Loading...
*  Kidney Outer Medulla Section, H&E Stain, LM X200 Photographic Print by Alvin Tesler at AllPosters.com
Kidney Outer Medulla Section, H&E Stain, LM X200 Photographic Print by Alvin Tesler - at AllPosters.com. Choose from over 500,000 Posters & Art Prints. Value Framing, Fast Delivery, 100% Satisfaction Guarantee.
  http://www.allposters.com/-sp/Kidney-Outer-Medulla-Section-H-E-Stain-LM-X200-Posters_i9010620_.htm
*  Plus it
The role of renal papillary blood flow in regulation of fluid and electrolyte excretion was examined. The effects of an acute infusion of diltiazem (5 micrograms.kg-1 x min-1) into the renal medullary interstitium on papillary blood flow and sodium and water excretion were studied. Changes of renal blood flow were measured using an electromagnetic flow probe. Cortical and papillary blood flows were measured using laser-Doppler flowmetry. Renal and cortical blood flows were unchanged during medullary interstitial infusion of diltiazem, but papillary blood flow increased 26% (P , 0.05) and remained elevated for 1 h after diltiazem infusion was discontinued. Glomerular filtration rate (GFR) of the infused kidney increased by 21% from a control of 1.0 +/- 0.1 ml.min-1 x g-1 during infusion of diltiazem (P , 0.05), but it returned to control after diltiazem infusion was stopped. Urine flow and sodium excretion increased by 70% (P , 0.05), and ...
  http://ajpregu.physiology.org/content/263/5/R1064
*  Pyruvate kinase from kidney medulla of rabbits in insulin deficiency
Abstract: A decrease in activity of pyruvate kinase by 43% in kidney medulla was observed in rabbits, which lasted for 10-16 days. In kidney medulla of rabbits with alloxan diabetes the pyruvate kinase activity was increased by 39% as compared with control animals ...
  http://pbmc.ibmc.msk.ru/index.php/en/article/PBMC-1975-21-3-332-en
*  Plus it
It is well recognized that prolonged elevations of AVP do not produce sustained hypertension (2). In contrast, chronic administration of a V1AG delivered either systemically or into the renal medullary space of rats does result in a mild and sustained form of hypertension (22). It has been shown in anesthetized rats that both AVP and V1AG effectively reduce renal medullary blood flow (17). If such effects were sustained, one would anticipate that both compounds could produce a sustained elevation of arterial pressure because chronic reductions of blood flow to the medulla result in hypertension (1, 12, 15). We hypothesized therefore that the failure of AVP to produce hypertension could be related to an inability of this endogenous peptide to produce a sustained reduction of medullary blood flow. The results of the present study support this hypothesis and show that chronic reduction of blood flow to the inner medulla was not ...
  http://ajpregu.physiology.org/content/275/5/R1420
*  Renal medulla | definition of renal medulla by Medical dictionary
Looking for online definition of renal medulla in the Medical Dictionary? renal medulla explanation free. What is renal medulla? Meaning of renal medulla medical term. What does renal medulla mean?
  http://medical-dictionary.thefreedictionary.com/renal+medulla
*  P2Y2 receptor knock-out mice display normal NaCl absorption in medullary thick ascending limb - Danish National Research...
Local purinergic signals modulate renal tubular transport. Acute activation of renal epithelial P2 receptors causes inhibition of epithelial transport and thus, should favor increased water and salt excretion by the kidney. So far only a few studies have addressed the effects of extracellular nucleotides on ion transport in the thick ascending limb (TAL). In the medullary thick ascending limb (mTAL), basolateral P2X receptors markedly (~25%) inhibit NaCl absorption. Although this segment does express both apical and basolateral P2Y2 receptors, acute activation of the basolateral P2Y2 receptors had no apparent effect on transepithelial ion transport. Here we studied, if the absence of the P2Y2 receptor causes chronic alterations in mTAL NaCl absorption by comparing basal and AVP-stimulated transepithelial transport rates. We used perfused mouse mTALs to electrically measure NaCl absorption in juvenile (,35 days) and adult (,35 days) male mice. Using ...
  http://www.forskningsdatabasen.dk/catalog/250602200
*  Prostaglandin E-Prostanoid4 Receptor Mediates Angiotensin II-Induced (Pro)Renin Receptor Expression in the Rat Renal...
