*  Deciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicine | Genome Biology |...
... encoding tumor protein p53), were always subclonal, and thus probably involved in ccRCC progression. Selection for mutations in ... In fact, inactivating mutations in the Von Hippel-Lindau tumor suppressor gene and loss of heterozygosity at chromosome 3p were ... Tumor A shows a linear evolution pattern; tumors B and C display a branched pattern. Single snapshots of Tumors B and C may ... Branched tumor evolution has been found in many tumor types, including breast [12], ovarian [13], prostate [14], pancreatic [15 ...
  https://genomebiology.biomedcentral.com/articles/10.1186/s13059-014-0453-8
*  Aggregation dynamics and identification of aggregation-prone mutants of the von Hippel Lindau tumor suppressor protein |...
... the biology of the PIDDosome multiprotein complex and recent advances that link PIDDosome-dependent CASP2 activation to p53 ... Aggregation dynamics and identification of aggregation-prone mutants of the von Hippel Lindau tumor suppressor protein ... Aggregation dynamics and identification of aggregation-prone mutants of the von Hippel Lindau tumor suppressor protein ... Aggregation dynamics and identification of aggregation-prone mutants of the von Hippel Lindau tumor suppressor protein ...
  http://jcs.biologists.org/content/early/2016/05/12/jcs.184846
*  481044: p53 Tumor Suppressor Gene Protein,... | LabCorp
Accumulation of p53 tumor suppressor gene protein: An independent marker of prognosis in breast cancers. J Natl Cancer Inst. ... p53 Tumor Suppressor Gene Protein, Immunohistochemical, Paraffin Block. TEST: 481044 Test number copied ... Alterations of the p53 tumor suppressor gene have been shown to serve as an independent prognostic marker in a wide variety of ... Association of p53 protein expression with tumor cell proliferation rate and clinical outcome in node-negative breast cancer. J ...
  https://www.labcorp.com/test-menu/32621/p53-tumor-suppressor-gene-protein-immunohistochemical-paraffin-block
*  Tumor-Suppressor P53 Gene Regulates Protein That Blocks Immune Attack on Cancer
Identifying this role for tumor-suppressing p53 provides both a potential biomarker for response to important new cancer ... Tumor-Suppressor P53 Gene Regulates Protein That Blocks Immune Attack on Cancer. ... Welsh and colleagues found that p53 also blocks a protein called PDL1 that tumor cells can wield to halt immune attack. Like a ... Tumors with p53 mutated had higher levels of PDL1 and lower levels of miR-34a. Patients with either low PDL1 and high p53 ...
  http://www.medindia.net/news/tumor-suppressor-p53-gene-regulates-protein-that-blocks-immune-attack-on-cancer-155678-1.htm
*  Involvement of the p53 tumor-suppressor protein in the development of antinociceptive tolerance to morphine
... Tan-No, Koichi ... The present study was designed to determine whether the p53 tumor-suppressor protein is involved in the development of ... Moreover, p53 expression in the spinal cord had increased significantly 14h after the last morphine administration. These ... Morphine, Antinociceptive tolerance, p53, Caspase, Nitric oxide, Intrathecal injection National Category Pharmaceutical ...
  http://uu.diva-portal.org/smash/record.jsf?pid=diva2:302486
*  The structure of p53 tumour suppressor protein reveals the basis for its funcitonal plasticity - White Rose Research Online
p53 major tumour suppressor protein has presented a challenge for structural biology for two decades. The intact and complete ... The structure of p53 tumour suppressor protein reveals the basis for its funcitonal plasticity ... 5 more authors) (2006) The structure of p53 tumour suppressor protein reveals the basis for its funcitonal plasticity. EMBO ... which enables the protein to bind variably spaced DNA target sequences, essential for p53 transactivation and tumour suppressor ...
  http://eprints.whiterose.ac.uk/6065/
*  p53 Tumor Suppressor Protein Antibody - Without BSA and Azide - Mouse Monoclonal Antibody [Clone BP53-12 ] WB, IHC-P, IF, FC -...
p53 Tumor Suppressor Protein Antibody - Without BSA and Azide, Mouse Monoclonal Antibody [Clone BP53-12 ] validated in WB, IHC- ... p53 Tumor Suppressor Protein Antibody - Without BSA and Azide p53 Tumor Suppressor Protein Antibody - Without BSA and Azide. ... Cellular tumor antigen p53, Antigen NY-CO-13, Phosphoprotein p53, Tumor suppressor p53, TP53, P53. ... p53 Tumor Suppressor Protein Antibody - Without BSA and Azide is for research use only and not for use in diagnostic or ...
  http://www.abgent.com/products/AH10775-p53-Tumor-Suppressor-Protein-Antibody-Without-BSA-and-Azide
*  p53 Tumor Suppressor Protein Antibody - With BSA and Azide - Purified Mouse Monoclonal Antibody WB, IHC, FC, IP, E - Buy Now! ...
