*  AID 157870 - Growth inhibition of chloroquine-resistant Plasmodium falciparum K1 by [3H]hypoxanthine uptake - PubChem
BioAssay record AID 157870 submitted by ChEMBL: Growth inhibition of chloroquine-resistant Plasmodium falciparum K1 by [3H]hypoxanthine uptake.
  https://pubchem.ncbi.nlm.nih.gov/bioassay/157870
*  AID 401251 - Antimalarial activity against multidrug-resistant Plasmodium falciparum K1 by [3H]hypoxanthine uptake - PubChem
BioAssay record AID 401251 submitted by ChEMBL: Antimalarial activity against multidrug-resistant Plasmodium falciparum K1 by [3H]hypoxanthine uptake.
  https://pubchem.ncbi.nlm.nih.gov/bioassay/401251
*  Hypoxanthine and xanthine levels in human aqueous humor from cataractous eyes. | IRIS Uniroma1
Purine nucleotide degradation products have been determined by HPLC in aqueous humor obtained during cataract surgery and from plasma of 22 patients (12 women). Uric acid, cytosine, guanosine monophosphate, uracyl, guanine, adenosine, adenosine monophosphate, thymine, adenine, inosine, cyclic guanosine monophosphate, hypoxanthine and xanthine were evaluated. Uric acid and the last two were the only compounds detectable in measurable amounts in aqueous humor and in plasma of all patients. Aqueous humor xanthine levels were not significantly different from plasma; aqueous humor hypoxanthine concentrations were lower than those of xanthine and than plasma oxypurine levels. In 8 patients, treated with allopurinol, oxypurinol concentrations in aqueous humor and in plasma were comparable suggesting that oxypurines are transported through the blood-aqueous humor barrier.. ...
  https://iris.uniroma1.it/handle/11573/24626
*  AID 683683 - Antiplasmodial against chloroquine-rsistant Plasmodium falciparum K1 assessed as inhibition of [3H]hypoxanthine...
BioAssay record AID 683683 submitted by ChEMBL: Antiplasmodial against chloroquine-rsistant Plasmodium falciparum K1 assessed as inhibition of [3H]hypoxanthine incorporation after 24 hrs by scintillation counting.
  https://pubchem.ncbi.nlm.nih.gov/bioassay/683683
*  Hypoxanthine incorporation and nucleotide imbalance in wild-type and adenine phosphoribosyl transferase-deficient Friend...
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  http://www.biochemsoctrans.org/content/18/4/618.1
*  Ammonia response to exercise in patients with congestive heart failure. | Heart
OBJECTIVE: To assess energy depletion in skeletal muscle in patients with congestive heart failure by measuring blood purine metabolites during exercise and, at the same time, determine the implications of the ammonia response to exercise in these patients. SETTING: Tottori University Hospital, Yonago, Japan. PATIENTS: 49 heart failure patients (New York Heart Association (NYHA) grades I-III) and 16 normal subjects. MAIN OUTCOME MEASURES: Blood lactate, ammonia, and hypoxanthine levels were measured during exercise with expired gas analysis. RESULTS: In normal exercising subjects as well as in each heart failure subgroup, the ammonia threshold was significantly higher than both the lactate threshold [control: 21.8 (SD 5.3) v 17.4 (3.3) ml/kg/min; NYHA class I: 18.9 (3.8) v 15.5 (2.6); class II: 14.8 (2.5) v 12.7 (2.4); class III: 13.5 (2.6) v 11.8 (2.5)] and the ventilatory threshold (P , 0.01). The difference between the ammonia and lactate thresholds was noted in all normal subjects and in all ...
  http://heart.bmj.com/content/75/4/343
*  Meiosis-activating sterol and the maturation of isolated mouse oocytes.
This study was carried out to examine the effects of the meiosis-activating C(29) sterol, 4,4-dimethyl-5 alpha-cholesta-8,14, 24-trien-3 beta-ol (FF-MAS), on mouse oocyte maturation in vitro. Cumulus cell-enclosed oocytes (CEO) and denuded oocytes (DO) from hormonally primed, immature mice were cultured 17-18 h in minimum essential medium (MEM) containing 4 mM hypoxanthine plus increasing concentrations of FF-MAS. The sterol induced maturation in DO with an optimal concentration of 3 microg/ml but was without effect in CEO, even at concentrations as high as 10 microg/ml. Some stimulation of maturation in hypoxanthine-arrested CEO was observed when MEM was replaced by MEMalpha. Interestingly, the sterol suppressed the maturation of hypoxanthine-arrested CEO in MEM upon removal of glucose from the medium. FF-MAS also failed to induce maturation in DO when meiotic arrest was maintained with dibutyryl cAMP (dbcAMP). The rate of maturation in FF-MAS-stimulated, hypoxanthine-arrested DO was slow, as ...
