*  Synergy Testing of FDA-Approved Drugs Identifies Potent Drug Combinations against Trypanosoma cruzi - GOV.UK
An estimated 8 million persons, mainly in Latin America, are infected with Trypanosoma cruzi, the etiologic agent of Chagas ... When tested alone in the murine model of Trypanosoma cruzi infection, most compounds had insufficient efficacy to lower ... Synergy Testing of FDA-Approved Drugs Identifies Potent Drug Combinations against Trypanosoma cruzi ... Synergy Testing of FDA-Approved Drugs Identifies Potent Drug Combinations against Trypanosoma cruzi ...
  https://www.gov.uk/dfid-research-outputs/synergy-testing-of-fda-approved-drugs-identifies-potent-drug-combinations-against-trypanosoma-cruzi
*  Development of bis-thiazoles as inhibitors of triosephosphate isomerase from Trypanosoma cruzi. Identification of new non...
Triosephosphate isomerase from Trypanosoma cruzi (TcTIM), the etiologic agent of this disease, has been proposed as a druggable ... DEVELOPMENT OF BIS-THIAZOLES AS INHIBITORS OF TRIOSEPHOSPHATE ISOMERASE FROM TRYPANOSOMA CRUZI. IDENTIFICATION OF NEW NON- ... On the other hand, new bioactive furane-containing thiazoles have been described as excellent in vivo anti-T. cruzi agents. ... cruzi agent surpassing the "hit-to-lead" stage in the drug development process. (©)2015 Elsevier Science Ltd. All rights ...
  http://www.ifc.unam.mx/publications/development-bis-thiazoles-inhibitors-triosephosphate-isomerase-trypanosoma-cruzi-identification-mutagenic-agents-active-vivo/
*  JCVI: Cloning and Expression of Transgenes Using Linear Vectors in Trypanosoma Cruzi.
Cloning and Expression of Transgenes Using Linear Vectors in Trypanosoma Cruzi.. International Journal for Parasitology. 2014 ... Vectors for genetic manipulation in Trypanosoma cruzi basically include those that remain as circular episomes and those that ... Our results show that pTACs constitute useful tools for reverse functional genetics in T. cruzi that will contribute to a ... Furthermore, derived artificial chromosomes from pTAC-odc could complement the auxotrophy of T. cruzi for polyamines. ...
  http://www.jcvi.org/cms/publications/listing/abstract/article/cloning-and-expression-of-transgenes-using-linear-vectors-in-trypanosoma-cruzi/
*  Is Trypanosoma cruzi a New Threat to Our Blood Supply? | Annals of Internal Medicine | American College of Physicians
Is Trypanosoma cruzi a New Threat to Our Blood Supply?. Ann Intern Med. 1989;111:773-775. doi: 10.7326/0003-4819-111-10-773 ... Is Trypanosoma cruzi a New Threat to Our Blood Supply? Louis V. Kirchhoff, MD, MPH ... Septicemia from Concomitant Infection with Trypanosoma Cruzi and Neisseria Perflava: First Case of Laboratory-acquired Chagas' ... Chagas disease (American trypanosomiasis), a zoonosis caused by the protozoan parasite, Trypanosoma cruzi (1-3), is a typical " ...
  http://annals.org/aim/article-abstract/703497/trypanosoma-cruzi-new-threat-our-blood-supply
*  Molecules | Free Full-Text | Repositioning FDA Drugs as Potential Cruzain Inhibitors from Trypanosoma cruzi: Virtual Screening...
... is a neglected disease caused by the parasite Trypanosoma cruzi, which affects underdeveloped countries. The current drugs of ... Anti-Trypanosoma cruzi Activity. The four compounds were evaluated for their direct trypanocidal effects on blood samples ... Filardi, L.S.; Brener, Z. A rapid method for testing in vivo the susceptibility of different strains of Trypanosoma cruzi to ... Chagas disease (CD) is a neglected parasitic disease caused by the protozoan Trypanosoma cruzi. It represents a public health ...
  http://www.mdpi.com/1420-3049/22/6/1015/htm
*  Analogues of Fenarimol Are Potent Inhibitors of Trypanosoma cruzi and Are Efficacious in a Murine Model of Chagas Disease - GOV...
