Exploration of a Mutant p53 Reactivating Compound - Darren Carpizo
We identified NSC319726 (726) as a mutant p53 re... ... have defined p53 as one of the most critical tumor suppressors ... The p53 protein binds a single zinc ion, which is necessary for proper p53 structure and function. The p53-R175H mutation ... Arnold Levine whose laboratory discovered the p53 tumor suppressor and Dr. Joseph Bertino, an internationally recognized expert ... Aim #1 is to dissect the molecular mechanism by which the compound reactivates the p53-R175 mutant protein and other p53 zinc- ...http://grantome.com/grant/NIH/K08-CA172676-02
TP53INP1 Gene - GeneCards | T53I1 Protein | T53I1 Antibody
Protein Coding), Tumor Protein P53 Inducible Nuclear Protein 1, including: function, proteins, disorders, pathways, orthologs, ... TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-family proteins through the LC3-interacting region (LIR) and promotes ... Protein Symbol:. Q96A56-T53I1_HUMAN. Recommended name:. Tumor protein p53-inducible nuclear protein 1 Protein Accession:. ... TP53INP1 (Tumor Protein P53 Inducible Nuclear Protein 1) is a Protein Coding gene. Among its related pathways are TP53 ...http://www.genecards.org/cgi-bin/carddisp.pl?gene=TP53INP1
ATCC Cell Lines by TP53 Gene Mutation Page 1
... p53, which plays a significant role in regulating cellular responses to DNA damage and other genomic anomalies. ... TP53 encodes a major tumor suppressor transcription factor, ... Grade Iii, Mesodermal Tumor (Mixed) ; Consistent With Leiomy... ... Nucleic Acids, Proteins and Cell Extracts Services * Biorepository Management * Deposit Services * Custom Solutions ... Reactivation of mutant p53. Studies related to p53 molecular mechanisms. Testing small molecules or biologics for cancer drug ...https://www.atcc.org/en/Products/Cells_and_Microorganisms/By_Disease__Model/Cancer/Tumor_Cell_Panels/Cell_lines_by_genetic_mutation/TP53.aspx?dsNav=Nrc:id-1000506-dynrank-disabled%7Cid-1000507-dynrank-disabled&hasShowAll=1000506%7C1000507%7C
Dynamic Responses | Science Signaling
Expression of the tumor suppressor p53 is activated in response to cell stress. The dynamics of p53 activation can vary, ... In contrast, sustained p53 promoted induction of terminal genes leading to cellular senescence. Thus, protein dynamics can ... developed a method to control p53 dynamics in human cells. Pulsing p53 selectively activated genes involved in cell cycle ... J. E. Purvis, K. W. Karhohs, C. Mock, E. Batchelor, A. Loewer, G. Lahav, p53 dynamics control cell fate. Science 336, 1440-1444 ...http://stke.sciencemag.org/content/5/229/ec172
Tumor protein p53-inducible protein 11
PIG11 is considered to be a new candidate liver tumour suppressor gene.. ... Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein ... PIG11 protein binds to DNA in sequence-independent manner in vitro.. 16554811. 2006. Human chromosome 11 DNA sequence and ... PIG11 protein may play an important role by interaction with other biological molecules in the regulation of apoptosis and ...https://pharos.nih.gov/idg/targets/O14683
ATCC Cell Lines by TP53 Gene Mutation Page 1
... p53, which plays a significant role in regulating cellular responses to DNA damage and other genomic anomalies. ... TP53 encodes a major tumor suppressor transcription factor, ... Nucleic Acids, Proteins and Cell Extracts Services * ...https://www.atcc.org/en/Products/Cells_and_Microorganisms/By_Disease__Model/Cancer/Tumor_Cell_Panels/Cell_lines_by_genetic_mutation/TP53.aspx?dsNav=Up:Page_Product_Listing,N:4294927644
OriGene - TP73 (NM 001126240) cDNA Clone
Human tumor protein p73 (TP73), transcript variant 2 available for purchase from OriGene - Your Gene Company. ... Protein Families:. Transcription FactorsDruggable Genome. Protein Pathways:. p53 signaling pathwayNeurotrophin signaling ... and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely ... TP73 (untagged)-Human tumor protein p73 (TP73), transcript variant 2, NM_001126240.1, 10ug. $910. In Stock. ...http://www.origene.com/human_cdna/NM_001126240/SC323148.aspx
Cold viruses point the way to new cancer therapies - Salk Institute for Biological Studies
O'Shea's team studied E4-ORF3, a cancer-causing protein encoded by adenovirus, which prevents the p53 tumor suppressor protein ... p53 normally suppresses tumors by causing cells with DNA damage-a hallmark of cancer-to self-destruct. The p53 tumor suppressor ... "It doesn't resemble any known proteins that assemble polymers or that function in cellular tumor suppressor pathways," he says ... key that opened that box was revealing the interactions between small DNA tumor virus proteins and cellular tumor suppressor ...http://www.salk.edu/news-release/cold-viruses-point-the-way-to-new-cancer-therapies/
Nutlin-3a Induces Cytoskeletal Rearrangement and Inhibits the Migration and Invasion Capacity of p53 Wild-Type Cancer Cells |...
