Loading...
*  anti-RKIP antibody | Mouse RKIP Monoclonal Antibody-NP 002558.1
... relieving inhibition of the Raf/MAP kinase signaling cascade. Binds ATP, opioids and phosphatidylethanolamine. Has lower ... RKIP: a metastasis suppressor that regulates extracellular matrix remodeling and tumor survival. Binds to and inhibits Raf-1. ... tissue type plasminogen activator and elastase Inhibits the kinase activity of RAF1 by inhibiting its activation and by ... Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, ...
  https://www.mybiosource.com/prods/Antibody/Monoclonal/RKIP/datasheet.php?products_id=415300
*  Molecular Pathways: Targeting the Kinase Effectors of RHO-Family GTPases | Clinical Cancer Research
... are a family of serine-threonine kinases that translate signals from cell surface receptors to MAPKs. MLKs can function as MAP ... to promote activation of AKT, androgen receptor, and negatively regulate the tumor suppressor WWOX (23). Recent findings ... Activated CDC42 kinase (ACK or TNK2) is a ubiquitously expressed nonreceptor tyrosine kinase that binds to and is activated by ... Activation of LIM kinases by myotonic dystrophy kinase-related Cdc42-binding kinase alpha. J Biol Chem 2001;276:23092-6. ...
  http://clincancerres.aacrjournals.org/content/21/1/24
*  Plus it
The MAP/ERK kinase (MEK)-c-jun-NH-kinase (JNK) pathway suppresses PTEN transcription via activation of nuclear factor κB (NF-κB ... Tumor suppression by PTEN requires the activation of the PKR-eIF2α phosphorylation pathway. Sci Signal 2009;2:ra85. ... PTEN dephosphorylates phosphorylated serine, threonine, and tyrosine residues in peptide substrates in vitro (8), protein ... which directly binds to and suppresses the PTEN promoter (18); whereas PTEN opposes JNK signaling independent of Akt inhibition ...
  http://clincancerres.aacrjournals.org/content/16/17/4325
*  Application # 2017/0143726. ADENOSINE RECEPTOR AGONISTS AND ANTAGONISTS TO MODULATE T CELL RESPONSES - Patents.com
... recent studies indicate that serine/threonine protein phosphatase, mitogen-activated protein kinase (MAP kinase), PKC, and ... Interestingly, tumors have been shown to evade immune destruction by impeding T cell activation through inhibition of co- ... It binds to an immunophilin, followed by the binding of the complex to calcineurin and the inhibition of its phosphatase ... increased activation of PKA, MAP kinases, PKC, Epac or phospholipase D. Agonists can be either full or partial agonists at the ...
  http://patents.com/us-20170143726.html
*  Trk | China-Mainland | Sigma-Aldrich
Activation. ERK1/2. ERK5. PI 3-kinase. Akt. PLC-γ1. GSK-3β. ILK. Rac1. PKCi. ERK1/2. ERK5. PI 3-kinase. Akt. PLC-γ1. ERK1/2. PI ... These proteins link Trk to the Ras/Raf/MEK/MAP kinase, Rap1/Braf, PI3-kinase/Akt/GSK3-β/ILK, ΔNp73 (p53 family member) and PKC ... In tumor cells, TrkA activation induces the neuronal differentiation of neuroblastoma cells and the apoptosis of ... NGF binds most specifically to TrkA; BDNF and NT-4 to TrkB; and NT-3 to TrkC. On their own, Trk and p75NTR, in most cases, bind ...
  https://www.sigmaaldrich.com/china-mainland/zh/technical-documents/articles/biology/rbi-handbook/protein-serine-threonine-tyrosine-kinases/trk.html
*  PPM1A - Wikipedia
MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by ... Das AK, Helps NR, Cohen PT, Barford D (1997). "Crystal structure of the protein serine/threonine phosphatase 2C at 2.0 A ... Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to ... 2004). "Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3". Proc. Natl. Acad. ...