We report the discovery of nontoxic fungicide fenarimol (1) as an inhibitor of Trypanosoma cruzi (T. cruzi), the causative ... Analogues of Fenarimol Are Potent Inhibitors of Trypanosoma cruzi and Are Efficacious in a Murine Model of Chagas Disease ... Analogues of Fenarimol Are Potent Inhibitors of Trypanosoma cruzi and Are Efficacious in a Murine Model of Chagas Disease ... Analogues of Fenarimol Are Potent Inhibitors of Trypanosoma cruzi and Are Efficacious in a Murine Model of Chagas Disease. ...
  https://www.gov.uk/dfid-research-outputs/analogues-of-fenarimol-are-potent-inhibitors-of-trypanosoma-cruzi-and-are-efficacious-in-a-murine-model-of-chagas-disease
*  Proteomic and Bioinformatic Analysis of Trypanosoma cruzi Chemotherapy and Potential Drug Targets: New Pieces for an Old Puzzle...
Title:Proteomic and Bioinformatic Analysis of Trypanosoma cruzi Chemotherapy and Potential Drug Targets: New Pieces for an Old ... Abstract:Chagas disease is endemic in Latin America and is caused by the protozoan hemoflagellate parasite Trypanosoma cruzi. ... Chagas disease is endemic in Latin America and is caused by the protozoan hemoflagellate parasite Trypanosoma cruzi. Nowadays, ... Proteomic and Bioinformatic Analysis of Trypanosoma cruzi Chemotherapy and Potential Drug Targets: New Pieces for an Old Puzzle ...
  http://www.eurekaselect.com/115457/article
*  New Perspectives for Therapeutic Intervention during the Chronic Phase of <i>Trypanosoma Cruzi</i...
Trypanosoma cruzi modulates the profile of memory CD8 T cells in chronic Chagas' disease patients. (2006) Int Immunol 18(3): ... Trypanosoma cruzi Experimental Infection Impacts on the Thymic Regulatory T Cell Compartment. (2016) PLoS Negl Trop Dis 10(1): ... The intracellular protozoan parasite Trypanosoma cruzi causes Chagas's disease in humans[1]. About 5 million to 8 million ... Trypanosoma cruzi, Chagas disease, Interleukin-2, anti-CD25, regulatory T cells, treatment ...
  https://www.ommegaonline.org/article-details/New-Perspectives-for-Therapeutic-Intervention-during-the-Chronic-Phase-of-iTrypanosoma-Cruzii-Infection/597
*  A novel protein phosphatase 2A (PP2A) is involved in the transformation of human protozoan parasite Trypanosoma cruzi |...
A novel protein phosphatase 2A (PP2A) is involved in the transformation of human protozoan parasite Trypanosoma cruzi. Jorge ... Here we provide evidence for a critical role of PP2As (protein phosphatase 2As) in the transformation of Trypanosoma cruzi. In ... A novel protein phosphatase 2A (PP2A) is involved in the transformation of human protozoan parasite Trypanosoma cruzi ... A novel protein phosphatase 2A (PP2A) is involved in the transformation of human protozoan parasite Trypanosoma cruzi ...
  http://www.biochemj.org/content/374/3/647
*  Analogues of Fenarimol are potent inhibitors of Trypanosoma cruzi and are efficacious in a murine model of Chagas Disease -...
We report the discovery of nontoxic fungicide fenarimol (1) as an inhibitor of Trypanosoma cruzi (T. cruzi), the causative ... Analogues of Fenarimol are potent inhibitors of Trypanosoma cruzi and are efficacious in a murine model of Chagas Disease ... 2012) Analogues of Fenarimol are potent inhibitors of Trypanosoma cruzi and are efficacious in a murine model of Chagas Disease ... cruzi whole cell in vitro assay. Lead compounds suppressed blood parasitemia to virtually undetectable levels after once daily ...
  http://researchrepository.murdoch.edu.au/id/eprint/8801/
*  The contemporary distribution of Trypanosoma Cruzi infection in humans, alternative hosts and vectors. - Durham Research Online
It is caused by the Trypanosoma cruzi parasite, which is transmitted by triatomine vectors to humans and a wide range of ... The contemporary distribution of Trypanosoma Cruzi infection in humans, alternative hosts and vectors. ... The contemporary distribution of Trypanosoma Cruzi infection in humans, alternative hosts and vectors. ... The contemporary distribution of Trypanosoma Cruzi infection in humans, alternative hosts and vectors.', Scientific data., 4 . ...
  http://dro.dur.ac.uk/21556/
*  PLOS Neglected Tropical Diseases: Structural Characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei Bound to...
