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*  Chromogranin A: Reference Range, Interpretation, Collection and Panels
It belongs to the family of granins that includes chromogranin B, chromogranin C, and secretogranin II. ... found in the large dense-core vesicles of the neuroendocrine cells. ... Chromogranin A is a secretory protein, composed of 439 amino acids, ... Chromogranin A (CgA) is a secretory protein, composed of 439 amino acids, found in the large dense-core vesicles of the ...
  https://emedicine.medscape.com/article/2114314-overview
*  SCG2 polyclonal antibody - (PAB17107) - Products - Abnova
... secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The ... The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. ... Differential reovirus-specific and herpesvirus-specific AP-1 activation of secretogranin II leads to altered virus secretion.. ... Prolactin granulogenesis is associated with increased secretogranin expression and aggregation in the Golgi apparatus of GH4C1 ...
  http://www.abnova.com/products/products_detail.asp?catalog_id=PAB17107
*  Recombinant Human SCG2 Protein, His-tagged SCG2-350H - Creative BioMart
... secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The ... The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. ... SCG2; secretogranin II; secretogranin-2; CHGC; chromogranin C; secretoneurin; SgII; SN; chromogranin-C; EM66;. ... Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.. ...
  https://www.creativebiomart.net/recombinant-human-scg2-protein-his-tagged-502117.htm
*  Protocols and Video Articles Authored by Heikki Rauvala
Acute Brain Trauma in Mice Followed By Longitudinal Two-photon Imaging', 'Flat-floored Air-lifted Platform: A New Method for ... Chromogranin B, a component of secretory vesicles in endocrine cells and neurons, was found to be up-regulated by RAGE ... chromogranin A and secretogranin II. Ligation of RAGE by amphoterin lead to rapid phosphorylation and nuclear localization of ... Two models of acute brain trauma studied with in vivo two-photon imaging of brain are demonstrated in this protocol. ...
  https://www.jove.com/author/Heikki_Rauvala
*  CHGA Gene - GeneCards | CMGA Protein | CMGA Antibody
Chromogranin A, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene ... The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It ... Cytoplasmic vesicle, secretory vesicle lumen. Cytoplasmic vesicle, secretory vesicle membrane. Secreted. Note=Associated with ... Two other peptides, catestatin and chromofungin, have antimicrobial activity and antifungal activity, respectively. Two ...
  http://www.genecards.org/cgi-bin/carddisp.pl?id_type=entrezgene&id=1113
*  SCG2 - Wikipedia
... secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The ... SCG2, also called secretogranin II (chromogranin C), is a protein which in humans is encoded by the SCG2 gene. The protein ... "The primary structure of human secretogranin II, a widespread tyrosine-sulfated secretory granule protein that exhibits low pH ... of Pdcd4 results in induction of proprotein convertase 1/3 and potent secretion of chromogranin A and secretogranin II in a ...
  https://en.wikipedia.org/wiki/SCG2
*  CHGB Gene - GeneCards | SCG1 Protein | SCG1 Antibody
Chromogranin B, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene ... chromogranin B (catecholamine and norepenephrine secretory protein) *CHGB. UniProtKB/Swiss-Prot Function: Secretogranin-1 is a ... Chromogranin B: isolation from pheochromocytoma, N-terminal sequence, tissue distribution and secretory vesicle processing. ( ... The primary structure of human secretogranin I (chromogranin B): comparison with chromogranin A reveals homologous terminal ...
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=CHGB
*  granins - oi
... secretogranin 1) was initially characterized in a rat pheochromocytoma cell line. Chromogranin C (secretogranin II) was ... A family of related acidic proteins (chromogranins, secretogranins, 400-600 aa) found in many endocrine cell secretory vesicles ... Secretogranin V (pituitary polypeptide 7B2; secretory granule neuroendocrine protein-1; 212 aa) is a specific chaperone for ... Chromogranin A (parathyroid secretory protein) is stored and coreleased with catecholamines and parathyroid hormone from ...
  http://oxfordindex.oup.com/view/10.1093/oi/authority.20110803095903649
*  WikiGenes - SCG2 - secretogranin II
... indicated that DTT treatment diverted newly synthesized chromogranin B to constitutive secretory vesicles, whereas the ... Two distinct populations of vesicles were formed: immature secretory granules containing secretogranin II and constitutive ... chromogranin A, secretogranin I (chromogranin B), and secretogranin II. Wiedenmann, B., Waldherr, R., Buhr, H., Hille, A., Rosa ... chromogranin A, secretogranin I (chromogranin B), and secretogranin II [8]. ...
  https://www.wikigenes.org/e/gene/e/7857.html
*  Frontiers | Role of Adaptor Proteins in Secretory Granule Biogenesis and Maturation | Endocrinology
... a cytosolic protein which interacts with both AP-1A and cargo that has been phosphorylated by casein kinase II. A cargo/PACS-1/ ... secretory granules (SGs) store peptide hormones that are released on demand. SGs are formed at the trans-Golgi network (TGN) ... secretory granules (SGs) store peptide hormones that are released on demand. SGs are formed at the trans-Golgi network (TGN) ... a cytosolic protein which interacts with both AP-1A and cargo that has been phosphorylated by casein kinase II. A cargo/PACS-1/ ...
