Gap junction - Wikipedia
Other findings show connexins associate with protein scaffolds used in another junction, the zonula occludens ZO1. While ... May 1996). "Protein and messenger RNA expression of connexin43 in astrocytomas: implications in brain tumor gene therapy". J. ... with scaffolding contributed by zonula occludens-1". J. Neurosci. 28 (39): 9769-89. doi:10.1523/JNEUROSCI.2137-08.2008. PMC ... a protein from rat heart homologous to a gap junction protein from liver". The Journal of Cell Biology. 105 (6 Pt 1): 2621-9. ...https://en.wikipedia.org/wiki/Gap_junction
Varicose: a MAGUK required for the maturation and function of Drosophila septate junctions | BMC Developmental Biology | Full...
In vari mutants, essential SJ proteins NeurexinIV and FasciclinIII are mislocalized basally and epithelia develop a leaky ... We characterize here a Drosophila MAGUK member, Varicose (Vari), the homologue of vertebrate scaffolding protein PALS2. ... In addition, vari mutants display irregular tracheal tube diameters and have reduced lumenal protein accumulation, suggesting ... superfamily function as adapters linking cytoplasmic and cell surface proteins to the cytoskeleton to regulate cell-cell ...https://bmcdevbiol.biomedcentral.com/articles/10.1186/1471-213X-8-99
Vang-like protein 2 and Rac1 interact to regulate adherens junctions | Journal of Cell Science
To test whether the PDZ (post synaptic density protein, Drosophila disc large tumor suppressor and zonula occludens-1 protein)- ... Here, we investigate the function of the mammalian PCP protein Vang-like protein 2 (Vangl2). RNAi knockdown of Vangl2 impaired ... Vang-like protein 2 and Rac1 interact to regulate adherens junctions Message Subject (Your Name) has sent you a message from ... Vang-like protein 2 and Rac1 interact to regulate adherens junctions. Maria Lindqvist, Zachi Horn, Vitezslav Bryja, Gunnar ...http://jcs.biologists.org/content/123/3/472
Localization of nectin-free afadin at the leading edge and its involvement in directional cell movement induced by platelet...
... post synaptic density protein, Drosophila disc large tumor suppressor, and zonula occludens-1 protein) domain, three proline- ... The protein concentrations of the samples were determined using an RC DC protein assay kit (Bio-Rad) with BSA as a reference ... 5A). Rap1GAP is a GTPase-activating protein (GAP) for Rap1. In the in vitro binding assay, we used pure recombinant proteins of ... Afadin is a protein that binds nectin and actin filaments (F-actin) and thus connects nectins to the actin cytoskeleton (Mandai ...http://jcs.biologists.org/content/122/23/4319
SHROOM3 is a novel candidate for heterotaxy identified by whole exome sequencing | Genome Biology | Full Text
... a rho kinase protein required for left-right patterning. Screening 96 sporadic heterotaxy patients identified four additional ... SNP genotyping identified absence-of-heterozygosity regions in the heterotaxy proband on chromosomes 1, 4, 7, 13, 15, 18, ... zonula occludens-1 protein.. Mutation screening. SHROOM3 was analyzed in 96 sporadic heterotaxy patients with unknown genetic ... a.a, amino acid; ASD, Apx/Shrm domain; Dlg1, Drosophila disc large tumor suppressor; PDZ, post-synaptic density protein (PSD95 ...https://genomebiology.biomedcentral.com/articles/10.1186/gb-2011-12-9-r91
CXXC4 Gene - GeneCards | CXXC4 Protein | CXXC4 Antibody
Protein Coding), CXXC Finger Protein 4, including: function, proteins, disorders, pathways, orthologs, and expression. ... Drosophila disc large tumor suppressor/ zonula occludens-1 protein domain of Dishevelled, a scaffolding protein required for ... Protein Symbol:. Q9H2H0-CXXC4_HUMAN. Recommended name:. CXXC-type zinc finger protein 4 Protein Accession:. Q9H2H0. ... Interacting Proteins for CXXC4 Gene. Selected Interacting proteins: Q9H2H0-CXXC4_HUMAN for CXXC4 Gene via IID ...http://www.genecards.org/cgi-bin/carddisp.pl?gene=CXXC4
Up-regulated expression of zonula occludens protein-1 in human melanoma associates with N-cadherin and contributes to invasion...
