Cyclic nucleotide - Wikipedia
... including receptor-effector coupling, down-regulation of drug responsiveness, protein-kinase cascades, and transmembrane signal ... where it stimulates a protein kinase called cyclic AMP-dependent protein kinase. By phosphorylating proteins, cyclic AMP- ... G proteins). The two most well-studied cyclic nucleotides are cyclic AMP (cAMP) and cyclic GMP (cGMP), while cyclic CMP (cCMP) ... Eckly-Michel A, Martin V, Lugnier C (September 1997). "Involvement of cyclic nucleotide-dependent protein kinases in cyclic AMP ...https://en.wikipedia.org/wiki/Cyclic_nucleotide
Protocols and Video Articles Authored by Rohini Kuner (Translated to Italian)
Presynaptically Localized Cyclic GMP-dependent Protein Kinase 1 is a Key Determinant of Spinal Synaptic Potentiation and Pain ... In contrast, glycogen synthase kinase-3 beta, another effector of phosphoinositide-3-kinase signalling, was not involved. Thus ... Among these are the 7-transmembrane receptors (G protein-coupled receptors) coupling to G(s), G(i/o), G₁₂/₁₃, or G(q/11) G ... The encoded protein displayed high homology to the MARK family of serine-threonine protein kinases and has recently been ...https://www.jove.com/author/Rohini_Kuner?language=Italian
Activation of Distinct cAMP-Dependent and cGMP-Dependent Pathways by Nitric Oxide in Cardiac Myocytes | Circulation Research
Purified cyclic GMP-dependent protein kinase catalyzes the phosphorylation of cardiac troponin inhibitory subunit (TN-I). J ... could proportionately regulate the function of the effector protein. Such proportionate control of protein function via the ... could result in the cAMP/PKA-dependent stimulation of transmembrane Ca2+ influx, increasing the trigger for the Ca2+-induced Ca ... Méry PF, Lohman SM, Walter U, Fischmeister R. Ca2+ current is regulated by cyclic GMP-dependent protein kinase in mammalian ...http://circres.ahajournals.org/content/84/9/1020
Waldman, Scott - Philadelphia University + Thomas Jefferson University - Thomas Jefferson University
Recently, signaling by GCC and its downstream effector, cyclic GMP (cGMP) has emerged as a principal regulator of proliferation ... in mucosal sheets ex vivo and intestinal cells in vitro inhibited proliferation by activating cGMP-dependent protein kinase and ... Guanylyl cyclase C (GCC) is an apical transmembrane receptor that regulates fluid and electrolyte homeostasis whose expression ... is exclusively expressed in the apical membranes of enterocytes and supplies intracellular cyclic GMP (cGMP), maintaining ...https://www.jefferson.edu/university/jmc/departments/pharmacology/faculty_staff/faculty/waldman.html
Probing Receptor Structure/Function with Chimeric G-Protein-Coupled Receptors | Molecular Pharmacology
Wang HY and Malbon CC (2003) Wnt signaling, Ca2+ and cyclic GMP: visualizing frizzled functions. Science (Wash DC) 300: 1529- ... The intracellular loops are accessible to protein kinases, such as protein kinases A and C and G protein-coupled receptor ... Additional evidence for a common transmembrane signaling and G protein coupling mechanism in G protein-coupled receptors. J ... an agonist-specific GTP-dependent shift in affinity dependent on the presence of Gq (the cognate G-protein of Rfz1) as well as ...http://molpharm.aspetjournals.org/content/65/6/1323
Cyclic GMP-Dependent Protein Kinases and the Cardiovascular System | Circulation Research
High concentrations of cGKI were detected in human platelets at a time when the heterogeneity of cGMP effector systems was only ... 139 and cystic fibrosis transmembrane conductance regulator (CFTR) Cl− channels.140 However, the CFTR channel is unlikely to ... Activation of mitogen-activated protein kinase pathways by cyclic GMP and cyclic GMP-dependent protein kinase in contractile ... Cyclic AMP- and cyclic GMP-dependent protein kinases differ in their regulation of cyclic AMP response element-dependent gene ...http://circres.ahajournals.org/content/93/10/907.full
Evidence for the Role of Membrane Receptor Lateral Movement in GTP-Binding Protein-Mediated Signal Transduction | SpringerLink
