Tetracycline-controlled transcriptional activation is a method of inducible gene expression where transcription is reversibly ... "Transcriptional activation by tetracyclines in mammalian cells". Science. 268 (5218): 1766-9. Bibcode:1995Sci...268.1766G. doi: ... It is also human codon optimized and composed of three minimal VP16 activation domains. However, the Tet-On 3G protein has five ... In the Cre and FRT systems, activation or knockout of the gene is irreversible once recombination is accomplished, whereas, in ...

... dependent transcriptional corepressor. Microarray analyses of MCF-7 cells transfected with control or SMRT small interfering ... Activation of p53 transcriptional activity by SMRT: a histone deacetylase 3-independent function of a transcriptional ... p53 bound to the SMRT deacetylase activation domain (DAD), which mediates HDAC3 binding and activation, and HDAC3 could ... Moreover, an HDAC3 binding-deficient SMRT DAD mutant coactivated p53 transcriptional activity. Collectively, these data ...

... dc.contributor. ... Sirt1 Mediates Neuroprotection from Mutant Huntingtin by Activation of TORC1 and CREB Transcriptional Pathway. en_US. ... Sirt1 mediates neuroprotection from mutant huntingtin by activation of TORC1 and CREB transcriptional pathway. Nature Medicine ... These studies suggest a key role of Sirt1 in transcriptional networks in normal and HD brain and offer an opportunity for ...

Transcriptional activation and sensing propertiesof DegS-DegU: a two-component system involvedin the osmotic regulation of ... In parallel to exploring the role of the DegS-DegU system at the transcriptional and at the protein level, some additional ... Taken together, the data from the present work shed a light on the transcriptional regulation of DegS-DegU two-component system ... demonstrated that the activation of the system is rather an osmotic response and not consequence of salt-specific stimulation. ...

... flanking region of the human pS2 gene mediates its transcriptional activation by estrogen in MCF-7 cells Biochemical and ... flanking region of the mouse Cyp1a2 gene required for transcriptional activation by 3-methylcholanthrene and 2,3,7,8- ... Identification of additional major 5-flanking regulatory elements responsible for transcriptional activation of the rat sodium ... transcriptional regulatory elements and activation by Pitx1 and estrogen. Kimura, N.; Tomizawa, S.; Arai, K.N.; Osamura, R.Y.; ...

1509-C Transcriptional activation of mouse LINE-1 promoter by transcription factor YY1 ... 1509-C Transcriptional activation of mouse LINE-1 promoter by transcription factor YY1 ... These results indicate that YY1 is a transcriptional activator of mouse LINE-1 Tf_I subfamily. On the other hand, our data ... Therefore, investigating LINE-1 transcriptional regulation is important for our understanding of LINE-1s role in cancer. In ...

Endothelial NOS, estrogen receptor beta, and HIFs cooperate in the activation of a prognostic transcriptional pattern in ... Endothelial NOS, estrogen receptor ?, and HIFs cooperate in the activation of a prognostic transcriptional pattern in ... and HIFs cooperate in the activation of a prognostic transcriptional pattern in aggressive human prostate cancer., The Journal ... Genetic or pharmacologic modulation of eNOS expression and activity resulted in reciprocal conversion of the transcriptional ...

Wheeler, M. A., Townsend, M. K., Yunker, L. A., & Mauro, L. J. (2002). Transcriptional activation of the tyrosine phosphatase ... Transcriptional activation of the tyrosine phosphatase gene, OST-PTP, during osteoblast differentiation. Journal of Cellular ... Transcriptional activation of the tyrosine phosphatase gene, OST-PTP, during osteoblast differentiation. In: Journal of ... Transcriptional activation of the tyrosine phosphatase gene, OST-PTP, during osteoblast differentiation. / Wheeler, Marie A.; ...

Furthermore, lactate generation appears to be critical for the activation of HFSCs as deletion of lactate dehydrogenase (Ldha) ... Inducing Ldha through Mpc1 inhibition or Myc activation successfully reactivates the hair cycle in quiescent follicles. ... deletion accelerated their activation and the hair cycle. Finally, we identify small molecules that increase lactate production ... prevented their activation. Conversely, genetically promoting lactate production in HFSCs through mitochondrial pyruvate ...

