*  Cardiomyocyte-Specific Knockout and Agonist of Peroxisome Proliferator-Activated Receptor-γ Both Induce Cardiac Hypertrophy in...
Gene-inactivation studies have established the role of nuclear transcription factor PPAR-γ in trophoblast function,1 adipocyte ... PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro. Mol Cell. 1999; 4: 611-617. ... TZDs have been shown to activate p38-MAPK independent of PPAR-γ in other cell types.39 Rosiglitazone significantly increased ... RT-QPCR was used to measure expression levels of cardiac genes. GAPDH was used as an endogenous control. LC indicates ...
  http://circres.ahajournals.org/content/97/4/372
*  Peroxisome proliferator-activated receptor - Wikipedia
... when the PPAR binds its ligand, transcription of target genes is increased or decreased, depending on the gene. The RXR also ... and 15-HpETE activate to varying degrees PPAR alpha, beta/delta, and gamma. PPARγ activation by agonist RS5444 may inhibit ... 1] (PPAR Resource Page, Penn State University). [2] (Nuclear Receptor Resource). PPAR reference outline (Rutgers University). ... Endogenous ligands for the PPARs include free fatty acids and eicosanoids. PPARγ is activated by PGJ2 (a prostaglandin) and ...
  https://en.wikipedia.org/wiki/Peroxisome_proliferator-activated_receptor
*  Transcriptional Regulation by Nuclear Corepressors and PGC-1α: Implications for Mitochondrial Quality Control and Insulin...
The journal also welcomes preclinical and clinical trials of drugs that can modulate PPAR activity, with a view to treating ... PPAR Research is a peer-reviewed, Open Access journal that publishes original research and review articles on advances in basic ... α and nuclear corepressors. PPARγ and ERRα activate the transcription of a broad range of genes that control glucose uptake, ... Ligand-dependent SUMOylation of the PPARγ targets PPARγ to NCoR1-HDAC3 (histone deacetylases 3) complexes on gene promoters. ...
  https://www.hindawi.com/journals/ppar/2012/348245/
*  PPAR- Signaling Crosstalk in Mesenchymal Stem Cells
The journal also welcomes preclinical and clinical trials of drugs that can modulate PPAR activity, with a view to treating ... PPAR Research is a peer-reviewed, Open Access journal that publishes original research and review articles on advances in basic ... noncanonical Wnt-5a was capable to repress activation by PPAR-γ recombinant and endogenous PPAR-. target gene promoters. We ... Peroxisome proliferator-activated receptor-gamma (PPAR-γ) belongs to the nuclear receptor (NR) superfamily and regulates target ...
  https://www.hindawi.com/journals/ppar/2010/341671/
*  Hepodxilin analog enantiomers - Patent # 8710252 - PatentGenius
... controlling the biological effects of PPAR mediated transcriptional control for the treatment of diseases such as cancer, ... a PPAR gamma agonist can be used to gain fatty tissue. Some PPAR gamma partial agonists may only activate a subset of genes, ... Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that regulate gene transcription in response ... PPAR gamma is the target ofthiazolidinediones, a class of antidiabetic drugs that function as direct ligands for PPAR gamma and ...
  http://www.patentgenius.com/patent/8710252.html
*  Rajnish Gupta, MD, Ph.D | Stanford Medicine Profiles
... gamma in benign and malignant prostate tissues and the ability of 15S-HETE to activate PPARgamma-dependent transcription and ... In contrast, PPARgamma-selective targets included genes linked to growth regulatory pathways (regenerating gene IA), colon ... The ability of H. pylori to activate nuclear factor (NF)-kappaB and increase levels of the NF-kappaB target IL-8 was blocked by ... These results support the hypothesis that 15-LOX-2-derived 15S-HETE may constitute an endogenous ligand for PPARgamma in the ...