Rod outer segment structure influences the apparent kinetic parameters of cyclic GMP phosphodiesterase. J Gen Physiol 1994; 103 ... The protein kinase homologue Ste20p is required to link the yeast pheromone response G-protein (3y subunits to downstream ... New roles for G-protein fry-dimers in transmembrane signalling. Nature 1993; 365: 403-406.PubMedCrossRefGoogle Scholar ... Receptor-effector coupling by G proteins: implications for normal and abnormal signal transduction. Endocrine Rev 1992; 13: 536 ...https://link.springer.com/chapter/10.1007/978-1-4757-0680-2_5
Protocols and Video Articles Authored by Peter Nagy (Translated to Norwegian)
... binds to and activates protein kinase C-θ (PKCθ). EA-dependent activation of PKCθ induces an insulin-resistant phenotype, ... and cyclic GMP levels are restored at equimolar ratios. Similar results are observed when intracellular sulfide levels are ... Selective autophagic degradation of ubiquitinated proteins is mediated by Ref(2)P/p62. The transmembrane protein Atg9 ... Dec, 2014 , Pubmed ID: 25229186 Hydrogen sulfide (H2S) is an endogenously generated and putative signaling/effector molecule. ...https://www.jove.com/author/Peter_Nagy?language=Norwegian
CALM2 calmodulin 2 [Homo sapiens (human)] - Gene - NCBI
... organism-specific biosystemThe Ca2+-calmodulin-dependent protein kinase (CaM kinase) cascade includes three kinases: CaM-kinase ... cGMP-PKG signaling pathway, conserved biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action ... SLC-mediated transmembrane transport, organism-specific biosystemProteins with transporting functions can be roughly classified ... When dissociated Galpha-GTP and Gbeta-gamma can activate or inhibit different signalling cascades and effector proteins. The ...https://www.ncbi.nlm.nih.gov/gene/805
ASMscience | Type III Secretory Prote
The T3SS and the effector proteins encoded by P. aeruginosa provide model systems for fundamental studies of host-pathogen ... The first identified T3SS effector, exoenzyme S (ExoS), was actually discovered before the components of the secretory system ... cyclic-GMP in virulence. Proc. Natl. Acad. Sci. USA 103:2839-2844.. ... Pseudomonas aeruginosa pyocyanin inactivates lung epithelial vacuolar ATPase-dependent cystic fibrosis transmembrane ...http://www.asmscience.org/content/book/10.1128/9781555815851.ch01
Frontiers | Type I Interferons in the Pathogenesis of Tuberculosis: Molecular Drivers and Immunological Consequences |...
The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I ... TLRs are type I transmembrane proteins that localize to the cell membrane or endosomal membranes. They sense microbial ... The serine/threonine kinase, TANK-binding kinase 1 (TBK1), is a central driver of type I IFN expression in M. tuberculosis- ... The mechanism for type I interferon induction by Mycobacterium tuberculosis is bacterial strain-dependent. PLoS Pathog (2016) ...https://www.frontiersin.org/articles/10.3389/fimmu.2017.01633/full
Nureki Laboratory - 2016
"Cyclic GMP-AMP as an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA." ... "ATP-dependent modulation of MgtE in Mg2+ homeostasis.". Tomita A, Zhang M, Jin F, Zhuang W, Takeda H, Maruyama T, Osawa M, ... "Membrane protein structure determination by SAD, SIR, or SIRAS phasing in serial femtosecond crystallography using an ... "Crystal structure of the plant receptor-like kinase TDR in complex with the TDIF peptide." ...http://nurekilab.net/index.php/en?cmd=read&page=Publication%2F2016-
Biomolecules | Free Full-Text | The TORC2‐Dependent Signaling Network in the Yeast Saccharomyces cerevisiae | HTML
... associated events by directly phosphorylating and thereby stimulating the activity of two types of effector protein kinases: ... In Saccharomyces cerevisiae, a plasma membrane‐localized protein kinase complex, Target of Rapamicin (TOR) complex‐2 (TORC2) ( ... associated protein kinase Pkh1 (mammalian ortholog is PDK1) and a paralog (Pkh2). For cell survival under various stresses, ... Pkc1 is also regulated by Pkh1‐ and TORC2‐dependent phosphorylation, but, in addition, by interaction with Rho1‐GTP and lipids ...http://www.mdpi.com/2218-273X/7/3/66/htm
Aer on the inside looking out: paradigm for a PAS-HAMP role in sensing oxygen, redox and energy - Taylor - 2007 - Molecular...
