DR. OYUGI JULIUS OTIENO
Certain human leukocyte antigens, by presenting conserved immunogenic epitopes for T cell recognition, may, in part, account ... Human leukocyte antigen (HLA) B*18 and protection against mother- to-child HIV type1 transmission. AIDS Res Hum Retro . ... HLA-A*6802 and HLA-B18. Estimates using a modified interferon-gamma Elispot assay indicate a circulating frequency of CTL to ... viral ribonucleic acid (RNA) detection by molecular assays, and viral antigen detection by immunocapture enzyme-linked ...https://profiles.uonbi.ac.ke/oyugi_otieno/
Professor John Frater - Nuffield Department of Medicine
Certain viral polymorphisms encode human leukocyte antigen (HLA)-associated immune escape, potentially overcoming limited ... Selection of T-cell vaccine antigens for chronic persistent viral infections has been largely empirical. To define the ... in particular those expressing human leukocyte antigen (HLA)-B18 where reverse transcriptase-E138X arises as an immune escape ... Azathioprine hypersensitivity presenting as septic shock with encephalopathy. BMJ case reports, 2013 , Show Abstract ...https://www.ndm.ox.ac.uk/principal-investigators/researcher/john-frater
JCI - Autoreactive T cells in type 1 diabetes
... viruses may contribute to T1D pathogenesis by eliminating infected β cells presenting viral epitopes in the context of HLA-I ... Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes. Nat Med. 2016;22(12 ... Selected HLA-I variants such as HLA-A2, HLA-A24, HLA-B39, HLA-B57, and HLA-B18 contribute to T1D risk (3, 6). HLA-A2 is also ... Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes. Diabetologia. 2016;59(11):2448-2458. ...https://jinxiuwang.net.insight.mobile.jci.org/articles/view/94549
Phase I study with ONCOS-102 for the treatment of solid tumors - an evaluation of clinical response and exploratory analyses of...
... were collected at baseline and during the study to assess antigen specificity of CD8+ T cells by interferon gamma (IFNγ) enzyme ... Two patients showed marked infiltration of CD8+ T cells to tumors and concomitant systemic induction of tumor-specific CD8+ T ... Importantly, treatment resulted in infiltration of CD8+ T cells to tumors and up-regulation of PD-L1, highlighting the ... Interestingly, high expression levels of genes associated with activated TH1 cells and TH1 type immune profile were observed in ...http://jitc.biomedcentral.com.preview-live.oscarjournals.springer.com/articles/10.1186/s40425-016-0121-5
Viruses | Free Full-Text | How much of Virus-Specific CD8 T Cell Reactivity is Detected with a Peptide Pool when Compared to...
The presence of such T cells with very high functional avidity for the viral antigens can explain why the effect of peptide ... Peptides, when restricted by the same HLA allele, and presented from within the same peptide pool, can compete for HLA binding ... we assessed peptide competition in PBMC from 42 human subjects. The magnitude of the peptide pool-elicited CD8 T cell responses ... What impact such competition has on functional T cell stimulation, however, is not clear. Using a model peptide pool that is ...http://www.mdpi.com/1999-4915/4/11/2636/htm
Publications | KNH-UoN Ethics and Research Committee
Certain human leukocyte antigens, by presenting conserved immunogenic epitopes for T cell recognition, may, in part, account ... Human Leukocyte Antigen (HLA) B*18 And Protection Against Mother- To-child HIV Type1 Transmission. Click to View Abstract ... Hepatitis B Infection Is Highly Prevalent Among Patients Presenting With Jaundice In Kenya.. Click to View Abstract Viral ... HLA-A*6802 and HLA-B18. Estimates using a modified interferon-gamma Elispot assay indicate a circulating frequency of CTL to ...http://erc.uonbi.ac.ke/uon_publications/author/4139