Myostatin-induced inhibition of the long noncoding RNA Malat1 | lncRNA Blog
Myostatin, a member of the transforming growth factor-β (TGF-β) superfamily of secreted proteins, is a potent negative ... Down-regulation of long non-coding RNA AFAP1-AS1 inhibits tumor growth, promotes apoptosis and decreases metastasis in thyroid ... of Malat1 mRNA during the differentiation of myoblasts into myotubes. Conversely, targeted knockdown of Malat1 using siRNA ... Free myostatin induces the phosphorylation of the Smad family of transcription factors, which, in turn, regulates gene ...http://www.lncrnablog.com/myostatin-induced-inhibition-of-the-long-noncoding-rna-malat1/
ActoFactor™ Recombinant Human Myostatin (Plant) | Creative Bioarray
... growth differentiation factors (GDFs), activins and inhibins. As other members of this superfamily, it is synthesized and ... 267-375 of O14793 Growth/differentiation factor 8) and a 6XHistidine-based tag. It has a predicted molecular mass of 26.8 kDa ( ... Circulating Tumor Cell (CTC) FISH. *Transgene Mapping. *Karyotyping (G-Banded). *Molecular Karyotyping (aCGH) ... Myostatin (GDF8, MSTN) belongs to the transforming growth factor β (TGFBs) superfamily, which includes: TGF-βs, the bone ...https://www.creative-bioarray.com/ActoFactor-Recombinant-Human-Myostatin-Plant-CSC-CTK0468-item-3794.htm
Ovarian follicle activation - Wikipedia
... growth differentiation factor 9 (GDF9) and bone morphogenic protein 15 (BMP15). Follicular activation rate is increased in ... Phosphatase and tensin homolog (PTEN) is a tumour suppressor gene whose actions directly affect the activation of primordial ... nerve growth factor (NGF) and its tyrosine receptor kinase (NTRK1), neurotrophin 4 (NT4), brain-derived neurotrophic factor ( ... AMH (Anti-mullerian Hormone) is a member of the transforming growth factor beta (TGF-b), that has a very important role in ...https://en.wikipedia.org/wiki/Ovarian_follicle_activation
Inflammatory Biomarkers Predict Heart Failure Severity and Prognosis in Patients With Heart Failure With Preserved Ejection...
... fibroblast growth factor 23; Gal-3, galectin-3; GDF-15, growth/differentiation factor 15; IL, interleukin; KLK6, kallikrein-6; ... tissue factor; TNF-R, tumor necrosis factor receptor; TRAIL, TNF-related apoptosis-inducing ligand; TRANCE, TNF-related ... Growth differentiation factor 15 in heart failure with preserved vs. reduced ejection fraction. Eur J Heart Fail. 2016;18:81-88 ... Growth differentiation factor-15 is a useful prognostic marker in patients with heart failure with preserved ejection fraction. ...http://circgenetics.ahajournals.org/content/10/1/e001633
JCI - Welcome
We determined that the gene encoding growth differentiation factor 6 (GDF6), which is the ligand for the BMP family, is ... thereby preventing differentiation, inhibiting cell death, and promoting tumor growth. GDF6 was specifically expressed in ... Expression and secretion of the osteoclastogenesis inhibitory factor osteoprotegerin enabled early growth of SS18-SSX2- ... Additionally, GDF6 repressed the melanocyte differentiation gene MITF and the proapoptotic factor SOX9, ...https://www.jci.org/tags/19
Midkine is a NF-κB-inducible gene that supports prostate cancer cell survival | BMC Medical Genomics | Full Text
... some growth factors (epidermal growth factor, androgen, insulin-like growth factor-I, and hepatocyte growth factor) and ... cell viability was determined by the trypan blue exclusion assay when the LNCaP cells were treated with tumor necrosis factor ... Induction of midkine expression in LNCaP cells by serum, growth factors and cytokines was determined by Western blot analysis ... These findings provide the first demonstration that midkine expression is induced by certain growth factors and cytokines, ...https://bmcmedgenomics.biomedcentral.com/articles/10.1186/1755-8794-1-6
IL6 (interleukin 6 (interferon beta 2))
... interleukin 6 (interferon beta 2)), Authors: Stefan Nagel, Roderick A F MacLeod. Published in: Atlas Genet Cytogenet Oncol ... as a B cell hybridoma/plasmacytoma growth factor induced by interleukin 1 and tumor necrosis factor.. ... cell differentiation positive regulation of T-helper 2 cell differentiation positive regulation of osteoblast differentiation ... Growth factors activating the phosphatidylinositol (PI)-3 kinase/AKT and MAP kinase pathways, and - B-cell-activating factor ( ...http://atlasgeneticsoncology.org/Genes/GC_IL6.html
Cooperation of neurotrophin receptor TrkB and Her2 in breast cancer cells facilitates brain metastases | Breast Cancer Research...
