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*  Frontiers | Bacterium-Like Particles for Efficient Immune Stimulation of Existing Vaccines and New Subunit Vaccines in Mucosal...
The focus of the overview is on the development of intranasal BLP-based vaccines to prevent diseases caused by influenza and ... respiratory syncytial virus, and includes a selection of Phase I clinical data for the intranasal FluGEM vaccine. ... The focus of the overview is on the development of intranasal BLP-based vaccines to prevent diseases caused by influenza and ... respiratory syncytial virus, and includes a selection of Phase I clinical data for the intranasal FluGEM vaccine. ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2013.00282/full
*  Vaccinia virus serpins B13R and B22R do not inhibit antigen presentation to class I-restricted cytotoxic T lymphocytes. -...
Recombinant VVs were constructed which express influenza virus proteins HA, NP or NS1 and which lack serpin gene B13R or both ... inhibits the presentation of certain epitopes from influenza virus nucleoprotein (NP), haemagglutinin (HA) and non-structural 1 ... virus-specific CD8+ CTL was compared to the lysis of cells infected with viruses expressing both the influenza proteins and the ... The lysis of cells infected with these viruses by influenza ... NS1) proteins to CD8+ cytotoxic T lymphocytes (CTL) by an ...
  https://www.rdm.ox.ac.uk/publications/16717
*  Plus it
... the hemagglutinin and neuraminidase glycoproteins, are also the most variable structural proteins of the virus (36). VP1-3 ... to CVB4 antigens in type 1 diabetes by developing protocols for the generation of viral coat and nonstructural proteins from E2 ... Controls, healthy nondiabetic donors; FLU, influenza A virus; Long T1DM, long-standing type 1 diabetic patients; New T1DM, ... and VP4 structural proteins and the P2C nonstructural protein. cDNAs encoding these CVB4 proteins were cloned, expressed, and ...
  http://diabetes.diabetesjournals.org/content/51/6/1745
*  H5N1 genetic structure - Wikipedia
... segmented RNA viruses. "The influenza virus RNA polymerase is a multifunctional complex composed of the three viral proteins ... HA codes for hemagglutinin which is an antigenic glycoprotein found on the surface of the influenza viruses and is responsible ... he pathogenicity of influenza virus was related to the nonstructural (NS) gene of the H5N1/97 virus".NS1: Non-structural: ... Viruses of this family contain 7 to 8 segments of linear negative-sense single-stranded RNA. Influenza virus "Influenza virus" ...
  https://en.wikipedia.org/wiki/H5N1_genetic_structure
*  An Overview of Live Attenuated Recombinant Pseudorabies Viruses for Use as Novel Vaccines
... with human adenovirus 5 recombinant viruses expressing the hemagglutinin and the nucleoprotein of H3N2 swine influenza virus," ... There are several nonstructural proteins of PRV such as thymus kinase (TK) and protein kinase (PK), which are associated with ... 2.8.4. Rabies Virus/PRV Recombinants. A rPRV expressing the rabies virus glycoprotein was constructed [61]. This recombinant ... fowlpox virus, and orf virus. MVA has been a smallpox vaccine for many years and more recently it has been used as a viral ...
  https://www.hindawi.com/journals/jir/2014/824630/
*  Cleavage site and Ectodomain of HA2 sub-unit sequence of three equine influenza virus isolated in Morocco | BMC Research Notes ...
... the identified and reported mutations certainly played a permissive role of infection viral process. ... of the HA2 subunit including the cleavage site of three equine influenza viruses (H3N8) isolated in Morocco: A/equine/Nador/1/ ... The equine influenza (EI) is an infectious and contagious disease of the upper respiratory tract of horses. Two outbreaks were ... surface glycoproteins hemagglutinin (HA) and neuraminidase (NA), major nucleocapsid protein (NP), matrix protein (M1), ionic ...
