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*  Subcellular Behaviour Evaluation of Nanopharmaceuticals with Aggregation-Induced Emission Molecules
Deciphering these subcellular behaviours of nanopharmaceuticals can provide detailed information to guide drug design, drug ... The aromatic cores of AIE molecules are always hydrophobic and do not undergo the ACQ effect even at high concentrations. Hence ... such as mitigated side effects and targeted therapies. Unveiling the subcellular behaviours of these nanopharmaceuticals allows ... Otherwise, PEI suffers from undesirable cytotoxicity, which greatly hinders its biological applications. To overcome these ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC4816494/
*  User Engagement, Training, and Support for Conducting N-of-1 Trials (Chapter 6) | Effective Health Care Program
... it is possible that patients may prefer trials of medical devices as opposed to drug trials due to potential side effects and ... 10 Patients must be willing to undergo multiple treatment periods and, if important to trial design, to take a blinded ... or if the treatment leads to undesirable side effects.. Increased collaboration between providers and patients. Patients ... This includes addressing problems encountered by both patients and clinicians as well as designing systems that support ...
  https://effectivehealthcare.ahrq.gov/topics/n-1-trials/research/
*  Frontiers | Lipid- and sugar-modified endomorphins: novel targets for the treatment of neuropathic pain | Pharmacology
This review discusses the application of glycosylation and lipidation strategies to improve the drug-like properties of ... Pharmacologically active endomorphin analogues with less adverse effects are also discussed. ... This review discusses the application of glycosylation and lipidation strategies to improve the drug-like properties of ... Pharmacologically active endomorphin analogues with less adverse effects are also discussed. ...
  https://www.frontiersin.org/articles/10.3389/fphar.2013.00155/full
*  Awards made
The likelihood of side effects of medicines, drug interactions and potentially inappropriate prescribing increase with the ... Patients who undergo this treatment for oesophageal cancer experience a number of weakening side-effects which... ... Hospital design for supporting people with dementia and their carers The relationship between health and wellbeing and the ... Designing, evaluating and implementing a pilot complex intervention in childhood obesity Childhood obesity is a serious problem ...
  https://www.hrb.ie/funding/funding-awarded/awards-made/
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
This underestimation could, in part, explain the low success rate of drug approval due to undesirable or toxic side effects. ... Drug Design, optimization (mathematics), Amino Acids, Peptides, and Proteins, De novo protein and peptide design, Drug design, ... Then, after recovery at gestational age day 30 (full term), the same rabbit undergoes examination of fetal cardiac function. ... Low costs and rapid turnaround time in this technique lower the barrier to iteratively designing and prototyping complex ...
  https://www.jove.com/visualize/abstract/24416193/predictors-grandparental-investment-decisions-contemporary-europe
*  C60-Fullerenes: detection of intracellular photoluminescence and lack of cytotoxic effects | Journal of Nanobiotechnology |...
RH and DLC helped in designing some experiments and interpretation of the data. GLP designed the overall project and wrote the ... C60 undergoes modifications during the preparation of water soluble C60, and such changes are responsible for the cytotoxic ... However, some undesirable properties of C60 present specific challenges. For example, due to its inherent hydrophobicity, C60 ... and drug carriers (taxol) [10]. Our laboratory is interested in exploring whether novel multifunctional nanoparticles can be ...
  https://jnanobiotechnology.biomedcentral.com/articles/10.1186/1477-3155-4-14
*  Frontiers | Intermittent Hypoxia in Childhood: The Harmful Consequences Versus Potential Benefits of Therapeutic Uses |...
This review article provides an updated and impartial analysis on the currently available evidence in supporting either side of ... This review article provides an updated and impartial analysis on the currently available evidence in supporting either side of ... There are numerous reports indicating adverse effects of intermittent hypoxia on development, behavior, academic achievement ... There are numerous reports indicating adverse effects of intermittent hypoxia on development, behavior, academic achievement ...
  https://www.frontiersin.org/articles/10.3389/fped.2015.00044/full
*  Patent US20070043345 - Tissue ablation with irreversible electroporation - Google Patents
It involves the placement of electrodes into or near the vicinity of the undesirable tissue through the application of ... A new method for the ablation of undesirable tissue such as cells of a cancerous or non-cancerous tumor is disclosed. ... electrical pulses causing irreversible electroporation of the cells throughout the entire area of the undesirable tissue. The ... Effects of a high-voltage electrical impulse and an anticancer drug on in vivo growing tumors. Japanese Journal of Cancer ...
  http://www.google.ca/patents/US20070043345
*  Delayed educational reminders for long-term medication adherence in ST-elevation myocardial infarction (DERLA-STEMI): Protocol...
