*  Abstract 6074: Vitamin K Epoxide Reductase Genotype Alters Warfarin Dose Requirements in Pediatric Patients | Circulation
There was no relationship between ethnicity & VKORC1 alleles. Pts with VKORC1 AA + AG allele required a significantly lower ... Abstract 6074: Vitamin K Epoxide Reductase Genotype Alters Warfarin Dose Requirements in Pediatric Patients. Cheryl M Takao, ... In this study, pts with VKORC1 AA + AG alleles require a 47% lower dose/kg compared to pts with GG alleles. This preliminary ... Blood sample tested for CYP2C9 & VKORC1 genotypes & correlated with above variables. Dose at time of stable INR was compared to ...
  http://circ.ahajournals.org/content/118/Suppl_18/S_1056.1
*  Sequence Variation in Vitamin K Epoxide Reductase Gene Is Associated With Survival and Progressive Coronary Calcification in...
Objective-Sequence variations in the gene(s) encoding vitamin K epoxide reductase complex subunit 1 (VKORC1), the enzyme target ... Conclusions-Patients with the CG/GG genotype of VKORC1 had a higher risk of CAC progression and a poorer survival. These data ... Sequence Variation in Vitamin K Epoxide Reductase Gene Is Associated With Survival and Progressive Coronary Calcification in ... Sequence Variation in Vitamin K Epoxide Reductase Gene Is Associated With Survival and Progressive Coronary Calcification in ...
  http://atvb.ahajournals.org/content/34/7/1591.short?rss=1
*  VKORC1 - Wikipedia
VKORC1 is involved in the vitamin K cycle by reduction of vitamin K epoxide to vitamin K, which is the rate-limiting step in ... The VKORC1 protein is a key enzyme in the vitamin K cycle. VKORC1 is a 163 amino acid integral membrane protein associated with ... Garcia AA, Reitsma PH (2008). "VKORC1 and the vitamin K cycle". Vitamins and Hormones. 78: 23-33. doi:10.1016/S0083-6729(07) ... The availability of reduced vitamin K is of importance for activation vitamin K 2,3-epoxide. The reduction of vitamin K epoxide ...
  https://en.wikipedia.org/wiki/VKORC1
*  Frontiers | DNA Sequence Analysis in Clinical Medicine, Proceeding Cautiously | Molecular Biosciences
VKORC1 Vitamin K epoxide reductase complex.. Population differences exist in genotypes of these genes and these differences can ... VKORC1 variants leading to adverse drug effects were observed primarily in white Americans. Dunnenberger et al. listed the top ...
  https://www.frontiersin.org/articles/10.3389/fmolb.2017.00024/full
*  Cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC1) genotypes as determinants of acenocoumarol sensitivity. ...
Cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC1) genotypes as determinants of acenocoumarol sensitivity.. ... Cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC1) genotypes as determinants of acenocoumarol sensitivity. ... Home» Cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC1) genotypes as determinants of acenocoumarol ... VKORC1 haplotypes were associated with the pharmacologic response, and this association can be explained only by the effect of ...
  https://dial.uclouvain.be/pr/boreal/object/boreal:25828
*  List of OMIM disorder codes - Wikipedia
CYP27B1 Vitamin K-dependent clotting factors, combined deficiency of, 2; 607473; VKORC1 Vitamin K-dependent coagulation defect ... vitamin B12-responsive; 251100; MMAA Methylmalonic aciduria, vitamin B12-responsive, due to defect in synthesis of ... RPIA Rickets due to defect in vitamin D 25-hydroxylation; 600081; CYP2R1 Rickets, vitamin D-resistant, type IIA; 277440; VDR ... VKORC1 Warfarin sensitivity; 122700; CYP2C9 Warsaw breakage syndrome; 613398; DDX11 Watson syndrome; 193520; NF1 Weaver ...
  https://en.wikipedia.org/wiki/List_of_OMIM_disorder_codes
*  Pharmacogenetics and Metabolism: Past, Present and Future | IntechOpen
2009) and CYP2C9 plus VKORC1 (vitamin K epoxide reductase complex subunit 1) before warfarin treatment (Leey et al. 2009, You ... 2011 "Contribution of VKORC1 and CYP2C9 polymorphisms in the interethnic variability of warfarin dose in Malaysian populations ... 2006 "Different contributions of polymorphisms in VKORC1 and CYP2C9 to intra- and inter-population differences in maintenance ...
  https://www.intechopen.com/books/topics-on-drug-metabolism/pharmacogenetics-and-metabolism-past-present-and-future-/
*  Welcome to CDC stacks | The landscape of recombination in African Americans - 41840 | CDC Public Access
VKORC1 (vitamin K epoxide reductase complex subunit 1, 16p11.2) is the main genetic determinant of human response to oral ... Positive Selection in the Chromosome 16 VKORC1 Genomic Region Has Contributed to the Variability of Anticoagulant Response in ...