  https://bmcresnotes.biomedcentral.com/articles/10.1186/1756-0500-7-448
*  Amplificación del genoma completo del subtipo 2 del virus de la influenza equina
... glycoproteins located in the surface of the virion: haemagglutinin (HA) involved in binding of the virus to host cells and ... and the other segment for non-structural protein 1 (NS1) and nuclear export protein (NEP) (5).. The analysis of virion RNA from ... end present in all viral genomic segments of influenza A virus were used, according to the consensus sequence regions ... the analysis of influenza virus genes: application to the reassortment of equine influenza virus genes. Virus Res 1994; 32: 391 ...
  http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0325-75412009000400002&lng=es&nrm=iso&tlng=en
*  Strategies for Control of Pandemic Influenza: Active and Passive Immunization - Semantic Scholar
... similar to seasonal flu viruses and different from H5N1 highly pathogenic avian influenza viruses. Most people had acquired ... WHO Collaborating Centre for Research and Reference on Influenza Influenza Virus Research Center, National Institute of ... The virus was susceptible to neuraminidase inhibitors and drug-resistant viruses did not spread, unlike former seasonal H1N1 ... against H1N1pdm09 virus. The pandemic started in the North America, where US CDC detected and identified the causative virus ...
  https://www.semanticscholar.org/paper/Strategies-for-Control-of-Pandemic-Influenza-Activ-Nguyen/bf2f6144d9f8e259d66be996999e9bd83beadd29
*  HIGH GROWTH REASSORTANT INFLUENZA A VIRUS - Patent application
... hemagglutinin (HA) and neuraminidase (NA); the nonstructural protein (NS1) and nuclear export protein (NEP). Most influenza A ... viral proteins. [0008] Genomic viral RNA must be packaged into viral particles in order for the virus to be transmitted. The ... Influenza virus adsorbs via HA to sialyloligosaccharides in cell membrane glycoproteins and glycolipids. Following endocytosis ... 0047] The master virus of the invention can be an attenuated influenza virus. Specifically the influenza virus comprises ...
  http://www.patentsencyclopedia.com/app/20110262481
*  Viral protein - Wikipedia
Some of these glycoproteins include: Hemagglutinin, neuraminidase, and M2 protein in the influenza virus. gp160, composed of ... and groups of viral proteins include structural proteins, nonstructural proteins, regulatory, and accessory proteins. Viruses ... An example of a Class III viral fusion protein is the rabies virus glycoprotein, G. Class IV: Class IV viral fusion proteins ... The viral envelope is made up of a lipid bilayer embedded with viral proteins, including viral glycoproteins. These viral ...
  https://en.wikipedia.org/wiki/Viral_protein
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... recombinant influenza viruses. Such studies include virus replication, function of viral proteins, the contribution of specific ... Influenza A virus, Orthomyxoviridae Infections, Influenza, Human, Influenza in Birds, Influenza Vaccines, hemagglutinin, ... Although here we focus on influenza virus surface glycoproteins, this method can also be used to produce other viral and ... of which ORF1 occupies most of the genome and encodes seven non-structural proteins (NS1-7) released from a polyprotein ...
  https://www.jove.com/visualize/abstract/23593400/sulfatide-regulates-caspase-3-independent-apoptosis-influenza-virus
*  Influenza Viral Proteins: Identification and Synthesis | SpringerLink
So much has been learnt about the proteins of influenza virus during the last three years that most of the gene products can ... Eckert, E. A.: Properties of an antigenic glycoprotein isolated from influenza virus hemagglutinin. J. Virol. 11, 183-192 (1973 ... Lazarowitz, S. G., Compans, R. W., Choppin, P. W.: Influenza virus structural and nonstructural proteins in infected cells and ... Electrophoretic distribution of the proteins and glycoproteins of influenza virus and Sendai virus. J. Virol. 6, 707-716 (1970 ...
  https://link.springer.com/chapter/10.1007/978-3-642-65775-7_1
*  Influenza: Molecular Virology
Subjects covered include the NS1 protein of influenza A virus, the structure of influenza NS1, influenza B hemagglutinin, ... influenza A hemagglutinin glycoproteins, the M2 channel, virulence genes of the 1918 pandemic influenza, influenza virus ... however it is highly transmittable between people and a new influenza pandemic has been declared. If this virus were to acquire ... H1N1 influenza subtype causes a relatively mild infection in humans, ...