MDM2 is an E3 ubiquitin ligase that binds and ubiquitinates the tumor suppressor protein p53, leading to its proteasomal ... Nutlin-3a (Nutlin) is a preclinical drug that binds MDM2 and prevents the interaction between MDM2 and p53, leading to p53 ... Nutlin-3a Induces Cytoskeletal Rearrangement and Inhibits the Migration and Invasion Capacity of p53 Wild-Type Cancer Cells. ... Previous studies have reported that Nutlin promotes growth arrest and/or apoptosis in cancer cells that express wild-type p53. ...http://mct.aacrjournals.org/content/early/2010/04/02/1535-7163.MCT-09-1220
Grad Student Jin Hyup Lee receives a 2011 GEAB Impact Award - Biochemistry and Biophysics - UNC School of Medicine
The protein tumor suppressor p53 plays a critical role in apoptosis induced by anticancer drugs; however, at least 50 percent ... that ensures proper adaptation to the constantly changing environment-functionally activates the p73 tumor suppressor protein, ... lends support for the development of drugs as targeted therapies for the treatment of cancers with dysfunctional p53 protein, ... which induces cell death in p53-deficient cancer cells. His study indicates that this mechanism provides another way to ...http://www.med.unc.edu/biochem/news/2011/jin-lee-is-recipient-of-a-2011-geab-impact-award
Tumor-Suppressor P53 Gene Regulates Protein That Blocks Immune Attack on Cancer
Identifying this role for tumor-suppressing p53 provides both a potential biomarker for response to important new cancer ... Tumor-Suppressor P53 Gene Regulates Protein That Blocks Immune Attack on Cancer. ... Welsh and colleagues found that p53 also blocks a protein called PDL1 that tumor cells can wield to halt immune attack. Like a ... Tumors with p53 mutated had higher levels of PDL1 and lower levels of miR-34a. Patients with either low PDL1 and high p53 ...http://www.medindia.net/news/tumor-suppressor-p53-gene-regulates-protein-that-blocks-immune-attack-on-cancer-155678-1.htm
Involvement of the p53 tumor-suppressor protein in the development of antinociceptive tolerance to morphine
... Tan-No, Koichi ... The present study was designed to determine whether the p53 tumor-suppressor protein is involved in the development of ... Moreover, p53 expression in the spinal cord had increased significantly 14h after the last morphine administration. These ... Morphine, Antinociceptive tolerance, p53, Caspase, Nitric oxide, Intrathecal injection National Category Pharmaceutical ...http://uu.diva-portal.org/smash/record.jsf?pid=diva2:302486
The structure of p53 tumour suppressor protein reveals the basis for its funcitonal plasticity - White Rose Research Online
p53 major tumour suppressor protein has presented a challenge for structural biology for two decades. The intact and complete ... The structure of p53 tumour suppressor protein reveals the basis for its funcitonal plasticity ... 5 more authors) (2006) The structure of p53 tumour suppressor protein reveals the basis for its funcitonal plasticity. EMBO ... which enables the protein to bind variably spaced DNA target sequences, essential for p53 transactivation and tumour suppressor ...http://eprints.whiterose.ac.uk/6065/
p53 Tumor Suppressor Protein Antibody - Without BSA and Azide - Mouse Monoclonal Antibody [Clone BP53-12 ] WB, IHC-P, IF, FC -...
