*  Cardiomyocyte-Specific Knockout and Agonist of Peroxisome Proliferator-Activated Receptor-γ Both Induce Cardiac Hypertrophy in...
Gene-inactivation studies have established the role of nuclear transcription factor PPAR-γ in trophoblast function,1 adipocyte ... PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro. Mol Cell. 1999; 4: 611-617. ... TZDs have been shown to activate p38-MAPK independent of PPAR-γ in other cell types.39 Rosiglitazone significantly increased ... RT-QPCR was used to measure expression levels of cardiac genes. GAPDH was used as an endogenous control. LC indicates ...
  http://circres.ahajournals.org/content/97/4/372
*  Peroxisome proliferator-activated receptor - Wikipedia
... when the PPAR binds its ligand, transcription of target genes is increased or decreased, depending on the gene. The RXR also ... and 15-HpETE activate to varying degrees PPAR alpha, beta/delta, and gamma. PPARγ activation by agonist RS5444 may inhibit ... 1] (PPAR Resource Page, Penn State University). [2] (Nuclear Receptor Resource). PPAR reference outline (Rutgers University). ... Endogenous ligands for the PPARs include free fatty acids and eicosanoids. PPARγ is activated by PGJ2 (a prostaglandin) and ...
  https://en.wikipedia.org/wiki/Peroxisome_proliferator-activated_receptor
*  Nuclear receptor - Wikipedia
Other synthetic nuclear receptor ligands have no apparent effect on gene transcription in the absence of endogenous ligand. ... "Structure of the intact PPAR-gamma-RXR-alpha nuclear receptor complex on DNA". Nature. 456 (7220): 350-356. doi:10.1038/ ... referred to as transcription coregulators) that facilitate or inhibit the transcription of the associated target gene into mRNA ... Because the expression of a large number of genes is regulated by nuclear receptors, ligands that activate these receptors can ...
  https://en.wikipedia.org/wiki/Nuclear_receptor
*  Eicosanoid - Wikipedia
Prostanoids also activate the PPARγ members of the steroid/thyroid family of nuclear hormone receptors, and directly influence ... directly activate gene transcription. Of these, the action on eicosanoids is the best explored. In general, the eicosanoids ... Dihomo-gamma-linolenic acid (DGLA), 8Z, 11Z,14Z-eicosatrienoic acid is an ω-6 fatty acid with three cis double bonds, each ... In this view, the opposing effects of ω-6 PUFA-derived and ω-3 PUFA-derived eicosanoids on key target cells underlie the ...
  https://en.wikipedia.org/wiki/Eicosanoid
*  Hepodxilin analog enantiomers - Patent # 8710252 - PatentGenius
... controlling the biological effects of PPAR mediated transcriptional control for the treatment of diseases such as cancer, ... a PPAR gamma agonist can be used to gain fatty tissue. Some PPAR gamma partial agonists may only activate a subset of genes, ... Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that regulate gene transcription in response ... PPAR gamma is the target ofthiazolidinediones, a class of antidiabetic drugs that function as direct ligands for PPAR gamma and ...
  http://www.patentgenius.com/patent/8710252.html
*  Rajnish Gupta, MD, Ph.D | Stanford Medicine Profiles
... gamma in benign and malignant prostate tissues and the ability of 15S-HETE to activate PPARgamma-dependent transcription and ... In contrast, PPARgamma-selective targets included genes linked to growth regulatory pathways (regenerating gene IA), colon ... The ability of H. pylori to activate nuclear factor (NF)-kappaB and increase levels of the NF-kappaB target IL-8 was blocked by ... These results support the hypothesis that 15-LOX-2-derived 15S-HETE may constitute an endogenous ligand for PPARgamma in the ...
  https://med.stanford.edu/profiles/rajnish-gupta
*  PPAR: The Portrait of a Target Ally to Cancer Chemopreventive Agents
The journal also welcomes preclinical and clinical trials of drugs that can modulate PPAR activity, with a view to treating ... PPAR Research is a peer-reviewed, Open Access journal that publishes original research and review articles on advances in basic ... are ligand-activated nuclear receptors that function as transcription factors regulating the expression of genes involved in ... Peroxisome proliferator-activated receptor-gamma (PPAR. ), one of three ligand-activated transcription factors named PPAR, has ...
