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*  Ion channels and neurology | Archives of Disease in Childhood
Mutations in one of two voltage gated potassium channel subunit genes, KCNQ2 and KCNQ3, cause BNFC.6 7 A slow, repolarising ... voltage-gated sodium channels and the action potential spreads across the muscle fibre causing T tubule calcium channels to ... is entirely dependent on voltage gated ion channels. As the transmembrane voltage changes a voltage gated sodium channel opens ... Mutations in the voltage gated sodium channel, SCNA4, underlie this disorder. Channels open later or for longer after ...
  http://adc.bmj.com/content/84/3/277
*  Neural transcriptome reveals molecular mechanisms for temporal control of vocalization across multiple timescales | BMC...
... encode ion channels and neurotransmitter receptors, hormone receptors and biosynthetic enzymes, neuromodulators, aerobic ... channels composed of potassium voltage-gated channel subfamily kqt member 2-like (kcnq2/Kv7.2) subunits, also elevated in VMN ( ... These included an isoform of cx30, GABA A receptor subunit pi-like (gabrp), and two calcium-activated potassium channel subunit ... Potassium sodium hyperpolarization-activated cyclic nucleotide-gated channel 2-like. Potassium voltage-gated channel subfamily ...
  https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-015-1577-2
*  Cation channel superfamily - Wikipedia
These include the sodium, potassium, calcium, ryanodine receptor, HCN, CNG, CatSper, and TRP channels. This large group of ion ... Ren D, Navarro B, Xu H, Yue L, Shi Q, Clapham DE (December 2001). "A prokaryotic voltage-gated sodium channel". Science. 294 ( ... KCNQ2), Kv7.3 (KCNQ3), Kv7.4 (KCNQ4), Kv7.5 (KCNQ5) Kvα10.x: Kv10.1 (KCNH1) Kvα1.x - Shaker-related: Kv1.4 (KCNA4) Kvα3.x - ... Payandeh J, Scheuer T, Zheng N, Catterall WA (July 2011). "The crystal structure of a voltage-gated sodium channel". Nature. ...
  https://en.wikipedia.org/wiki/Cation_channel_superfamily
*  Voltage-gated potassium channel - Wikipedia
... are highly conserved in all voltage-gated potassium, sodium, or calcium channels. However, the extent of their movement and ... KCNQ2), Kv7.3 (KCNQ3), Kv7.4 (KCNQ4), Kv7.5 (KCNQ5) Kvα10.x: Kv10.1 (KCNH1) rapidly inactivating Kvα1.x - Shaker-related: Kv1.4 ... Voltage-gated potassium channels (VGKCs) are transmembrane channels specific for potassium and sensitive to voltage changes in ... Voltage-Gated Potassium Channels at the US National Library of Medicine Medical Subject Headings (MeSH) "Voltage-Gated ...
  https://en.wikipedia.org/wiki/Voltage-gated_potassium_channel
*  Seminars | Physiology and Biophysics
The voltage-gated sodium (NaV) and calcium (CaV) channels constitutes two major ion-channel superfamilies with custom molecular ... defining the role of KCNQ2/3 channels in the brain. My seminar will focus on KCNQ channels, a potassium channel family ... Coupling of L-type calcium channels and excitability. L-type CaV1.2 and CaV1.3 calcium channels are key players in the ... I will first discuss the role of KCNQ2/3 channels in interneurons. Previous research on the function of KCNQ2/3 channels nearly ...
  http://depts.washington.edu/pbiopage/seminars/action~agenda/page_offset~-1/time_limit~1505977200/cat_ids~42,44/request_format~html/
*  List of MeSH codes (D12.776.157) - Wikipedia
... potassium channels, tandem pore domain MeSH D12.776.157.530.400.600.900 -- potassium channels, voltage-gated MeSH D12.776. ... kcnq1 potassium channel MeSH D12.776.157.530.400.600.900.124.249.750 -- kcnq2 potassium channel MeSH D12.776.157.530.400.600. ... potassium-hydrogen antiporters MeSH D12.776.157.530.450.162.442 -- sodium-calcium exchanger MeSH D12.776.157.530.450.162.775 ... potassium channels MeSH D12.776.157.530.400.600.150 -- potassium channels, calcium-activated MeSH D12.776.157.530.400.600. ...
  https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776.157)
*  Activation of voltage-gated KCNQ/Kv7 channels by anticonvulsant retigabine attenuates mechanical allodynia of inflammatory...