  https://www.frontiersin.org/articles/10.3389/fendo.2013.00101/full
*  Granin - Wikipedia
... chromogranin B (CgB) secretogranin II (SgII) (see also secretoneurin) secretogranin III (SgIII) secretogranin V (SgV) Two other ... There is also evidence that CgA, and perhaps other granins, regulate the biogenesis of dense-core secretory vesicles and ... Granin (chromogranin and secretogranin) is a protein family of regulated secretory proteins ubiquitously found in the cores of ... Huttner WB, Gerdes HH, Rosa P (January 1991). "The granin (chromogranin/secretogranin) family". Trends in Biochemical Sciences ...
  https://en.wikipedia.org/wiki/Granin
*  Specificity of Elevated Plasma EM66 Levels in Pheochromocytoma - Full Text View - ClinicalTrials.gov
Plasma EM66 [ Time Frame: two years ]. Secondary Outcome Measures : *Plasma Chromogranin A levels [ Time Frame: before ... They are characterized by the occurrence, in their cytoplasm, of dense-core secretory vesicles containing hormones, ... We setup a radioimmunoassay of EM66 (a secretogranin II-derived peptide) that allowed us to demonstrate that (i) plasma ... lead to increase plasma chromogranin A (CgA) concentrations (false-positive cases). In addition, while hypertension account for ...
  https://clinicaltrials.gov/ct2/show/NCT01022515?cond=%22Carotid+body+tumor%22&rank=18
*  The bovine chromogranin A gene: structural basis for hormone regulation and generation of biologically active peptides. -...
Two of the differences in the gene result in two amino acid changes in the region encoded by exon 6. The structural ... Chromogranin-A is encoded by eight exons, which organize the coding region into several distinct structural and functional ... Exon 6 represents the variable domain and encodes a region that is identical to the novel chromogranin-A-derived peptide ... organization of the chromogranin-A gene resembles that of the chromogranin-B gene in the exons corresponding to the signal ...
  https://www.semanticscholar.org/paper/The-bovine-chromogranin-A-gene%3A-structural-basis-f-Iacangelo-Grimes/4fa7f0da6decd29db0689310dae28cbc88e176f1
*  Imaging of evoked dense-core-vesicle exocytosis in hippocampal neurons reveals long latencies and kiss-and-run fusion events |...
Regulated exocytosis in neurons involves at least two types of secretory vesicles: synaptic vesicles (SVs) and dense-core ... Huttner, W. B., Gerdes, H. H. and Rosa, P. ( 1991). The granin (chromogranin/secretogranin) family. Trends Biochem. Sci. 16, 27 ... Functional and spatial segregation of secretory vesicle pools according to vesicle age. Nature 422, 176-180. ... All of the ANF-EGFP-containing puncta in the evanescent field were positive for secretogranin II (SgII) ( Fig. 1B, first row), ...
  http://jcs.biologists.org/content/122/1/75
*  SCG5 - Wikipedia
"Entrez Gene: SCG5 secretogranin V (7B2 protein)". Mbikay M, Seidah NG, Chrétien M (July 2001). "Neuroendocrine secretory ... Taupenot L, Harper KL, O'Connor DT (Mar 2003). "The chromogranin-secretogranin family". N Engl J Med. 348 (12): 1134-49. doi: ... 1986). "CNS distribution of a novel pituitary protein '7B2': localization in secretory and synaptic vesicles". Brain Res. 380 ( ... 1991). "The production by alternate splicing of two mRNAs differing by one codon could be an intrinsic property of ...
  https://en.wikipedia.org/wiki/SCG5
*  GenePORTER 2 Citations by Cell Type
Sorting of the Neuroendocrine Secretory Protein Secretogranin II into the Regulated Secretory Pathway: Role of N- and C- ... Identification of a novel sorting determinant for the regulated pathway in the secretory protein chromogranin A. J. Cell Sci. ... Cathepsin L expression is directed to secretory vesicles for enkephalin neuropeptide biosynthesis and secretion. J Biol Chem ... Role of H+-ATPase-mediated Acidification in Sorting and Release of the Regulated Secretory Protein Chromogranin A: EVIDENCE FOR ...
  http://www.genlantis.com/citations-geneporter2.html
*  Catecholamine Release-Inhibitory Peptide Catestatin (Chromogranin A352-372) | Circulation
The catecholamine storage vesicle protein chromogranin A (CHGA)1 plays a necessary role in formation of catecholamine secretory ... The chromogranin-secretogranin family. N Engl J Med. 2003; 348: 1134-1149. ... However, the coupling of reduced catecholamine secretion (Table II and Figure 3) to augmented baroreceptor activity (Table II ... The catecholamine storage vesicle protein chromogranin A plays a role in the formation of catecholamine secretory granules and ...
