The multiple roles of microRNA-155 in oncogenesis | Journal of Clinical Bioinformatics | Full Text
... strands of non-coding RNA that regulate the expression of multiple genes . They are important post-transcriptional ... MGST1, CCNE2, NFIX, TFDP1, GSTM5, NQO2, POLA1, CDK6, CCND1, GSTO1, CHEK1, MYC, TGM2, CCNA2, CCND3, ALDH1A1, MGST2, E2F1, DHFR, ... of all protein-coding genes . MiRNAs control cell functions by silencing genes or gene clusters and may inhibit RNA ... The suppressor gene suppressor of cytokine signaling (SOCS-1) and BACH1 were predicted as potential target genes by ...https://jclinbioinformatics.biomedcentral.com/articles/10.1186/2043-9113-3-17
Burkitt Lymphoma and Burkitt-like Lymphoma: Practice Essentials, Background, Etiology and Pathophysiology
... that is characterized by the translocation and deregulation of the c-myc gene on chromosome 8. Malignant small noncleaved ... Genes like cyclin D2, TRAP1, and HLA-DRB1 are induced with c-myc overexpression, whereas others like p21 and platelet-derived ... A biologic definition of Burkitt's lymphoma from transcriptional and genomic profiling. N Engl J Med. 2006 Jun 8. 354(23):2419- ... In all the other cases, c-myc has been translocated close to one of the immunoglobulin light chain genes on chromosome 2 (kappa ...https://emedicine.medscape.com/article/1447602-overview
Chromosomal amplifications, 3q gain and deletions of 2q33-q37 are the frequent genetic changes in cervical carcinoma | BMC...
... which harbor the MYC gene and was previously shown as a candidate amplified gene in CC by Southern blot analysis . A ... Redon R, Hussenet T, Bour G, Caulee K, Jost B, Muller D, Abecassis J, du Manoir S: Amplicon mapping and transcriptional ... Increase in gene dosage by DNA amplification is a common mechanism to achieve over-expression of genes in tumors. Gene ... Genes Dev. 2002, 16: 984-93. 10.1101/gad.973602.View ArticlePubMedPubMed CentralGoogle Scholar. ...https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-4-5
lncRNA MYU plays a critical role in the proliferation and tumorigenicity of colon cancer cells. | lncRNA Blog
c-Myc regulates multiple biological processes through its ability to directly modulate gene expression. Here, researchers from ... Long non-coding RNAs: evolution of new epigenetic and post-transcriptional functions. July 24, 2014 ... These results suggest that the MYU/hnRNP-K/CDK6 pathway functions downstream of Wnt/c-Myc signaling and plays a critical role ... Wnt/β-catenin signaling induces the expression of the transcription factor c-Myc, leading to cell proliferation and ...http://www.lncrnablog.com/lncrna-myu-plays-a-critical-role-in-the-proliferation-and-tumorigenicity-of-colon-cancer-cells/
WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma | Cancer...
WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma. Yuting ... Gene expression analysis revealed that WDR5 target genes included those with MYC-binding elements at promoters such as MDM2. We ... WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma ... WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma ...http://cancerres.aacrjournals.org/content/early/2015/11/17/0008-5472.CAN-15-0423
Recombinant Human NME2 protein (ab93692) | Abcam
Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein ...http://www.abcam.com/recombinant-human-nme2-protein-ab93692.html
Human Metabolome Database: Showing metabocard for Uridine triphosphate (HMDB0000285)
Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein ... and gene expression. Required for neural development including neural patterning and cell fate determination. Gene Name:. NME1 ... Gene Name:. ENTPD1. Uniprot ID:. P49961 Molecular weight:. 58706.0. Reactions. Uridine triphosphate + Water → Uridine 5'- ... Gene Name:. ENTPD3. Uniprot ID:. O75355 Molecular weight:. 59104.76. Reactions. Uridine triphosphate + Water → Uridine 5'- ...http://www.hmdb.ca/metabolites/HMDB0000285
Frontiers | Viral Impact in Autoimmune Diseases: Expanding the "X Chromosome-Nucleolus Nexus" Hypothesis | Immunology
... viral RNA and proteins enter the nucleolus and indirectly when viruses induce increased expression of cellular polyamine genes ... viral RNA and proteins enter the nucleolus and indirectly when viruses induce increased expression of cellular polyamine genes ... The ornithine decarboxylase gene is a transcriptional target of c-Myc. Proc Natl Acad Sci U S A (1993) 90:7084-8. doi:10.1073/ ... The MYC interactome consists of approximately 15% of genes throughout the host genome (71, 72). Included among these are genes ...https://www.frontiersin.org/articles/10.3389/fimmu.2017.01657/full
Human Metabolome Database: Showing metabocard for Magnesium (HMDB0000547)
Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein ... and gene expression. Required for neural development including neural patterning and cell fate determination. Gene Name:. NME1 ...http://www.hmdb.ca/metabolites/HMDB0000547
IVNS1ABP - Wikipedia