  https://en.wikipedia.org/wiki/PPM1A
*  The Proapoptotic Effect of Traditional and Novel Nonsteroidal Anti-Inflammatory Drugs in Mammalian and Yeast Cells
Modulation of MAP-Kinase Activity. Mitogen activated protein (MAP) kinases are serine/threonine-specific proteins which respond ... protein kinase but inhibits tumor necrosis factor-induced c-Jun N-terminal kinase/stress-activated protein kinase activation," ... κB may be due to the specificity by which this transcription factor binds to DNA and activates target genes. Such specificity ... and the p38 MAP kinases [121]. NSAIDs such as aspirin and its metabolite salicylate have long been shown to modulate MAP kinase ...
  https://www.hindawi.com/journals/omcl/2013/504230/
*  PRKCH Gene - GeneCards | KPCL Protein | KPCL Antibody
Protein Kinase C Eta, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene ... Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation mechanism. ... This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein ... In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) ...
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=PRKCH&keywords=hsa-mir-1343-3p
*  Mitogen-activated protein kinase 9 - Wikipedia
"A mammalian scaffold complex that selectively mediates MAP kinase activation". Science. 281 (5383): 1671-4. doi:10.1126/science ... This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, ... Hu MC, Qiu WR, Wang YP (Nov 1997). "JNK1, JNK2 and JNK3 are p53 N-terminal serine 34 kinases". Oncogene. 15 (19): 2277-87. doi: ... Lin Y, Khokhlatchev A, Figeys D, Avruch J (Dec 2002). "Death-associated protein 4 binds MST1 and augments MST1-induced ...
  https://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase_9
*  Proteomic changes in a childhood acute lymphoblastic leukemia cell line during the adaptation to vincristine | Boletín Médico...
Negligible PIP5 kinase activity. Binds to ubiquitinated proteins STK25 Serine/threonine-protein kinase 25 O00506 Kinase ... CCKR signaling map, T-cell activation Dual specificity protein kinase which acts as an essential component of the MAP kinase ... Implication of tumor microenvironment in chemoresistance: tumor-associated stromal cells protect tumor cells from cell death ... Serine/threonine-protein kinase VRK1 Q99986 Non-receptor serine/threonine protein kinase Serine/threonine kinase involved in ...
  http://www.elsevier.es/es-revista-boletin-medico-del-hospital-infantil-401-articulo-proteomic-changes-in-childhood-acute-S1665114617300473
*  Phosphoinositide 3-kinase - Wikipedia
Full activation of AKT occurs upon phosphorylation of serine 473 by the TORC2 complex of the mTOR protein kinase. The "PI3-k/ ... It is the single most mutated kinase in glioblastoma, the most malignant primary brain tumor. The PtdIns(3,4,5)P3 phosphatase ... The pleckstrin homology domain of AKT binds directly to PtdIns(3,4,5)P3 and PtdIns(3,4)P2, which are produced by activated PI 3 ... "A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling". Cell. 125 (4): 733-47. doi: ...
  https://en.wikipedia.org/wiki/Phosphoinositide_3-kinase
*  EGFR (human)
Grb2 and SHC bind to phospho-EGFR and are involved in the activation of MAP kinase signaling pathways. Phosphorylation on Ser ... Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group; Tumor suppressor. ... Activated EGFR binds the SH2 domain of phospholipase C-gamma (PLC-gamma), activating PLC-gamma-mediated downstream signaling. ... positive regulation of peptidyl-serine phosphorylation; positive regulation of phosphorylation; positive regulation of protein ...
  https://www.phosphosite.org/proteinAction.action?id=592
*  WikiGenes - MAP3K1 - mitogen-activated protein kinase kinase...