The zonula occludens (ZO) protein-1 is a membrane-associated component of both the tight and adherens junctions found at sites ... Up-regulated expression of zonula occludens protein-1 in human melanoma associates with N-cadherin and contributes to invasion ... Up-Regulated Expression of Zonula Occludens Protein-1 in Human Melanoma Associates with N-Cadherin and Contributes to Invasion ... Up-Regulated Expression of Zonula Occludens Protein-1 in Human Melanoma Associates with N-Cadherin and Contributes to Invasion ...https://www.ncbi.nlm.nih.gov/pubmed/15855653?dopt=Abstract
PDZ domain - Wikipedia
... post synaptic density protein (PSD95), Drosophila disc large tumor suppressor (Dlg1), and zonula occludens-1 protein (zo-1). ... Researchers found that the protein ezrin enhances the binding of the PDZ protein NHERF1. PDZ proteins are a family of proteins ... Post-synaptic density protein 95 (PSD-95) is a synaptic protein found only in the brain. Drosophila disc large tumor suppressor ... Regulation of receptor proteins occurs when the PDZ domain on the EBP50 protein binds to the C-terminus of the beta-2 ...https://en.wikipedia.org/wiki/PDZ_domain
Immunocytochemical Localization of the Postsynaptic Density Protein PSD-95 in the Mammalian Retina | Journal of Neuroscience
... in the Drosophila tumor suppressor gene "disks large" (Dlg), and in cell-cell adhesion proteins like zonula occludens-1 (ZO1). ... a novel presynaptic protein homologous to SAP90 and the Drosophila discs-large tumor suppressor protein. J Neurosci 15:2354- ... 1993) SAP 90, a rat presynaptic protein related to the product of the Drosophila tumor suppressor gene dlg-A. J Biol Chem 268: ... 1992) The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein. ...http://www.jneurosci.org/content/18/23/10136
Pigment epithelium-derived factor regulates microvascular permeability through adipose triglyceride lipase in sepsis | Clinical...
... ribosomal protein SA; TER, transendothelial electrical resistance; TNF, tumour necrosis factor; VDAC, voltage-dependent anion ... zonula occludens-1 ... patatin-like phospholipase domain-containing protein 2; RIPA, ... channel; VE, vascular endothelial; VEGF, vascular endothelial growth factor; WB, Western blotting; ZO-1, ...http://www.clinsci.org/content/129/1/49
The Rockefeller University » Publications search
... zonula occludens-1 and occludin) and antimicrobial proteins (Reg3g and lysozyme C) in the small intestine, leading to reduced ... Modulation of PD-L1 expression by VTP in human xenograft tumors was also assessed. Results: Treatment of renal tumors with VTP ... Organelles, proteins, and mRNA are transported bidirectionally along microtubules by plus-end directed kinesin and minus-end ... Analysis of tumor-infiltrating lymphocytes revealed that treatment effect was associated with increased CD8thorn: regulatory T ...https://www.rockefeller.edu/research/?p=2136
Frontiers | Regulation of Lung Epithelial Sodium Channels by Cytokines and Chemokines | Immunology
... sodium enters via sodium-permeable channels in the apical membranes of alveolar type 1 and 2 cells followed by active extrusion ... sodium enters via sodium-permeable channels in the apical membranes of alveolar type 1 and 2 cells followed by active extrusion ... TNF-α reduces the expression of tight junction proteins, including the claudins and zonula occludens protein 1, thus increasing ... A novel tumor necrosis factor-mediated mechanism of direct epithelial sodium channel activation. Am J Respir Crit Care Med ( ...https://www.frontiersin.org/articles/10.3389/fimmu.2017.00766/full
Targeting different domains of gap junction protein to control malignant glioma, Neuro-Oncology | 10.1093/neuonc/nox207 |...
