Ion channels and neurology | Archives of Disease in Childhood
Mutations in one of two voltage gated potassium channel subunit genes, KCNQ2 and KCNQ3, cause BNFC.6 7 A slow, repolarising ... voltage-gated sodium channels and the action potential spreads across the muscle fibre causing T tubule calcium channels to ... is entirely dependent on voltage gated ion channels. As the transmembrane voltage changes a voltage gated sodium channel opens ... Mutations in the voltage gated sodium channel, SCNA4, underlie this disorder. Channels open later or for longer after ...http://adc.bmj.com/content/84/3/277
Cation channel superfamily - Wikipedia
These include the sodium, potassium, calcium, ryanodine receptor, HCN, CNG, CatSper, and TRP channels. This large group of ion ... Ren D, Navarro B, Xu H, Yue L, Shi Q, Clapham DE (December 2001). "A prokaryotic voltage-gated sodium channel". Science. 294 ( ... KCNQ2), Kv7.3 (KCNQ3), Kv7.4 (KCNQ4), Kv7.5 (KCNQ5) Kvα10.x: Kv10.1 (KCNH1) Kvα1.x - Shaker-related: Kv1.4 (KCNA4) Kvα3.x - ... Payandeh J, Scheuer T, Zheng N, Catterall WA (July 2011). "The crystal structure of a voltage-gated sodium channel". Nature. ...https://en.wikipedia.org/wiki/Cation_channel_superfamily
Seminars | Physiology and Biophysics
The voltage-gated sodium (NaV) and calcium (CaV) channels constitutes two major ion-channel superfamilies with custom molecular ... defining the role of KCNQ2/3 channels in the brain. My seminar will focus on KCNQ channels, a potassium channel family ... Coupling of L-type calcium channels and excitability. L-type CaV1.2 and CaV1.3 calcium channels are key players in the ... I will first discuss the role of KCNQ2/3 channels in interneurons. Previous research on the function of KCNQ2/3 channels nearly ...http://depts.washington.edu/pbiopage/seminars/action~agenda/page_offset~-1/time_limit~1505977200/cat_ids~42,44/request_format~html/
List of MeSH codes (D12.776.157) - Wikipedia
... potassium channels, tandem pore domain MeSH D12.776.157.530.400.600.900 -- potassium channels, voltage-gated MeSH D12.776. ... kcnq1 potassium channel MeSH D12.776.157.530.400.600.900.124.249.750 -- kcnq2 potassium channel MeSH D12.776.157.530.400.600. ... potassium-hydrogen antiporters MeSH D12.776.157.530.450.162.442 -- sodium-calcium exchanger MeSH D12.776.157.530.450.162.775 ... potassium channels MeSH D12.776.157.530.400.600.150 -- potassium channels, calcium-activated MeSH D12.776.157.530.400.600. ...https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776.157)
Voltage-gated potassium channel - Wikipedia
... are highly conserved in all voltage-gated potassium, sodium, or calcium channels. However, the extent of their movement and ... KCNQ2), Kv7.3 (KCNQ3), Kv7.4 (KCNQ4), Kv7.5 (KCNQ5) Kvα10.x: Kv10.1 (KCNH1) rapidly inactivating Kvα1.x - Shaker-related: Kv1.4 ... Voltage-gated potassium channels (VGKCs) are transmembrane channels specific for potassium and sensitive to voltage changes in ... Voltage-Gated Potassium Channels at the US National Library of Medicine Medical Subject Headings (MeSH) "Voltage-Gated ...https://en.wikipedia.org/wiki/Voltage-gated_potassium_channel
Molecular microdomains in a sensory terminal, the vestibular calyx ending
Ion channels of interest include three potassium channel families [KCNQ (KV7), erg (KV11), and KV1] that include low-voltage- ... Voltage-gated calcium channel currents in type I and type II hair cells isolated from the rat crista. J Neurophysiol. 2003 Jul; ... Regulation of the voltage-gated cardiac sodium channel Nav1.5 by interacting proteins. Trends Cardiovasc Med. 2005;15:35-40. [ ... The low-voltage-activated channel, KV1.1, is, like KCNQ2, expressed in Domain 1 in all calyces, both central and peripheral ( ...http://pubmedcentralcanada.ca/pmcc/articles/PMC3276652/?lang=en-ca