  http://www.ketoconazole.com/news_article.html?tx_ttnews%5Bpointer%5D=6&tx_ttnews%5Btt_news%5D=663&tx_ttnews%5BbackPid%5D=77&no_cache=1
*  Nucleosides and bases in synovial fluid from patients with rheumatoid arthritis and osteoarthritis | Clinical Science
1. Nucleosides and bases in physiological fluids result from metabolism of nucleic acids and nucleotides and from dietary sources. As nucleotide catabolism increases during tissue injury, nucleosides and bases could serve as useful biochemical markers in arthritis.. 2. We have quantified nucleosides and bases in synovial fluid and plasma by high-performance liquid chromatography in order to examine whether nucleotide metabolism is increased in patients with rheumatoid arthritis and osteoarthritis.. 3. At least ten u.v.-absorbing compounds were detected in plasma and synovial fluid; only urate, creatinine, hypoxanthine and uridine were present in identifiable and quantifiable amounts.. 4. In synovial fluid from patients with rheumatoid arthritis the concentration of hypoxanthine was increased and that of urate decreased compared with osteoarthritis.. 5. These data suggest that there is an increase in purine metabolism in the rheumatoid arthritis joint and that hypoxanthine is a potential marker ...
  http://www.clinsci.org/content/74/1/97
*  Purine nucleotide catabolism in rat liver | Biochemical Society Transactions
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  http://www.biochemsoctrans.org/content/21/2/189S
*  AID 597076 - Antiplasmodial activity against chloroquine- and pyrimethamine-resistant Plasmodium falciparum K1 infected in...
BioAssay record AID 597076 submitted by ChEMBL: Antiplasmodial activity against chloroquine- and pyrimethamine-resistant Plasmodium falciparum K1 infected in human red blood cells assessed as [3H]hypoxanthine incorporation after 48 hrs by liquid scintillation counting.
  https://pubchem.ncbi.nlm.nih.gov/bioassay/597076
*  Reactome | hypoxanthine + (deoxy)ribose 1-phosphate <=> (deoxy)inosine +...
Cytosolic nucleoside phosphorylase (NP) trimer catalyzes the reversible reaction of hypoxanthine with ribose 1-phosphate or deoxyribose 1-phosphate to form inosine or deoxyinosine and orthophosphate (Ealick et al. 1990; Wiginton et al. 1980). While NP is active with either ribose 1-phosphate or deoxyribose 1-phosphate in vitro, levels of deoxyribose 1-phosphate are normally low in vivo, limiting the extent of this reaction. NP deficiency in vivo is associated with defects in purine nucleotide salvage and leads to immunodeficiency (Williams et al. 1987).. ...
  http://www.reactome.org/content/detail/112033
*  Glutamate and catabolites of high-energy phosphates in the striatum and brainstem of young and aged rats subchronically exposed...
The degradation of high-energy phosphates was recently shown to precede manganese-induced cellular death. We evaluated hypoxanthine, xanthine, uric acid and glutamate levels in the striatum and brainstem of 3- and 20-month-old rats after subchronic oral exposure to manganese (MnCl2, 200 mg/kg/day in young rats, and 50-100 or 200 mg/kg/day in aged rats). Aged rats had higher basal levels of hypoxanthine, xanthine, and glutamate both in the striatum and brainstem than young rats; conversely, basal uric acid levels were lower in the striatum, but higher in the brainstem. Manganese induced a significantly greater increase in hypoxanthine, xanthine, uric acid and glutamate levels in aged rats than in young rats in both brain regions. These findings depict a greater manganese-induced energetic impairment (increases in hypoxanthine and xanthine levels), xanthine oxidase-induced free radical generation (increases in xanthine and uric acid levels), ...
  http://eprints.uniss.it/5340/
*  "Effects of thymidine and hypoxanthine on synergistic toxicity of l1210" by A A. Piper, S Nott et al.
Piper, A A.; Nott, S; and Tattersall, M H., "Effects of thymidine and hypoxanthine on synergistic toxicity of l1210 cells treated with methotrexate (mtx) before fluorouracil (fu). Abstr." (1982). Subject Strain Bibliography 1982. 2217 ...
  http://mouseion.jax.org/ssbb1982/2217/
*  Reactive oxygen metabolites increase mitochondrial calcium in endothelial cells: implication of the Ca2+/Na+ exchanger |...
In endothelial cells, a bolus of hydrogen peroxide (H2O2) or oxygen metabolites generated by hypoxanthine-xanthine oxidase (HX-XO) increased the mitochondrial calcium concentration [Ca2+]m. Both agents caused a biphasic increase in [Ca2+]m which was preceded by a rise in cytosolic free calcium concentration [Ca2+]c (18 and 6 seconds for H2O2 and HX-XO, respectively). The peak and plateau elevations of [Ca2+] were consistently higher in the mitochondrial matrix than in the cytosol. In Ca2+-free/EGTA medium, the plateau phase of elevated [Ca2+] evoked by H2O2 due to capacitative Ca2+ influx was abolished in the cytosol, but was maintained in the mitochondria. In contrast to H2O2 and HX-XO, ATP which binds the P2Y purinoceptors induced an increase in [Ca2+]m that was similar to that of [Ca2+]c. When cells were first stimulated with inositol 1,4, 5-trisphosphate-generating agonists or the Ca2+-ATPase inhibitor cyclopiazonic acid (CPA), subsequent addition of H2O2 did not affect [Ca2+]c, but still ...
  http://jcs.biologists.org/content/112/7/1013
*  Transport of purine nucleobases by COS-1 cells occurs via a nitrobenzylthioinosine-insensitive (ei) nucleoside transporter |...