  https://med.stanford.edu/profiles/rajnish-gupta
*  PPAR: The Portrait of a Target Ally to Cancer Chemopreventive Agents
The journal also welcomes preclinical and clinical trials of drugs that can modulate PPAR activity, with a view to treating ... PPAR Research is a peer-reviewed, Open Access journal that publishes original research and review articles on advances in basic ... are ligand-activated nuclear receptors that function as transcription factors regulating the expression of genes involved in ... Peroxisome proliferator-activated receptor-gamma (PPAR. ), one of three ligand-activated transcription factors named PPAR, has ...
  https://www.hindawi.com/journals/ppar/2008/436489/
*  Nuclear receptor - Wikipedia
Other synthetic nuclear receptor ligands have no apparent effect on gene transcription in the absence of endogenous ligand. ... "Structure of the intact PPAR-gamma-RXR-alpha nuclear receptor complex on DNA". Nature. 456 (7220): 350-356. doi:10.1038/ ... referred to as transcription coregulators) that facilitate or inhibit the transcription of the associated target gene into mRNA ... Because the expression of a large number of genes is regulated by nuclear receptors, ligands that activate these receptors can ...
  https://en.wikipedia.org/wiki/Nuclear_receptor
*  The Role of PPAR in the Transcriptional Control by Agonists and Antagonists
The journal also welcomes preclinical and clinical trials of drugs that can modulate PPAR activity, with a view to treating ... PPAR Research is a peer-reviewed, Open Access journal that publishes original research and review articles on advances in basic ... γ target gene transcription. We then analyzed the molecular mechanism of cPA's action on PPARγ. In this paper, we summarize the ... M. Schupp and M. A. Lazar, "Endogenous ligands for nuclear receptors: digging deeper," Journal of Biological Chemistry, vol. ...
  https://www.hindawi.com/journals/ppar/2012/362361/
*  Current Advances in the Biochemical and Physiological Aspects of the Treatment of Type 2 Diabetes Mellitus with...
The journal also welcomes preclinical and clinical trials of drugs that can modulate PPAR activity, with a view to treating ... PPAR Research is a peer-reviewed, Open Access journal that publishes original research and review articles on advances in basic ... The resulting complexes activate the transcription of specific target genes, resulting in the induction of signaling cascades ... blood glucose levels and circulating triglycerides by binding to the nuclear peroxisome proliferator-activated receptor gamma ( ...
  https://www.hindawi.com/journals/ppar/2016/7614270/
*  PPARγ-Activating Angiotensin Type-1 Receptor Blockers Induce Adiponectin | Hypertension
Consistently with its PPARγ-activating properties, irbesartan also induced adipose expression of the PPARγ-target gene aP2 ( ... that a subset of ARBs including irbesartan has the potential to activate the insulin-sensitizing nuclear hormone receptor PPARγ ... PPARalpha inhibits TGF-beta-induced beta5 integrin transcription in vascular smooth muscle cells by interacting with Smad4. ... indicating that endogenous Ang II effects including AT2R activation are not required for the ARB effects in our system. However ...
  http://hyper.ahajournals.org/content/46/1/137
*  Eicosanoid - Wikipedia
Prostanoids also activate the PPARγ members of the steroid/thyroid family of nuclear hormone receptors, and directly influence ... directly activate gene transcription. Of these, the action on eicosanoids is the best explored. In general, the eicosanoids ... Dihomo-gamma-linolenic acid (DGLA), 8Z, 11Z,14Z-eicosatrienoic acid is an ω-6 fatty acid with three cis double bonds, each ... In this view, the opposing effects of ω-6 PUFA-derived and ω-3 PUFA-derived eicosanoids on key target cells underlie the ...
