*  ATCC Cell Lines by TP53 Gene Mutation Page 4
... p53, which plays a significant role in regulating cellular responses to DNA damage and other genomic anomalies. ... TP53 encodes a major tumor suppressor transcription factor, ... Nucleic Acids, Proteins and Cell Extracts Services * Federal ... Biological understanding of top genetic alterations across tumor types. Novel anti-cancer drug targeting ... Colon Cancer p53 Hotspot Mutation Cell Panel (ATCC® TCP-2020™) ATCC® Number: TCP-2020™ Organism: Homo sapiens, human ...
  https://www.atcc.org/en/Products/Cells_and_Microorganisms/By_Disease__Model/Cancer/Tumor_Cell_Panels/Cell_lines_by_genetic_mutation/TP53.aspx?dsNav=Ro:10,Up:Page_Product_Listing,Nrc:id-1000506-dynrank-disabled&hasShowAll=1000506%7C
*  TP53INP1 Gene - GeneCards | T53I1 Protein | T53I1 Antibody
Protein Coding), Tumor Protein P53 Inducible Nuclear Protein 1, including: function, proteins, disorders, pathways, orthologs, ... TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-family proteins through the LC3-interacting region (LIR) and promotes ... Protein Symbol:. Q96A56-T53I1_HUMAN. Recommended name:. Tumor protein p53-inducible nuclear protein 1 Protein Accession:. ... TP53INP1 (Tumor Protein P53 Inducible Nuclear Protein 1) is a Protein Coding gene. Among its related pathways are TP53 ...
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=TP53INP1
*  ATCC Cell Lines by TP53 Gene Mutation Page 1
... p53, which plays a significant role in regulating cellular responses to DNA damage and other genomic anomalies. ... TP53 encodes a major tumor suppressor transcription factor, ... Grade Iii, Mesodermal Tumor (Mixed) ; Consistent With Leiomy... ... Nucleic Acids, Proteins and Cell Extracts Services * Biorepository Management * Deposit Services * Custom Solutions ... Reactivation of mutant p53. Studies related to p53 molecular mechanisms. Testing small molecules or biologics for cancer drug ...
  https://www.atcc.org/en/Products/Cells_and_Microorganisms/By_Disease__Model/Cancer/Tumor_Cell_Panels/Cell_lines_by_genetic_mutation/TP53.aspx?dsNav=Nrc:id-1000506-dynrank-disabled%7Cid-1000507-dynrank-disabled&hasShowAll=1000506%7C1000507%7C
*  Dynamic Responses | Science Signaling
Expression of the tumor suppressor p53 is activated in response to cell stress. The dynamics of p53 activation can vary, ... In contrast, sustained p53 promoted induction of terminal genes leading to cellular senescence. Thus, protein dynamics can ... developed a method to control p53 dynamics in human cells. Pulsing p53 selectively activated genes involved in cell cycle ... J. E. Purvis, K. W. Karhohs, C. Mock, E. Batchelor, A. Loewer, G. Lahav, p53 dynamics control cell fate. Science 336, 1440-1444 ...
  http://stke.sciencemag.org/content/5/229/ec172
*  Tumor protein p53-inducible protein 11
PIG11 is considered to be a new candidate liver tumour suppressor gene.. ... Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein ... PIG11 protein binds to DNA in sequence-independent manner in vitro.. 16554811. 2006. Human chromosome 11 DNA sequence and ... PIG11 protein may play an important role by interaction with other biological molecules in the regulation of apoptosis and ...
  https://pharos.nih.gov/idg/targets/O14683
*  ATCC Cell Lines by TP53 Gene Mutation Page 1
... p53, which plays a significant role in regulating cellular responses to DNA damage and other genomic anomalies. ... TP53 encodes a major tumor suppressor transcription factor, ... Nucleic Acids, Proteins and Cell Extracts Services * ...
  https://www.atcc.org/en/Products/Cells_and_Microorganisms/By_Disease__Model/Cancer/Tumor_Cell_Panels/Cell_lines_by_genetic_mutation/TP53.aspx?dsNav=Up:Page_Product_Listing,N:4294927644
*  OriGene - TP73 (NM 001126240) cDNA Clone
Human tumor protein p73 (TP73), transcript variant 2 available for purchase from OriGene - Your Gene Company. ... Protein Families:. Transcription FactorsDruggable Genome. Protein Pathways:. p53 signaling pathwayNeurotrophin signaling ... and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely ... TP73 (untagged)-Human tumor protein p73 (TP73), transcript variant 2, NM_001126240.1, 10ug. $910. In Stock. ...