  https://stacks.cdc.gov/view/cdc/41840
*  prof. dr. A. (Anthonius) de Boer - Bètawetenschappen - Universiteit Utrecht
Dosing algorithms for vitamin K antagonists across VKORC1 and CYP2C9 genotypes. Journal of Thrombosis and Haemostasis, 15 (3 ... Maitland-van der Zee, A.H., de Boer, Anthonius & Manolopoulos, V.G. (2014). Genotype-Guided Dosing of Vitamin K Antagonists. ... Long-term anticoagulant effects of CYP2C9 and VKORC1 genotypes in phenprocoumon users. Journal of Thrombosis and Haemostasis, ... Prolonged outpatient vitamin K antagonist use and risk of venous thromboembolism in patients undergoing total hip or knee ...
  https://www.uu.nl/medewerkers/AdeBoer/0
*  Biomarkers of bone turnover in diagnosis and therapy of osteoporosis | SpringerLink
Vitamin K epoxide reductase (VKORC1) gene mutations in osteoporosis: a pilot study. Transl Res. 2010;156:37-44.PubMedCrossRef ... Assessment of vitamin D and calcium status in healthy adult Austrians. Eur J Clin Invest. 2003;33:323-31.PubMedCrossRefGoogle ... IOF position statement: vitamin D recommendations for older adults. Osteporos Int. 2010;21:1151-4.CrossRefGoogle Scholar ... Prediction of bone density from vitamin D receptor alleles. Nature. 1994;367:284-7.PubMedCrossRefGoogle Scholar ...
  https://link.springer.com/article/10.1007/s10354-012-0133-9
*  Warfarin induced coagulopathy in children: assessment of a conservative approach
VKORC1 encodes a subunit of the vitamin K epoxide reductase. It was... ... VKORC1 a key gene controlling response to warfarin. Roden, Dan M. // Cardiology Today;Jul2008, Vol. 11 Issue 7, p23 The article ... Clinical Usage of Vitamin K and FFP in Reduction of Hospitalization in Patients with Warfarin Overactivity. Haghighi, S. A.; ... In 2004, the interest on warfarin intensified when a loss-of-function mutation was reported in VKORC1 in a patient with a rare ...
  http://connection.ebscohost.com/c/articles/60964064/warfarin-induced-coagulopathy-children-assessment-conservative-approach
*  GPL Blog Source - The Great Plains Laboratory, Inc.
Vitamin K Epoxide Reductase Complex Subunit 1(VKORC1). This is an enzyme that is necessary for the reduction of vitamin K 2,3- ... Vitamin D receptor (VDR) is a nuclear hormone receptor for vitamin D3. Vitamin D3 interacts with this receptor to influence ... Vitamin D receptor mutations can also lead to vitamin-D-dependent rickets type 2. Patients with VDR polymorphisms are ... So what markers in the OAT are important for patients with MTHFR mutations? The first one we have is vitamin B12. We evaluate ...
  https://www.greatplainslaboratory.com/gpl-blog-source
*  Sequence Detail
Vkorc1 description:vitamin K epoxide reductase complex, subunit 1 ... Vkorc1. vitamin K epoxide reductase complex, subunit 1. 26. 2. 6. 4. ...
  http://www.informatics.jax.org/sequence/OTTMUSP00000040668
*  Metabolism, Part 2 - Exam #1 Flashcards by whitney miller | Brainscape
Vitamin K Epoxide Reductase Complex subunit 1 (VKORC1) enzyme recycles reduced Vitamin K and promotes blood clotting through ... Vitamins A and D (and many others) → Bind to binding proteins that function as transcription factors ... Different alleles between people might cause them to require higher or lower doses of anticoagulants to act on VKORC1 to ... What do various alleles have on Vitamin K Epoxide Reductase Complex and coagulation? ...
  https://www.brainscape.com/flashcards/metabolism-part-2-exam-1-1929171/packs/3337284
*  Acenocoumarol | definition of acenocoumarol by Medical dictionary
Cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC1) genotypes as determinants of acenocoumarol sensitivity.. ... A fast-acting vitamin K-antagonist anticoagulant. In patients with proximal vein thrombosis, it can be co-administered with ... A fast-acting vitamin K-antagonist anticoagulant. acenocoumarol, acenocoumarin. a warfarin derivative used as an anticoagulant ... VKORC1 and CYP2C9 genotypes and acenocoumarol anticoagulation status: interaction between both genotypes affects ...
  https://medical-dictionary.thefreedictionary.com/acenocoumarol
*  Pharm: Pharmacogenomics I Foreign Language Flashcards - Cram.com
vitamin K epoxide reductase (VKORC1) clotting factor that is a key warfarin target, 25% of warfarin variability due to VKORC1 ...
  http://www.cram.com/flashcards/pharm-pharmacogenomics-i-490197
*  Warfarin Sensitivity Testing
The enzyme Vitamin K Epoxide Reductase, known as VKORC1, converts Vitamin K to the reduced form required to activate clotting ... factors II, VII, IX, and X. Genetic variants in VKORC1 decrease enzyme activity causing warfarin to induce a more profound ...