The present study examined the EP subtypes involved. In primary cultures of rat IMCD cells, EP4 antagonism with structurally distinct EP4 antagonists completely abolished Ang II-induced PRR expression, and EP4 agonism alone elevated the expression. In Sprague-Dawley rats, EP4 antagonism effectively suppressed the increases in renal medullary PRR expression, renal medullary and urinary renin levels, as well as blood pressure in response to Ang II infusion. Interestingly, in vitro data also suggested involvement of the EP1 but not the EP3 subtype in Ang II-induced PRR expression.. PGE2 is a major prostanoid produced in the kidney, particularly in the CD. As an autocrine/paracrine factor, PGE2exerts a diverse range of action at the site of its production, affecting renal medullary blood flow and tubular sodium and water transport, as well as cell survival.26,27 The biological action of PGE2 is mediated by 4 distinct EP4 receptors (EP1-4). We ...
  http://hyper.ahajournals.org/content/64/2/369
*  Interactions Between Nitric Oxide and Angiotensin II on Renal Cortical and...
Previous studies have shown that blockade of NO reduces renal blood flow and sodium and water excretion.1 2 3 4 5 This effect seems to be due, at least in part, to the potentiation of the renal vasoconstrictor systems.6 7 10 11 In addition, this potentiation of the renin-angiotensin and sympathetic systems seems to be an important factor in the pathogenesis of hypertension induced by chronic NO synthesis blockade.8 9 12 13 The renal medulla plays an important role in sodium and water homeostasis and in long-term control of arterial pressure.16 However, at present no data are available about the interactions between NO and the renal vasoconstrictor systems in the control of renal medullary blood flow.. An extensive sympathetic innervation of the efferent arteriolar vessels of the juxtamedullary glomeruli, which eventually divide to form the afferent vasa recta, has been described.29 However, at present, its functional importance remains obscure. It has been ...
  http://hyper.ahajournals.org/content/30/5/1175
*  Inhibition of Cyclooxygenase-2 in the Rat Renal Medulla Leads to Sodium-Sensitive Hypertension | Hypertension
Thank you for your interest in spreading the word on Hypertension.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. ...
  http://hyper.ahajournals.org/content/early/2004/08/16/01.HYP.0000140924.91479.03
*  Spermidine Stimulates the Activity of Na+K+ ATPase Activity in the Rat Renal Medulla | Clinical Science
Thank you for your interest in spreading the word about Clinical Science.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
  http://www.clinsci.org/content/77/s21/13P.1
*  Renal Fellow Network: Surviving Stress in the Kidney Medulla
All opinions expressed on the website are those of the respective authors and not of their employer. Information provided here is for medical education only. It is not intended as and does not substitute for medical advice. If you are a patient, please see your doctor for evaluation. The appearance of external hyperlinks to other websites does not constitute endorsement. We do not verify, endorse or take responsibility for the accuracy, currency, completeness or quality of the content contained in these sites. There is no real life patient data on this website. The Renal Fellow Network does not profit from any of the material on this website. No advertisements are accepted. The Renal Fellow Network is not funded by any agency or company. Any information collected by our website, such as email addresses, will never be passed on to any third party, unless required by law. The Renal Fellow Network is moderated occasionally and posteriorly. Moderators are volunteers. Internet users posting comments ...
  http://renalfellow.blogspot.com/2011/08/surviving-stress-in-kidney-medulla.html
*  Publications [#243683] of Anita T. Layton
We used a mathematical model of O(2) transport and the urine concentrating mechanism of the outer medulla of the rat kidney to study the effects of blood pH and medullary blood flow on O(2) availability and Na(+) reabsorption. The model predicts that in vivo paracellular Na(+) fluxes across medullary thick ascending limbs (mTALs) are small relative to transcellular Na(+) fluxes and that paracellular fluxes favor Na(+) reabsorption from the lumen along most of the mTAL segments. In addition, model results suggest that blood pH has a significant impact on O(2) transport and Na(+) reabsorption owing to the Bohr effect, according to which a lower pH reduces the binding affinity of hemoglobin for O(2). Thus our model predicts that the presumed greater acidity of blood in the interbundle regions, where mTALs are located, relative to that in the vascular bundles, facilitates the delivery of O(2) to support the high metabolic ...