... properties and suppress cortical neuron activities by enhancing neuronal voltage-gated potassium KCNQ/Kv7 channels (M-current ... Administration of centrally acting M-channel opener retigabine (2.5 and 7.5 mg/kg) can dose-dependently raise the head ... withdrawal threshold of mechanical allodynia, and this analgesic effect can be reversed by the specific KCNQ channel blocker ... TMJ pain and pharmacological intervention for controlling central hyperexcitability by activation of neuronal KCNQ/M-channels ...
  https://molecularpain.biomedcentral.com/articles/10.1186/1744-8069-6-49
*  Molecular microdomains in a sensory terminal, the vestibular calyx ending
Ion channels of interest include three potassium channel families [KCNQ (KV7), erg (KV11), and KV1] that include low-voltage- ... Voltage-gated calcium channel currents in type I and type II hair cells isolated from the rat crista. J Neurophysiol. 2003 Jul; ... Regulation of the voltage-gated cardiac sodium channel Nav1.5 by interacting proteins. Trends Cardiovasc Med. 2005;15:35-40. [ ... The low-voltage-activated channel, KV1.1, is, like KCNQ2, expressed in Domain 1 in all calyces, both central and peripheral ( ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3276652/?lang=en-ca
*  KCNQ4 Potassium Channel Monoclon - Miscellaneous antibodies - Bioreagent
These are then seperated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels, ... There are a few main classifications of gated ion channels. There are voltage-gated ion channels, ligand-gated, other gating ... calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels ... such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by ...
  http://www.bertin-bioreagent.com/pr442/kcnq4-potassium-channel-monoclonal-antibody-clone-s43-wbr-6
*  List of MeSH codes (D12.776.543) - Wikipedia
... potassium channels, tandem pore domain MeSH D12.776.543.550.425.750.900 -- potassium channels, voltage-gated MeSH D12.776. ... kcnq1 potassium channel MeSH D12.776.543.550.425.750.900.124.249.750 -- kcnq2 potassium channel MeSH D12.776.543.550.425.750. ... potassium-hydrogen antiporters MeSH D12.776.543.585.450.162.442 -- sodium-calcium exchanger MeSH D12.776.543.585.450.162.775 ... potassium channels, tandem pore domain MeSH D12.776.543.585.400.750.900 -- potassium channels, voltage-gated MeSH D12.776. ...
  https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776.543)
*  XE 991 dihydrochloride Supplier | CAS 122955-13-9 | XE991 | Tocris Bioscience
Potent, selective KV7 (KCNQ) channel blocker; blocks M-currents. Cited in 32 publications. ... Potassium Channels / Voltage-gated Potassium (KV) Channels / Voltage-gated Potassium (KV) Channel Blockers / XE 991 ... Potassium, KV, Channels, voltage-gated, voltage-dependent, K+, KCNQ2, KCNQ3, KCNQ1, XE991, dihydrochloride, KV7.1, Voltage- ... Geier et al (2011) Dynamic interplay of excitatory and inhibitory coupling modes of neuronal L-type calcium channels. Am J ...
  https://www.tocris.com/products/xe-991-dihydrochloride_2000
*  Plus it
Voltage-gated sodium and calcium channels are closely related members of the ion channel protein superfamily (Yu and Catterall ... 2). In one study, the combination of mild mutations in Scn2a and the potassium channel gene Kcnq2 resulted in a severe seizure ... Calcium channels and inherited migraine. Like sodium channels, voltage-gated calcium channels are the molecular targets for ... The pore-forming α1 subunits of voltage-gated calcium channels resemble the α subunits of sodium channels in structure with ...
  http://www.jneurosci.org/content/28/46/11768
*  FDSS7000EX Functional Drug Screening System | 浜松ホトニクス
Shuzo Watanabe Discovery of voltage-gated sodium-channel blockers for the treatment of neuropathic pain Nihon Yakurigaku Zasshi ... A novel assay of Gi/o-linked G protein-coupled receptor coupling to potassium channels provides new insights into the ... Hongkang Zhang, Beiyan Zou, Fang Du, Kaiping Xu, and Min Li Reporting Sodium Channel Activity Using Calcium Flux: ... A small molecule activator of KCNQ2 and KCNQ4 channels. Probe Reports from the NIH Molecular Libraries Program [Internet]. ...