p53 Tumor Suppressor Protein Antibody - With BSA and Azide, Purified Mouse Monoclonal Antibody validated in WB, IHC, FC, IP, E ... p53 Tumor Suppressor Protein Antibody - With BSA and Azide p53 Tumor Suppressor Protein Antibody - With BSA and Azide. Purified ... Cellular tumor antigen p53, Antigen NY-CO-13, Phosphoprotein p53, Tumor suppressor p53, TP53, P53. ... p53 Tumor Suppressor Protein Antibody - With BSA and Azide is for research use only and not for use in diagnostic or ...
  http://www.abgent.com/products/AH10154-p53-Antibody-Clone-DO-7
*  Sub-Solid Lung Nodules Pose Greater Cancer Risk to Women
Tumor-Suppressor P53 Gene Regulates Protein That Blocks Immune Attack on Cancer. Identifying this role for tumor-suppressing ... Unripe green papaya fruit is a rich source of important nutrients including vitamins, proteins, & ... ... p53 provides both a potential biomarker for response to important new cancer immunotherapy drugs. ...
  http://www.medindia.net/news/sub-solid-lung-nodules-pose-greater-cancer-risk-to-women-155771-1.htm
*  HealthyMuslim.Com | Withaferin a Induces P53-Dependent Apoptosis by Repression of HPV Oncogenes and Upregulation of Tumor...
Withaferin A induces p53-dependent apoptosis by repression of HPV oncogenes and upregulation of tumor suppressor proteins in ... Withaferin a Induces P53-Dependent Apoptosis by Repression of HPV Oncogenes and Upregulation of Tumor Suppressor Proteins in ... which are known to inactivate tumor suppressor proteins p53 and pRb, respectively. Repression of HPV oncoproteins would ... In vivo, WA resulted in reduction of nearly 70% of the tumor volume in athymic nude mice with essentially similar trend in the ...
  http://www.healthymuslim.com/print.cfm?wbsyttanu
*  Differential effects of garcinol and curcumin on histone and p53 modifications in tumour cells.
For example, reduced levels of acetylated H4K16 and trimethylated H4K20 are associated with high tumour grade and poor survival ... of histones and other proteins are perturbed in tumours. ... 0/Tumor Suppressor Protein p53; 78824-30-3/garcinol; EC 2.1. ... Garcinol alters expression and acetylation of tumour suppressor p53 The transcription factor p53 is an important regulator of ... 0/Antineoplastic Agents; 0/CREBBP protein, human; 0/Enzyme Inhibitors; 0/H2AFX protein, human; 0/Histones; 0/TP53 protein, ...
  http://www.biomedsearch.com/nih/Differential-effects-garcinol-curcumin-histone/23356739.html
*  Medical Xpress - cell proliferation(... continued page 3)
Mutated p53 tumor suppressor protein uses epigenetics to drive aggressive cancer growth. Aggressive cancer growth and ... are associated with mutant p53 proteins, according to new research from the Perelman School of Medicine at the University ... ... The gene p53 has been described as the "guardian of the genome" due to its prominent role in preventing genetic mutations. More ... Scientists at EPFL have found a way to starve liver cancer cells by blocking a protein that is required for glutamine breakdown ...
  https://medicalxpress.com/tags/cell+proliferation/page3.html
*  Cancers | Free Full-Text | Emerging Biomarkers in Glioblastoma | HTML
... tumor suppressor protein p53, phosphatase and tensin homolog (PTEN), p16INK4a gene, cytochrome c oxidase (CcO), phospholipid ... Molecular signatures associated with tumor aggressiveness as well as with disease progression and their relation to differences ... and 7 transmembrane domain-containing protein 1 on chromosome 1 (ELTD1), vascular endothelial growth factor (VEGF), ... the most common primary brain tumor, has few available therapies providing significant improvement in survival. ...
  http://www.mdpi.com/2072-6694/5/3/1103/htm
*  11 | MD Anderson Cancer Center
Tumor-suppressor p53 regulates protein that stifles immune attack on cancer. *MD Anderson receives $22.2 million in CPRIT ... Distinguished contributions to understanding p53 tumor suppression in stem cells and breakthrough advances in treating breast ... Tumor-suppressor p53 regulates protein that stifles immune attack on cancer BY anonymous ...
  https://www.mdanderson.org/newsroom/2015/11.html
*  Sorafenib With Irinotecan in Metastatic Colorectal Cancer (mCRC) and K-RAS Mutation
Tumor Suppressor Protein P53. Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control ... Tumor suppressor genes located in the 5q21 region on the long arm of human chromosome 5. The mutation of these genes is ... Tumor suppressor genes located in the 18q21-qter region of human chromosome 18. The absence of these genes is associated with ... A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER. ...
  https://www.bioportfolio.com/resources/trial/72123/Sorafenib-With-Irinotecan-in-Metastatic-Colorectal-Cancer-mCRC-and-K-RAS-Mutation.html
*  A Study of Bevacizumab Plus Carboplatin and Paclitaxel in Subjects With Advanced, Previously Untreated, Squamous Non-Small Cell...
