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*  Vesicular monoamine transporter - Wikipedia
Researchers discovered inhibitors that blocked the uptake of neurotransmitters into vesicles, suggesting the existence of VMATs ... VMAT inhibitors include: Reserpine(RES), bietaserpine, and ketanserin(KET) (potent inhibitors of VMAT2 mediated serotonin ... VMAT inhibitors tend to fall into two classes; those that interact with the RES binding site and those that interact with the ... As addressed above, VMAT inhibitors tend to fall into two classes; those that interact with the RES binding site and those that ...
  https://en.wikipedia.org/wiki/Vesicular_monoamine_transporter
*  Vesicular monoamine transporter 2 - Wikipedia
VMAT2 inhibitors like tetrabenazine and reserpine reduce the concentration of monoamine neurotransmitters in the synaptic cleft ... by inhibiting uptake through VMAT2; the inhibition of VMAT2 uptake by these drugs prevents the storage of neurotransmitters in ... suggesting they might bind to the same site on VMAT. George Uhl's laboratory similarly reported that AMPH displaced the VMAT2 ... VMAT2 is essential for enabling the release of neurotransmitters from the axon terminals of monoamine neurons into the synaptic ...
  https://en.wikipedia.org/wiki/Vesicular_monoamine_transporter_2
*  Reuptake inhibitor - Wikipedia
VMAT) inhibitor - reserpine, tetrabenazine Releasing agent Iversen L. (2006). "Neurotransmitter transporters and their impact ... an inhibitor of anandamide uptake, prevents pain behaviour and modulates cytokine and apoptotic pathways in a rat model of ... inhibitor Glycine reuptake inhibitor Monoamine reuptake inhibitor Dopamine reuptake inhibitor Norepinephrine reuptake inhibitor ... Amino acid reuptake inhibitor Excitatory amino acid reuptake inhibitor (or glutamate-aspartate reuptake inhibitor) GABA ...
  https://en.wikipedia.org/wiki/Reuptake_inhibitor
*  Monoamine transporter - Wikipedia
Serotonin-norepinephrine re-uptake inhibitors (SNRIs) act by blocking both SERTs and NETs. Triple re-uptake inhibitors (TRIs) ... Neurotransmitter Transporters. Humana Press Inc. ISBN 0-89603-372-4. Miller GM (January 2011). "The emerging role of trace ... VMAT) Plasma membrane monoamine transporter (PMAT) Extraneuronal monoamine transporter (EMT) Torres, Gonzalo E.; Raul R. ... The tricyclic antidepressant desipramine is an antidepressant drug that is a relatively selective inhibitor of NE uptake. ...
  https://en.wikipedia.org/wiki/Monoamine_transporter
*  Reuptake inhibitor - Wikipedia
Vesicular acetylcholine transporter (VAChT) inhibitor - vesamicol. *Vesicular monoamine transporter (VMAT) inhibitor - ... Pure vesicular reuptake inhibitors tend to actually lower synaptic neurotransmitter concentrations, as blocking the repackaging ... an inhibitor of anandamide uptake, prevents pain behaviour and modulates cytokine and apoptotic pathways in a rat model of ... Amino acid reuptake inhibitor *Excitatory amino acid reuptake inhibitor (or glutamate-aspartate reuptake inhibitor) ...
  https://en.wikipedia.org/wiki/Non-selective_monoamine_reuptake_inhibitors
*  Functionally important carboxyls in a bacterial homologue of the vesicular monoamine transporter (VMAT). - PubMed - NCBI
3H]MPP+ uptake into proteoliposomes. [3H]MPP+ uptake was assayed as described in the legend for , with liposomes prepared from ... Antibiotic Resistance; Membrane Transport; Multidrug Transporter; Neurotransmitter; Neurotransmitter Transport; Proton ... D, inhibition of MPP+ transport by 10 μm of known substrates (ethidium, acriflavine, methyl viologen) or inhibitors ( ... Functionally important carboxyls in a bacterial homologue of the vesicular monoamine transporter (VMAT).. Yaffe D1, Vergara- ...