Voltage-gated sodium and calcium channels are closely related members of the ion channel protein superfamily (Yu and Catterall ... 2). In one study, the combination of mild mutations in Scn2a and the potassium channel gene Kcnq2 resulted in a severe seizure ... Calcium channels and inherited migraine. Like sodium channels, voltage-gated calcium channels are the molecular targets for ... The pore-forming α1 subunits of voltage-gated calcium channels resemble the α subunits of sodium channels in structure with ...http://www.jneurosci.org/content/28/46/11768
List of MeSH codes (D12.776.543) - Wikipedia
... potassium channels, tandem pore domain MeSH D12.776.543.550.425.750.900 -- potassium channels, voltage-gated MeSH D12.776. ... kcnq1 potassium channel MeSH D12.776.543.550.425.750.900.124.249.750 -- kcnq2 potassium channel MeSH D12.776.543.550.425.750. ... potassium-hydrogen antiporters MeSH D12.776.543.585.450.162.442 -- sodium-calcium exchanger MeSH D12.776.543.585.450.162.775 ... potassium channels, tandem pore domain MeSH D12.776.543.585.400.750.900 -- potassium channels, voltage-gated MeSH D12.776. ...https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776.543)
FDSS7000EX Functional Drug Screening System | 浜松ホトニクス
Shuzo Watanabe Discovery of voltage-gated sodium-channel blockers for the treatment of neuropathic pain Nihon Yakurigaku Zasshi ... A novel assay of Gi/o-linked G protein-coupled receptor coupling to potassium channels provides new insights into the ... Hongkang Zhang, Beiyan Zou, Fang Du, Kaiping Xu, and Min Li Reporting Sodium Channel Activity Using Calcium Flux: ... A small molecule activator of KCNQ2 and KCNQ4 channels. Probe Reports from the NIH Molecular Libraries Program [Internet]. ...http://www.hamamatsu.com/jp/ja/product/application/1503/5333/FDSS7000EX/index.html
FDSS/µCELL 創薬スクリーニング支援システム C13299 | 浜松ホトニクス
Shuzo Watanabe Discovery of voltage-gated sodium-channel blockers for the treatment of neuropathic pain Nihon Yakurigaku Zasshi ... A novel assay of Gi/o-linked G protein-coupled receptor coupling to potassium channels provides new insights into the ... Hongkang Zhang, Beiyan Zou, Fang Du, Kaiping Xu, and Min Li Reporting Sodium Channel Activity Using Calcium Flux: ... A small molecule activator of KCNQ2 and KCNQ4 channels. Probe Reports from the NIH Molecular Libraries Program [Internet]. ...http://www.hamamatsu.com/jp/ja/product/application/1503/5333/FDSS_uCELL/index.html
KCNE2 - Wikipedia
... pacemaker channels in human heart and in the hearts of other species, as well as the Cav1.2 voltage-gated calcium channel. In ... Tinel N, Diochot S, Lauritzen I, Barhanin J, Lazdunski M, Borsotto M (September 2000). "M-type KCNQ2-KCNQ3 potassium channels ... "Relationship between genetic variants in myocardial sodium and potassium channel genes and QT interval duration in diabetics: ... This protein belongs to the potassium channel KCNE family and is one five single transmembrane domain voltage-gated potassium ( ...https://en.wikipedia.org/wiki/KCNE2
Activation and Inhibition of Neuronal G Protein-Gated Inwardly Rectifying K+ Channels by P2Y Nucleotide Receptors | Molecular...
KCNQ2/3) K+ channels and/or N-type voltage-gated Ca2+ channels (reviewed in Brown et al., 2000; Filippov et al., 2000, 2003). ... Hill JJ and Peralta EG (2001) Inhibition of a Gi-activated potassium channel (GIRK1/4) by the Gq-coupled m1 muscarinic ... Trouslard J, Marsh SJ, and Brown DA (1993) Calcium entry through nicotinic receptor channels and calcium channels in cultured ... was added to bath solution to block the fast sodium current. Membrane currents were recorded using a discontinuous (`switching ...http://molpharm.aspetjournals.org/content/66/3/468
Frontiers | The Role of DPO-1 and XE991-Sensitive Potassium Channels in Perivascular Adipose Tissue-Mediated Regulation of...