  https://www.labroots.com/webinar/warfarin-sensitivity-testing
*  Personalized vascular medicine: Individualizing drug therapy
Polymorphisms of the vitamin K epoxide reductase complex (VKORC1) gene also contribute to the variance in warfarin sensitivity ... The target enzyme of warfarin, VKORC1 recycles the oxidized form of vitamin K to its reduced form that functions as a cofactor ... The relationship of vitamin D deficiency to statin myopathy. Atherosclerosis. 2011;215:23-29. [PubMed] ... Yang L, Ge W, Yu F, Zhu H. Impact of VKORC1 gene polymorphism on interindividual and interethnic warfarin dosage requirement-a ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3761360/?lang=en-ca
*  Hematology/Oncology Flashcards by Andrew Rivera | Brainscape
Metabolism affected by polymorphisms in the gene for vitamin K epoxide reductase complex (VKORC1).. In lab assay, has effect on ... Oxidized vitamin K becomes reduced vitamin K thanks to Epoxide reductase.. Reduced vitamin K acts as cofactor for conversion of ... Warfarin inhibits the enzyme Vitamin K epoxide reductase. Neonates lack enteric bacteria, which produce vitamin K. Vitamin K ... t(15;17) leads to M3 subtype - responds well to all-trans retinoic acid (Vitamin A), inducing differentiation of myeloblasts; ...
  https://www.brainscape.com/flashcards/hematology-oncology-3698361/packs/5585230
*  VKORC1 overexpression lysate - LY402968 | acris-antibodies.com
Transient overexpression lysate of vitamin K epoxide reductase complex, subunit 1 (VKORC1), transcript variant 1 ... Transient overexpression lysate of vitamin K epoxide reductase complex, subunit 1 (VKORC1), transcript variant 1. ... VKORC1 HEK293T cell transient overexpression lysate (as WB positive control). Background. ...
  https://www.acris-antibodies.com/lysates/vkorc1-overexpression-lysate-ly402968.htm
*  Thyroid Hormone Levels and Your Genes - Genetic Lifehacks
One gene involved in vitamin K metabolism is VKORC1. There are quite a few studies on it (and other vitamin K genes) in ... Vitamin K2 is mostly missing in diets and we have impaired vital vitamin K actions via such drugs as statins, bisphosphonates, ... Vitamin D supplement has been shown to reduce Hashimoto's antibody levels. [study] This is the one that I use that has coconut ... MK-4 is made from consumed vitamin K (both K1 and K2 of all forms) in a complex and recently discovered way. First, the K is ...
  http://www.geneticlifehacks.com/thyroid-issues-and-genetics/
*  Food, Food Allergies, and Nutrition sub-cluster 0
The +2255 polymorphism of the vitamin K epoxide reductase gene (VKORC1) was shown to be associated with the recycling rate of ... Specific data on vitamin D2 and vitamin D3 are needed to enable the assessment of vitamin D dietary intake. These forms of the ... Vitamin D deficiency is now recognized as a pandemic. The major cause of vitamin D deficiency is the lack of appreciation that ... The most common explanations for poor vitamin B12 status are a low dietary intake of the vitamin (i.e., a low intake of animal- ...
  http://www.biomedsearch.com/cluster/49/Food-Food-Allergies-and-Nutrition/sub-0-p3.html
*  Most recent papers with the keyword Coagulation & Hemostasis | Read by QxMD
VKORC1, whose vitamin K reduction supports vitamin K-dependent (VKD) protein carboxylation, and VKORC1-like 1 (VKORC1L1), whose ... Vkorc1-/- mice survived longer (1 week) than Ggcx-/- mice (midembryogenesis or birth), and we assessed whether VKORC1L1 could ... VKOR paralog VKORC1L1 supports vitamin K-dependent protein carboxylation in vivo.. Julie Lacombe, Mark A Rishavy, Kathleen L ... Vertebrates possess 2 proteins with vitamin K oxidoreductase (VKOR) activity: ...
  https://www.readbyqxmd.com/keyword/48012
*  Responsiveness to low-dose warfarin associated with genetic variants of VKORC1, CYP2C9, CYP2C19, and CYP4F2 in an Indonesian...
... this study was to assess the pharmacokinetics and pharmacodynamics of warfarin associated with genetic polymor phisms in VKORC1 ... and vitamin K epoxide reductase (VKORC1) genes for the warfarin dose adjustment by the SMart-amplification process version 2. ... Genotyping of VKORC1, CYP2C9, CYP2C19, and CYP4F2 was carried out in 103 patients treated with a daily dose of 1-2 mg warfarin ... Pautas E, Moreau C, Gouin-Thibault I, Golmard JL, Mahe I, Legendre C et al (2010) Genetic factors (Vkorc1, Cyp2C9, Ephx1, and ...
  https://link.springer.com/article/10.1007%2Fs00228-012-1356-9