  https://www.ncbi.nlm.nih.gov/pubmed/25336661
*  PHENYLPIPERIDINE COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS - Patent application
0078] When used herein the terms "Selective serotonin re-uptake inhibitors" or "serotonin-specific reuptake inhibitor (SSRIs)" ... 0073] As used herein the terms "monoamines" or "monoamine neurotransmitters" refer to neurotransmitters and neuromodulators ... It acts by blocking the vesicular monoamine transporter VMAT which normally transports free norepinephrine, serotonin, and ... neurotransmitter receptors, characterized in that at least one of the monoaminergic neurotransmitter receptors with a need for ...
  http://www.patentsencyclopedia.com/app/20130197032
*  Frontiers | What Mechanisms Are Responsible for the Reuptake of Levodopa-Derived Dopamine in Parkinsonian Striatum? |...
... also potentially uptake dopamine when high-affinity transporters do not work normally. Selective serotonin reuptake inhibitors ... Selective serotonin reuptake inhibitors and serotonin and norepinephrine reuptake inhibitors are often administered to patients ... Thus, it is important to address the potential of these drugs to modify dopamine metabolism and uptake through blockade of the ... Thus, it is important to address the potential of these drugs to modify dopamine metabolism and uptake through blockade of the ...
  https://www.frontiersin.org/articles/10.3389/fnins.2016.00575/full
*  Reserpine - Wikipedia
It may take the body days to weeks to replenish the depleted VMAT, so reserpine's effects are long-lasting. This depletion of ... Reserpine-mediated depletion of monoamine neurotransmitters in the synapses is often cited as evidence to the theory that ... Reserpine almost irreversibly blocks the uptake (and storage) of norepinephrine (i.e. noradrenaline) and dopamine into synaptic ... notably the ACE inhibitors and the angiotensin II receptor antagonists. It was previously used to treat symptoms of dyskinesia ...
  https://en.wikipedia.org/wiki/Reserpine
*  Vesicular monoamine transporter 1 - Wikipedia
... associated with the uptake of monoamines and acetylcholine into vesicles developed due to the discovery of specific inhibitors ... It is thought that disruption in transport of monoamine neurotransmitters due to variation in the VMAT1 gene may be relevant to ... Talaei F, Schmidt M, Henning RH (2012). "Induction of VMAT-1 and TPH-1 expression induces vesicular accumulation of serotonin ... It has been found that these inhibitors are less effective at inhibiting VMAT1 than VMAT2, and the inhibitory effects of the ...
  https://en.wikipedia.org/wiki/Vesicular_monoamine_transporter_1
*  Adderall - Wikipedia
DHK-sensitive, EAAT2 uptake was not altered by AMPH (Figure 1A). The remaining glutamate transport in these midbrain cultures ... Monoamine oxidase inhibitors (MAOIs) taken with amphetamine may result in a hypertensive crisis if taken within two weeks after ... As substrates for both DAT and VMAT, amphetamines can be taken up to the cytosol and then sequestered in vesicles, where they ... It also triggers the release of several other hormones (e.g., epinephrine) and neurotransmitters (e.g., serotonin and histamine ...
  https://en.wikipedia.org/wiki/Adderall
*  Norepinephrine - wikidoc
Uptake Transporter Vmax (nmol/g/min)[9] KM[9] Specificity[10] Location Other substrates[10] Inhibitors [11] ... VMAT[11] -[11] ~0.2[11] norepinephrine , epinephrine , isoprenaline[11] Synaptic vesicle membrane[11] *dopamine[11] ... Serotonin, a neurotransmitter that is in many ways the opposite of the catecholamines, is also directly synthesized from an ... Uptake. Extracellular uptake of norepinephrine into the cytosol is either done presynaptically (uptake 1) or by non-neuronal ...
  http://wikidoc.org/index.php?title=Norepinephrine&oldid=570956
*  Neuro Flashcards by Katherine Dodd | Brainscape
Influence synaptic transmission (neurotransmitter uptake).. Critical for normal neural development (radial glia).. Activated in ... Using your knowledge of NT modulation at the synapse, will a NT reuptake inhibitor increase post synaptic receptor activation? ... 1. Dopamine loaded into vesicles by vesicular monamine transporter (VMAT).. 2. Reuptake via Na dependent dopamine transporter ( ... mediate delivery and uptake of glutamine from glial cells to neurons.. In neurons - glutamate loaded into vesicles by VGLUT. ...