  http://www.hamamatsu.com/jp/ja/product/application/1503/5333/FDSS7000EX/index.html
*  FDSS/µCELL 創薬スクリーニング支援システム C13299 | 浜松ホトニクス
Shuzo Watanabe Discovery of voltage-gated sodium-channel blockers for the treatment of neuropathic pain Nihon Yakurigaku Zasshi ... A novel assay of Gi/o-linked G protein-coupled receptor coupling to potassium channels provides new insights into the ... Hongkang Zhang, Beiyan Zou, Fang Du, Kaiping Xu, and Min Li Reporting Sodium Channel Activity Using Calcium Flux: ... A small molecule activator of KCNQ2 and KCNQ4 channels. Probe Reports from the NIH Molecular Libraries Program [Internet]. ...
  http://www.hamamatsu.com/jp/ja/product/application/1503/5333/FDSS_uCELL/index.html
*  KCNE2 - Wikipedia
... pacemaker channels in human heart and in the hearts of other species, as well as the Cav1.2 voltage-gated calcium channel. In ... Tinel N, Diochot S, Lauritzen I, Barhanin J, Lazdunski M, Borsotto M (September 2000). "M-type KCNQ2-KCNQ3 potassium channels ... "Relationship between genetic variants in myocardial sodium and potassium channel genes and QT interval duration in diabetics: ... This protein belongs to the potassium channel KCNE family and is one five single transmembrane domain voltage-gated potassium ( ...
  https://en.wikipedia.org/wiki/KCNE2
*  Frontiers | Functional effects of KCNQ K+ channels in airway smooth muscle | Physiology
While KCNQ channels do control resting potentials, they appear to play a redundant role with BK calcium-activated K+ channels ... However a role for KCNQ channels was revealed when BK-K+ channel activities are reduced. While KCNQ channels do control resting ... KCNQ channels begin to activate at voltages near resting potentials for ASM cells, and indeed XE991 depolarized resting ... KCNQ channels begin to activate at voltages near resting potentials for ASM cells, and indeed XE991 depolarized resting ...
  https://www.frontiersin.org/articles/10.3389/fphys.2013.00277/full
*  Activation and Inhibition of Neuronal G Protein-Gated Inwardly Rectifying K+ Channels by P2Y Nucleotide Receptors | Molecular...
KCNQ2/3) K+ channels and/or N-type voltage-gated Ca2+ channels (reviewed in Brown et al., 2000; Filippov et al., 2000, 2003). ... Hill JJ and Peralta EG (2001) Inhibition of a Gi-activated potassium channel (GIRK1/4) by the Gq-coupled m1 muscarinic ... Trouslard J, Marsh SJ, and Brown DA (1993) Calcium entry through nicotinic receptor channels and calcium channels in cultured ... was added to bath solution to block the fast sodium current. Membrane currents were recorded using a discontinuous (`switching ...
  http://molpharm.aspetjournals.org/content/66/3/468
*  Frontiers | The Role of DPO-1 and XE991-Sensitive Potassium Channels in Perivascular Adipose Tissue-Mediated Regulation of...
Recent evidence has implicated the XE991-sensitive voltage-gated Kv (KCNQ) channels in the regulation of arterial tone by PVAT ... These channels are present in VSMCs and very potently inhibited by the KCNQ channel blocker XE991. BKCa channels and/or DPO-1 ... since XE991 effects may involve Ca2+ activated BKCa channels and/or voltage-dependent Kv1.5 channels sensitive to diphenyl ... since XE991 effects may involve Ca2+ activated BKCa channels and/or voltage-dependent Kv1.5 channels sensitive to diphenyl ...
