Raventoxin - Wikipedia
Magi 5 binds at site 4 of the alpha subunit of the mammalian voltage-gated sodium channel Nav1.2 (SCN2A). Binding of Magi 5 to ... "Solution Structure and Alanine Scan of a Spider Toxin That Affects the Activation of Mammalian Voltage-gated Sodium Channels. ( ... the sodium channels shifts both activation and inactivation to more hyperpolarized voltages and slows the recovery from ... Combined, these effects may lead to increased inactivation of the sodium channels at rest, leading to inhibition and blockage ...https://en.wikipedia.org/wiki/Raventoxin
RCSB PDB - Protein Feature View - Beta-theraphotoxin-Cm1a - P84507 (TX1 CERMR)
Inhibits several subtypes of voltage-gated sodium channels (Nav1.1/SCN1A, Nav1.2/SCN2A, Nav1.4/SCN4A, Nav1.5/SCN5A, Nav1.7/ ... the voltage dependence of channel activation to more depolarized potentials and by blocking the inward component of the sodium ... Is significantly more potent against Nav1.2/SCN2A than the other Nav channel subtypes (PubMed:16267209). In vivo, this toxin ...http://www.rcsb.org/pdb/protein/P84507
CK2-An Emerging Target for Neurological and Psychiatric Disorders
NAv1.2 and 1.6) . CK2 was further found to directly phosphorylate the voltage gated sodium channel NAv1, thereby enhancing ... CK2 activity is required for the interaction of FGF14 with voltage-gated sodium channels and neuronal excitability. FASEB J. ... Another family of membrane proteins that modulate synaptic activity are the voltage gated sodium channels (NAvs). Recently, the ... of the fibroblast growth factor receptor FGF14 and reduced interaction of FGF14 with voltage gated sodium channels ( ...http://pubmedcentralcanada.ca/pmcc/articles/PMC5374411/
Aurora Biomed Inc. Profile on Environmental XPRT
... voltage-gated sodium channels ( Nav1.5, Nav1.2), voltage-gated calcium channels, voltage-gated chloride channels and ... and ion channel cell line licensing. Applications of the ICR 8000 and ICR 12000 include voltage-gated potassium channels (hERG ... Ion Channel Research. Aurora Biomed focuses on high-throughput ion channel drug discovery as to address the recent shift of ... Aurora's family of Ion Channel Screening products include the atomic absorption spectroscopy-based Ion Channel Readers (ICR8000 ...https://www.environmental-expert.com/companies/aurora-biomed-inc-47075
ATX-II - Wikipedia
ATX-II is highly potent at voltage-gated sodium channels subtype 1.1 and 1.2 (Nav1.1 and Nav1.2) with an EC50 of approximately ... ATX-II slows down the inactivation of different voltage-gated sodium channels, including Nav1.1 and Nav1.2, thus prolonging ... The binding of the toxin can only occur when the sodium channel is open. The major action of ATX-II is to delay sodium channel ... Neurotoxins that Act on Voltage-Sensitive Sodium Channels in Excitable Membranes. Annual Review of Pharmacology and Toxicology ...https://en.wikipedia.org/wiki/ATX-II
Frontiers | Propranolol Blocks Cardiac and Neuronal Voltage-Gated Sodium Channels | Pharmacology
2008). Impaired NaV1.2 function and reduced cell surface expression in benign familial neonatal-infantile seizures. Epilepsia ... Propranolol blocks cardiac and neuronal voltage-gated sodium channels. Dao W. Wang1,2, Akshitkumar M. Mistry1, Kristopher M. ... Voltage-gated sodium channels are established pharmacological targets for local anesthetics and many other drugs with shared ... We found that the ability of propranolol to block voltage-gated sodium channels is not stereospecific, nor a class effect of β- ...https://www.frontiersin.org/articles/10.3389/fphar.2010.00144/full
APETx1 - Wikipedia
... channel, a type of voltage-gated potassium channel, and as a blocker of voltage-gated sodium channels, including Nav1.2 and ... of the hERG channels at maximum affinity suggests that APETx1 is a gating modifier. APETx1 blocks voltage-gated sodium channels ... In addition, APETx1 blocks several mammalian voltage-gated sodium channels, including Nav1.2 with an IC50 of 31 nM, and Nav1.8 ... APETx1 inhibits the hERG channel, a type of voltage-gated potassium channel. APETx1 is thought to interact with three aromatic ...https://en.wikipedia.org/wiki/APETx1
Co-expression of β Subunits with the Voltage-Gated Sodium Channel NaV1.7: the Importance of Subunit Association and...