... cruzi and T. brucei, both bound to the anti-fungal drugs fluconazole or posaconazole. The structures provide a basis for a ... Author Summary Chagas Disease is caused by kinetoplastid protozoa Trypanosoma cruzi, whose sterols resemble those of fungi, in ...
  http://journals.plos.org/plosntds/article/authors?id=10.1371/journal.pntd.0000651&imageURI=info:doi/10.1371/journal.pntd.0000651.t002
*  PLOS Neglected Tropical Diseases: T. cruzi OligoC-TesT: A Simplified and Standardized Polymerase Chain Reaction Format for...
Routine diagnosis of Trypanosoma cruzi infection generally is based on detection of the host's antibodies against the parasite ... is caused by the protozoan parasite Trypanosoma cruzi and represents a major public health problem in Latin America. ... We here present the development and evaluation of the T. cruzi OligoC-TesT, a simple and standardized dipstick format for ... detection of PCR amplified T. cruzi DNA. The new tool is an important step towards simplified and standardized molecular ...
  http://journals.plos.org/plosntds/article/comments?id=10.1371/journal.pntd.0000450&imageURI=info:doi/10.1371/journal.pntd.0000450.t002
*  Welcome to CDC stacks | Trypanosoma cruzi in Persons without Serologic Evidence of Disease, Argentina - 14218 | Emerging...
We report a case of chagasic meningoencephalitis reactivation in a pregnant woman co-infected with Trypanosoma cruzi and HIV ... Background : Millions of people are infected with Trypanosoma cruzi, the causative agent of Chagas disease in Latin America. ... Chagas disease, caused by Trypanosoma cruzi, is a major neglected tropical disease affecting the Americas. The epidemiology of ... We used 5 diagnostic tests in a cross-sectional investigation of the prevalence of Trypanosoma cruzi in Tejupilco municipality ...
  https://stacks.cdc.gov/view/cdc/14218
*  Trypanosoma cruzi Chagas ATCC ® 50797™
Trypanosoma cruzi ATCC ® 50797™ Designation: I/INF/PY/81/P63 CL1 Isolation: Triatoma infestans, Paraquay, 1981, cloned by M. ... Trypanosoma cruzi Chagas (ATCC® 50797™) Strain Designations: I/INF/PY/81/P63 CL1 / Depositor: JA Dvorak / Biosafety Level: 2 ... Trypanosoma cruzi: analysis of the population dynamics of heterogeneous mixtures. J. Protozool. 34: 409-415, 1987. PubMed: ...
  https://www.atcc.org/en/Products/All/50797.aspx
*  Trypanosoma cruzi Chagas ATCC ® 50796™
Trypanosoma cruzi ATCC ® 50796™ Designation: M/HOM/AR/80/MIRANDA CL88 Isolation: human male, Argentina, 1980, cloned by J. ... Trypanosoma cruzi Chagas (ATCC® 50796™) Strain Designations: M/HOM/AR/80/MIRANDA CL88 / Depositor: JA Dvorak / Biosafety Level ... Trypanosoma cruzi: flow cytometric analysis. I. Analysis of total DNA/organism by means of mithramycin-induced fluorescence. J ... Trypanosoma cruzi: biological characterization of 19 clones derived from two chronic chagasic patients. I. Growth kinetics in ...
  https://www.atcc.org/en/Products/Cells_and_Microorganisms/Protozoa/Parasitic_Protozoa/50796.aspx?p=1&rel=%7B0%7D
*  Trypanosoma cruzi Chagas ATCC ® 50830™
Trypanosoma cruzi ATCC ® 50830™ Designation: WA250 CL1 Isolation: clone 1 derived from strain WA-250 which was originally ... Trypanosoma cruzi Chagas (ATCC® 50830™) Strain Designations: WA250 CL1 / Depositor: JA Dvorak / Biosafety Level: 2 ... Trypanosoma cruzi: flow cytometric analysis. I. Analysis of total DNA/organism by means of mithramycin-induced fluorescence. J ... Trypanosoma cruzi: antigenic analysis of cloned stocks. Am. J. Trop. Med. Hyg. 32: 716-722, 1983. PubMed: 6349399 ...