  http://www.origene.com/human_cdna/NM_001126240/SC323148.aspx
*  Cold viruses point the way to new cancer therapies - Salk Institute for Biological Studies
O'Shea's team studied E4-ORF3, a cancer-causing protein encoded by adenovirus, which prevents the p53 tumor suppressor protein ... p53 normally suppresses tumors by causing cells with DNA damage-a hallmark of cancer-to self-destruct. The p53 tumor suppressor ... "It doesn't resemble any known proteins that assemble polymers or that function in cellular tumor suppressor pathways," he says ... key that opened that box was revealing the interactions between small DNA tumor virus proteins and cellular tumor suppressor ...
  http://www.salk.edu/news-release/cold-viruses-point-the-way-to-new-cancer-therapies/
*  Nutlin-3a Induces Cytoskeletal Rearrangement and Inhibits the Migration and Invasion Capacity of p53 Wild-Type Cancer Cells |...
MDM2 is an E3 ubiquitin ligase that binds and ubiquitinates the tumor suppressor protein p53, leading to its proteasomal ... Nutlin-3a (Nutlin) is a preclinical drug that binds MDM2 and prevents the interaction between MDM2 and p53, leading to p53 ... Nutlin-3a Induces Cytoskeletal Rearrangement and Inhibits the Migration and Invasion Capacity of p53 Wild-Type Cancer Cells. ... Previous studies have reported that Nutlin promotes growth arrest and/or apoptosis in cancer cells that express wild-type p53. ...
  http://mct.aacrjournals.org/content/early/2010/04/02/1535-7163.MCT-09-1220
*  Tumor Suppressor Proteins - Proteins, Tumor Suppressor Summary Report | CureHunter
Deficiencies or abnormalities in these proteins may lead to unregulated cell growth and tumor development. ... Proteins that are normally involved in holding cellular growth in check. ... and activating potent tumor suppressor proteins (PTEN and p53) intricately linked to tumor growth and survival.". 10/02/2015 ... Tumor Suppressor Proteins (Proteins, Tumor Suppressor). Subscribe to New Research on Tumor Suppressor Proteins ...
  http://www.curehunter.com/public/keywordSummaryD025521-Tumor-Suppressor-Proteins-Proteins--Tumor-Suppressor.do
*  anti-p53 antibody [DO-7] (ready-to-use) | GeneTex
... tumor protein p53) for IHC-Fr, IHC-P. Anti-p53 mAb (GTX20911) is tested in Human samples. 100% Ab-Assurance. ... Transformation Related Protein p53 TRP 53 TRP53 Tumor protein p53 Li Fraumeni syndrome Tumor suppressor p53 Tumour Protein p53 ... tumor protein p53. Background. The 393 amino acid tumor suppressor phosphoprotein p53 plays a major role in the cellular ... p53 is phosphorylated at multiple sites in vivo and by several different protein kinases in vitro. p53 can apparently be ...
  http://www.genetex.com/p53-antibody-DO-7-ready-to-use-GTX20911.html
*  Grad Student Jin Hyup Lee receives a 2011 GEAB Impact Award - Biochemistry and Biophysics - UNC School of Medicine
The protein tumor suppressor p53 plays a critical role in apoptosis induced by anticancer drugs; however, at least 50 percent ... that ensures proper adaptation to the constantly changing environment-functionally activates the p73 tumor suppressor protein, ... lends support for the development of drugs as targeted therapies for the treatment of cancers with dysfunctional p53 protein, ... which induces cell death in p53-deficient cancer cells. His study indicates that this mechanism provides another way to ...