Constitutive mutant and putative regulatory serine phosphorylation site of mammalian MAP kinase kinase (MEK1). Pagès, G., ... HTLV-I Tax protein binds to MEKK1 to stimulate IkappaB kinase activity and NF-kappaB activation. Yin, M.J., Christerson, L.B., ... Human mitogen-activated protein kinase kinase 4 as a candidate tumor suppressor. Teng, D.H., Perry, W.L., Hogan, J.K., Baumgard ... Specific association of activated MAP kinase kinase kinase (Raf) with the plasma membranes of ras-transformed retinal cells. ...
  https://www.wikigenes.org/e/gene/e/4214.html
*  Aurora A kinase - Wikipedia
Aurora A phosphorylation directs the cytoplasmic polyadenylation translation of mRNA's, like the MAP kinase kinase kinase ... Aurora kinase A also known as serine/threonine-protein kinase 6 is an enzyme that in humans is encoded by the AURKA gene. ... Zhou H, Kuang J, Zhong L, Kuo WL, Gray JW, Sahin A, Brinkley BR, Sen S (October 1998). "Tumour amplified kinase STK15/BTAK ... This signal subsequently activates the kinase RSK which in turn binds to the protein Myt1. Myt1, in complex with RSK, is now ...
  https://en.wikipedia.org/wiki/Aurora_A_kinase
*  NUAK1 binds to βTrCP(A) HA-NUAK1 was immunoprecipita | Open-i
NUAK1 binds to βTrCP(A) HA-NUAK1 was immunoprecipitated (IP) from U2OS Flp/In cells expressing empty vector (Cntl) or with ... MARK, MAP/microtubule affinity-regulating kinase. Mentions: We employed mass spectrometry to identify proteins that ... Protein-Serine-Threonine Kinases/antagonists & inhibitors/genetics*/metabolism. *Proto-Oncogene Proteins/antagonists & ... and NUAK2 protein kinases are activated by the LKB1 tumour suppressor and have been implicated in regulating multiple processes ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC4109838_bj2014-0408i001&req=4
*  Role of Chemokine Network in the Development and Progression of Ovarian Cancer: A Potential Novel Pharmacological Target
... and the activation of phosphatidyl inositol 3 kinase (PI3K)/Akt cascade and Ras/MAP kinase signalling [3]. ... PI3K/Akt and ERK1/2 MAP kinase), leading to different cellular processes involved in tumor development, such as cell division ... In general, ligand binding causes chemokine receptor activation, hallmarked by the phosphorylation of C-terminal serine/ ... it was reported that CXCL12 binds also to another receptor, named CXCR7 [34]. CXCR7 is expressed in several cell types, ...
  https://www.hindawi.com/journals/jo/2010/426956/
*  http://ufdc.ufl.edu/UFE0042955/00001
Interleuk in 22 (IL22) activates the JAK/STAT, ERK, JNK, and p38 MAP kinase pathways in a rat hepatoma cell line. Pathways that ... binds IL10), IL 20R1 (binds IL26) or IL 28R1 (binds IL28 IL 28, and IL29) (69) In a series of experiments conducted by the ... IL22 can transduce a signal through phosphorylation of tyrosine kinases Jak1 and Tyk2, followed PAGE 19. 19 by the activation ... it is speculated that Jak1 would thus be the kinase associated with IL3, serine phosphorylation is vital for optimal ...
  http://ufdc.ufl.edu/UFE0042955/00001
*  Application # 2002/0137106. Detection of biological pathway components - Patents.com
... serine residues. MEK phosphorylates and activates MAP kinase, another serine/threonine kinase. MAP kinase phosphorylates many ... 2A). The signal induced by ligand binding is carried via Grb2 and Sos to Ras, leading to its activation. Activated Ras binds to ... 3A and 3B illustrate the p53 tumor suppressor signal transduction pathway, and capture reagents or baits that can be used to ... serine/threonine kinase. Raf binds to and phosphorylates MEK, a dual-specificity protein kinase that phosphorylates both ...