We examined how auxiliary β2 and β3 subunits and the phosphorylation state of the channel influence its biophysical... ... The voltage-gated sodium ion channel NaV1.7 is crucial in pain signaling. ... Das S, Gilchrist J, Bosmans F, Van Petegem F (2016) Binary architecture of the Nav1.2-β2 signaling complex. elife 5. https:// ... an additional auxiliary subunit of the voltage-sensitive sodium channel that modulates channel gating with distinct kinetics. ...https://link.springer.com/article/10.1007%2Fs12031-018-1082-6
Genetics of Pain - Neurowiki 2014
The endocanabinoid anandamide inhibits voltage-gated sodium channels nav1.2, nav 1.6, nav 1.7, and nav 1.8 in Xenopus oocytes. ... SCN9A is a gene that encodes for a type IX alpha subunit of a voltage gated sodium channel, generally found in nociceptors.18 ... Peripheral neurons with this voltage-gated sodium channel are essential for pain and olfaction in both mice and humans.19. ... Cao, Y. Voltage-gated calcium channels and pain. Pain 126, 5-9 (2006) ...http://neurowiki2014.wikidot.com/individual:genetics-of-pain
Beta-hexatoxin-Mg1a precursor - Macrothele gigas (Spider)
... sodium channels and shifts the activation voltage of the mammalian Nav1.2a/SCN2A channel to more hyperpolarized voltages, ... whereas the insect channel, DmNav1 (para), is not affected. Competes for binding at site 3 of the insect sodium channel. Causes ... Binds to site 4 of mammalian voltage-gated sodium channels and shifts the activation voltage of the mammalian Nav1.2a/SCN2A ... Ion channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin. ...http://www.uniprot.org/uniprot/P83561
Synthetic GsAF-1 TOXPP-530S - Creative BioMart
GsAF-Ipeptide toxin is reported to block the following voltage-gated sodium channel isoforms: Nav1.1, Nav1.2, Nav1.3, Nav1.4, ... This product is a blocker of voltage-gated sodium channels with the formula of C160H245N47O41S7.. ...https://www.creativebiomart.net/synthetic-gsaf-1-478882.htm
Cangitoxin - Wikipedia
Sea anemone toxins act on voltage-gated sodium channels (NaV1.1, NaV1.2, NaV1.4, NaV1.5, NaV1.6, NaV1.7) and depending on their ... which most likely acts by prolonging the inactivation of voltage-gated sodium channels (NaV channels). Cangitoxin is a ... According to its sequence homology, it is likely that cangitoxin prolongs the inactivation of the voltage-gated sodium channels ... Catterall, WA; Cestele, S; Yarov-Yarovoy, V; Yu, FH; Konoki, K; Scheuer, T (2007). "Voltage-gated ion channels and gating ...https://en.wikipedia.org/wiki/Cangitoxin
Phrixotoxin - Wikipedia
... inhibits several voltage gated sodium channel subtypes (Nav1.1/SCN1A, Nav1.2/SCN2A, Nav1.4/SCN4A, Nav1.5/SCN5A, and Nav1.8/ ... Phrixotoxin-1 and -2 block A-type voltage-gated potassium channels; phrixotoxin-3 blocks voltage-gated sodium channels. Similar ... voltage-gated sodium channels by causing a depolarizing shift in gating kinetics and by blocking the inward component of sodium ... "Four novel tarantula toxins as selective modulators of voltage-gated sodium channel subtypes". Mol Pharmacol. 69 (2): 419-29. ...https://en.wikipedia.org/wiki/Phrixotoxin
The Role of Non-pore-Forming β Subunits in Physiology and Pathophysiology of Voltage-Gated Sodium Channels | SpringerLink