"Targeting different domains of gap junction protein to control malignant glioma, Neuro-Oncology" on DeepDyve, the largest ... terminus of the gap junction protein connexin43 indicates signaling between binding domains for c-Src and zonula occludens-1 . ... Thus, this protein regulates glioma cell proliferation and tumor initiation in a variety of ways. The structure of Cx43 ... Thus, this protein regulates glioma cell proliferation and tumor initiation in a variety of ways. The structure of Cx43 ...https://www.deepdyve.com/lp/ou_press/targeting-different-domains-of-gap-junction-protein-to-control-31J92U1yXo
ORBi: Browsing ORBi
... linked to the actin cytoskeleton through cytoplasmic adaptor molecules including those of the zonula occludens family (ZO-1, -2 ... During tumor invasion, tumor epithelial cells acquire migratory and invasive properties involving important phenotypic ... Slug and fibroblast-specific protein-1) and diminished expression of epithelial molecules (E-cadherin, ZO-3 and JAM-A). ... During tumor invasion, tumor epithelial cells acquire migratory and invasive properties involving important phenotypic ...http://orbi.ulg.ac.be/browse?type=authorulg&rpp=20&value=Syne%2C+La%C3%AFdya+p028297
ORBi: Browsing ORBi
... linked to the actin cytoskeleton through cytoplasmic adaptor molecules including those of the zonula occludens family (ZO-1, -2 ... During tumor invasion, tumor epithelial cells acquire migratory and invasive properties involving important phenotypic ... Both cell types expressed the 67 kD laminin receptor, at both mRNA and protein level, but did not express the alpha 6 subunit ... During tumor invasion, tumor epithelial cells acquire migratory and invasive properties involving important phenotypic ...http://orbi.ulg.ac.be/browse?type=journal&value=Clinical+%26+Experimental+Metastasis
Healthcare | Free Full-Text | Modeling Melanoma In Vitro and In Vivo | HTML
However, in order to mimic the three-dimensional architecture of a melanoma, as well as its interactions with the tumor ... In vivo melanoma models have typically relied on the growth of tumor xenografts in immunocompromised mice. Several genetically ... we have utilized the spheroid model to study the contribution of zonula occludens protein 1 (ZO-1) to the oncogenic behavior of ... Up-regulated expression of zonula occludens protein-1 in human melanoma associates with N-cadherin and contributes to invasion ...http://www.mdpi.com/2227-9032/2/1/27/htm
Membrane localization of acetylated CNK1 mediates a positive feedback on RAF/ERK signaling | Science Advances
... postsynaptic density protein/Drosophila disc large tumor suppressor/zonula occludens-1 protein) are followed by a PH domain and ... Drosophila disc large tumor suppressor/zonula occludens-1 protein; PH, pleckstrin homology; CC, coiled coil; CaaX, C-terminal ... CNK proteins share a common domain structure (Fig. 1A) (14). The three protein-protein interaction domains SAM (sterile α motif ... Acetylated scaffold protein CNK1 promotes ERK-dependent cell proliferation and migration in normal cells and in tumor cells. ...http://d3a5ak6v9sb99l.cloudfront.net/content/3/8/e1700475.full
Angiotensin II Receptor Blocker (ARB)
Telmisartan Increases the Permeability of Endothelial Cells through Zonula Occludens-1 - Biol Pharm Bull. 2009 Mar;32(3):416-20 ... 24-hour urine protein - Medline Plus - 'Increased urinary protein is usually measured when glomerular disease is suspected. The ... which improve tumor blood flow by repairing the abnormal structure of tumor blood vessels, angiotensin inhibitors open up those ... highly sensitive C-protein-reactive protein values were higher in NMHT (0.33 +/- 0.07 mg.dl) than in MHT (0.14 +/- 0.06 mg.dl; ...http://qualitycounts.com/drugs/hypertension/fparb.html
adult acute non lymphocytic leukemia in remission 2005:2010[pubdate] *count=100 - BioMedLib™ search engine