... stopping medications due to side effects; taking one or two or three medication classes concurrently; a perfect Morisky ... This intervention is designed to be easily generalizable. If effective, it could be implemented broadly. If it does not change ... Patients from one health region in Ontario, Canada who undergo a coronary angiogram during their admission for ST-elevation ... For a sample of patients aged 65 and older, the Ontario Drug Benefit database will be used to examine the accuracy of the self- ...
  https://implementationscience.biomedcentral.com/articles/10.1186/1748-5908-7-54
*  Frontiers | Immunoglobulin Fc Heterodimer Platform Technology: From Design to Applications in Therapeutic Antibodies and...
Epo is a glycoprotein hormone drug of ~34 kDa that exerts its effects by binding to the Epo receptor to stimulate red blood ... Unlike the human IgG1 isotype, IgG4 has been shown to undergo Fab arm exchange (FAE) both in vivo and in vitro, in which one ... A sub-optimal linker can cause undesirable problems, such as loss of antigen binding, due to binding site hindrance, poor ... Molecular properties of human IgG subclasses and their implications for designing therapeutic monoclonal antibodies against ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2016.00394/full
*  Patent US5331573 - Method of design of compounds that mimic conformational features of selected ... - Google Patents
The rational design of novel compounds, useful as drugs, e.g., bioactive peptidomimetic compounds, and constrained analogs ... A method of rational drug design includes simulating polypeptides in a way that predicts the most probable secondary and/or ... 3C is thus illustrative of the "lock-and-key" analogy associated with drug design. Only by designing the conformation of one ... it is desired that the peptide drug survive in its active form until it reaches the site where it exerts its biological effect. ...
  http://www.google.com/patents/US5331573?dq=inventor:%22Arthur+R.+Hair%22&ei=VAy0Tsa4NYTl0QGQiqWiBA
*  Our Funded Projects - 2013 - Rettsyndrome.org
Unfortunately, mGlu5 drug discovery has been plagued by the presence of adverse side effects, including seizures, which have ... By designing oligonucleotide drugs that targeting the inactive X chromosome (Xi) in Rett syndrome would circumvent the effects ... Gogliotti's goal is to assess both the efficacy and the adverse effect liability of therapeutics designed to modulate ... Indeed, reactivating the entire Xi would be undesirable, as they have shown that global X-reactivation results in cancer. ...
  https://www.rettsyndrome.org/research/our-funded-programs/research-awardees/2013
*  Targeted Therapies: A New Generation of Cancer Treatments - - American Family Physician
Small molecule inhibitors are metabolized by cytochrome P450 enzymes and are subject to multiple drug interactions. Targeted ... the assessment of drug effectiveness and toxicity, and the economics of cancer care. As more persons are diagnosed with cancer ... but they are associated with several adverse effects, such as acneiform rash, cardiac dysfunction, thrombosis, hypertension, ... Drug. Target. Antibody type. FDA-approved indications. Toxicities, side effects, and precautions. Monitoring. ...
  https://www.aafp.org/afp/2008/0201/p311.html
*  Discovering Plausible Mechanistic Details of Hepatic Drug Interactions | Drug Metabolism & Disposition
2) is different from that on the left side. Software components are designed, coded, verified, assembled, and connected guided ... Bailey SM and Reinke LA (2000) Effect of low flow ischemia-reperfusion injury on liver function. Life Sci 66: 1033-1044. ... To date, designing and conducting new wet-lab experiments have been the only practicable means to falsify experimentally those ... without either having undergone metabolism. That similarity indicates that rifampicin and quinidine metabolism was very modest ...
  http://dmd.aspetjournals.org/content/37/1/237
*  Immune system - Wikipedia
Glucocorticoids are the most powerful of these drugs; however, these drugs can have many undesirable side effects, such as ... The entry of another toxin called granulysin (a protease) induces the target cell to undergo apoptosis. T cell killing of host ... In developed countries, obesity, alcoholism, and drug use are common causes of poor immune function. However, malnutrition is ... Salzet M, Tasiemski A, Cooper E (2006). "Innate immunity in lophotrochozoans: the annelids". Current Pharmaceutical Design. 12 ...
  https://en.wikipedia.org/wiki/Immune_system
*  Protocols and Video Articles Authored by Elizabeth Jaffee (Translated to Norwegian)
... systemic exposure to agents for therapy or prevention is accompanied by undesirable side effects. We hypothesized that it is ... Low toxicity, the potential for circumventing drug cross-resistance, and the potential for persistence of the antitumor effect ... We designed a neoadjuvant and adjuvant clinical trial comparing an irradiated, granulocyte-macrophage colony-stimulating factor ... There are a multitude of challenges to designing effective vaccine strategies. The components of a vaccine strategy start with ...
  https://www.jove.com/author/Elizabeth_Jaffee?language=Norwegian
*  Download A Cold War In The Soviet Bloc Polish East German Relations 1945 1962
... have badly to develop an modern drug to be as to practitioners you have one-sided in. After sizing download a cold war in the ... present grant environmental variables, grant death, co-design utilities, metals, molecules, Topics, submission design members, ... recommendations brought with side effect and wallpapers in perception - operating the something models and kernel regions from ... I long undergo models that do actively plastically, about like I seek download a cold war chronicles, but I can be those ...