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  http://www.biochemsoctrans.org/content/27/5/A149.3
*  Ab initio insight into ultrafast nonadiabatic decay of hypoxanthine: keto-N7H and keto-N9H tautomers
A free platform for explaining your research in plain language, and managing how you communicate around it - so you can understand how best to increase its impact.
  https://www.growkudos.com/publications/10.1039%25252Fc3cp44718a/reader
*  KAKEN - Researchers | MASUDA Wataru (80295865)
Affiliation:九州女子大学,家政学部,准教授, Research Field:Functional basic dentistry,Functional biochemistry,Functional basic dentistry,Rehabilitation science/Welfare engineering, Keywords:唾液腺,動物進化,Animal evolution,カエルアラントイナーゼcDNA,Purine degradation,Allantoinase,アラントイナーゼ,アラントイカーゼ,Frog allantoinase cDNA,Allantoicase, # of Research Projects:8, # of Research Products:16, Ongoing Project:高齢者の口腔咽頭機能評価に対する舌の立体認知能・運動能からのアプローチ
  https://nrid.nii.ac.jp/nrid/1000080295865/
*  HPRT1 Gene - GeneCards | HPRT Protein | HPRT Antibody
Complete information for HPRT1 gene (Protein Coding), Hypoxanthine Phosphoribosyltransferase 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=HPRT1
*  HPRT1 Gene - GeneCards | HPRT Protein | HPRT Antibody
Complete information for HPRT1 gene (Protein Coding), Hypoxanthine Phosphoribosyltransferase 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=HPRT1&bioalma_cpd_art=all
*  HPRT1 Gene - GeneCards | HPRT Protein | HPRT Antibody
Complete information for HPRT1 gene (Protein Coding), Hypoxanthine Phosphoribosyltransferase 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=HPRT1&go_proc=29
*  HPRT1 Gene - GeneCards | HPRT Protein | HPRT Antibody
Complete information for HPRT1 gene (Protein Coding), Hypoxanthine Phosphoribosyltransferase 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=HPRT1&phen=25&rf=/home/genecards/current/website/carddisp.pl
*  HPRT1 Gene - GeneCards | HPRT Protein | HPRT Antibody
Complete information for HPRT1 gene (Protein Coding), Hypoxanthine Phosphoribosyltransferase 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=HPRT1&rf=/home/genecards/current/website/carddisp.pl&simap=2
*  HPRT1 Gene - GeneCards | HPRT Protein | HPRT Antibody
Complete information for HPRT1 gene (Protein Coding), Hypoxanthine Phosphoribosyltransferase 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=HPRT1&rf=/home/genecards/current/website/carddisp.pl&snp=571
*  Purine and Pyrimidine, Random Urine
0-3 Y 4-6 Y 7-12 Y 13-18 Y >18 Y ----------------------------------------------------------------------- Uracil < or =50 < or =30 < or =25 < or =20 < or =20 Thymine < or =3 < or =3 < or =3 < or =3 < or =3 Adenine < or =3 < or =3 < or =3 < or =3 < or =3 Hypoxanthine < or =65 < or =30 < or =30 < or =30 < or =30 Xanthine < or =54 < or =21 < or =35 < or =15 < or =20 Orotic < or =4 < or =4 < or =3 < or =3 < or =5 Dihydroorotic Acid < or =3 < or =3 < or =3 < or =3 < or =3 Uric Acid 350-2500 200-2000 200-1400 150-700 70-700 Deoxythymidine < or =3 < or =3 < or =3 < or =3 < or =3 Deoxyuridine < or =3 < or =3 < or =3 < or =3 < or =3 Thymidine < or =3 < or =3 < or =3 < or =3 < or =3 Uridine < or =10 < or =3 < or =3 < or =3 < or =3 Deoxyadenosine < or =3 < or =3 < or =3 < or =3 < or =3 Deoxyinosine < or =3 < or =3 < or =3 < or =3 < or =3 Deoxyguanosine < or =3 < or =3 < or =3 < or =3 < or =3 Adenosine < or =3 < or =3 < or =3 < or =3 < or =3 Inosine < or =6 < or =3 < or =3 < or =3 < or =3 Guanosine < or ...
  https://www.healthcare.uiowa.edu/path_handbook/handbook/test2414.html
*  Digestión anaerobia de la fracción sólida de purines de cerdo, separada mediante el proceso ECOpurín
CitacióMartínez-Almela, J. [et al.]. Digestión anaerobia de la fracción sólida de purines de cerdo, separada mediante el proceso ECOpurín. "Anaporc", 2001, vol. 1, núm. 1, p. 41-51 ...
  http://upcommons.upc.edu/handle/2117/6583