  https://www.caister.com/influenza
*  Human mortality from H5N1 - Wikipedia
The H5 hemagglutinin (HA) is found in influenza viruses that typically infect avian species, so efficient person-to-person ... The PB1 gene codes for the PB1 protein and the PB1-F2 protein. The PB1-F2 protein probably contributes to viral pathogenicity ... NS codes for two nonstructural proteins (NS1 and NEP). The NS1 gene of the highly pathogenic avian H5N1 viruses circulating in ... Neuraminidase is an antigenic glycoprotein enzyme found on the surface of the influenza viruses. It helps the release of ...
  https://en.wikipedia.org/wiki/Human_mortality_from_H5N1
*  virusberriostechegaray: octubre 2013
4] O'Neill RE, Talon J, Palese P. The influenza virus NEP (NS2 protein) mediates the nuclear export of viral ribonucleoproteins ... Reassortants with equine 1 (H7N7) influenza virus hemagglutinin in an avian influenza virus genetic background are pathogenic ... Immunization with a vaccinia virus recombinant expressing herpes simplex virus type 1 glycoprotein D: long-term protection and ... and one segment codes for nonstructural protein 1(NS1) and nuclear export protein (NEP) [1,2]. In some strains, the +1 reading ...
  http://virusberriostechegaray.blogspot.com/2013/10/
*  Frontiers | Complement Evasion Strategies of Viruses: An Overview | Microbiology
... cleaving complement proteins by encoding protease, and inhibiting the synthesis of complement proteins. Additionally, viruses ... Here, we provide an overview on the complement subversion mechanisms adopted by the members of various viral families including ... cleaving complement proteins by encoding protease, and inhibiting the synthesis of complement proteins. Additionally, viruses ... the complement system keeps a constant vigil against viruses. Its ability to recognize a large panoply of viruses and virus- ...
  https://www.frontiersin.org/articles/10.3389/fmicb.2017.01117/full
*  MGM Nicholas Heaton, PhD - Publications
Dengue virus nonstructural protein 3 redistributes fatty acid synthase to sites of viral replication and increases cellular ... Genome-wide mutagenesis of influenza virus reveals unique plasticity of the hemagglutinin and NS1 proteins. Proc Natl. Acad Sci ... Mutational analysis of measles virus suggests constraints on antigenic variation of the glycoproteins. Cell Reports. 2015 Jun 9 ... Limiting influenza virus, HIV, and dengue virus infection by targeting viral proteostasis. Immunity. 2016 Jan 19;44:46-58 doi: ...
  https://mgm.duke.edu/faculty-and-research/primary-faculty/nicholas-heaton-phd/nicholas-heaton-phd-publications/
*  Search: All Pfam signatures | InterPro | EMBL-EBI
We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their ... InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites ... Influenza A virus NS1 protein (IPR000256) Pfam signature: PF00600 Influenza non-structural protein (NS2) (IPR000968) Pfam ... Hepatitis C virus non-structural protein NS2 (IPR002518) Pfam signature: PF01538 Hepatitis C virus envelope glycoprotein E1 ( ...
  http://www.ebi.ac.uk/interpro/member-database/Pfam
*  Migration of the Swine Influenza Virus δ-Cluster Hemagglutinin N-Linked Glycosylation Site from N142 to N144 Results in Loss of...