p53 Tumor Suppressor Protein Antibody - Without BSA and Azide, Mouse Monoclonal Antibody [Clone BP53-12 ] validated in WB, IHC- ... p53 Tumor Suppressor Protein Antibody - Without BSA and Azide p53 Tumor Suppressor Protein Antibody - Without BSA and Azide. ... Cellular tumor antigen p53, Antigen NY-CO-13, Phosphoprotein p53, Tumor suppressor p53, TP53, P53. ... p53 Tumor Suppressor Protein Antibody - Without BSA and Azide is for research use only and not for use in diagnostic or ...http://www.abgent.com/products/AH10775-p53-Tumor-Suppressor-Protein-Antibody-Without-BSA-and-Azide
p53 Tumor Suppressor Protein Antibody - With BSA and Azide - Purified Mouse Monoclonal Antibody WB, IHC, FC, IP, E - Buy Now! ...
p53 Tumor Suppressor Protein Antibody - With BSA and Azide, Purified Mouse Monoclonal Antibody validated in WB, IHC, FC, IP, E ... p53 Tumor Suppressor Protein Antibody - With BSA and Azide p53 Tumor Suppressor Protein Antibody - With BSA and Azide. Purified ... Cellular tumor antigen p53, Antigen NY-CO-13, Phosphoprotein p53, Tumor suppressor p53, TP53, P53. ... p53 Tumor Suppressor Protein Antibody - With BSA and Azide is for research use only and not for use in diagnostic or ...http://www.abgent.com/products/AH10154-p53-Antibody-Clone-DO-7
Cancers | Free Full-Text | Emerging Biomarkers in Glioblastoma | HTML
... tumor suppressor protein p53, phosphatase and tensin homolog (PTEN), p16INK4a gene, cytochrome c oxidase (CcO), phospholipid ... Molecular signatures associated with tumor aggressiveness as well as with disease progression and their relation to differences ... and 7 transmembrane domain-containing protein 1 on chromosome 1 (ELTD1), vascular endothelial growth factor (VEGF), ... the most common primary brain tumor, has few available therapies providing significant improvement in survival. ...http://www.mdpi.com/2072-6694/5/3/1103/htm
Evaluation of a New Anti-cancer Vaccine for Patients With Non-small Cell Lung Cancer, After Tumor Removal by Surgery
Tumor Suppressor Protein P53. Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control ... A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER. ... Tumor-specific T Cells in Lung Cancer. Non-small cell lung cancer is characterized by aggressive growth and treatment ... Mixed-lineage leukemia protein 2 (MLL2 or KMT2D) is a histone methyltransferase whose mutation has been associated with a poor ...https://www.bioportfolio.com/resources/trial/62995/Evaluation-of-a-New-Anti-cancer-Vaccine-for-Patients-With-Non-small.html
Actinic cheilitis and squamous cell carcinoma of the lip: clinical, histopathological and immunogenetic aspects
Protooncogene proteins c-bcl-2; Tumor suppressor protein p53. ... Tumor suppressor genes and cell proliferation regulatory ... In general, physicians and dentists know little about what causes oral tumor development and progression. ... Keywords : Carcinoma; squamous cell; Cheilitis; Cyclin-dependent kinase inhibitor proteins; Cyclin D1; ... proteins play a role in the progression of actinic cheilitis to squamous cell carcinoma and in its biological behavior. ...http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0365-05962012000100013&lng=en&nrm=iso&tlng=en
Carboxyamidotriazole in Treating Patients With Stage III or Stage IV Non-Small Cell Lung Cancer
Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It ... ... Tumor Suppressor Protein P53. Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control ... A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER. ... RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is ...https://www.bioportfolio.com/resources/trial/125878/Carboxyamidotriazole-in-Treating-Patients-With-Stage-III-or-Stage-IV-Non-Small.html
The transduction of His-TAT-p53 fusion protein into the human osteogenic sarcoma cell line (Saos-2) and its influence on cell...