  https://www.hindawi.com/journals/ppar/2008/436489/
*  The Role of PPAR in the Transcriptional Control by Agonists and Antagonists
The journal also welcomes preclinical and clinical trials of drugs that can modulate PPAR activity, with a view to treating ... PPAR Research is a peer-reviewed, Open Access journal that publishes original research and review articles on advances in basic ... γ target gene transcription. We then analyzed the molecular mechanism of cPA's action on PPARγ. In this paper, we summarize the ... M. Schupp and M. A. Lazar, "Endogenous ligands for nuclear receptors: digging deeper," Journal of Biological Chemistry, vol. ...
  https://www.hindawi.com/journals/ppar/2012/362361/
*  PPARγ-Activating Angiotensin Type-1 Receptor Blockers Induce Adiponectin | Hypertension
Consistently with its PPARγ-activating properties, irbesartan also induced adipose expression of the PPARγ-target gene aP2 ( ... that a subset of ARBs including irbesartan has the potential to activate the insulin-sensitizing nuclear hormone receptor PPARγ ... PPARalpha inhibits TGF-beta-induced beta5 integrin transcription in vascular smooth muscle cells by interacting with Smad4. ... indicating that endogenous Ang II effects including AT2R activation are not required for the ARB effects in our system. However ...
  http://hyper.ahajournals.org/content/46/1/137
*  Bisphenol A affects androgen receptor function via multiple mechanisms
Estrogen-related receptor gamma modulates energy metabolism target genes in human trophoblast. Placenta. 2012;33:688-695. [ ... was screened for the ability of these substances to activate or inhibit transcription by a panel of 10 different nuclear ... PPARγ (peroxisome proliferator-activated receptor gamma), PPARδ (peroxisome proliferator-activated receptor delta), RXRα ( ... Nuclear receptor redistribution assays. Endogenous ER and AR receptors are highly mobile and dynamic within cells. Upon ligand ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3722857/?lang=en-ca
*  Frontiers | Cannabinoids Modulate Neuronal Activity and Cancer by CB1 and CB2 Receptor-Independent Mechanisms | Pharmacology
Considering the CNS and cancer together allows identification of non-cannabinoid receptor targets that are shared and divergent ... Considering the CNS and cancer together allows identification of non-cannabinoid receptor targets that are shared and divergent ... This comparative approach allows the identified targets to be compared and contrasted, suggesting potential new areas of ... This comparative approach allows the identified targets to be compared and contrasted, suggesting potential new areas of ...
  https://www.frontiersin.org/articles/10.3389/fphar.2017.00720/full
*  Protocols and Video Articles Authored by Faramarz Dehghani (Translated to Norwegian)
PPAR-alpha but not PPAR-gamma is the endogenous binding site for PEA-mediated neuroprotection, and (3) PEA may activate PPAR- ... transactivator of transcription)-Glo1. In summary, there are strong indications that Glo1 seems to be a suitable target to ... mapped the rodent brain and pituitary for an ICER immunoreaction and found a nuclear staining for this transcription factor. ... mRNA levels for the clock genes Period1, Cryptochrome1, Clock, and Bmal1, and also amounts of corresponding clock gene proteins ...