Aer has a HAMP (histidine kinases, adenylyl cyclases, methyl-accepting chemotaxis proteins, phosphatases) domain, and the PAS ... Genomic analysis of cyclic-di-GMP-related genes in rhizobial type strains and functional analysis in Rhizobium etli, Applied ... Breakthroughs in Understanding c-di-GMP Effector Systems, Annual Review of Cell and Developmental Biology, 2012, 28, 1, 439. ... Falke, J.J., and Hazelbauer, G.L. (2001) Transmembrane signaling in bacterial chemoreceptors. Trends Biochem Sci 26: 257-265. * ...http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2958.2007.05889.x/full
Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof - Patent # 6410294 ...
... paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides. ... the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid ... The cyclic-AMP dependent protein kinases (PKA) are important members of the STK family. Cyclic-AMP is an intracellular mediator ... Where the protein binds or potentially binds to another protein or ligand (such as, for example, in a kinase-effector protein ...http://www.patentgenius.com/patent/6410294.html
Cyclic adenosine monophosphate (cAMP) is certainly an essential intracellular second messenger - HDAC Inhibition for the...
... and cyclic guanosine monophosphate (cGMP). cAMP and cGMP bind towards the regulatory products of proteins kinase A(PKA) ... enabling phosphorylation hence transducing sign cascades in the cell C. Therefore, by severing these cA/GMP-dependent ... and leads to a fatal immune system reaction with continuous activation of immune system effector cells that create suffered or ... Orphan 7-Transmembrane Receptors *Orphan G-Protein-Coupled Receptors *Orphan GPCRs *OT Receptors ...http://recyclers-info.com/cyclic-adenosine-monophosphate-camp-is-certainly-an-essential-intracellular-second-messenger/
JCI - The host STING pathway at the interface of cancer and immunity
... via the DNA sensor cyclic GMP-AMP synthase (cGAS/MB21D1), which catalyzes the synthesis of cyclic GMP-AMP (cGAMP) from GTP and ... However, deficiency in STING (also known as transmembrane protein 173 [TMEM173], MITA, ERIS, and MPYS) or the transcription ... Activation of mitogen-activated protein kinases by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) plays an important role in ... STING-dependent cytosolic DNA sensing promotes radiation-induced type I interferon-dependent antitumor immunity in immunogenic ...https://gimee-gz.com.www.mobile.jci.org/articles/view/86892
Frontiers | PDE5 Inhibitors as Potential Tools in the Treatment of Cystic Fibrosis | Pharmacology
Moreover, vardenafil, but not sildenafil, stimulates chloride transport through the normal CFTR protein. We developed a ... vardenafil or taladafil at clinical doses are able to restore the decreased CFTR-dependent chloride transport across the nasal ... Moreover, vardenafil, but not sildenafil, stimulates chloride transport through the normal CFTR protein. We developed a ... vardenafil or taladafil at clinical doses are able to restore the decreased CFTR-dependent chloride transport across the nasal ...https://www.frontiersin.org/articles/10.3389/fphar.2012.00167/full
AMPK Alpha 1-Induced RhoA Phosphorylation Mediates Vasoprotective Effect of Estradiol | Arteriosclerosis, Thrombosis, and...