2008). "The kelch protein NS1-BP interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control". ... "Entrez Gene: IVNS1ABP influenza virus NS1A binding protein". Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF ... Influenza virus NS1A-binding protein is a protein that in humans is encoded by the IVNS1ABP gene. In melanocytic cells IVNS1ABP ... 2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ ...https://en.wikipedia.org/wiki/IVNS1ABP
ATAD2 Is a Novel Cofactor for MYC, Overexpressed and Amplified in Aggressive Tumors | Cancer Research
ATAD2 binds to MYC target genes and cooperates with MYC in transcriptional activation. Next, we performed experiments to test ... In summary, these data show that ATAD2 is required for the efficient transcriptional activation of a subset of MYC target genes ... Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation. Genes Dev 2001; 15: 2069 ... B, ATAD2 binds to MYC target genes. Chromatin immunoprecipitation of P493-6 cells using antibodies against ATAD2 and MYC. HA ...http://cancerres.aacrjournals.org/content/69/21/8491
A Myc-regulated transcriptional network controls B-cell fate in response to BCR triggering | BMC Genomics | Full Text
Myc+/+ and MycΔ/Δ. Genes in orange have been reported as neighbors of the Myc-network in B cells , and genes with a red ... of all genes that are thought to be regulated by Myc and classifies Myc as the hub gene of our network. Among the 21 genes of ... C) Transcriptional regulation of cell cycling genes in mature Myc+/+ and MycΔ/Δ B cells was examined by qPCR at 18 h of BCR- ... Myc functions as a hub gene of the BCR-operated transcriptional network to control life and death of B cells. (A) Steady-state ...https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-10-323
Table of Contents | Cancer Research
WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma ... These results identify the histone methylation regulator WDR5 as a key cofactor for N-Myc-driven transcriptional activation and ...http://cancerres.aacrjournals.org/content/75/23
Anti-CTCF antibody [KT71] (ab111136) | Abcam
Acts as transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene. Also binds to the PLK and PIM1 ... Acts as a transcriptional activator of APP. Regulates APOA1/C3/A4/A5 gene cluster and controls MHC class II gene expression. ... Participates to the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, binding ... Sumoylated on Lys-74 and Lys-689; sumoylation of CTCF contributes to the repressive function of CTCF on the MYC P2 promoter. ...http://www.abcam.com/ctcf-antibody-kt71-ab111136.html
Transforming Growth Factor-β and Receptor Tyrosine Kinase-Activating Growth Factors Negatively Regulate Collagen Genes in...
Transcriptional suppression of cellular gene expression by c-myc. Mol Cell Biol. 1991;11:2291-2295. ... TGF-β1 and c-myc Oncoprotein mRNA. Because the oncoprotein c-myc has the potential to inhibit collagen gene transcription,26 27 ... Nuclear Accumulation of c-myc Oncoprotein. Because the ability of c-myc oncoprotein to affect gene transcription is dependent ... A differential pattern of c-myc gene expression was also apparent when the VSMCs from the two strains of rats were exposed to ...http://hyper.ahajournals.org/content/31/4/986
RAG1 | Cancer Genetics Web
... mainly due to gene amplification and Myc-mediated transcriptional upregulation. Here we show that B cell-specific miR-17~92 ... Gene array analyses of SmartDC/tWT1 demonstrated upregulation of several genes related to innate immunity. Thus, SmartDC/tWT1 ... Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. ... We experimentally identified miR-17~92 target genes by PAR-CLIP and validated select target genes in miR-17~92 transgenic mice ...http://www.cancerindex.org/geneweb/RAG1.htm
Assessing quality and completeness of human transcriptional regulatory pathways on a genome-wide scale | Springer for Research ...
Number of genes in common between MYC transcriptional targets derived from ten different pathway databases. Cells are colored ... For example, since it is known that MYC is an activator for most target genes , we expect that in siRNA experiments genes ... Given that MYC is involved in the transcriptional regulation of approximately 15% of all genes , one cannot argue that the ... That is why we transformed all gene sets to the HUGO Gene Nomenclature Committee approved gene symbols and names . ...https://rd.springer.com/article/10.1186/1745-6150-6-15
Bello-Fernandez C., Packham G., Cleveland J. L. The ornithine decarboxylase gene is a transcriptional target of c-Myc. Proc. ... myc is a transcriptional activator of ODC (29 , 30) and that ODC is a mediator of c-myc-induced apoptosis in murine myeloid ... Caco-2 cells are one of the few colon tumor lines that contain a normal K-ras gene (36 , 37) . These cells possess many of the ... The activation of K-ras may lead to the down-regulation of genes that are not necessary for growth but are necessary for cell ...http://cebp.aacrjournals.org/content/9/11/1155
KAKEN - Research Projects | Clarification of molecular mechanisims of hepatocellular carcinoma caused by hepatitis virus...