  http://patents.com/us-20020137106.html
*  Protein kinase C - Wikipedia
"Phosphorylation of Activation Transcription Factor-2 at Serine 121 by Protein Kinase C Controls c-Jun-mediated Activation of ... MAP kinase, transcription factor inhibitor IκB, the vitamin D3 receptor VDR, Raf kinase, calpain, and the epidermal growth ... Thus, effects of PKC are cell-type-specific: Protein kinase C, activated by tumor promoter phorbol ester, may phosphorylate ... This is also where the pseudosubstrate domain of the regulatory region binds.[context needed] Another feature of the PKC ...
  https://en.wikipedia.org/wiki/Protein_kinase_C
*  CRAF elisa kit | Human C-Raf Proto Oncogene Serine/Threonine Protein Kinase ELISA Kit-BAB83675.1
Human C-Raf Proto Oncogene Serine/Threonine Protein Kinase ELISA Kit-BAB83675.1 (MBS077112) product datasheet at MyBioSource, ... protein serine/threonine kinase activity; protein binding; Ras GTPase binding; MAP kinase kinase kinase activity; protein ... ARMS-mediated Activation Pathway antibodies. ARMS-mediated Activation Pathway Diagram. Activation Of NMDA Receptor Upon ... Functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated Raf-1 can ...
  https://www.mybiosource.com/prods/ELISA-Kit/Human/C-Raf-Proto-Oncogene-Serine-Threonine-Protein-Kinase/CRAF/datasheet.php?products_id=77112
*  Structural Diversity in Conserved Regions Like the DRY-Motif among Viral 7TM Receptors-A Consequence of Evolutionary Pressure?
... as well as signals through MAP kinases [64] leading to the activation of numerous transcription factors, cell proliferation and ... Quickly after receptor activation and G protein interaction, GRKs initiate phosphorylation of serine and threonine residues in ... In addition to the Gαi coupling, the authors tested the impact of the EAT-motif in NIH3T3 cell transformation and tumor growth ... by internalizing the endogenous chemokine ligands that binds to the receptor and thereby removing the chemokines from the host ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3414077/
*  ILK (integrin-linked kinase)
... integrin-linked kinase), Authors: Isabel Serrano, Paul McDonald, Shoukat Dedhar. Published in: Atlas Genet Cytogenet Oncol ... a sequence motif present in PH domains binds to the second messenger PI(3,4,5)P3 and a PI3-kinase-dependent kinase activation ... Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and ... Integrin-linked kinase expression increases with ovarian tumour grade and is sustained by peritoneal tumour fluid.. ...
  http://atlasgeneticsoncology.org/Genes/GC_ILK.html
*  Plus it
1994) JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell ... 1993) A divergence in the MAP kinase regulatory network defined by MEK kinase and raf. Science 260:315-319. ... Activation of the small GTP binding proteins leads to modulation of serine/threonine kinases in the mitogen-activated protein ... 2 suppression of tumor necrosis factor α-mediated apoptosis requires RAS and the activation of mitogen-activated protein kinase ...
  http://www.jneurosci.org/content/18/1/104
*  Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof - Patent # 6410294 ...
... paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides. ... the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid ... The mitogen-activated protein kinases (MAP) are also members of the STK family. MAP kinases also regulate intracellular ... protein tyrosine kinases, PTK) and those that phosphorylate serine or threonine residues (serine/threonine kinases, STK). A ...
  http://www.patentgenius.com/patent/6410294.html
*  Therapeutic Implications of PPAR in Cardiovascular Diseases
... publishes original research and review articles on advances in basic research focusing on mechanisms involved in the activation ... knockout mice through activation of p38 MAP kinase independent of PPAR. . Ding et al. reported that cardiomyocyte-specific PPAR ... bind to coactivator complexes, resulting in the activation of target genes. In the absence of ligand, PPAR. binds to the ... IL-6, inducible nitric oxide synthase and tumor necrosis factor-. (TNF-. ), by inhibiting the activity of transcription factors ...
  https://www.hindawi.com/journals/ppar/2010/876049/