  http://circ.ahajournals.org/content/115/17/2271
*  TRIP Database
Secretogranin III directs secretory vesicle biogenesis in mast cells in a manner dependent upon interaction with chromogranin A ... Yeast two-hybrid. Rat. N-terminus. Rat. Brain. cDNA library. 18802106. (. : click the arrow icon to show interactions only ... Our studies suggest that the Secretogranin III (SgIII) protein is involved in secretory granule biogenesis in mast cells. SgIII ... indicating that they function as bona fide secretory vesicles. In mast cells, as in neuroendocrine cells, we show that SgIII is ...
  http://trpchannel.org/references/18802106
*  Synaptotagmin IV is necessary for the maturation of secretory granules in PC12 cells | JCB
pH-dependent processing of secretogranin II by the endopeptidase PC2 in isolated immature secretory granules. Biochem. J. 321: ... Synaptotagmins I and II are localized on the same synaptic vesicle and heterodimerize in the presence of calcium. J. Biol. Chem ... D) PC12 cells cotransfected with HA-Syt IV CD and PC2 were fixed and labeled with anti-HA, anti-PC2, and chromogranin B (CgB) ... Proteolytic maturation of insulin is a post-Golgi event which occurs in acidifying clathrin-coated secretory vesicles. Cell. 49 ...
  http://jcb.rupress.org/content/173/2/241
*  DiVA - Search result
... secretory pathway in the brain is affected in patients with bipolar disorder by measuring chromogranin B and secretogranin II, ... Catestatin is a bioactive peptide of chromogranin A (CHGA) that is co-released with catecholamines from secretory vesicles. ... Interestingly, immunoreactivity for secretogranin II, secretogranin III and chromogranin B was identified in myoepithelial ... two hormone sensitive and two hormone refractory. We used a panel of chromogranin A and chromogranin B antibodies against ...
  http://uu.diva-portal.org/smash/resultList.jsf?af=%5B%5D&aq=%5B%5B%7B%22organisationId%22%3A%2211254%22%7D%5D%5D&aqe=%5B%5D&aq2=%5B%5B%5D%5D&language=en&query=
*  CHGB - Secretogranin-1 precursor - Homo sapiens (Human) - CHGB gene & protein
Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active ... "Chromogranin B: isolation from pheochromocytoma, N-terminal sequence, tissue distribution and secretory vesicle processing.". ... It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have ... "The primary structure of human secretogranin I (chromogranin B): comparison with chromogranin A reveals homologous terminal ...
  http://www.uniprot.org/uniprot/P05060
*  Biological implications of preformed mast cell mediators | SpringerLink
... in their secretory granules. When mast cells degranulate, these are released and have a profound impact on any condition in... ... Secretogranin III directs secretory vesicle biogenesis in mast cells in a manner dependent upon interaction with chromogranin A ... Dell'Italia LJ, Husain A (2002) Dissecting the role of chymase in angiotensin II formation and heart and blood vessel diseases ... Blott EJ, Griffiths GM (2002) Secretory lysosomes. Nat Rev Mol Cell Biol 3:122-131PubMedGoogle Scholar ...
  https://link.springer.com/article/10.1007%2Fs00018-010-0587-0
*  https://www.cancer.gov/types/gi-carcinoid-tumors/hp/gi-carcinoid-treatment-pdq
... chromogranin B (secretogranin I), chromogranin C (secretogranin II) and pancreastatin in plasma and urine from patients with ... Small vesicle-associated markers such as synaptophysin and synaptic vesicle protein 2 (high sensitivity and high specificity). ... Large secretory granule-associated markers such as chromogranins A, B, and C and CD57 (low sensitivity and high specificity). ... Serum chromogranin A is identified as a significant prognostic factor.[2]. Table 12. Primary Tumor (T)a,b. aReprinted with ...
  https://www.cancer.gov/types/gi-carcinoid-tumors/hp/gi-carcinoid-treatment-pdq
*  Gastrointestinal Carcinoid Tumors Treatment (PDQ®): Treatment - Health Professional Information [NCI] | UW...
Epidemiology The age-adjusted incidence of carcinoid tumors worldwide is approximately 2 per 100,000 persons.[1,2] The average ... age at diagnosis is 61.4 years.[3] Carcinoid tumors represent about 0.5% of all newly diagnosed malignancies.[2,3] Anatomy ... chromogranin B (secretogranin I), chromogranin C (secretogranin II) and pancreastatin in plasma and urine from patients with ... Small vesicle-associated markers such as synaptophysin and synaptic vesicle protein 2 (high sensitivity and high specificity). ...
  https://www.uwhealth.org/health/topic/nci/gastrointestinal-carcinoid-tumors-treatment-pdq-treatment-health-professional-information-nci/ncicdr0000062893.html
*  Chromogranin A - Wikipedia
"Dispersion of chromogranin/secretogranin secretory protein family loci in mammalian genomes". Genomics. 33 (1): 135-9. doi: ... is a member of the granin family of neuroendocrine secretory proteins, i.e., it is located in secretory vesicles of neurons and ... It is present in islet beta cell secretory granules. Chromogranin A is the precursor to several functional peptides including ... In humans, chromogranin A protein is encoded by the CHGA gene. Examples of cells producing chromogranin A (ChgA) are chromaffin ...
  https://en.wikipedia.org/wiki/Chromogranin_A