Chemical-registry-number] 0 / Membrane Proteins; 0 / Phosphoproteins; 0 / TJP1 protein, human; 0 / Zonula Occludens-1 Protein ... Tumor Suppressor Protein p53 / antagonists & inhibitors. Tumor Suppressor Protein p53 / genetics. Tumor Suppressor Protein p53 ... DNA-Binding Proteins; 0 / Nuclear Proteins; 0 / Tumor Suppressor Proteins; 0 / tumor suppressor protein p73 ... Cell Line, Tumor. Female. HL-60 Cells. Humans. Male. Middle Aged. Polymerase Chain Reaction. Young Adult. Zonula Occludens-1 ...http://www.bmlsearch.com/?kwr=adult+acute+non+lymphocytic+leukemia+in+remission+2005:2010%5Bpubdate%5D&cxts=100&stmp=b0
Reactome | Signaling by Hippo
TAZ interacts with zonula occludens-1 and -2 proteins in a PDZ-1 dependent manner. FEBS Lett. 2010. ... Phosphorylated MOB1A proteins associate with LATS proteins (Homo sapiens) * Translocation of YAP1 to the nucleus (Homo sapiens) ... KIBRA regulates Hippo signaling activity via interactions with large tumor suppressor kinases. J Biol Chem. 2011. ... 2010). This group of reactions is also notable for its abundance of protein:protein interactions mediated by WW domains and ...http://www.reactome.org/content/detail/2028269
ZASS - Zone Alarm Internet Security Suite | AcronymFinder
Drosophila Disc Large Tumor Suppressor) and ZO1 (Zonula Occludens-1 Protein)) Motif Protein (cell biology) ... Z-Band Alternatively Spliced PDZ (Psd-95 (Post Synaptic Density Protein), DlgA ( ...https://www.acronymfinder.com/Zone-Alarm-Internet-Security-Suite-
... disrupted architecture of the tight junction proteins, suppressed zonula occludens-1 (ZO-1) and occludin (OCL) and junctional ... The aim of this study was to evaluate the presence and extension of MPD involvement by tumor/OCP and assess the risk of ... disrupted architecture of the tight junction proteins, suppressed zonula occludens-1 (ZO-1) and occludin (OCL) and junctional ... The Gpg1 protein is a Ggamma subunit mimic implicated in the G-protein glucose-signaling pathway in Saccharomyces cerevisiae, ...http://atgcchecker.com
ALP/Enigma PDZ-LIM Domain Proteins in the Heart
Postsynaptic density 95, discs large and zonula occludens-1 (PDZ) and Lin-11, Isl1 and Mec-3 (LIM) domains, two common motifs ... RIL plays a role in tumor cell growth and neuronal signaling (Schulz et al., 2004; Iida et al., 2009), whereas Mystique may ... ALP/Enigma members also bind to multiple signaling proteins, including protein kinases and protein phosphatases, through their ... Protein-protein interaction of zinc finger LIM domains with protein kinase C. J. Biol. Chem. 1996;271:31029-31032. [PubMed] ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2905065/
The transcription factors Slug and Snail act as repressors of Claudin-1 expression in epithelial cells1 | Biochemical Journal
... green fluorescent protein; GST, glutathione S-transferase; HMEC, human mammary epithelial cell; m, mouse; MDCK, Madin-Darby ... zonula occludens-1 ... tumour. Footnotes. *. ↵1 This paper is dedicated to the memory ... We also demonstrate by band-shift assay that Snail and Slug bind to the E-box motifs present in the human Claudin-1 promoter. ... The transcription factors Slug and Snail act as repressors of Claudin-1 expression in epithelial cells1. Ofelia M. Martínez- ...http://www.biochemj.org/content/394/2/449
Vasomotor Responses of Rat Coronary Arteries to Isoflurane and Halothane Depend on Preexposure Tone and Vessel Size |...
Inhalational Anesthetics Disrupt Postsynaptic Density Protein-95, Drosophila Disc Large Tumor Suppressor, and Zonula Occludens- ... 1,8-9These factors and others make in vivo measurement of the direct effect of anesthetics on vasomotion problematic. ... 1Recent studies by Larach et al. 18and Crystal et al. 19have documented isoflurane-induced concentration-dependent increases in ... 1As summarized in a recent editorial, 2subsequent studies have confirmed that isoflurane is a coronary vasodilator. Recently, ...http://anesthesiology.pubs.asahq.org/article.aspx?articleid=2323559