Recent evidence has implicated the XE991-sensitive voltage-gated Kv (KCNQ) channels in the regulation of arterial tone by PVAT ... These channels are present in VSMCs and very potently inhibited by the KCNQ channel blocker XE991. BKCa channels and/or DPO-1 ... since XE991 effects may involve Ca2+ activated BKCa channels and/or voltage-dependent Kv1.5 channels sensitive to diphenyl ... since XE991 effects may involve Ca2+ activated BKCa channels and/or voltage-dependent Kv1.5 channels sensitive to diphenyl ...https://www.frontiersin.org/articles/10.3389/fphys.2016.00335/full
Activators of Cation Channels: Potential in Treatment of Channelopathies | Molecular Pharmacology
... one G protein-coupled inwardly rectifying potassium channel activator (flupirtine), one sodium channel activator (BDF 9148/ ... in the case of gating modifiers, as a result of faster activation, slower deactivation, altered voltage-dependence, or a ... The KCNQ2-5 channels form the classic M-channels and the activators retigabine and BMS-204352 might have a future for the ... Functional characterization of large conductance calcium-activated K+ channel openers in bladder and vascular smooth muscle. ...http://molpharm.aspetjournals.org/content/67/3/585
Unmyelinated type II afferent neurons report cochlear damage | PNAS
Gating-induced large aqueous volumetric remodeling and aspartate tolerance in the voltage sensor domain of Shaker K+ channels ... A) External potassium was elevated from 5.8 to 40 mM by substitution with sodium, shifting the potassium equilibrium (EK) ... 2015) Potent KCNQ2/3-specific channel activator suppresses in vivo epileptic activity and prevents the development of tinnitus ... B) Superfusion with "internal solution" (150 mM K-methanesulfonate, buffered calcium, no ATP) induced large inward currents in ...http://www.pnas.org/content/112/47/14723
Ocular albinism - Wikipedia
Diseases of ion channels. Calcium channel. Voltage-gated. *CACNA1A *Familial hemiplegic migraine 1 ... Potassium channel. Voltage-gated. *KCNA1 *Episodic ataxia 1. *KCNA5 *Familial atrial fibrillation 7 ... Sodium channel. Voltage-gated. *SCN1A *Familial hemiplegic migraine 3. *GEFS+ 2. *Febrile seizure 3A ...https://en.wikipedia.org/wiki/Ocular_albinism
Myotonia congenita - Wikipedia
Diseases of ion channels. Calcium channel. Voltage-gated. *CACNA1A *Familial hemiplegic migraine 1 ... Sodium channel myotonias (SCN4A). *Potassium-aggravated myotonia (acetazolamide responsive myotonia). *Paramyotonia congenita ... genetic testing not to have mutations in the chloride gene but rather in the alpha-subunit of the voltage gated sodium channel ... SCN4A). Like chloride channel mutations, patients with sodium channel mutations may have a very varied phenotype, making a ...https://en.wikipedia.org/wiki/Thomsen
Ionic conductances underlying excitability in tonically firing retinal ganglion cells of adult rat
Henne,J., Pottering,S., and Jeserich,G., Voltage-gated potassium channels in retinal ganglion cells of trout: a combined ... Inward conductance of RGCs is mediated by TTX-sensitive sodium and voltage-activated calcium channels [26;33].. ... Kv 1.1 channels (0.3 mM), and KCNQ2 (0.16-0.5 mM) [3;7;9;24;25]. However, these channel types can be distinguished from Kv3 by ... and Grantyn,R., Interaction of calcium-permeable non-N-methyl-D-aspartate receptor channels with voltage-activated potassium ...http://ykolodin.50webs.com
Experiments to Test the Role of Phosphatidylinositol 4,5-Bisphosphate in Neurotransmitter-Induced M-Channel Closure in Bullfrog...