  https://www.atcc.org/en/Products/All/50830.aspx
*  Trypanosoma cruzi Infection and Host Lipid Metabolism
... Qianqian Miao1,2 and Momar Ndao1,2 ... Qianqian Miao and Momar Ndao, "Trypanosoma cruzi Infection and Host Lipid Metabolism," Mediators of Inflammation, vol. 2014, ...
  https://www.hindawi.com/journals/mi/2014/902038/cta/
*  KEGG PATHWAY: DNA replication - Trypanosoma cruzi
DNA replication - Trypanosoma cruzi [ Pathway menu , Organism menu , Pathway entry , Download KGML , Show description , User ...
  http://www.genome.jp/kegg-bin/show_pathway?tcr03030+506835.120
*  Biological characterization of Trypanosoma cruzi strains
Biological parameters of five Trypanosoma cruzi strains from different sources were determined in order to know the laboratory ... Delimination of Trypanosoma cruzi zymodemes by numerical taxonomy. Trans R Soc Trop Med Hyg 74: 238-242. [ Links ]. ... Immunity to Trypanosoma cruzi. Adv Parasitol 18: 247-292. [ Links ]. *Brener Z, Chiari E 1967. Susceptibilidades de diferentes ... Estudo sobre os caracteres de una amostra boliviana do Trypanosoma cruzi . Rev Soc Bras Med Trop 8: 75-81. [ Links ]. ...
  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762001000100006&lng=pt&nrm=iso
*  KEGG PATHWAY: Base excision repair - Trypanosoma cruzi
Base excision repair - Trypanosoma cruzi [ Pathway menu , Organism menu , Pathway entry , Download KGML , Show description , ...
  http://www.genome.jp/kegg-bin/show_pathway?tcr03410+508881.80
*  LPD - Dihydrolipoyl dehydrogenase - Trypanosoma cruzi - LPD gene & protein
Trypanosoma cruzi marinkellei. Trypanosoma cruzi Dm28c. Trypanosoma cruzi (strain CL Brener). Trypanosoma cruzi. 477. UniRef90_ ... sp,P90597,DLDH_TRYCR Dihydrolipoyl dehydrogenase OS=Trypanosoma cruzi OX=5693 GN=LPD PE=1 SV=1 ... Trypanosoma cruzi. ,p>This subsection of the ,a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and ...
  http://www.uniprot.org/uniprot/P90597
*  Trypanosoma cruzi: Seroprevalence Detection in Suburban Population of Santiago de Querétaro (Mexico)
... Ángeles López-Céspedes,1 ... L. M. P. Luz, M. G. Coutinho, J. R. Cancado, and A. U. Krettli, "Hemocultura: tecnica sensivel na deteccao do Trypanosoma cruzi ... L. Galavíz-Silva, D. P. Molina-Garza, M. A. González-Santos et al., "Update on seroprevalence of anti-Trypanosoma cruzi ... Table 2: Evaluation of the reliability to detect Trypanosoma cruzi antibodies, using ELISA technique with SODeCRU antigen, in ...
  https://www.hindawi.com/journals/tswj/2012/914129/
*  Frontiers | The Complement System: A Prey of Trypanosoma cruzi | Microbiology
Moreover, T. cruzi promotes secretion of plasma membrane-derived vesicles from host cells, which prevent the activity of C3 ... In fact, several T. cruzi molecules are known to interfere in the initiation of all three pathways and in the assembly of C3 ... In this review, we aim to present an overview on the strategies used by T. cruzi in order to circumvent the activation of ... Most of individuals that are infected by T. cruzi may remain in asymptomatic form all lifelong, but up to 40% of them will ...
  https://www.frontiersin.org/articles/10.3389/fmicb.2017.00607/full
*  Trypanosoma cruzi SSP4 protein Summary Report | CureHunter
SSP4 protein from Trypanosoma cruzi amastigotes regulates nitric oxide production by macrophages; GenBank AF480943 ... Trypanosoma cruzi SSP4 protein. Subscribe to New Research on Trypanosoma cruzi SSP4 protein ... SSP4 protein from Trypanosoma cruzi amastigotes regulates nitric oxide production by macrophages; GenBank AF480943 ...
  http://www.curehunter.com/public/keywordSummaryC501457-Trypanosoma-cruzi-SSP4-protein.do