TrkB knockdown in breast cancer cells led to decreased frequency and growth of brain metastasis in animal models, suggesting ... The function of brain-derived neurotrophic factor (BDNF) on cell proliferation and TrkB/Her2 signaling and interactions were ... and tumor-derived cell lines using quantitative real-time PCR, western blot, and immunohistochemical assessment. TrkB function ... Patients with primary breast cancer that is positive for human epidermal growth factor receptor 2 (Her2+) have a high risk of ...https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-017-0844-3
Role of BCGFII in the differentiation to antibody secretion normal and tumor B cells. | The Journal of Immunology
This report describes the effects of B cell growth factor (BCGFII) and other lymphokines in the differentiation of normal and ... doses of BCGFII were mixed with one of several putative terminal differentiation factors we call B cell differentiation factors ... The involvement of BCGFII in all of these responses suggests that BCGFII acts as a growth factor for a population of B cells ... Role of BCGFII in the differentiation to antibody secretion normal and tumor B cells.. S L Swain ...http://www.jimmunol.org/content/134/6/3934.long
Protocols and Video Articles Authored by David H. Adams
... local differentiation from CD14++CD16- classical monocytes in response to transforming growth factor β and interleukin (IL)-10 ... We identified tumor necrosis factor α (TNF-α) as the major cytokine involved in this process. Importantly, this effect was not ... and growth factors (granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor), consistent ... The tumor necrosis factor super-family member CD154 can also induce hepatocyte apoptosis via activation of its receptor CD40 ...https://www.jove.com/author/David+H._Adams
Schisandra Lignan Extract Protects against Carbon Tetrachloride-Induced Liver Injury in Mice by Inhibiting Oxidative Stress and...
... is a key transcription factor that plays an important role in regulating cell growth, differentiation, apoptosis, and ... such as tumor necrosis factor α (TNF-a), interleukin-1β (IL-1β), and IL-6 . Thus, downregulation of NF-κB activity may ... G. Sethi, B. Sung, and B. B. Aggarwal, "Nuclear factor-κB activation: from bench to bedside," Experimental Biology and Medicine ... NF-κB is famous for a transcription factor that regulates the expression of various proinflammatory cytokines in kupffer cells ...https://www.hindawi.com/journals/ecam/2017/5140297/
Insulin-like Growth Factor I Secreted from Prostate Stromal Cells Mediates Tumor-Stromal Cell Interactions of Prostate Cancer |...
The insulin-like growth factor (IGF) axis is involved in the regulation of cellular proliferation, differentiation, and ... The tumor growth was measured (top) and the mice were sacrificed on day 52 for LNCaP and DU-145 tumors. The tumors were excised ... Plasma insulin-like growth factor-I, insulin-like growth factor-binding proteins, and prostate cancer risk: a prospective study ... Antisense RNA to the type I insulin-like growth factor receptor suppresses tumor growth and prevents invasion by rat prostate ...http://cancerres.aacrjournals.org/content/66/8/4419
Antibody-Mediated Blockade of Integrin αvβ6 Inhibits Tumor Progression In vivo by a Transforming Growth Factor-β-Regulated...