Wu L, Bauer CS, Zhen X-G, Xie C, Yang J ( 2002) Dual regulation of voltage-gated calcium channels by PtdIns(4,5)P2. Nature 419 ... KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Science 282: 1890-1893. ... 5 sodium fluoride, 0.1 sodium orthovanadate, and 10 sodium pyrophosphate (FVPP solution) (Huang et al., 1998). Inclusion of a ... KATP channels expressed in COS7 cells (Xie et al., 1999), and voltage-gated Ca2+ channels (Wu et al., 2002). Indeed, recent ...http://www.jneurosci.org/content/23/12/4931.full.print
p75 and TrkA Signaling Regulates Sympathetic Neuronal Firing Patterns via Differential Modulation of Voltage-Gated Currents |...
We chose the sodium current, delayed rectifier potassium current, and calcium-dependent potassium current because previous ... 2001) Nerve growth factor regulates sodium but not potassium channel currents in sympathetic B neurons of adult bullfrogs. J ... 2008) Differential neurotrophic regulation of sodium and calcium channels in an adult sympathetic neuron. J Neurophysiol 99: ... 2007) Activation of epidermal growth factor receptor inhibits KCNQ2/3 current through two distinct pathways: membrane PtdIns(4, ...http://www.jneurosci.org/content/29/17/5411
... α-DTX is a selective blocker of voltage-gated potassium channels Kv1.1, 1.2, and 1.6 (Coetzee et al., 1999). These channels ... 2004) KCNQ2 is a nodal K+ channel. J Neurosci 24:1236-1244, doi:10.1523/JNEUROSCI.4512-03.2004, pmid:14762142. ... of action potentials from vertebrate nerve terminals using potentiometric probes provides evidence for sodium and calcium ... a blocker of large conductance calcium-activated potassium channels; BK channels), or paxilline (PAX; 5 μm, Tocris Bioscience; ...http://www.jneurosci.org/content/35/47/15555
All L-type voltage gated Ca channels are characterized by high sensitivity to dihydropyridine (DHP) Ca2+ channel modulators, ... due to activation of big-conductance calcium-activating potassium (BKCa) channels (Gribkoff et al., 2001 ; Cheney et al ... CAP-1A binds to a conserved motif present in NaV1.8 linking voltage-gated sodium channels to clathrin, which is involved in ... KCNQ2. Co-injection of KCNQ5 with the dominant negative mutant KCNQ2(G279S) (7) or of KCNQ2 with the equivalent mutant KCNQ5( ...http://channelpedia.epfl.ch/reports/interaction
voltage-gated sodium channel complex. A sodium channel in a cell membrane whose opening is governed by the membrane potential. ... Calmodulin supports both inactivation and facilitation of L-type calcium channels. Nature, 1999 May 13 , 399 (159-62).. ... Potassium-aggravated myotonia * Congenital myasthenic syndrome. * Muscle stiffness . VSGC blockers such as mexiletine, ... Expression of voltage-gated sodium channel alpha subunit in human ovarian cancer. Oncol. Rep., 2010 May , 23 (1293-9).. ...http://channelpedia.epfl.ch/ionchannels/123
XE991 Reveals Differences in K+ Channels Regulating Chloride Secretion in Murine Airway and Colonic Epithelium | Molecular...
1997) KvLQT1, a voltage-gated potassium channel responsible for human cardiac arrhythmias. Proc Natl Acad Sci USA 94:4017-4021. ... 1998a) KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Science (Wash DC) 282:1890-1893. ... calcium-activated potassium channel. No primers for KCNQ3 and KCNE2 were made because the murine sequences for these are ... 1999a) Formal analysis of electrogenic sodium, potassium, chloride and bicarbonate transport in mouse colon epithelium. Br J ...http://molpharm.aspetjournals.org/content/60/4/753
Novel β-catenin target genes identified in thalamic neurons encode modulators of neuronal excitability | BMC Genomics | Full...
Nomenclature and molecular relationships of voltage-gated potassium channels. Pharmacol Rev. 2005, 57 (4): 473-508.View Article ... Ducky mouse phenotype of epilepsy and ataxia is associated with mutations in the Cacna2d2 gene and decreased calcium channel ... sodium dodecyl sulfate, 10 mM ethylenediamine tetraacetic acid [EDTA], 50 mM TrisHCl, pH 8.1, and protease inhibitor cocktail) ... and many anticonvulsant drugs target voltage-gated channels (e.g., T-type Ca2+ channels ). Specifically, the T-type voltage ...https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-13-635
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