  http://pd19.org/ebook/download-a-cold-war-in-the-soviet-bloc%3A-polish-east-german-relations%2C-1945-1962
*  Patent US7115652 - Aspartyl protease inhibitors - Google Patenten
In order to prolong the effect of a drug, it is often desirable to slow the absorption of the drug from subcutaneous or ... 14 of the A.C.S. Symposium Series, and in Edward B. Roche, ed., Bioreversible Carriers in Drug Design, American Pharmaceutical ... refers to treatment that is focused on the relief of symptoms of a disease and/or side effects of a therapeutic regimen, but is ... or it may be any one of a number of agents undergoing approval in the Food and Drug Administration that ultimately obtain ...
  http://www.google.nl/patents/US7115652
*  Protocols and Video Articles Authored by Meital Reches
Knowledge of the energy landscape of oligomerization may provide hints for rational drug design, preventing amyloid-associated ... To examine the effect of this group and its activity on the self-assembled structures, we irradiated the assemblies in solution ... Here we extend our research and explore the self-assembly of other homo-aromatic dipeptides in which their phenyl side-chains ... Jun, 2016 , Pubmed ID: 26773304 Biofouling is an undesirable process in which organisms and their by-products encrust a surface ...
  https://www.jove.com/author/Meital_Reches
*  2012-2013 Edition</span>
... pemphigus has typically been treated with systemic immunosuppressive agents with many undesirable side effects. Recently, ... The mechanism of action of either drug is not clear yet, but UNC1999's effects are likely not p16INK4A or p19ARF-dependent. So ... Of the 53 that underwent mesh excision, 24 (45%) were closed primarily and 9 patients have undergone definitive repair since ... Designing an Electrode to Monitor Cochlear Implant Surgery Christopher K. Giardina, Oliver F. Adunka, MD, Craig A. Buchman, MD ...
  http://www.med.unc.edu/dms/Fax-journal/2012-2013-edition
*  Deep Vein Thrombosis Natural Prevention | Life Extension
No adverse side effects were reported.. Too Much TV Can Lead to Pulmonary Embolism. Our parents always used to say that ... No adverse effects or undesirable bleeding were reported.4. French maritime pine bark extract was demonstrated to reduce ... Before designing human trials, scientists conducted animal studies that clearly demonstrated the beneficial effects of ... All subjects underwent ultrasound scans of their leg veins within 90 minutes before and after their flights to detect clots. ...
  http://www.lifeextension.com/Magazine/2017/1/Natural-Prevention-Of-Deep-Vein-Thrombosis/Page-01
*  Discovery Biology News
Hot discovery biology news stories in the field of drug discovery that showcase the latest technology and scientific ... of small-molecule drugs targeting GPCRs been few and far between due to undesirable central nervous system side effects ... A new drug, called dinutuxumab was granted priority review and orphan drug designation by the FDA. It is the first drug of its ... Designing the guide RNA is as simple as finding a sequence on your gene of interest with a requisite PAM sequence (NGG)… Or is ...
  https://www.genscript.com/DiscoveryBiology_news.html
*  EinNext Biosciences
Analyze the pulmonary drug delivery mechanism. Designing of an effective inhaler requires the knowledge to drug particle ... Better optimized stent designs could improve the efficacy of stents. Each design variant undergoes strict evaluation through ... This reduces the cement overflow and its related side effects for the patient. ... The most undesirable part of this is the trauma and swelling suffered by the patients post dental implantation. Repetitive ...
  http://www.einnext.com
*  Ellegaard Newsletter Spring 2013 by Burchardt Reklame AS - Issuu
a solid basis for assessing drug-induced side effects in cardiac. (2010). Regulatory acceptability of the minipig in the deve- ... nificant dialysing effects. Haemolysis will occur if intravenous. bient temperature. Hypothermia is undesirable in all ... This study was designed to determine the accuracy of P, Q, R, S and T points positioning with this new software. To that end, a ... endotracheal tubes should be used in pigs undergoing prolonged. stable levels of anaesthesia, because other factors affect ...
  https://issuu.com/burchardt-reklame/docs/ellegaard-newsletter-39?mode=window&viewMode=doublePage
*  3D Printing in Pharmaceutical and Medical Applications - Recent Achievements and Challenges
This process is designed to result in filaments with higher drug content and mechanical properties suitable for 3DP (46,48). Li ... Goyanes A, Robles Martinez P, Buanz A, Basit AW, Gaisford S. Effect of geometry on drug release from 3D printed tablets. Int J ... Sealing PVA cap was printed on the one side of the tube at the end of the printing. The construction of the unit provides the ... All patients underwent successful partial nephrectomy.. Silicon models of kidney, renal pelvis and ureter were developed in ...
  https://www.drugpatentwatch.com/blog/3d-printing-in-pharmaceutical-and-medical-applications-recent-achievements-and-challenges/