  https://www.jove.com/author/Faramarz_Dehghani?language=Norwegian
*  Role of free fatty acids in endothelial dysfunction
Free fatty acids activate renin-angiotensin system in 3T3-L1 adipocytes through nuclear factor-kappa B pathway. Journal of ... Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages. J Biol Chem. 2000; ... Targeting the AMPK/PI3K/Akt/eNOS signaling pathways: Importance of insulin and other endogenous targets. The AMPK/PI3K/Akt/eNOS ... Pioglitazone, a peroxisome proliferator-activated receptor gamma or PPARγ agonist, was shown to prevent ischemia-induced ED in ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC5530532/
*  Protocols and Video Articles Authored by Brandon K. Harvey (Translated to Portuguese)
PDYN, a Gene Implicated in Brain/mental Disorders, is Targeted by REST in the Adult Human Brain Biochimica Et Biophysica Acta. ... Suppression of Endogenous PPARγ Increases Vulnerability to Methamphetamine-induced Injury in Mouse Nigrostriatal Dopaminergic ... In the present study, we show that PDYN is targeted by the transcription factor REST in human neuroblastoma SH-SY5Y cells and ... Previous studies have shown that pretreatment with peroxisome proliferator-activated receptor gamma (PPARγ) agonist reduced ...
  https://www.jove.com/author/Brandon+K._Harvey?language=Portuguese
*  Articles Added on October 10, 2012
Genomic and gene-targeted studies of enhancer action revealed novel mechanisms of transcriptional activation over a distance. ... Enhancers are regulatory DNA sequences that activate transcription over long distances. Recent studies revealed a widespread ... PPARγ). Inhibition of PPARγ thus represents a potential therapeutic approach for age-related bone loss. In ... ... Normally, needles of Taxus baccata during the growth period prominently stain blue for nuclear flavanols with the histochemical ...
  http://www.biomedsearch.com/added/20121010-p9.html
*  Brain Sciences | Free Full-Text | Ethanol Neurotoxicity in the Developing Cerebellum: Underlying Mechanisms and Implications |...
Bastien, J.; Rochette-Egly, C. Nuclear retinoid receptors and the transcription of retinoid-target genes. Gene 2004, 328, 1-16 ... In vitro and in vivo studies show that ethanol can increases endogenous PG concentrations in the CNS [136,137], and expression ... Papi, A.; Tatenhorst, L.; Terwel, D.; Hermes, M.; Kummer, M.P.; Orlandi, M.; Heneka, M.T. PPARgamma and RXRgamma ligands act ... Zechel, C. Requirement of retinoic acid receptor isotypes alpha, beta, and gamma during the initial steps of neural ...
  http://mdpi.com/2076-3425/3/2/941/htm
*  Plus it
20). FXR can also negatively regulate transcription of specific target genes in an agonist-dependent manner. Although there is ... and may also enhance the expression of the NR1H4 gene itself via coactivation of the nuclear receptors PPARγ and HNF-α (108). ... Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. Mol Cell 3: 543-553, 1999. ... Decreased hepatic expression of PPAR-gamma coactivator-1 in cholesterol cholelithiasis. Eur J Clin Invest 36: 170-175, 2006. ...
  http://physiologyonline.physiology.org/content/23/5/286
*  Lipid Metabolism sub-cluster 89
Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-mediated transcription factor with roles in glucose, lipid ... Amino acids activate mammalian target of rapamycin complex 2 (mTORC2) via PI3K/Akt ... ... The gene responsible, estF, consisted of 1,080 bp that encoded 359 amino acid residues, with a typical N-terminal signal ... A series of endogenous fatty acid amides and their analogues (1-78) were prepared, and their inhibitory effects on pro- ...
  http://www.biomedsearch.com/cluster/14/Lipid-Metabolism/sub-89-p2.html
*  Pathogenic mechanism of second hand smoke induced inflammation and COPD.
Peroxisome proliferator-activated receptor-gamma (Pparγ)/PPARγ coactivator-1α (Pgc-1α). Relieves oxidative stress; expression ... and proinflammatory cytokines and chemokines through the upregulation of the transcription factors nuclear factor-κB (NF-κB) ... Regulates inflammation, antioxidant genes; downregulated in COPD. Mouse. FVBx129S6. Hwang et al., 2011 ... Tang K.,Rossiter H. B.,Wagner P. D.,Breen E. C.. (Year: 2004). Lung-targeted VEGF inactivation leads to an emphysema phenotype ...
  http://www.biomedsearch.com/nih/Pathogenic-mechanism-second-hand-smoke/22973236.html
*  Induction of Endothelial Nitric Oxide Synthase, SIRT1, and Catalase by Statins Inhibits Endothelial Senescence Through the Akt...
