyrin-G, a modular protein, plays a critical role in clustering voltage-gated sodium channels (Nav channels) in nodes of ...
  http://www.genes2cognition.org/db/Gene/G00001826
*  SCNN1A - Wikipedia
"A long isoform of the epithelial sodium channel alpha subunit forms a highly active channel". Channels. 9 (1): 30-43. doi: ... ENaC is expressed in epithelial cells and is different from the voltage-gated sodium channel that is involved in the generation ... heterogeneity in epithelial sodium channel alpha-subunit mRNA leads to distinct NH2-terminal variant proteins". The American ... "Cell-specific expression of epithelial sodium channel alpha, beta, and gamma subunits in aldosterone-responsive epithelia from ...
  https://en.wikipedia.org/wiki/SCNN1A
*  Ball and chain inactivation - Wikipedia
When voltage-gated sodium channels open, the S4 segment moves outwards from the channel and into the extracellular side. This ... Xia XM, Ding JP, Lingle CJ (2003). "Inactivation of BK Channels by the NH2 Terminus of the beta Auxiliary Subunit An Essential ... of amino acids connected to the main protein by a string of residues on the cytoplasmic side of the membrane. The ball enters ... Voltage-gated ion channels open upon depolarization of the cell membrane. This creates a current caused by the flow of ions ...
  https://en.wikipedia.org/wiki/Ball_and_chain_inactivation
*  End-plate potential - Wikipedia
... voltage-gated ion channel and ligand-gated ion channel. Voltage gated ion channels are responsive to changes in membrane ... Five subunits consisting of four different proteins from four different genes comprise the nicotinic acetylcholine receptors ... the voltage gated ion channels in the postsynaptic membrane open causes in influx of sodium ions and a sharp spike in ... In Alzheimer patients, beta amyloid attaches to the acetylcholine receptors and inhibits acetylcholine binding. This causes ...
  https://en.wikipedia.org/wiki/End-plate_potential
*  NFASC - Wikipedia
Jenkins SM, Bennett V (2002). "Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium ... Ratcliffe CF, Westenbroek RE, Curtis R, Catterall WA (2001). "Sodium channel beta1 and beta3 subunits associate with ... Neurofascin is a protein that in humans is encoded by the NFASC gene. Neurofascin is an L1 family immunoglobulin cell adhesion ... channels, and L1 CAMs at Purkinje neuron initial segments". J. Cell Biol. 155 (5): 739-46. doi:10.1083/jcb.200109026. PMC ...
  https://en.wikipedia.org/wiki/NFASC
*  Frontiers | Regulation of Lung Epithelial Sodium Channels by Cytokines and Chemokines | Immunology
Reabsorption is a two-step process: first, sodium enters via sodium-permeable channels in the apical membranes of alveolar type ... inflammation can have a particularly profound effect on lung sodium transport since they can alter both ion channel and barrier ... via sodium-permeable channels in the apical membranes of alveolar type 1 and 2 cells followed by active extrusion of sodium ... Cytokines and chemokines affect alveolar amiloride-sensitive epithelial sodium channels (ENaC) which play a crucial role in ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2017.00766/full
*  Generalized epilepsy with febrile seizures plus - Wikipedia
"An epilepsy mutation in the beta1 subunit of the voltage-gated sodium channel results in reduced channel sensitivity to ... some producing functional channels while others result in non-functional channels. Some functional channels result in membrane ... "A novel epilepsy mutation in the sodium channel SCN1A identifies a cytoplasmic domain for beta subunit interaction". J Neurosci ... Interestingly, the truncated mutant protein also seems to cause wild-type channels to inactivate at more hyperpolarized ...
  https://en.wikipedia.org/wiki/Generalized_epilepsy_with_febrile_seizures_plus
*  Protocols and Video Articles Authored by Rohini Kuner (Translated to Italian)
... normal voltage-gated sodium channel currents, and normal accumulation of ankyrin G and the sodium channels Nav1.6 at NR. The ... We report here a protein-protein interaction between nNOS and NOSIP (nitric oxide synthase-interacting protein) in rat brain in ... Inhibitor KappaB Kinase Beta Deficiency in Primary Nociceptive Neurons Increases TRP Channel Sensitivity The Journal of ... Roles of the AMPA Receptor Subunit GluA1 but Not GluA2 in Synaptic Potentiation and Activation of ERK in the Anterior Cingulate ...
  https://www.jove.com/author/Rohini_Kuner?language=Italian
*  Proteomics to Identify Proteins Interacting with P2X2 Ligand-Gated Cation Channels | Protocol
We describe a simple protocol to identify brain proteins that bind to the full length C terminus of ATP-gated P2X2 receptors. ... Profiling Voltage-gated Potassium Channel mRNA Expression in Nigral Neurons using Single-cell RT-PCR Techniques…. Published 9/ ... Each P2X subunit is thought to possess two membrane spanning segments (TM1 & TM2) separated by an extracellular region7 and ... Sodium dodecyl sulfate. Reagent. Sigma-Aldrich. L4509. SYPRO® Ruby protein gel stain. Reagent. Bio-Rad. 170-3125. ...
  https://www.jove.com/video/1178/proteomics-to-identify-proteins-interacting-with-p2x2-ligand-gated
*  KCNE2 - Wikipedia
MiRP1 is a voltage-gated potassium channel accessory subunit (beta subunit) associated with Long QT syndrome. It is ... KCNE proteins contain a single membrane-spanning region, extracellular N-terminal and intracellular C-terminal. KCNE proteins ... pacemaker channels in human heart and in the hearts of other species, as well as the Cav1.2 voltage-gated calcium channel. In ... "Relationship between genetic variants in myocardial sodium and potassium channel genes and QT interval duration in diabetics: ...
  https://en.wikipedia.org/wiki/KCNE2
*  Protocols and Video Articles Authored by Ki Ho Park (Translated to Russian)
MPS-1 is a single-transmembrane domain protein that coassembles with voltage-gated K+ channel KVS-1 in the nervous system of ... Dec, 2003 , Pubmed ID: 14563681 Voltage-gated potassium channels formed with the cardiac subunit HERG and a polymorphic variant ... Nov, 2005 , Pubmed ID: 16222231 We report the first example of a K+ channel beta-subunit that is also a serine/threonine kinase ... channels. They determine trafficking to the plasma membrane, surface expression, gating, permeation, and pharmacology. At least ...
  https://www.jove.com/author/Ki+Ho_Park?language=Russian