It encodes a nuclear phosphoprotein p53 involved in the regulation of cell cycle arrest and apoptosis to maintain the genomic ... As mutations of p53 gene are found in most human cancers, p5 ... The p53 gene is a tumor suppressor gene. ... Recombinant Fusion Proteins / isolation & purification, metabolism*. Transduction, Genetic*. Tumor Suppressor Protein p53 / ... 0/Gene Products, tat; 0/Recombinant Fusion Proteins; 0/Tumor Suppressor Protein p53 ...http://www.biomedsearch.com/nih/transduction-His-TAT-p53-fusion/17206471.html
Honokiol | GreenMedInfo | Substance | Natural Medicine | Alternative
Tumor Suppressor Protein p53 Upregulation. 1. 1. Vascular smooth muscle cell (VSMC) inhibitor. 1. 1. ... Activation of tumor suppressor LKB1 by honokiol abrogates cancer stem-like phenotype in breast cancer.Jun 04, 2017. ... Honokiol can repress human glioma growth by inducing apoptosis and cell cycle arrest in tumor cells.May 14, 2016. ... Honokiol is a promising candidate to suppress the development and even progression of lung tumors driven by EGFR deregulation. ...http://www.greenmedinfo.com/substance/honokiol
Resveratrol suppresses IGF-1 induced human colon cancer cell proliferation and elevates apoptosis via suppression of IGF-1R/Wnt...
0/TP53 protein, human; 0/Tumor Suppressor Protein p53; 0/Wnt Proteins; 136601-57-5/Cyclin D1; 147604-94-2/Cyclin-Dependent ... Resveratrol activates tumor suppressor protein p53 and elevates activated forkhead transcription factor 1 levels A critical ... Resveratrol treatment induced apoptosis by activating tumor suppressor p53 protein, whereas IGF-1R siRNA treatment did not ... The tumor suppressor p53, suppresses IGF-1R gene expression and phosphorylation. P53 attenuates IGF-1R transcription through ...http://www.biomedsearch.com/nih/Resveratrol-suppresses-IGF-1-induced/20504360.html
Roles of DNA-dependent protein kinase and ATM in cell-cycle-dependent radiation sensitivity in human cells.
The roles of DNA-dependent protein kinase (DNA-PK) and ATM in the cell-cycle-dependent radiosensitivity in human cells were ... 0/DNA-Binding Proteins; 0/Nuclear Proteins; 0/Tumor Suppressor Protein p53; 0/Tumor Suppressor Proteins; 19545-26-7/wortmannin ... Tumor Cells, Cultured. Tumor Suppressor Protein p53 / chemistry, metabolism, radiation effects. Tumor Suppressor Proteins. ... Cell Cycle Proteins. Cell Line. Cell Survival / radiation effects. DNA-Activated Protein Kinase. DNA-Binding Proteins*. G1 ...http://www.biomedsearch.com/nih/Roles-DNA-dependent-protein-kinase/12065055.html
Forever young? Exploring the link between rapamycin, longevity and cancer.
0/Antineoplastic Agents; 0/Tumor Suppressor Protein p53; 53123-88-9/Sirolimus; EC 22.214.171.124/TOR Serine-Threonine Kinases ... In two new studies, rapamycin was applied to highly tumor-prone p53+/− and p53−/− mice. Interestingly, rapamycin extended the ... Next Document: Arsenic activates endothelin-1 Gi protein-coupled receptor signaling to inhibit stem cell differenti.... ... There are at least two possibilities, (1) mice are tumor-prone animals, and rapamycin is toxic to cancer cells and can ...http://www.biomedsearch.com/nih/young-link-between-rapamycin-longevity/23152185.html
Cytotoxicity of natural extract from Tegillarca granosa on ovarian cancer cells is mediated by multiple molecules.
Proto-Oncogene Proteins c-bcl-2 / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Tumor Suppressor Protein p53 / ... 0/Antigens, CD24; 0/Antigens, CD44; 0/Antineoplastic Agents; 0/Proto-Oncogene Proteins c-bcl-2; 0/Tumor Suppressor Protein p53 ... Although p53 mediated apoptosis induced by HSS in OVCAR-3 cells, it was not required in SKOV-3 cells. CONCLUSION: HSS has a ... Cell Line, Tumor. Female. Flow Cytometry. Gene Expression Regulation, Neoplastic / drug effects. Humans. Ovarian Neoplasms / ...http://www.biomedsearch.com/nih/Cytotoxicity-natural-extract-from-Tegillarca/19796578.html
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