Voltage-gated sodium channel β1 and β2 subunits were discovered as auxiliary proteins that co-purify with pore-forming α ... McEwen DP, Meadows LS, Chen C, Thyagarajan V, Isom LL (2004) Sodium channel beta1 subunit-mediated modulation of Nav1.2 ... Brackenbury WJ (2012) Voltage-gated sodium channels and metastatic disease. Channels 6(5):352-361PubMedCentralPubMedGoogle ... Johnson D, Bennett ES (2006) Isoform-specific effects of the beta2 subunit on voltage-gated sodium channel gating. J Biol Chem ...https://link.springer.com/chapter/10.1007/978-3-642-41588-3_4
Clinical spectrum of SCN2A mutations. - PubMed - NCBI
NAV1.2 Voltage-Gated Sodium Channel. *Nerve Tissue Proteins/genetics*. *Seizures, Febrile/genetics ... Mutations in SCN2A, the gene encoding α2 subunit of the neuronal sodium channel, are associated with a variety of epilepsies: ...https://www.ncbi.nlm.nih.gov/pubmed/22029951
Clinical whole-genome sequencing in severe early-onset epilepsy reveals new genes and improves molecular diagnosis. - Oxford...
... which produced a substantial increase in potassium channel current. The fourth OS patient had a recessive mutation in PIGQ that ... NAV1.2 Voltage-Gated Sodium Channel ... KCNQ2 Potassium Channel, Genome-Wide Association Study, Young ... Potassium Channels, Membrane Proteins, Nerve Tissue Proteins, Mutation, Child, Child, Preschool, Male, Proto-Oncogene Proteins ... which produced a substantial increase in potassium channel current. The fourth OS patient had a recessive mutation in PIGQ that ...https://www.bdi.ox.ac.uk/publications/447735
... and ligand-gated (KATP, nAChR, etc.) potassium channels, voltage-gated sodium channels (SCN5a, Nav1.2) and transporters (Na/K- ... channel screening by the flux assay approach. The ICR 8000 displays broad utility; it can be applied to assess voltage-gated ( ... Ion Channel Reader 8000 and 12000, an atomic absorption spectroscopy and flux assay based ion channel activity detection system ... Fux assays utilize tracer ions to study the ion channel of interest. The Ion Channel Reader 8000 provides a medium throughput ...http://hopkinschemcore.org/facility/hardware.html
"Regulation of neuronal voltage-gated sodium channels by the ubiquitin " by Andrew B. Fotia, Jenny Ekberg et al.
... channel (Nav1.2 and Nav1.7, respectively) are readily ubiquitinated by Nedd4-2. In Xenopus oocytes, Nedd4-2 strongly inhibited ... We found that the carboxyl termini of the six voltage-gated Na+ (Nav) channels contain typical PY motifs (PPXY), and a further ... epithelial Na+ channel by Nedd4 and Nedd4-2 is mediated via interactions between the PY motifs of the epithelial sodium channel ... Our results provide evidence that Nedd4 and Nedd4-2 are likely to be key regulators of specific neuronal Nav, channels in vivo. ...http://ro.uow.edu.au/ihmri/672/
Mutations in SCN9A, encoding a sodium channel alpha subunit, in patients with primary erythermalgia | Journal of Medical...
Sangameswaran L, Fish LM, Koch BD, et al. A novel tetrodotoxin-sensitive, voltage-gated sodium channel expressed in rat and ... Nav1.2 (encoded by SCN2A), Nav1.3 (encoded by SCN3A), Nav1.4 (encoded by SCN4A), Nav1.5 (encoded by SCN5A), Nav1.6 (encoded by ... SCN9A encodes Nav1.7, a voltage gated sodium channel alpha subunit expressed primarily in sensory and sympathetic ganglia,14 ... The leucine and isoleucine at the two sites are highly conserved in most voltage gated sodium channel alpha subunit isoforms ( ...http://jmg.bmj.com/content/41/3/171
Taking Lamictal (Lamotrigine) For Anxiety Disorders: Does It Help?