The TGF-β1 cytokine is a pleiotropic growth factor that can regulate cell proliferation, differentiation, and immune responses ... had no effect on tumor growth ( Fig. 5C). rsTGF-βRII-Fc, at 2 mg/kg, resulted in a nearly complete inhibition of tumor growth ( ... Antibody-Mediated Blockade of Integrin αvβ6 Inhibits Tumor Progression In vivo by a Transforming Growth Factor-β-Regulated ... tumor cells often acquire a resistance to the growth-suppressive activities of TGF-β1 during tumor progression ( 24- 26). In ...http://cancerres.aacrjournals.org/content/68/2/561
Expression of ROS1 in cancer - Summary - The Human Protein Atlas
The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008]. ... This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase ... GO:0016049 [cell growth]. GO:0016301 [kinase activity]. GO:0016310 [phosphorylation]. GO:0016740 [transferase activity]. GO: ... GO:0030154 [cell differentiation]. GO:0032006 [regulation of TOR signaling]. GO:0038083 [peptidyl-tyrosine autophosphorylation] ...http://www.proteinatlas.org/ENSG00000047936-ROS1/pathology
Defective Osteogenic Differentiation in the Development of Osteosarcoma
By preventing terminal differentiation, tumors can retain their proliferative phenotypes, responsiveness to growth factors, and ... growth factors, and transcription factors [55, 59, 150-155] (Table 1). In addition to inducing terminal differentiation, these ... Chondrogenic differentiation is regulated by multiple transcription factors and growth factors, such as Sox9, BMP2, BMP7, and ... X. Luo, J. Chen, W. X. Song et al., "Osteogenic BMPs promote tumor growth of human osteosarcomas that harbor differentiation ...https://www.hindawi.com/journals/sarcoma/2011/325238/
Interactions between extracellular matrix and growth factors in wound healing - Schultz - 2009 - Wound Repair and Regeneration ...
Carey DJ. Control of growth and differentiation of vascular cells by extracellular matrix proteins. Annu Rev Physiol 1991; 53: ... Kumar CC. Integrin alpha v beta 3 as a therapeutic target for blocking tumor-induced angiogenesis. Curr Drug Targets 2003; 4: ... Role of extracellular matrix in the action of basic fibroblast growth factor: matrix as a source of growth factor for long-term ... transforming growth factor-beta, vascular endothelial growth factor, collagen remodeling, collagen stability, and defective ...http://onlinelibrary.wiley.com/doi/10.1111/j.1524-475X.2009.00466.x/references
Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor. J Biol Chem 270:13585 ... Miyashita T and Reed J. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80: 293-299, ... p53 is a pivotal transcription factor that is involved in cell growth and differentiation (46). In response to stresses such as ... Wang L, Ma W, Markovich R, Chen JW, and Wang PH. Regulation of cardiomyocyte apoptotic signaling by insulin-like growth factor ...http://ajpheart.physiology.org/content/290/6/H2606
8 Shocking Facts about Bovine Growth Hormone
Bovine growth hormone was approved in 1993 to increase milk production in cows. Now banned in many parts of the world, we ... These insulin growth factors are known to stimulate cell differentiation. It appears IGFs have a unique interaction with ... Advanced tumors demonstrated a high presence of IGF-1, while smaller localized prostate cancer tumors showed a lesser density ... Insulin like growth factor has a multitude of problems. A recently published scientific review focused on the relation of IGF-1 ...https://www.globalhealingcenter.com/natural-health/8-shocking-facts-bovine-growth-hormone/
Targeting Angiogenesis for Controlling Neuroblastoma
... and OPN is expressed in various tumor cells to act as a potent angiogenic factor contributing to tumor growth. OPN through its ... and differentiation of hematopoietic progenitors in synergy with other growth factors such as SCF, IL-3, IL-6, IL-12, and GM- ... fibroblast growth factor-2 (FGF-2), platelet derived growth factor (PDGF), epidermal growth factor (EGF), transforming growth ... "Osteopontin overproduced by tumor cells acts as a potent angiogenic factor contributing to tumor growth," Cancer Letters, vol. ...https://www.hindawi.com/journals/jo/2012/782020/
Visceral fat accumulation is an independent risk factor for hepatocellular carcinoma recurrence after curative treatment in...