  http://www.med.unc.edu/biochem/news/2011/jin-lee-is-recipient-of-a-2011-geab-impact-award
*  Anti-Human p53 Antibody | Human p53 Antibody | p53 Antibody
p53 is also known as cellular tumor antigen p53, p53 tumor suppressor, transformation-related protein 53, BCC7, LFS1, TRP53, ... TP53, cellular tumor antigen p53, p53 tumor suppressor, transformation-related protein 53, BCC7, LFS1, TRP53, antigen NY-CO-13 ... Anti-Human p53 (Bp53-12) Mouse IgG MoAb. Tumor protein p53, encoded in humans by the TP53 gene, was originally identified based ... Specificity: Reacts with both wild-type and mutant human p53 protein; does not cross-react with mouse or rat p53 ...
  http://www.clontech.com/US/Products/Cell_Biology_and_Epigenetics/Cancer_and_Inflammation/p53?sitex=10020:22372:US&PEBCL1=emJ41nU3QJoAgitO9S6N5SguI2&PEBCL1_pses=ZGDED148394D90EF4C33B8669482C7E1DA7943D5CC187D961A271A0D7E8BFC1E86D0EE22CA2084EF39A5A83EB50D02D50865002F0222472B31
*  481044: p53 Tumor Suppressor Gene Protein,... | LabCorp
Accumulation of p53 tumor suppressor gene protein: An independent marker of prognosis in breast cancers. J Natl Cancer Inst. ... p53 Tumor Suppressor Gene Protein, Immunohistochemical, Paraffin Block. TEST: 481044 Test number copied ... Alterations of the p53 tumor suppressor gene have been shown to serve as an independent prognostic marker in a wide variety of ... Association of p53 protein expression with tumor cell proliferation rate and clinical outcome in node-negative breast cancer. J ...
  https://www.labcorp.com/test-menu/32621/p53-tumor-suppressor-gene-protein-immunohistochemical-paraffin-block
*  Involvement of the p53 tumor-suppressor protein in the development of antinociceptive tolerance to morphine
... Tan-No, Koichi ... The present study was designed to determine whether the p53 tumor-suppressor protein is involved in the development of ... Moreover, p53 expression in the spinal cord had increased significantly 14h after the last morphine administration. These ... Morphine, Antinociceptive tolerance, p53, Caspase, Nitric oxide, Intrathecal injection National Category Pharmaceutical ...
  http://uu.diva-portal.org/smash/record.jsf?pid=diva2:302486
*  The structure of p53 tumour suppressor protein reveals the basis for its funcitonal plasticity - White Rose Research Online
p53 major tumour suppressor protein has presented a challenge for structural biology for two decades. The intact and complete ... The structure of p53 tumour suppressor protein reveals the basis for its funcitonal plasticity ... 5 more authors) (2006) The structure of p53 tumour suppressor protein reveals the basis for its funcitonal plasticity. EMBO ... which enables the protein to bind variably spaced DNA target sequences, essential for p53 transactivation and tumour suppressor ...
  http://eprints.whiterose.ac.uk/6065/
*  p53 Tumor Suppressor Protein Antibody - Without BSA and Azide - Mouse Monoclonal Antibody [Clone BP53-12 ] WB, IHC-P, IF, FC -...
p53 Tumor Suppressor Protein Antibody - Without BSA and Azide, Mouse Monoclonal Antibody [Clone BP53-12 ] validated in WB, IHC- ... p53 Tumor Suppressor Protein Antibody - Without BSA and Azide p53 Tumor Suppressor Protein Antibody - Without BSA and Azide. ... Cellular tumor antigen p53, Antigen NY-CO-13, Phosphoprotein p53, Tumor suppressor p53, TP53, P53. ... p53 Tumor Suppressor Protein Antibody - Without BSA and Azide is for research use only and not for use in diagnostic or ...
  http://www.abgent.com/products/AH10775-p53-Tumor-Suppressor-Protein-Antibody-Without-BSA-and-Azide
*  p53 Tumor Suppressor Protein Antibody - With BSA and Azide - Purified Mouse Monoclonal Antibody WB, IHC, FC, IP, E - Buy Now! ...
p53 Tumor Suppressor Protein Antibody - With BSA and Azide, Purified Mouse Monoclonal Antibody validated in WB, IHC, FC, IP, E ... p53 Tumor Suppressor Protein Antibody - With BSA and Azide p53 Tumor Suppressor Protein Antibody - With BSA and Azide. Purified ... Cellular tumor antigen p53, Antigen NY-CO-13, Phosphoprotein p53, Tumor suppressor p53, TP53, P53. ... p53 Tumor Suppressor Protein Antibody - With BSA and Azide is for research use only and not for use in diagnostic or ...