  https://www.frontiersin.org/articles/10.3389/fphys.2016.00335/full
*  Calm1 calmodulin 1 [Rattus norvegicus (Norway rat)] - Gene - NCBI
regulation of high voltage-gated calcium channel activity IMP Inferred from Mutant Phenotype. more info ... Polarized axonal surface expression of neuronal KCNQ potassium channels is regulated by calmodulin interaction with KCNQ2 ... Sodium/Calcium exchangers, organism-specific biosystem (from REACTOME) Sodium/Calcium exchangers, organism-specific biosystem ... voltage-gated potassium channel complex IEA Inferred from Electronic Annotation. more info ...
  https://www.ncbi.nlm.nih.gov/gene/24242
*  Activators of Cation Channels: Potential in Treatment of Channelopathies | Molecular Pharmacology
... one G protein-coupled inwardly rectifying potassium channel activator (flupirtine), one sodium channel activator (BDF 9148/ ... in the case of gating modifiers, as a result of faster activation, slower deactivation, altered voltage-dependence, or a ... The KCNQ2-5 channels form the classic M-channels and the activators retigabine and BMS-204352 might have a future for the ... Functional characterization of large conductance calcium-activated K+ channel openers in bladder and vascular smooth muscle. ...
  http://molpharm.aspetjournals.org/content/67/3/585
*  Unmyelinated type II afferent neurons report cochlear damage | PNAS
Gating-induced large aqueous volumetric remodeling and aspartate tolerance in the voltage sensor domain of Shaker K+ channels ... A) External potassium was elevated from 5.8 to 40 mM by substitution with sodium, shifting the potassium equilibrium (EK) ... 2015) Potent KCNQ2/3-specific channel activator suppresses in vivo epileptic activity and prevents the development of tinnitus ... B) Superfusion with "internal solution" (150 mM K-methanesulfonate, buffered calcium, no ATP) induced large inward currents in ...
  http://www.pnas.org/content/112/47/14723
*  Thyrotoxic periodic paralysis - Wikipedia
Diseases of ion channels. Calcium channel. Voltage-gated. *CACNA1A *Familial hemiplegic migraine 1 ... sodium and potassium) across cell membranes. The main ones are the L-type calcium channel α1-subunit[1] and potassium inward ... Furthermore, mutations have been reported in the genes coding for potassium voltage-gated channel, Shaw-related subfamily, ... the enzyme that moves potassium into cells and keeps sodium in the blood) leads to shift of potassium into tissues, and ...
  https://en.wikipedia.org/wiki/Thyrotoxic_periodic_paralysis
*  Genetic disorder - Wikipedia
Diseases of ion channels. Calcium channel. Voltage-gated. *CACNA1A *Familial hemiplegic migraine 1 ... Potassium channel. Voltage-gated. *KCNA1 *Episodic ataxia 1. *KCNA5 *Familial atrial fibrillation 7 ... Sodium channel. Voltage-gated. *SCN1A *Familial hemiplegic migraine 3. *GEFS+ 2. *Febrile seizure 3A ...
  https://en.wikipedia.org/wiki/Genetic_defects
*  Myotonia congenita - Wikipedia
Diseases of ion channels. Calcium channel. Voltage-gated. *CACNA1A *Familial hemiplegic migraine 1 ... Sodium channel myotonias (SCN4A). *Potassium-aggravated myotonia (acetazolamide responsive myotonia). *Paramyotonia congenita ... genetic testing not to have mutations in the chloride gene but rather in the alpha-subunit of the voltage gated sodium channel ... SCN4A).[20] Like chloride channel mutations, patients with sodium channel mutations may have a very varied phenotype, making a ...
  https://en.wikipedia.org/wiki/Thomsen
*  Scientific Materials | Hamamatsu Photonics
Discovery of voltage-gated sodium-channel blockers for the treatment of neuropathic pain. Nihon Yakurigaku Zasshi. 2012 Nov;140 ... Effect of tyrphostin AG879 on Kv4.2 and Kv4.3 potassium channels. Br J Pharmacol. 2015 Jul;172(13):3370-82.. doi: 10.1111/bph. ... Reporting Sodium Channel Activity Using Calcium Flux: Pharmacological Promiscuity of Cardiac Nav1.5. Mol Pharmacol. 2015 Feb;87 ... Novel KCNQ2 channel activators discovered using fluorescence-based and automated patch-clamp-based high-throughput screening ...
  https://fdss.hamamatsu.com/jp/en/scientific_material.html