... which plays an important role in tumour growth and differentiation.29 30 Visceral fat accumulation may be involved in both ... Insulin has growth-promoting properties and increases free insulin-like growth factor levels, ... tumour-related factors and liver function-related factors.. Results: The cumulative recurrence rates differed significantly ... An evaluation of the role of insulin-like growth factors (IGF) and of type-I IGF receptor signalling in hepatocarcinogenesis ...http://gut.bmj.com/content/58/6/839
No association between triple‑negative breast cancer and prognosis of patients receiving breast‑conserving treatment
... two mesenchymal subtypes with high expression of genes involved in differentiation and growth factor pathways; and one luminal ... Factors analyzed included clinical (age, menopause status, tumor-node-metastasis stage, tumor size), pathological (lymph node ... i] HER2, human epidermal growth factor receptor 2; TNBC, triple-negative breast cancer; HER2, human epidermal growth factor ... Data collected included standard prognostic factors, such as age, menopausal status, tumor size, lymph node, ER, PR, and HER2 ...https://www.spandidos-publications.com/ol/14/6/7862
Combination Treatment with Erlotinib and Pertuzumab against Human Tumor Xenografts Is Superior to Monotherapy | Clinical Cancer...
... like human epidermal growth factor receptors (HER, EGFR), are pivotal in regulating cell proliferation and differentiation ( ... In many solid tumors, overexpression of human epidermal growth factor receptors (e.g., HER1/EGFR and HER2) correlates with poor ... Tumor volume (V) was determined by the following equation: V = ab2 / 2. Tumor growth inhibition (TGI) for each group was ... Tumors were still present in all animals at necropsy. Tumor growth inhibition was confirmed by the dramatic reduction in mean ...http://clincancerres.aacrjournals.org/content/11/14/5300
Identification of a cancer stem cell-specific function for the histone deacetylases, HDAC1 and HDAC7, in breast and ovarian...
Sp1-dependent activation of HDAC7 is required for platelet-derived growth factor-BB-induced smooth muscle cell differentiation ... MS275 inhibits xenograft tumour growth. The OCI-P5X ovarian cancer cell line that express luciferase was treated either with ... HDAC5 and HDAC9 in medulloblastoma: novel markers for risk stratification and role in tumor cell growth. Clini Cancer Res: An ... Human CD271-positive melanoma stem cells associated with metastasis establish tumor heterogeneity and long-term growth. Cancer ...http://pubmedcentralcanada.ca/pmcc/articles/PMC5364039/
Recombinant Human Oncostatin M (aa 209) | Cell Sciences
... is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis an ... Background: Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, ... inhibits the growth of some normal and tumor cell lines. It also promotes cytokine release (e.g. IL-6, GM-CSF and GCSF) from ... OSM share several structural and functional characteristics with LIF, IL-6, and CNTF. Human OSM is active on mouse cells. ...http://www.cellsciences.com/recombinant-human-osm-aa-209
Activation of the Human Epidermal Growth Factor Receptor | SpringerLink
Polypeptide growth factors have been recognized as important determinants In the regulation of cellular proliferation and ... differentiation (for a review: Sporn and Roberts, 1988). They exert their... ... Lee LS and Weinstein IB (1978) Tumor promoting phorbol esters inhibit binding of epidermal growth factor to cellular receptors ... Epidermal Growth Factor Receptor Human Epidermal Growth Factor Receptor Epidermal Growth Factor Receptor Kinase Protein ...https://link.springer.com/chapter/10.1007/978-3-642-73142-6_14