Phylogenetic analysis of the hemagglutinin proteins of the swine influenza virus δ-cluster isolates used in this study. ... Killed viral vaccines are commonly used in the United States to control swine influenza virus. Most vaccines are multivalent, ... and nonstructural (NS) genes derived from A/swine/North Carolina/3793/08 to produce a reverse genetics-derived isolate (RG 10- ... based on knowledge of the orientation preference of glycans in known glycoproteins (3). We superimposed and replaced the HA in ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3428406/?lang=en-ca
*  Antisera and Monoclonal Antibodies Page 19
Immunological reagents to many viral agents are also available through the Virology Collection, including neutralizing antisera ... Mouse monoclonal antibody prepared against the nonstructural protein 1 (NS1) of West Nile virus (WNV) was purified from clone ... Mouse monoclonal antibody prepared against the H1 hemagglutinin (HA) of influenza virus A/South Carolina/1/1918 (H1N1) was ... Mouse monoclonal antibody prepared against the envelope glycoprotein of West Nile virus (WNV) was purified from clone E121 ...
  https://www.atcc.org/en/Products/Cells_and_Microorganisms/Viruses/Antisera_and_Monoclonal_Antibodies.aspx?dsNav=Ro:30,Up:Page_Product_Listing&slp=1
*  Human metapneumovirus - Wikipedia
... directed by the viral attachment protein, variously called G, H (hemagglutinin) or HN (hemagglutinin-neuraminidase). Human ... "Rates of Hospitalizations for Respiratory Syncytial Virus, Human Metapneumovirus, and Influenza Virus in Older Adults". The ... HMPV is thought to attach to the target cell via the glycoprotein (G) protein interactions with heparan sulfate and other ... The genomic organisation of HMPV is similar to RSV; however, HMPV lacks the non-structural genes, NS1 and NS2, and the HMPV ...
  https://en.wikipedia.org/wiki/Human_metapneumovirus
*  American Scientist Online - Influenza
Most pharmaceutical companies today split the virus into subunit vaccines, which contain only specific viral protein units. To ... Type A influenzas are categorized by the structural variations of two glycoproteins, hemagglutinin (HA) and neuraminidase (NA ... We removed the so-called nonstructural (NS) gene from H5N1 and inserted it into a previously benign strain of flu. Experiments ... These antineuraminidase drugs hobble the NA glycoprotein on the surface of the influenza virus. When NA is inhibited, the virus ...
  http://people.scs.carleton.ca/~soma/biosec/readings/influenza/influenza.html
*  A single-amino-acid substitution in the HA protein changes the replication and pathogenicity of the 2009 pandemic A (H1N1)...
... especially within the receptor binding domain of the hemagglutinin (HA) protein could result in more virulent virus stains, ... attention to further potentially severe influenza pandemic that may result from cross-host evolution of the influenza viruses. ... and this single residue variation dramatically increased the viral replication ability in MDCK cells and pathogenicity in BALB/ ... Here, we found that a single amino acid substitution of Asp-to-Gly at position 222 in the HA protein of the A (H1N1) virus ...
  https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-7-325
*  Coronaviruses and their Diseases | SpringerLink
Detection of Mouse Hepatitis Virus Nonstructural Proteins Using Antisera Directed Against Bacterial Viral Fusion Proteins ... The Haemagglutinin of Bovine Coronavirus Exhibits Significant Similarity to the Haemagglutinin of Type C Influenza Virus ... The Haemagglutinin-Esterase (HE) and Membrane (M) Glycoproteins. * Front Matter Pages 89-89 ... Differential Reactivity of Bovine Coronavirus (BCV) and Influenza C Virus with N-Acetyl-9-O-Acetylneuraminic Acid (NEU5,9AC2)- ...
  https://link.springer.com/book/10.1007/978-1-4684-5823-7
*  Characterization of Proprotein Convertases and Their Involvement in Virus Propagation | SpringerLink
Alternatively, agents preventing cleavage of viral surface (glyco)proteins block fusion capacity and multicyclic virus ... Complete nucleotide sequence of an influenza virus haemagglutinin gene from cloned DNA. Nature. 1979;282(5738):471-7.PubMed ... Delta-peptide is the carboxy-terminal cleavage fragment of the nonstructural small glycoprotein sGP of Ebola virus. Virology. ... The PCs cleave the viral fusion glycoprotein to trigger fusion of viral envelopes with cellular membranes to deliver the viral ...
  https://link.springer.com/chapter/10.1007%2F978-3-319-75474-1_9