... targeting rules for effective transcriptional activation, to demonstrate multiplexed activation of ten genes simultaneously, ... "Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex" 517, no. 7536 (2014). Konermann, Silvana et al. " ... "Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex" vol. 517, no. 7536, 2014. Export RIS Citation ... 2014). Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex. 517(7536). Konermann, Silvana et al. " ...

Site-directed targeting of transcriptional activation-associated proteins to repressed chromatin restores CRISPR activity René ... 1(b)] and DNA-binding fusion proteins that include a transcriptional activation associated protein (AAP) [Fig. 1(c)]. We ... René Daer, Fatima Hamna, Cassandra M. Barrett, Karmella A. Haynes; Site-directed targeting of transcriptional activation- ... Activation-associated Gal4 fusions restore CRISPR-mediated editing. Activation of gene expression may not be desirable at ...

The interaction of Pax5 (BSAP) with Daxx can result in transcriptional activation in B cells. / Emelyanov, Alexander V.; Kovac ... The interaction of Pax5 (BSAP) with Daxx can result in transcriptional activation in B cells. Journal of Biological Chemistry. ... The interaction of Pax5 (BSAP) with Daxx can result in transcriptional activation in B cells. In: Journal of Biological ... Dive into the research topics of The interaction of Pax5 (BSAP) with Daxx can result in transcriptional activation in B cells ...

Autocrine transforming growth factor-{beta}1 activation mediated by integrin {alpha}V{beta}3 regulates transcriptional ... Autocrine transforming growth factor-{beta}1 activation mediated by integrin {alpha}V{beta}3 regulates transcriptional ... Autocrine transforming growth factor-{beta}1 activation mediated by integrin {alpha}V{beta}3 regulates transcriptional ...

Reintroduction of APC removed beta-catenin from hTcf-4 and abrogated the transcriptional transactivation. Constitutive ... Reintroduction of APC removed beta-catenin from hTcf-4 and abrogated the transcriptional transactivation. Constitutive ...

... Pseudomonas aeruginosa. Doo Hwan Yeom, Su-Jin Im, ... Activation of Multiple Transcriptional Regulators by Growth Restriction in Pseudomonas aeruginosa. Doo Hwan Yeom, Su-Jin Im, ... Oxidative stress may be a partial cause of the activation of regulators in growth-restricted conditions. The activation of SoxR ... This difference in the extent of the activation indicates that while oxidative stress may be involved in the activation of ...

We found that the shedding of heparin-binding epidermal growth factor (HB-EGF) resulting from metalloproteinase activation and ... Transcriptional Activation Substances * Disintegrins * Hbegf protein, mouse * Hbegf protein, rat * Heparin-binding EGF-like ... We found that the shedding of heparin-binding epidermal growth factor (HB-EGF) resulting from metalloproteinase activation and ...

Activation and transcriptional profile of monocytes and CD8+ T cells are altered in checkpoint inhibitor-related hepatitis. ... Activation and transcriptional profile of monocytes and CD8+ T cells are altered in checkpoint inhibitor-related hepatitis. ... Transcriptional profiling indicated the presence of activated monocyte and enhanced effector CD8+ T cell populations in CPI-Hep ... Phenotypic and transcriptional profiling of peripheral immune subsets was performed and compared with 19 healthy controls (HCs ...

It inhibited the function of the MDM2/STAT2 complex and suppressed the transcriptional activation of RAGE, thereby exerting ... Echinacoside-Zinc Nanomaterial Inhibits Skin Glycation by Suppressing the Transcriptional Activation of the Receptor for ... showed that MDM2 can interact with STAT2 to form a transcriptional complex and thus promote RAGE transcriptional activation. In ... Echinacoside-Zinc Nanomaterial Inhibits Skin Glycation by Suppressing the Transcriptional ...

Stargell, L. A. & Struhl, K. Mechanisms of transcriptional activation in vivo: two steps forward. Trends Genet. 12, 311-315 ( ... Eberhardy, S. & Farnham, P. Myc recruits P-TEFb to mediate the final step in the transcriptional activation of the cad promoter ... Three functional classes of transcriptional activation domain. Mol. Cell. Biol. 16, 2044-2055 (1996). ... Ptashne, M. & Gann, A. Transcriptional activation by recruitment. Nature 386, 569-577 (1997). ...