  http://fds.duke.edu/db/aas/math/faculty/alayton/publications/243683/printer
*  Publications [#243615] of Anita T. Layton
The goal of this study was to investigate the reciprocal interactions among oxygen (O2), nitric oxide (NO), and superoxide (O2 (-)) and their effects on medullary oxygenation and urinary output. To accomplish that goal, we developed a detailed mathematical model of solute transport in the renal medulla of the rat kidney. The model represents the radial organization of the renal tubules and vessels, which centers around the vascular bundles in the outer medulla and around clusters of collecting ducts in the inner medulla. Model simulations yield significant radial gradients in interstitial fluid oxygen tension (Po2) and NO and O2 (-) concentration in the OM and upper IM. In the deep inner medulla, interstitial fluid concentrations become much more homogeneous, as the radial organization of tubules and vessels is not distinguishable. The model further predicts that due to the ...
  https://fds.duke.edu/db/aas/math/alayton/publications/243615
*  Urea and urine concentrating ability: new insights from studies in mice | Renal Physiology
In the 1970s-1980s, a number of clearance, micropuncture, and microperfusion studies as well as anatomic-functional correlations have brought a good understanding of the role of urea in the urinary concentrating mechanism (16, 87) (see reviews in Refs. 6 and 50). It has been understood that urea is accumulated and somehow "sequestrated" (104) in the renal medulla at a concentration increasing from the outer medulla to the tip of the papilla. This accumulation results from three associated processes (Fig. 2). 1) Urea becomes progressively concentrated along the CD because of vasopressin-dependent water reabsorption in a segment poorly permeable to urea, thus bringing a highly concentrated urea solution to the terminal CD. 2) A vasopressin-dependent increase in urea permeability of the terminal IMCD (due to UT-A1/3) enables this concentrated urea to be transported into the interstitial tissue of the deep inner medulla. 3) ...
  http://ajprenal.physiology.org/content/288/5/F881.full
*  Production and Actions of Superoxide in the Renal Medulla | Hypertension
The present study detected O2−·production in renal cortical and medullary tissues in the presence of different substrates for O2−· -producing enzymes by use of fluorescence spectrometry. This assay was based on the fluorogenic oxidation of DHE to Eth as a measure of O2−· and modified by the addition of salmon DNA in the assay mixture as a fluorescence enhancer. By use of a microtiter plate reader, this Eth-DNA fluorescence measurement can detect a minimal Eth con- centration of 2 nmol/L. Before application of this assay to measure O2−·production in the renal tissues, a classic O2−·-producing system, xanthine and purified XO, was used to determine the sensitivity and specificity of O2−·-dependent fluorogenic conversion of DHE to Eth. After the addition of xanthine and XO into the assay mixture containing DHE and salmon DNA, an enzyme activity-dependent increase in Eth-DNA fluorescence intensity was observed. However, the addition of another well-known free radical, NO (nonoate), ...
  http://hyper.ahajournals.org/content/37/2/547
*  Cellular response to hyperosmotic stresses.
