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*  Glucose-6-phosphate dehydrogenase and Trypanothione reductase interaction protects Leishmania donovani from metalloid...
Glucose-6-phosphate dehydrogenase and Trypanothione reductase interaction protectsLeishmania donovanifrom metalloid mediated ... and Trypanothione reductase (LdTryR) of Leishmania donovani displaying interconnection between central glucose metabolism and ... Interestingly, clinical isolates of L.donovani resistant to SAG exhibited enhanced interaction between LdG6PDH and LdTryR and ...
  https://insights.ovid.com/pubmed?PMID=28179112
*  <i>In Silico</i> Analyses of Epicoccamides on Selected <i>Leishmania</i> Trypanothione...
In Silico Analyses of Epicoccamides on Selected Leishmania Trypanothione Reductase Enzyme-based Target, Nighat Fatima, Amara ... Fig 5: Binding analysis of Leishmania trypanothione reductase.. (A) Binding site analysis of Leishmania trypanothione reductase ... Recent studies showed that more than 29 enzymes from L. major, L. donovani, L. Mexicana and L. infantum could be used as a ... trypanothione reductase. Thiol-reductase plays a key role in survival of Leishmania sp. Trypanothione reductase is a validated ...
  http://www.ijpsonline.com/articles/iin-silicoi-analyses-of-epicoccamides-on-selected-ileishmaniai-trypanothione-reductase-enzymebased-target.html
*  Leishmaniasis | Trypanothione Reductase | Epicoccamide Derivatives | In Silico Analysis
Fig 5: Binding analysis of Leishmania trypanothione reductase.. (A) Binding site analysis of Leishmania trypanothione reductase ... Recent studies showed that more than 29 enzymes from L. major, L. donovani, L. Mexicana and L. infantum could be used as a ... trypanothione reductase. Thiol-reductase plays a key role in survival of Leishmania sp. Trypanothione reductase is a validated ... amino acid trypanothione and enzyme trypanothione reductase, essential for survival of Leishmania sp., is considered important ...
  http://www.ijpsonline.com/articles/iin-silicoi-analyses-of-epicoccamides-on-selected-ileishmaniai-trypanothione-reductase-enzymebased-target.html?view=mobile
*  Owais Mohammad - Wikipedia
"Expression, purification, and characterization of Leishmania donovani trypanothione reductase in Escherichia coli". Protein ... Mohammad Owais (2009). Trypanothione reductase: a potential anti-leishmanial drug target: Recent trend of development of drug ... Leishmania donovani Escherichia coli India portal Biology portal Medicine portal Please see Selected bibliography section " ... Trypanothione reductase: a potential anti-leishmanial drug target and Antimicrobial properties of clove oil: clove oils as ...
  https://en.wikipedia.org/wiki/Owais_Mohammad
*  Trypanothione-disulfide reductase - Wikipedia
Cunningham ML, Fairlamb AH (1995). "Trypanothione reductase from Leishmania donovani. Purification, characterisation and ... "Febrifugine analogues as Leishmania donovani trypanothione reductase inhibitors: binding energy analysis assisted by molecular ... "Developing imidazole analogues as potential inhibitor for Leishmania donovani trypanothione reductase: virtual screening, ... simulations to develop benzoxaborole analogs as potential inhibitor against Leishmania donovani trypanothione reductase". ...
  https://en.wikipedia.org/wiki/Trypanothione-disulfide_reductase
*  Arun Prasath DAMODARAN | IGDR
Homology modeling of trypanothione reductase of Leishmania donovani. Ram K, Domadoran AP.. World Journal of Science and ...
  https://igdr.univ-rennes1.fr/en/research/research-groups/claude-prigent-group/group-members/arun-prasath-damodaran
*  The Concept of Fitness in Leishmania | SpringerLink
Down-regulation of Leishmania donovani trypanothione reductase by heterologous expression of a trans-dominant mutant homologue ... Glutathione and the redox control system trypanothione/trypanothione reductase are involved in the protection of Leishmania spp ... Evidence that trypanothione reductase is an essential enzyme in Leishmania by targeted replacement of the tryA gene locus. Mol ... Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages. ...