  https://www.brainscape.com/flashcards/neuro-6178443/packs/9533036
*  Characterization of the transporterB0AT3 (Slc6a17) in the rodent central nervous system | BMC Neuroscience | Full Text
Chen NH, Reith ME, Quick MW: Synaptic uptake and beyond: the sodium- and chloride-dependent neurotransmitter transporter family ... Bupropion acts as a dual NA and DA uptake inhibitor in several mesocorticolimbic areas [60]. The drug inhibit the reuptake of ... VIAAT and VMAT[38, 50]. However, some IHC staining presented here suggest that B0AT3 is also found in the soma of neurons, most ... without affecting release or transport of other neurotransmitters and without binding to other neurotransmitter receptors [61 ...
  https://bmcneurosci.biomedcentral.com/articles/10.1186/1471-2202-14-54
*  Immunomodulatory Effects Mediated by Dopamine
... possible relationship to neurotransmitter uptake sites," Pharmacology, vol. 42, no. 3, pp. 135-141, 1991. View at Publisher · ... Similarly, reserpine, a VAT inhibitor, lowers intracellular concentrations of DA and NE, and desipramine, an inhibitor of NE ... K. M. Ashe, W.-L. Chiu, A. M. Khalifa et al., "Vesicular monoamine transporter-1 (VMAT-1) mRNA and immunoreactive proteins in ... Dopamine (DA) is a monoamine that is best known for its neurotransmitter function, and like other neurotransmitters, its ...
  https://www.hindawi.com/journals/jir/2016/3160486/
*  Plus it
... incubation of the cells with either the DA uptake inhibitor GBR 12909 (10 μm) (Andersen, 1989) or the NA uptake inhibitor ... 1988) Impaired neurotransmitter uptake in PC12 cells overexpressing human Cu/Zn-superoxide dismutase: implication for gene ... as reserpine and tetrabenazine deplete intracellular DA stores by selectively interfering with transmitter uptake via the VMAT ... whereas incubation with the choline uptake inhibitor hemicholinium-3 (1 mm) (Birks and MacIntosh, 1957) reduced choline uptake ...
  http://www.jneurosci.org/content/16/19/6038
*  Dextroamphetamine - Wikipedia
Inhibitors of the enzymes that metabolize amphetamine (e.g., CYP2D6 and FMO3) will prolong its elimination half-life, meaning ... DHK-sensitive, EAAT2 uptake was not altered by AMPH (Figure 1A). The remaining glutamate transport in these midbrain cultures ... As substrates for both DAT and VMAT, amphetamines can be taken up to the cytosol and then sequestered in vesicles, where they ... Current models of ADHD suggest that it is associated with functional impairments in some of the brain's neurotransmitter ...
  https://en.wikipedia.org/wiki/Dextroamphetamine
*  Plus it
Although the nonselective irreversible high-affinity uptake inhibitor of VMAT1, reserpine, substantially inhibited uptake ... 2002) Vesicular neurotransmitter transporters, in Neurotransmitter Transporters: Structure, Function, and Regulation (Reith MEA ... VMAT. vesicular monoamine transporter. *Copyright © 2017 by The Author(s). This is an open access article distributed under the ... A total of 200 μl uptake buffer (total uptake) or uptake buffer containing 20 μM test compounds (final concentrations 10 μM) ...
  http://jpet.aspetjournals.org/content/361/3/454
*  Norepinephrine - Wikipedia
In skeletal muscles, an increase in glucose uptake. In adipose tissue (i. e., fat cells), an increase in lipolysis, that is, ... Monoamine oxidase inhibitors are antidepressants that inhibit the metabolic degradation of norepinephrine as well as serotonin ... Outside the brain, norepinephrine is used as a neurotransmitter by sympathetic ganglia located near the spinal cord or in the ... VMAT). Norepinephrine is stored in these vesicles until it is ejected into the synaptic cleft, typically after an action ...