Cells in the renal inner medulla are normally exposed to extraordinarily high levels of NaCl and urea. The osmotic stress causes numerous perturbations because of the hypertonic effect of high NaCl and the direct denaturation of cellular macromolecul
  http://www.biomedsearch.com/nih/Cellular-response-to-hyperosmotic-stresses/17928589.html
*  AQP4 role in renal K+ transport
The collecting duct principle cells (PC) play a major role for concentration of urine and regulation of K+ homeostasis. Two water channels, AQP3 and AQP4, are expressed in the PC basolateral membrane (BLM). Here we present evidence that AQP4 participates in regulation of renal K+ transport. K+ enters the cell via Na+,K+-ATPase mediated transport in BLM. The presence of K+ channels in BLM, which is deeply infolded, thus providing a diffusion limited space, permits K+ recirculation, considered important for maintenance of membrane potential. Here we show with co-immunoprecipitation and GST pulldown assays, that in rat renal papilla, AQP4, but not AQP3, assembles with Na+,K+-ATPase and the K+ channel Kir7.1. This led us to hypothesize that AQP4, Na+,K+-ATPase and Kir7.1 form a K+ transporting microdomain, where AQP4 water transport maintains a favorable gradient for K+ efflux and stabilizes membrane potential. A mathematical model of K+ transport across an epithelial cells with a deeply ...
  http://kth.diva-portal.org/smash/record.jsf?pid=diva2:680567
*  Gene Expression Image Detail
Labels: neocortex (NC); cerebellar granular cell layer (G); Purkinje cells (P); dentate gyrus (DG); olfactory bulb glomerulus (Gl); dorsal horn of the spinal cord(DH); ventral horn of the spinal cord (VH); bronchiole (B); seminiferous tubules (ST); Sertoli cells (SC); Leydig cells (L); kidney cortical region (C); kidney medulla (M); ventral vein of liver (CV). Scale bars represent 100 microns ...
  http://www.informatics.jax.org/image/MGI:5438547
*  Gene Expression Literature Detail
J:148046 Fogelgren B, Yang S, Sharp IC, Huckstep OJ, Ma W, Somponpun SJ, Carlson EC, Uyehara CF, Lozanoff S, Deficiency in Six2 during prenatal development is associated with reduced nephron number, chronic renal failure, and hypertension in Br/+ adult mice. Am J Physiol Renal Physiol. 2009 May;296(5):F1166-78 ...
  http://www.informatics.jax.org/gxdlit/key/90228
*  Bassett Collection - Lane Medical Library - Stanford University School of Medicine
Dissection of the renal parenchyma has exposed the latex-filled arteries and veins within the kidney. Smaller vessels have been trimmed away. The suprarenal cortex has been removed near the center of the gland to expose the brownish medullary tissue as well as to demonstrate the tributaries of the right suprarenal vein within the medulla ...
  http://lane.stanford.edu/biomed-resources/bassett/bassettView.html?bn=150-4
*  Gene Expression Literature Detail
J:97734 Chen L, Al-Awqati Q, Segmental expression of Notch and Hairy genes in nephrogenesis. Am J Physiol Renal Physiol. 2005 May;288(5):F939-52 ...
  http://www.informatics.jax.org/gxdlit/key/47188
*  Cortex & Medulla | Not Rocket Surgery
Cortex and Medulla are words which pop up all over the subject of anatomy. The cortex is always the bit around the outside of a structure and the medulla is always the bit in the middle. Examples include: The Renal Cortex - the bit around the outside of the kidney The Adrenal Cortex - the…
  https://notrocketsurgery.net/2012/02/08/cortex-medulla/
*  Blood Flow in the Renal Medulla | Circulation Research
The accumulation of intra-arterially injected I131 albumin in the papilla of the kidney was measured in a series of 33 anesthetized dogs producing hypertonic urine. Although the data were widely scattered, an estimate of the average rate of this accumulation during the first half-minute following the start of the infusion was made. From the data, the plasma perfusion rate in the papilla under the experimental conditions was calculated and appears to average 25 ml./100 Gm./min.. ...
  http://circres.ahajournals.org/content/9/3/614
*  SIU SOM Histology CRR
Dye injected into the vascular system highlights blood vessels in this image of renal medulla. Vasa recta are conspicuous. Click on one of the thumbnails below to see this view in context or to see a similar view of the renal cortex.. ...
  http://www.siumed.edu/~dking2/crr/RN023b.htm
*  M-Impresión: #marchanoroeste - la recta final
has moved to a new address:. M-Impresión: #marchanoroeste - la recta final Sorry for the inconvenience… Redirection provided by Blogger to WordPress Migration Service ...
  http://mimpresion.blogspot.com/2011/07/marchanoroeste-la-recta-final.html