  https://link.springer.com/chapter/10.1007%2F978-3-319-74186-4_15
*  EC 1.7 and EC 1.8
3. Cunningham, M.L. and Fairlamb, A.H. Trypanothione reductase from Leishmania donovani. Purification, characterisation and ... Other name(s): glutathione reductase; glutathione reductase (NADPH); NADPH-glutathione reductase; GSH reductase; GSSG reductase ... Accepted name: trypanothione-disulfide reductase. Reaction: trypanothione + NADP+ = trypanothione disulfide + NADPH + H+. For ... Other name(s): trypanothione reductase; NADPH2:trypanothione oxidoreductase. Systematic name: trypanothione:NADP+ ...
  https://www.qmul.ac.uk/sbcs/iubmb/enzyme/EC1/07p.html
*  Study on the roles of O-acetylserine (thiol) lyase and thiol dependent reductase 1 of Leishmania - Enlighten: Theses
Attempts were made to generate Δtdr1 null mutants in Leishmania donovani, but these were unsuccessful despite the fact that ... glutathione and trypanothione, as well as redox active thiol-containing proteins. In addition, cysteine is important for the ... Thiol dependent reductase 1 (TDR1) of Leishmania has been implicated in both the activation of pentavalent antimonial drugs and ... McCaig, Lesley (2009) Study on the roles of O-acetylserine (thiol) lyase and thiol dependent reductase 1 of Leishmania. PhD ...
  http://theses.gla.ac.uk/1281/
*  Alan Fairlamb - Wikipedia
"Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress". Mol. Microbiol ... "Dual action of antimonial drugs on thiol redox metabolism in the human pathogen Leishmania donovani". J. Biol. Chem. 279 (38): ... Trypanothione allows the parasites to fend off free radicals and other toxic oxidants produced by the immune system of the ... Studies on the effect of drugs on trypanothione metabolism resulted in the discovery that fexinidzole is a potential oral ...
  https://en.wikipedia.org/wiki/Alan_Fairlamb
*  Anti Leishmanial Activities of Some Antidepressant Drugs | Open Access Journals
Leishmaniasis is a complex vector-borne disease caused by different species of Leishmania. It affects at least 12 million ... ii) The enzyme trypanothione reductase is upregulated in SSG resistant LD and Imipramine can inhibit this enzyme [54]. ... Leishmania donovani affects antigen presentation of macrophage by disrupting lipid rafts. J Immunol. 2005; 175: 3214-3224. ... The mechanism of action of the drug Imipramine on Kala-azar patients infected with antimony-resistant Leishmania donovani [Sb(R ...
  http://www.rroij.com/open-access/anti-leishmanial-activities-of-some-antidepressant-drugs-.php?aid=66554
*  Fresh insights into the pyrimidine metabolism in the trypanosomatids | Parasites & Vectors | Full Text
Modeled structure of trypanothione reductase of Leishmania infantum. BMB Rep. 2008;41:444-7.View ArticlePubMedGoogle Scholar. ... Tc, Trypanosoma cruzi; Tb, Trypanosoma brucei; Ld, Leishmania donovani; Lm, Leishmania major; Cl, Crithidia luciliae; GFC, gel ... Biochemical investigation of ATCase in trypanosomatids has been done for Leishmania and Crithidia species. Leishmania donovani ... donovani parasites. Leishmania donovani pyrimidine auxotrophs (cps and umps) were sensitive toward 4-thiouracil, with an EC50 ...
  https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-018-2660-8
*  Interplay between a cytosolic and a cell surface carbonic anhydrase in pH homeostasis and acid tolerance of Leishmania |...
1997). Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in ... 1994). Plasma membrane K+/H(+)-ATPase from Leishmania donovani. J. Cell. Physiol. 159, 60-66. doi:10.1002/jcp.1041590109. ... 1988). pH homeostasis in Leishmania donovani amastigotes and promastigotes. Proc. Natl. Acad. Sci. USA 85, 7602-7606. doi: ... reported that Leishmania donovani amastigotes as well as promastigotes have an amazing ability to maintain their intracellular ...
  http://jcs.biologists.org/content/130/4/754
*  Frontiers | New Approaches to Overcome Transport Related Drug Resistance in Trypanosomatid Parasites | Pharmacology
Leishmania and Trypanosoma are members of the Trypanosomatidae family that cause severe human infections such as leishmaniasis ... Leishmania and Trypanosoma are members of the Trypanosomatidae family that cause severe human infections such as leishmaniasis ... Trypanothione is the major thiol in Leishmania. Antimonites exhibit in vitro inhibition of trypanothione reductase, an enzyme ... 2012). Mechanism of amphotericin B resistance in clinical isolates of Leishmania donovani. Antimicrob. Agents Chemother. 56, ...