Tumor Suppressor Protein P53. Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control ... A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER. ... A quinazoline derivative and ANTINEOPLASTIC AGENT that functions as a PROTEIN KINASE INHIBITOR for EGFR associated tyrosine ... Influences the Sensitivity of Non-Small Cell Lung Cancer to Paclitaxel by Regulating NF-κB Pathway and Its Downstream Proteins. ...
  https://www.bioportfolio.com/resources/trial/107993/A-Study-of-Bevacizumab-Plus-Carboplatin-and-Paclitaxel-in-Subjects-With-Advanced.html
*  Oltipraz in the Prevention of Lung Cancer in People Who Smoke
Tumor Suppressor Protein P53. Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control ... A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER. ... The study goal is to collect blood samples from individuals at risk for lung cancer in order to identify protein markers for ... The immune checkpoint-blockade (ICB) tumor therapy has led to striking improvement of long-term survival for some lung cancer ...
  https://www.bioportfolio.com/resources/trial/124351/Oltipraz-in-the-Prevention-of-Lung-Cancer-in-People-Who-Smoke.html
*  Sonography After Thoracic Surgery (SATS)
Tumor Suppressor Protein P53. Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control ... A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER. ...
  https://www.bioportfolio.com/resources/trial/63399/Sonography-After-Thoracic-Surgery-SATS.html
*  Cisplatin, Etoposide & Bevacizumab in Treating Patients With Previously Untreated Extensive-Stage Small Cell Lung Cancer
... work in different ways to stop tumor cells from div... ... Tumor Suppressor Protein P53. Nuclear phosphoprotein encoded by ... the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein ... Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or deliver tumor-killing ... Giving chemotherapy with a monoclonal antibody may kill more tumor cells.. PURPOSE: This phase II trial is studying how well ...
  https://www.bioportfolio.com/resources/trial/120723/Cisplatin-Etoposide-Bevacizumab-in-Treating-Patients-With-Previously-Untreated-Extensive-Stage-Small.html
*  Evaluation of a New Anti-cancer Vaccine for Patients With Non-small Cell Lung Cancer, After Tumor Removal by Surgery
Tumor Suppressor Protein P53. Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control ... A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER. ... Tumor-specific T Cells in Lung Cancer. Non-small cell lung cancer is characterized by aggressive growth and treatment ... Mixed-lineage leukemia protein 2 (MLL2 or KMT2D) is a histone methyltransferase whose mutation has been associated with a poor ...
  https://www.bioportfolio.com/resources/trial/62995/Evaluation-of-a-New-Anti-cancer-Vaccine-for-Patients-With-Non-small.html
*  Nimotuzumab Plus Docetaxel in Chemotherapy-Refractory/Resistant Patients With Advanced Non-Small-Cell Lung Cancer
Tumor Suppressor Protein P53. Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control ... A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER. ... Nimotuzumab has demonstrated a unique clinical profile, where anti-tumor activity was observed in absence of severe skin, renal ... PI-88 is a new experimental drug that inhibits tumour growth by reducing the formation of new blood vessels into tumours. ...
  https://www.bioportfolio.com/resources/trial/72469/Nimotuzumab-Plus-Docetaxel-in-Chemotherapy-Refractory-Resistant-Patients-With-Advanced-Non-Small.html
*  Actinic cheilitis and squamous cell carcinoma of the lip: clinical, histopathological and immunogenetic aspects
Protooncogene proteins c-bcl-2; Tumor suppressor protein p53. ... Tumor suppressor genes and cell proliferation regulatory ... In general, physicians and dentists know little about what causes oral tumor development and progression. ... Keywords : Carcinoma; squamous cell; Cheilitis; Cyclin-dependent kinase inhibitor proteins; Cyclin D1; ... proteins play a role in the progression of actinic cheilitis to squamous cell carcinoma and in its biological behavior. ...
  http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0365-05962012000100013&lng=en&nrm=iso&tlng=en
*  Carboxyamidotriazole in Treating Patients With Stage III or Stage IV Non-Small Cell Lung Cancer
Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It ... ... Tumor Suppressor Protein P53. Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control ... A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER. ... RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is ...
  https://www.bioportfolio.com/resources/trial/125878/Carboxyamidotriazole-in-Treating-Patients-With-Stage-III-or-Stage-IV-Non-Small.html
*  Predictive Factors for the Optimization of Cetuximab in the Treatment of Patients With Advanced Colorectal Cancer
Tumor Suppressor Protein P53. Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control ... Tumor suppressor genes located in the 5q21 region on the long arm of human chromosome 5. The mutation of these genes is ... Tumor suppressor genes located in the 18q21-qter region of human chromosome 18. The absence of these genes is associated with ... A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER. ...
  https://www.bioportfolio.com/resources/trial/67935/Predictive-Factors-for-the-Optimization-of-Cetuximab-in-the-Treatment-of-Patients.html
*  Diflomotecan (BN80915) Administered Once Every 3 Weeks in Treating Patients With Sensitive Small Cell Lung Cancer (SCLC)
Tumor Suppressor Protein P53. Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control ... A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER. ... Mixed-lineage leukemia protein 2 (MLL2 or KMT2D) is a histone methyltransferase whose mutation has been associated with a poor ... RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE ...
  https://www.bioportfolio.com/resources/trial/120672/Diflomotecan-BN80915-Administered-Once-Every-3-Weeks-in-Treating-Patients-With-Sensitive.html