  https://en.wikipedia.org/wiki/Eicosanoid
*  Bisphenol A affects androgen receptor function via multiple mechanisms
Estrogen-related receptor gamma modulates energy metabolism target genes in human trophoblast. Placenta. 2012;33:688-695. [ ... was screened for the ability of these substances to activate or inhibit transcription by a panel of 10 different nuclear ... PPARγ (peroxisome proliferator-activated receptor gamma), PPARδ (peroxisome proliferator-activated receptor delta), RXRα ( ... Nuclear receptor redistribution assays. Endogenous ER and AR receptors are highly mobile and dynamic within cells. Upon ligand ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3722857/?lang=en-ca
*  Frontiers | Cannabinoids Modulate Neuronal Activity and Cancer by CB1 and CB2 Receptor-Independent Mechanisms | Pharmacology
Considering the CNS and cancer together allows identification of non-cannabinoid receptor targets that are shared and divergent ... Considering the CNS and cancer together allows identification of non-cannabinoid receptor targets that are shared and divergent ... This comparative approach allows the identified targets to be compared and contrasted, suggesting potential new areas of ... This comparative approach allows the identified targets to be compared and contrasted, suggesting potential new areas of ...
  https://www.frontiersin.org/articles/10.3389/fphar.2017.00720/full
*  Antaeus Labs Introduces: Lipomorph - AnabolicMinds.com
Peroxisome proliferator-activated receptor alpha target genes. PPAR Res 2010.. [6] Barbera, M.J., Schluter, A., Pedraza, N., ... Target(s):. Stearoyl vanillylamide, capsaicin and similar compounds activate the transient receptor potential cation channel V1 ... 2003). Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-α. Nature 425, 90-93 ... PGC-1α is a transcriptional coactivator that binds to and activates transcription factors that regulate the genes involved in ...
  http://anabolicminds.com/forum/antaeus-labs/251859-antaeus-labs-introduces.html
*  Protocols and Video Articles Authored by Cam Patterson (Translated to Hebrew)
PPAR) transcription factors are nuclear receptors initially identified for their key role in regulating metabolic processes. ... led to the concomitant upregulation of this SWI/SNF target gene. Using a THBS1 promoter-reporter gene, we further show that BAF ... However, the exact function of endogenous XIAP in regulating mammalian apoptosis is less clear. Endogenous XIAP strictly ... HG did not activate the ubiquitin proteasome system (UPS) in cardiomyocytes as indicated by a UPS reporter, nor did it increase ...
  https://www.jove.com/author/Cam_Patterson?language=Hebrew
*  The Role of Skeletal Muscle Estrogen Receptors in Metabolic Homeostasis and Insulin Sensitivity | SpringerLink
Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of ... The nuclear receptor PPARbeta/delta programs muscle glucose metabolism in cooperation with AMPK and MEF2. Genes & Development, ... Multiple signalling pathways redundantly control glucose transporter GLUT4 gene transcription in skeletal muscle. The Journal ... Nadal, A., Alonso-Magdalena, P., Soriano, S., Quesada, I., & Ropero, A. B. (2009). The pancreatic beta-cell as a target of ...
  https://link.springer.com/chapter/10.1007/978-3-319-70178-3_13
*  Protocols and Video Articles Authored by Li Cai (Translated to Arabic)
Treatments with various ligands of nuclear receptors reveal that Angptl3 is a target gene of liver X receptor, while Angptl4 ... Rats were given AGEs alone by iv injection at 100 mg/kg daily with or without oral supplementation of PPAR-gamma agonist ... and other transcription factors to activate gluconeogenesis and increase hepatic glucose output. Given the broad spectrum of ... Inhibition of endogenous ARC expression by ARC antisense oligonucleotides reduced the inhibitory effect of preconditioning on ...
  https://www.jove.com/author/Li_Cai?language=Arabic
*  Protocols and Video Articles Authored by Faramarz Dehghani (Translated to Norwegian)
PPAR-alpha but not PPAR-gamma is the endogenous binding site for PEA-mediated neuroprotection, and (3) PEA may activate PPAR- ... transactivator of transcription)-Glo1. In summary, there are strong indications that Glo1 seems to be a suitable target to ... mapped the rodent brain and pituitary for an ICER immunoreaction and found a nuclear staining for this transcription factor. ... mRNA levels for the clock genes Period1, Cryptochrome1, Clock, and Bmal1, and also amounts of corresponding clock gene proteins ...