cAMP- and cyclic GMP-dependent protein kinases (PKA and PKG) phosphorylate RhoA on Ser188.4,5 Both in vitro and in vivo ... In the vasculature, RhoA and its downstream effector Rho associated protein kinase (Rock) have been shown to regulate processes ... A transmembrane intracellular estrogen receptor mediates rapid cell signaling. Science. 2005;307:1625-1630. ... Cyclic GMP-dependent protein kinase signaling pathway inhibits RhoA-induced Ca2+ sensitization of contraction in vascular ...http://atvb.ahajournals.org/content/31/11/2634
Gaseous signaling molecules - Wikipedia
"Cyclic GMP-dependent protein kinase regulates vascular smooth muscle cell phenotype". Journal of Vascular Research. 34 (4): 245 ... Ethylene is perceived by a family of five transmembrane protein dimers such as the ETR1 protein in Arabidopsis. The gene ... "IFN-gamma inhibits development of Plasmodium berghei exoerythrocytic stages in hepatocytes by an L-arginine-dependent effector ... which is a heterodimeric enzyme with subsequent formation of cyclic-GMP. Cyclic-GMP activates protein kinase G, which causes ...https://en.wikipedia.org/wiki/Gaseous_signaling_molecules
"Structure of a tRNA-dependent kinase essential for selenocysteine decoding". Araiso Y, Sherrer RL, Ishitani R, Ho JM, S�ll D, ... "Cyclic GMP-AMP as an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA." ... Tracing Biology Evolution in Protein and Gene Structures, (Edited by M. Go and P. Schimmel) Elsevier Science, pp. 23-35 (1995). ... "Conductance of P2X4 purinergic receptor is determined by conformational equilibrium in the transmembrane region." ...http://www.nurekilab.net/index.php/ja?Publication
Molecular Mechanisms of Mammalian Sperm-Zona Pellucida Interaction: Crosstalk Between Sperm and Egg | SpringerLink
Kikkawa, U. and Nishizuka, Y. (1986) The role of protein kinase C in transmembrane signalling. Ann. Rev. Cell Biol. 2, 149-178. ... Stryer, L. (1986) Cyclic GMP cascade of vision. Arm. Rev. Neurosci. 9, 87.CrossRefGoogle Scholar ... Casey, P.J. and Gilman, A.G. (1988) G protein involvement in receptor-effector coupling. J. Biol. Chem. 263, 2577-2580.PubMed ... Saling, P.M., Wolf, D.P. and Storey, B.T. (1978) Calcium-dependent binding of mouse epididymal spermatozoa to the zona ...https://link.springer.com/chapter/10.1007/978-1-4613-0645-0_47
The Yin and Yang of SagS: Distinct Residues in the HmsP Domain of SagS Independently Regulate Biofilm Formation and Biofilm...
A c-di-GMP effector system controls cell adhesion by inside-out signaling and surface protein cleavage. PLoS Biol 9:e1000587. ... Mechanism of transmembrane signaling by sensor histidine kinases. Science 356:eaah6345. doi:10.1126/science.aah6345. ... LapD is a bis-(3′, 5′)-cyclic dimeric GMP-binding protein that regulates surface attachment by Pseudomonas fluorescens Pf0-1. ... HmsP, a putative phosphodiesterase, and HmsT, a putative diguanylate cyclase, control Hms-dependent biofilm formation in ...https://msphere.asm.org/content/3/3/e00192-18
A Single Second Messenger | Circulation Research
A-kinase anchoring proteins (AKAPs) are known to localize cAMP-dependent protein kinase (PKA) to different subcellular ... guanylyl cyclase for synthesis of cyclic GMP (cGMP), cyclic nucleotide phosphodiesterase (PDE) for hydrolysis of cAMP and cGMP ... The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways. Nature. 2005; 437: 574-578. ... AC1-9 are transmembrane proteins with a number of membrane spanning α-helices, whereas sAC lacks transmembrane spanning domains ...http://circres.ahajournals.org/content/99/8/790
Initiation of Plasmodium sporozoite motility by albumin is associated with induction of intracellular signaling
Sudo A, Kato K, Kobayashi K, Tohya Y, Akashi H. Susceptibility of Plasmodium falciparum cyclic AMP-dependent protein kinase and ... Inhibition of cyclic GMP hydrolysis with zaprinast reduces basal and cyclic AMP-elevated L-type calcium current in guinea-pig ... is classically activated when a ligand binds to the cell surface component of a transmembrane receptor coupled to a G protein ... Albumin was the first defined effector shown to induce a specific cellular process in Plasmodium, yet its mechanism of action ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2813373/