  https://en.wikipedia.org/wiki/Norepinephrine
*  Dopamine transporter - Wikipedia
As substrates for both DAT and VMAT, amphetamines can be taken up to the cytosol and then sequestered in vesicles, where they ... Wheeler DD, Edwards AM, Chapman BM, Ondo JG (1993). "A model of the sodium dependence of dopamine uptake in rat striatal ... Zinc binds at ... extracellular sites of the DAT [103], serving as a DAT inhibitor. In this context, controlled double-blind ... trigger neurotransmitter release. The initial determination of the membrane topology of DAT was based upon hydrophobic sequence ...
  https://en.wikipedia.org/wiki/Dopamine_transporter
*  Monoaminergic modulation of photoreception in ascidian: evidence for a proto-hypothalamo-retinal territory | BMC Biology | Full...
The TPH/vMAT expressing cells, which are localized dorso-laterally to the CNS are shown only on the right side. The central ... The uptake of 5-HT was inhibited by pre-treating larvae with Fluoxetine (50 μM) diluted in ASWH for 30 minutes before ... In particular, amacrine cells of the vertebrate retina make a class of auxiliary cells expressing various neurotransmitters, ... a widely used SERT inhibitor, has a robust inhibitory effect on the swimming activity induced by shadowing, in Ciona larvae. ...
  https://0-bmcbiol-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/1741-7007-10-45
*  How to reduce stimming - Page 4 - AutismWeb Forum
Echinacea contains quercetin, which is a MAO-A inhibitor. Cocoa is also a MAO-B inhibitor, which is not good.. Garlic - ... Gotu Kola - inhibits the uptake of glutamate and increases GABA in the brain, but excessive doses can be slightly narcotic and ... My son is unique in the sense that he has severe methylation mutations which limit the production of neurotransmitters. At the ... Also, Vinpocetine may temporarily deplete the monoamines serotonin, dopamine and norepinephrine by inhibiting VMAT, thus ...
  http://www.autismweb.org/forum/viewtopic.php?p=225364
*  SFB35 - Transmembrane Transporters in Health and Disease - Seminars
Surprisingly, in addition to ABCB1 inhibitors, we identified potent and highly selective inhibitors of the ABCG2 transporter [3 ... At the ablu-minal membrane, LRP appears to be responsible for the first step of Abeta uptake. Our data indicate that the second ... The released neurotransmitter elicits a postsynaptic response through its pre- and post-synaptic receptors. Excitatory amino ... vGLUT and vMAT accumulate their substrate into synaptic vesicles, which upon fusion with the pre-synaptic membrane release the ...
  http://www.sfb35.at/eng/seminars.html
*  Vmat2 Heterozygous Mutant Mice Display a Depressive-Like Phenotype | Journal of Neuroscience
Because reserpine (a VMAT inhibitor) can precipitate depressive-like symptoms in humans, we investigated whether Vmat2 ... 1988) Accumulation of biological amines into chromaffin granules: a model for hormone and neurotransmitter transport. Physiol ... 1988) Energy-driven uptake of the neurotoxin 1-methyl-4-phenylpyridinium into chromaffin granules via the catecholamine ... It is noteworthy that reserpine, a VMAT inhibitor, can also reduce motor activity (Fischer and Heller, 1967). ...
  http://www.jneurosci.org/content/27/39/10520.long
*  Presynaptic Regulation of Quantal Size by the Vesicular Glutamate Transporter VGLUT1 | Journal of Neuroscience
Uptake in the presence of either the competitive VGLUT1 inhibitor trypan blue (□) or the noncompetitive VGLUT1 inhibitor Rose ... Colliver TL, Pyott SJ, Achalabun M, Ewing AG (2000) VMAT-mediated changes in quantal size and vesicular volume. J Neurosci 20: ... Sulzer D, Edwards R (2000) Vesicles: equal in neurotransmitter concentration but not in volume. Neuron 28: 5-7. ... CCCP-sensitive uptake in this and similar preparations of vesicles is considered a valid indicator of the H+-dependent uptake ...
  http://www.jneurosci.org/content/25/26/6221.long