  https://www.frontiersin.org/articles/10.3389/fphar.2016.00351/full
*  The Role of Proteomics in the Study of Drug Resistance | Springer for Research & Development
The recent completion of the genomic sequencing of three species of Leishmania, L. (L.) major, L. (L.) infantum, and L. (V.) ... Proteomic analysis of the secretome of Leishmania donovani. Genome Biol. 2008;9:R35.PubMedPubMedCentralCrossRefGoogle Scholar ... Structural characterization of the As/Sb reductase LmACR2 from Leishmania major. J Mol Biol. 2009;386:1229-39.PubMedCrossRef ... Trypanothione overproduction and resistance to antimonials and arsenicals in Leishmania. Proc Natl Acad Sci USA. 1996;93:10383- ...
  https://rd.springer.com/chapter/10.1007%2F978-3-319-74186-4_10
*  Patent US6359004 - Manipulating nitrosative stress to upregulate nitrosative stress defenses - Google Patents
Leishmania species including Leishmania donovani (visceral leishmaniasis or kala azar) and Leishmania braziliensis (mucotaneous ... glutathione reductase also known as glutathione disulfide reductase) inhibitors, except when these agents or inhibitors are ... Glutathione is also involved in the synthesis of the thiol trypanothione which as indicated above protects against nitrosative ... As indicated above, ovothiol A protects against nitrosative stress in Leishmania donovani and other microbes producing ovothiol ...
  http://www.google.com/patents/US6359004?dq=4168396
*  trypanocidal agents
Investigation of trypanothione reductase as a drug target in Trypanosoma brucei. Daniel Spinks. Drug Discovery Unit, College of ... Assessing the essentiality of Leishmania donovani nitroreductase and its role in nitro drug activation. Susan Wyllie. Division ... Synthesis, inhibition potency, binding mode, and antiprotozoal activities of fluorescent inhibitors of trypanothione reductase ... donovani promastigotes, combined with the limited resistance shown by NTR single knockout cells, suggests that the potential ...
  http://www.labome.org/topics/chemicals/chemical/pharmacologic/therapeutic/anti/antiparasitic/antiprotozoal/trypanocidal-agents-16003.html
*  87
J Pharmacol Exp Ther 316:17-24 Khan MO (2007) Trypanothione reductase: a viable chemotherapeutic target for antitrypanosomal ... Detriment of virulence in Leishmania donovani skimpy in an amastigote-specific protein, A2. Intelligibly many technological ... The investigation of Leishmania arginase genes revealed the propinquity of one of the most visit glycosome betoken signals, the ...
  http://www.gruz-transport.com/cargo/find_86.htm
*  Browse by Uncontrolled Keywords - LSHTM Research Online | London School of Hygiene and Tropical Medicine
el Tai, NO; el Fari, M; Mauricio, I; Miles, MA; Oskam, L; el Safi, SH; Presber, WH; Schonian, G; (2001) Leishmania donovani: ... on the dihydrofolate reductase gene for the detection of Cryptosporidium parvum genotypes 1 and 2. Parasitology, 125 (Pt 1). pp ... The Trypanosoma cruzi enzyme TcGPXI is a glycosomal peroxidase and can be linked to trypanothione reduction by glutathione or ... Mauricio, IL; Gaunt, MW; Stothard, JR; Miles, MA; (2001) Genetic typing and phylogeny of the Leishmania donovani complex by ...
  http://researchonline.lshtm.ac.uk/view/keywords/DNA.html
*  Ateras, Marik, Angir and Fabio Paraguay - ?????? 8
Developmentally induced changes of the proteome in the protozoan sponger Leishmania donovani. The indweller Institution of ... The biosynthesis and practise of trypanothione relies on enzymes that are consonant in trypanosomatids and wanting from the ... Our bodies reason against oxidization finished enzymes titled dismutases, catalases, reductases and peroxidases generic 50mg ... Annu Rev Microbiol 41:127-151 Opperdoes FR, Szikora JP (2006) In silico prophecy of the glycosomal enzymes of Leishmania ...
  http://medgost.ru/2forum/index.php?action=vthread&forum=1&topic=137&page=8