Lamotrigine's modulation of voltage-gated sodium channels, and to a lesser extent, modulation of voltage-gated calcium channels ... NaV1.2, NaV1.3, and Nav1.6. Their research using cell cultures indicates that lamotrigine facilitates a significant shift in ... In addition to blocking various voltage-gated sodium and calcium channels, lamotrigine appears to modulate voltage-gated ... Though the role of voltage-gated sodium channels in anxiety disorders remains unknown, it's possible that decreasing voltage- ...https://mentalhealthdaily.com/2016/10/04/lamictal-lamotrigine-for-anxiety-disorders/?replytocom=149006
SCN2A2 (Human) Recombinant Protein (Q01) - (H00006326-Q01) - Products - Abnova
... voltage-gated, type II, alpha,sodium channel, voltage-gated, type II, alpha 1 polypeptide,sodium channel, voltage-gated, type ... HBA,HBSCI,HBSCII,NAC2,Na(v)1.2,Nav1.2,SCN2A1,SCN2A2. *Gene Description: ... Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane ... OTTHUMP00000041049,OTTHUMP00000041050,sodium channel protein, brain type 2 alpha subunit,sodium channel, ...http://www.abnova.com/products/products_detail.asp?catalog_id=H00006326-Q01
Sodium - Voltage-gated - Ion Channels - Products
Sodium. Voltage-gated sodium channels, which produce the inward membrane current necessary for regenerative action potential ... Nine members of the family of voltage-gated sodium channels have been identified thus far, consisting of a large alpha subunit ... Nomenclature and structure-function relationships of voltage-gated sodium channels. W.A. Catterall, A.L. Goldin, S.G. Waxman. ... Ligand gated sodium channels (e.g. nicotinic receptors) are activated by endogenous acetylcholine. Activation causes a ...https://www.axonmedchem.com/products/ion-channels/voltage-gated/sodium
Frontiers | Ankyrin G Membrane Partners Drive the Establishment and Maintenance of the Axon Initial Segment | Frontiers in...
... voltage-gated sodium channels (Nav) or neurofascin-186) led to a decrease of ankG concentration and perturbed the AIS formation ... rescued by expressing a recombinant AIS-targeted Nav or by a minimal construct containing the ankyrin-binding domain of Nav1.2 ... voltage-gated sodium channels (Nav) or neurofascin-186) led to a decrease of ankG concentration and perturbed the AIS formation ... rescued by expressing a recombinant AIS-targeted Nav or by a minimal construct containing the ankyrin-binding domain of Nav1.2 ...https://www.frontiersin.org/articles/10.3389/fncel.2017.00006/full
Nav1.2 - Wikipedia
Sodium channels which contain the Navα1.2 subunit are called Nav1.2 channels. Voltage-gated sodium channels are transmembrane ... Navα1.2, also known as the sodium channel, voltage-gated, type II, alpha subunit is a protein that in humans is encoded by the ... 1992). "Primary structure, chromosomal localization, and functional expression of a voltage-gated sodium channel from human ... Nomenclature and structure-function relationships of voltage-gated sodium channels". Pharmacol. Rev. 57 (4): 397-409. doi: ...https://en.wikipedia.org/wiki/Nav1.2
JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... voltage-gated sodium channel (VGSC). Sodium channels have been considered as therapeutic targets for pain. Several animal ... µ-SLPTX-Ssm6a has more than 150-fold selectivity for NaV1.7 over all other human NaV subtypes, with the exception of NaV1.2, ... Loss-of-function mutations in the human voltage-gated sodium channel NaV1.7 result in a congenital indifference to pain. ... A novel 60-residue neurotoxin peptide (anntoxin) that inhibited tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channel ( ...https://www.jove.com/visualize?author=Ren-Hau+Lai