  https://www.jove.com/author/Faramarz_Dehghani?language=Norwegian
*  Articles Added on October 10, 2012
Genomic and gene-targeted studies of enhancer action revealed novel mechanisms of transcriptional activation over a distance. ... Enhancers are regulatory DNA sequences that activate transcription over long distances. Recent studies revealed a widespread ... PPARγ). Inhibition of PPARγ thus represents a potential therapeutic approach for age-related bone loss. In ... ... Normally, needles of Taxus baccata during the growth period prominently stain blue for nuclear flavanols with the histochemical ...
  http://www.biomedsearch.com/added/20121010-p9.html
*  Role of free fatty acids in endothelial dysfunction
Free fatty acids activate renin-angiotensin system in 3T3-L1 adipocytes through nuclear factor-kappa B pathway. Journal of ... Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages. J Biol Chem. 2000; ... Targeting the AMPK/PI3K/Akt/eNOS signaling pathways: Importance of insulin and other endogenous targets. The AMPK/PI3K/Akt/eNOS ... Pioglitazone, a peroxisome proliferator-activated receptor gamma or PPARγ agonist, was shown to prevent ischemia-induced ED in ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC5530532/
*  METHODS AND COMPOSITIONS FOR TREATING ALZHEIMER'S DISEASE - Eleanore Bennett Charitable Trust #2
... peroxisome proliferator-activated receptor gamma) agonists mainly in peripheral adipose tissue, to activate transcription of ... gene product, mammalian target of rapamycin (mTOR), PDK1 itself, a still unknown kinase or an autophosphorylation event ( ... These cell extracts (100 μg) were used to IP endogenous Akt, and from this pull-down, determine the levels of associated PDK by ... In order to facilitate delivery of the composition of the invention across cell and/or nuclear membranes, compositions of ...
  http://www.freepatentsonline.com/y2015/0247857.html
*  Protocols and Video Articles Authored by Brandon K. Harvey (Translated to Portuguese)
PDYN, a Gene Implicated in Brain/mental Disorders, is Targeted by REST in the Adult Human Brain Biochimica Et Biophysica Acta. ... Suppression of Endogenous PPARγ Increases Vulnerability to Methamphetamine-induced Injury in Mouse Nigrostriatal Dopaminergic ... In the present study, we show that PDYN is targeted by the transcription factor REST in human neuroblastoma SH-SY5Y cells and ... Previous studies have shown that pretreatment with peroxisome proliferator-activated receptor gamma (PPARγ) agonist reduced ...
  https://www.jove.com/author/Brandon+K._Harvey?language=Portuguese
*  Frontiers | Chrysophanic Acid Suppresses Adipogenesis and Induces Thermogenesis by Activating AMP-activated Protein Kinase...
In addition, uncoupling protein 1 (UCP1) and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α), the ... PPARγ) and CCAAT/enhancer-binding protein alpha (C/EBPα) in 3T3-L1 adipocytes. In addition, uncoupling protein 1 (UCP1) and ... peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α), the brown fat specific thermogenic genes, were up ... PPARγ) and CCAAT/enhancer-binding protein alpha (C/EBPα) in 3T3-L1 adipocytes. ...
  https://www.frontiersin.org/articles/10.3389/fphar.2016.00476/full
*  Brain Sciences | Free Full-Text | Ethanol Neurotoxicity in the Developing Cerebellum: Underlying Mechanisms and Implications |...
Bastien, J.; Rochette-Egly, C. Nuclear retinoid receptors and the transcription of retinoid-target genes. Gene 2004, 328, 1-16 ... In vitro and in vivo studies show that ethanol can increases endogenous PG concentrations in the CNS [136,137], and expression ... Papi, A.; Tatenhorst, L.; Terwel, D.; Hermes, M.; Kummer, M.P.; Orlandi, M.; Heneka, M.T. PPARgamma and RXRgamma ligands act ... Zechel, C. Requirement of retinoic acid receptor isotypes alpha, beta, and gamma during the initial steps of neural ...
  http://mdpi.com/2076-3425/3/2/941/htm