The genome at the break of dawn - illuminating transcriptional control of zygotic genome activation in mosquitoes. Rebecca ...

The role of basal and myogenic factors in the transcriptional activation of utrophin promoter A: implications for therapeutic ... The role of basal and myogenic factors in the transcriptional activation of utrophin promoter A: implications for therapeutic ...

NK-cell activation is associated with increased HIV transcriptional activity following allogeneic hematopoietic cell ... NK-cell activation is associated with increased HIV transcriptional activity following allogeneic hematopoietic cell ... 00NK-cell activation is associated with increased HIV transcriptional activity following allogeneic hematopoietic cell ...

ZNF322, a novel human C2H2 Kruppel-like zinc-finger protein, regulates transcriptional activation in MAPK signaling pathways.. ... Transcriptional Activation, Zinc Fingers. Abstract: Cardiac differentiation involves a cascade of coordinated gene expression ... Furthermore, overexpression of ZNF322 in COS-7 cells activates the transcriptional activity of SRE and AP-1. Together, these ... Reporter gene assays show that ZNF322 is a transcriptional activator. ...

Strikingly, for some of these genes, the heat stress-induced transcriptional activation in the hrde-1 mutant intensifies in the ... we revealed an epigenetic role of HRDE-1 in repressing heat stress-induced transcriptional activation of over 280 genes. Many ... elegans are sensitive to heat-induced transcriptional activation. This effect at certain genomic loci including LTR ... Germline nuclear RNAi antagonizes this temperature effect at the transcriptional level and therefore may play a key role in ...

NF-κB transcriptional activation by TNFα requires phospholipase C, extracellular signal-regulated kinase 2 and poly(ADP-ribose ... Cyt: NF-κB transcriptional activation by TNFα requires phospholipase C, extracellular signal-regulated kinase 2 and… https://t. ...

... the Hippo pathway is inactivated through poorly understood mechanisms that result in the activation of the transcriptional ... which promotes cell proliferation and symmetrical cell divisions through transcriptional activation of Ki-67 and Sox2. In ... Here, we show that YAP/TAZ activation initiates gastric tumorigenesis Related: Signal Transduction Stomach Cancer Gastric ... The Hippo pathway transcriptional coactivators YAP/TAZ were implicated as drivers in GBM progression and could be therapeutic ...

We also evaluate the feasibility and safety of novel therapeutic approaches aiming at targeting specific transcriptional ... Figure 1. Activation steps of regulatory T cells (Treg cells) and their transcriptional regulation. The figure depicts the main ... Figure 1. Activation steps of regulatory T cells (Treg cells) and their transcriptional regulation. The figure depicts the main ... Foxp3 can interact with a myriad other transcriptional regulators, thereby enabling potent repression or activation of gene ...

The growth factor independent 1 transcriptional repressor (GFI-1), as a zinc-finger transcriptional repressor, can bind histone ... This abolishes effective activation of these enhancers and their cognate target genes, and it leads to the inhibition of ERα- ... We also show that WDR13 is a part of multi protein complex c-Jun/NCoR1/HDAC3 and it acts as a transcriptional activator of AP1 ... In addition, miR-181d expression could be directly induced by an activation of c-myc signaling. Together, our data indicate an ...

Non (protein)-coding RNAs are the most abundant transcriptional products of the coding genome, and comprise several different ... Non (protein)-coding RNAs are the most abundant transcriptional products of the coding genome, and comprise several different ... as in the increased chemotherapy resistance associated with transcriptional activation of GAS6-AS2 lncRNA in multiple cancers ... This also induces transcriptional silencing. In contrast, lncRNA HOTTIP guides WDR5 to H3K4 and recruits the MLL complex. This ...

EGCG suppresses IL-1β- and hyperosmolar-induced AP-1 and NFκB transcriptional activation. It has been reported that MAPK ... AP-1 and NFκB transcriptional activity. The AP-1 and NFκB transcriptional activities were measured using an inducible reporter ... Figure 6A,B shows that NFκB and AP-1 transcriptional activities were significantly increased by IL-1β. EGCG at 3 or 30 μM ... These sites have been demonstrated to be associated with the activation state of these proteins [37]. Exposure of HCEpiC to 1 ...