Publications] Koike,K.et al.: 'Transcriptional activation of the human c-Myc gene by simian virus 40 large Tantigen without ... Publications] Shimazu T.: 'Post-transcriptional control of the level of mRNA by hepatitis B virus X gene in the transient ... Cytoplasmic retention of the p53 tumor suppressor gene product is observed in the hepatitis B virus X gene-transfected cells.' ... Publications] Noda K.: 'Gene expression of α 1-6 fucosyltransferase in human hepatoma tissues: A pos sible implication for ...https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09253102/
Bello-Fernandez C., Packham G., Cleveland J. L. The ornithine decarboxylase gene is a transcriptional target of c-Myc. Proc. ... Ben-Yosef T., Yanuka O., Halle D., Benvenisty N. Involvement of Myc targets in c-myc and N-myc induced human tumors. Oncogene, ... Similar to the human VEGF gene, the mouse gene for VEGF has been shown to encode three alternatively spliced forms of VEGF ( ... Hung, W. C., Chai, C. Y., Huang, J. S., and Chuang, C. Y. Expression of cyclin D1 and c-Ki-ras gene product in human epithelial ...http://cancerres.aacrjournals.org/content/60/20/5696
Gartel AL and Shchors K (2003) Mechanisms of c-myc-mediated transcriptional repression of growth arrest genes. Exp Cell Res 283 ... Because c-Myc also represses p27 transcription by direct binding of Myc/Max complexes in p27 promoter, HIF-1α can derepress p27 ... Construction and Assay of a p21 Reporter Gene. To make a p21 promoter-driven luciferase reporter gene, the DNA coding human p21 ... 2004) demonstrated the mechanism of p21 induction by HIF-1α (i.e., c-Myc represses p21 transcription): HIF-1α displaces c-Myc ...http://molpharm.aspetjournals.org/content/70/6/1856
Regulatory Mechanisms of Metamorphic Neuronal Remodeling Revealed Through a Genome-Wide Modifier Screen in Drosophila...
1988 An initiation site of DNA replication with transcriptional enhancer activity present upstream of the c-myc gene. EMBO J. 7 ... 1998 c-Myc gene single-strand binding protein-1, MSSP-1, suppresses transcription of alpha-smooth muscle actin gene in chicken ... 2000b MSSP promotes ras/myc cooperative cell transforming activity by binding to c-Myc. Genes Cells 5: 127-141. ... In contrast, crosses of the test stock with Myc2 and Myc4 failed to suppress the wing expansion phenotype, and Myc4 failed to ...http://www.genetics.org/content/206/3/1429?rss=1
Ornithine decarboxylase - Wikipedia
"The ornithine decarboxylase gene is a transcriptional target of c-Myc". Proc. Natl. Acad. Sci. U.S.A. 90 (16): 7804-8. doi: ... ODC is a transcriptional target of the oncogene Myc and is upregulated in a wide variety of cancers. The polyamine products of ... polyamines also upregulate gap junction genes and downregulate tight junction genes. Gap junction genes are involved in ... ODC gene expression is induced by a large number of biological stimuli including seizure activity in the brain. Inactivation of ...https://en.wikipedia.org/wiki/Ornithine_decarboxylase
FUBP1 (far upstream element (FUSE) binding protein 1)
As described in the previous paragraph these characteristics are important for the transcriptional regulation of the c-myc gene ... Transcriptional regulation of the c-myc promoter by the FUBP family Because of the unconventional binding properties of FUBP1 ( ... FUBP1 is a transcriptional regulator and fulfills an important function in the precise control of c-myc transcription ( ... The pro-apoptotic genes Bik, Noxa, TRAIL and TNF-α showed a reduced expression in the absence of FUBP1, whereas gene-expression ...http://atlasgeneticsoncology.org/Genes/FUBP1ID50675ch1p31.html
An expression module of WIPF1-coexpressed genes identifies patients with favorable prognosis in three tumor types | SpringerLink
Literature gene network analysis revealed that among WIPF1 co-expressed genes known direct transcriptional targets of c-myc, ... Fused transcriptional regulation network of genes of the WIPF1 module that are regulated by c-myc, ESR1 or p53. Here we show ... like the gene list of the WIPF1 signature) or genes lists associated with Gene Ontology (GO) terms in gene lists of literature ... Significance of enrichment of gene groups (be it WIPF1 coexpressed genes or genes associated with GO categories) in subnetworks ...https://link.springer.com/article/10.1007%2Fs00109-009-0467-y