  http://www.abgent.com/products/AH10154-p53-Antibody-Clone-DO-7
*  Cancers | Free Full-Text | Emerging Biomarkers in Glioblastoma | HTML
... tumor suppressor protein p53, phosphatase and tensin homolog (PTEN), p16INK4a gene, cytochrome c oxidase (CcO), phospholipid ... Molecular signatures associated with tumor aggressiveness as well as with disease progression and their relation to differences ... and 7 transmembrane domain-containing protein 1 on chromosome 1 (ELTD1), vascular endothelial growth factor (VEGF), ... the most common primary brain tumor, has few available therapies providing significant improvement in survival. ...
  http://www.mdpi.com/2072-6694/5/3/1103/htm
*  Sorafenib With Irinotecan in Metastatic Colorectal Cancer (mCRC) and K-RAS Mutation
Tumor Suppressor Protein P53. Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control ... Tumor suppressor genes located in the 5q21 region on the long arm of human chromosome 5. The mutation of these genes is ... Tumor suppressor genes located in the 18q21-qter region of human chromosome 18. The absence of these genes is associated with ... A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER. ...
  https://www.bioportfolio.com/resources/trial/72123/Sorafenib-With-Irinotecan-in-Metastatic-Colorectal-Cancer-mCRC-and-K-RAS-Mutation.html
*  A Study of OSI-906 and Irinotecan in Patients With Advanced Cancer With Expanded Cohorts of Patients With KRAS Mutant...
Tumor Suppressor Protein P53. Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control ... Tumor suppressor genes located in the 5q21 region on the long arm of human chromosome 5. The mutation of these genes is ... Tumor suppressor genes located in the 18q21-qter region of human chromosome 18. The absence of these genes is associated with ... A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER. ...
  https://www.bioportfolio.com/resources/trial/70653/A-Study-of-OSI-906-and-Irinotecan-in-Patients-With-Advanced-Cancer.html
*  A Study of Bevacizumab Plus Carboplatin and Paclitaxel in Subjects With Advanced, Previously Untreated, Squamous Non-Small Cell...
Tumor Suppressor Protein P53. Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control ... A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER. ... A quinazoline derivative and ANTINEOPLASTIC AGENT that functions as a PROTEIN KINASE INHIBITOR for EGFR associated tyrosine ... Influences the Sensitivity of Non-Small Cell Lung Cancer to Paclitaxel by Regulating NF-κB Pathway and Its Downstream Proteins. ...
  https://www.bioportfolio.com/resources/trial/107993/A-Study-of-Bevacizumab-Plus-Carboplatin-and-Paclitaxel-in-Subjects-With-Advanced.html
*  Oltipraz in the Prevention of Lung Cancer in People Who Smoke
Tumor Suppressor Protein P53. Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control ... A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER. ... The study goal is to collect blood samples from individuals at risk for lung cancer in order to identify protein markers for ... The immune checkpoint-blockade (ICB) tumor therapy has led to striking improvement of long-term survival for some lung cancer ...
  https://www.bioportfolio.com/resources/trial/124351/Oltipraz-in-the-Prevention-of-Lung-Cancer-in-People-Who-Smoke.html
*  Sonography After Thoracic Surgery (SATS)
Tumor Suppressor Protein P53. Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control ... A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER. ...
  https://www.bioportfolio.com/resources/trial/63399/Sonography-After-Thoracic-Surgery-SATS.html
*  Cisplatin, Etoposide & Bevacizumab in Treating Patients With Previously Untreated Extensive-Stage Small Cell Lung Cancer
... work in different ways to stop tumor cells from div... ... Tumor Suppressor Protein P53. Nuclear phosphoprotein encoded by ... the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein ... Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or deliver tumor-killing ... Giving chemotherapy with a monoclonal antibody may kill more tumor cells.. PURPOSE: This phase II trial is studying how well ...
  https://www.bioportfolio.com/resources/trial/120723/Cisplatin-Etoposide-Bevacizumab-in-Treating-Patients-With-Previously-Untreated-Extensive-Stage-Small.html