Real-Time Quantitative Reverse Transcription. Total RNA in HUVEC was isolated with Isogen (Nippon Gene Inc, Toyama, Japan). ... Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature. 2004; 429: 771-776. ... The expression levels of nuclear respiratory factor 1 (NRF-1) and mitochondrial transcription factor A (TFAM) relative to GAPDH ... Because HEK 293 cells lack an endogenous eNOS, we used HEK 293 cells to estimate accurate exogenous eNOS function. As shown in ...
  http://atvb.ahajournals.org/content/30/11/2205
*  IP receptor-dependent activation of PPARγ by stable prostacyclin analogues
Given that PPARγ suppresses proliferation of many cell types, suggests that this nuclear receptor may be a molecular target ... Activation of gene transcription by prostacyclin analogues is mediated by the peroxisome-proliferators-activated receptor (PPAR ... So far these agents have been reported to activate PPARα and PPARδ but not PPARγ. Given PPARγ agonists and prostacyclin ... It is less clear if PGI2 is a major endogenous ligand for PPARα and PPARγ. ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC1997304/
*  Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARγ agonist | Biochemical Journal
... can activate PPARγ as an agonist and regulate the expression levels of PPARγ target genes during adipocyte differentiation. ... 1994) Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell 79:1147-1156. ... the mevalonate pathway in mammals has been shown to affect several nuclear hormone receptors (such as PPARα, PPARγ and liver X ... PPARγ is a ligand-dependent transcription factor binding to the promoter of its target genes only as a heterodimer with RXR ( ...
  http://www.biochemj.org/content/438/1/111
*  Genetic Interference With Endothelial PPAR-γ (Peroxisome Proliferator-Activated Receptor-γ) Augments Effects of Angiotensin II...
PPAR-γ interacts with NF-κB (nuclear factor-kappa B), inhibiting its activation.4 NADPH oxidase is also a target of NF-κB.20 We ... Does peroxisome proliferator-activated receptor-gamma (PPAR gamma) protect from hypertension directly through effects in the ... 40 PPAR-γ regulates expression of target genes in part through interactions with NF-κB.4 Supporting this concept, human ... Much less is known on the cell-specific impact of PPAR-γ when driven by endogenous ligands. Recently, we found that endothelial ...
  http://hyper.ahajournals.org/content/70/3/559
*  Overview of MMP Biology and Gene Associations in Human Diseases | IntechOpen
Overview of MMP Biology and Gene Associations in Human Diseases , IntechOpen, Published on: 2017-12-20. Authors: Tamara Djuric ... Transcriptional gene silencing in mammalian cells by miRNA mimics that target gene promoters. Nucleic Acids Research. 2011;39: ... Moreover, once activated MMPs are able to activate other pro-MMPs. For example, MMP-3 could activate pro-MMP-1, -7, -8, -9 and ... Transcription could be also modified by genetic variation within the MMPs gene promoters. In the past two decades, the SNPs ...
  https://www.intechopen.com/books/the-role-of-matrix-metalloproteinase-in-human-body-pathologies/overview-of-mmp-biology-and-gene-associations-in-human-diseases/
*  Anti-beta Actin antibody [mAbcam 8226] - Loading Control (ab8226) References
Sarshad A et al. Nuclear myosin 1c facilitates the chromatin modifications required to activate rRNA gene transcription and ... Muruganandan S et al. Chemerin, a novel peroxisome proliferator-activated receptor gamma (PPARgamma) target gene that promotes ... Chen H et al. Inducing goat pluripotent stem cells with four transcription factor mRNAs that activate endogenous promoters. BMC ... Creyghton MP et al. H2AZ is enriched at polycomb complex target genes in ES cells and is necessary for lineage commitment. Cell ...
  http://www.abcam.com/beta-actin-antibody-mabcam-8226-loading-control-ab8226-references.html