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*  Oncogenic Potential of the miR-106-363 Cluster and Its Implication in Human T-Cell Leukemia | Cancer Research
We finally found that myosin regulatory light chain-interacting protein (Mylip), retinoblastoma-binding protein 1-like (Rbp1- ... 5B). Interestingly, tumor 139.1, which showed the highest miRNA levels, also exhibited the lowest protein level for both Mylip ... Arrow in the box, transcription orientation. Arrows, six miRNAs of the miR-106-363 cluster in 3′-end of Kis2 ncRNA (miR-106a, ... Furthermore, we identified myosin regulatory light chain-interacting protein, retinoblastoma-binding protein 1-like, and ...
  http://cancerres.aacrjournals.org/content/67/12/5699
*  Prognostic significance of RBP2-H1 variant of JARID1B in melanoma | BMC Cancer | Full Text
Retinoblastoma-binding protein 2-homolog 1: a retinoblastoma-binding protein downregulated in malignant melanomas. Mod Pathol. ... 11, 12] suggested that in melanoma the protein is essential for tumor growth and is a marker of a dynamically changing ... Functional analysis of the transcription repressor PLU-1/JARID1B. Mol Cell Biol. 2007;27:7220-35.View ArticlePubMedPubMed ... Facompre ND, Harmeyer KH, Basu D. Regulation of oncogenic PI3-kinase signaling by JARID1B. Oncotarget. 2017;8:7218-9.PubMed ...
  https://bmccancer.biomedcentral.com/articles/10.1186/s12885-017-3836-x
*  Retinoblastoma protein - Wikipedia
Hirsch HA, Gu L, Henry RW (December 2000). "The Retinoblastoma Tumor Suppressor Protein Targets Distinct General Transcription ... whose members have a pocket for the functional binding of other proteins. Should an oncogenic protein, such as those produced ... "Differential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding protein". Mol. Cell. ... The retinoblastoma protein (protein name abbreviated pRb; gene name abbreviated RB or RB1) is a tumor suppressor protein that ...
  https://en.wikipedia.org/wiki/Retinoblastoma_protein
*  Retinoblastoma-like protein 1 - Wikipedia
In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. ... The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is ... has oncogenic activity and associates with p107 in vivo". Genes & Development. 8 (22): 2680-90. doi:10.1101/gad.8.22.2680. PMID ... "Differential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding protein". Molecular and ...
  https://en.wikipedia.org/wiki/Retinoblastoma-like_protein_1
*  SV40 large T antigen - Wikipedia
"The binding domain structure of retinoblastoma-binding proteins". Protein Science. 2 (2): 155-64. doi:10.1002/pro.5560020204. ... SV40 large TAg, other polyomavirus large T antigens, adenovirus E1a proteins, and oncogenic human papillomavirus E7 proteins ... The transforming activity of TAg is due in large part to its perturbation of the retinoblastoma (pRb) and p53 tumor suppressor ... and T-antigen directs transcription and replication. SV40 DNA replication is initiated by binding of large T-antigen to the ...
  https://en.wikipedia.org/wiki/SV40_large_T_antigen
*  The Emerging Epigenetic Landscape in Melanoma | IntechOpen
Retinoblastomabinding protein 2‐homolog 1: a retinoblastomabinding protein downregulated in malignant melanomas. Modern ... impairs tumor growth Potentiates Ras‐driven transcription in NF1‐mutant tumors. [119-123]. ... The disease is driven by molecular alterations in oncogenic signaling pathways, such as mitogen‐activated protein kinase (MAPK ... binding protein MBD1 to silence tumor suppressor genes, such as RASSF1A and p53BP2 [83, 85]. In 2011, the SETDB1 gene, located ...
  https://www.intechopen.com/books/human-skin-cancer-potential-biomarkers-and-therapeutic-targets/the-emerging-epigenetic-landscape-in-melanoma/
*  LMO2 - Wikipedia
Mao S, Neale GA, Goorha RM (Apr 1997). "T-cell oncogene rhombotin-2 interacts with retinoblastoma-binding protein 2". Oncogene ... "LIM-only protein Lmo2 forms a protein complex with erythroid transcription factor GATA-1". Leukemia. 11 Suppl 3: 307-12. PMID ... Warren AJ, Colledge WH, Carlton MB, Evans MJ, Smith AJ, Rabbitts TH (Jul 1994). "The oncogenic cysteine-rich LIM domain protein ... "The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity". The ...
  https://en.wikipedia.org/wiki/LMO2
*  Protocols and Video Articles Authored by D. Gary Gilliland (Translated to Turkish)
Retinoblastoma binding protein 2 (RBP2), a nuclear protein implicated in the regulation of transcription and differentiation by ... the retinoblastoma tumor suppressor protein, contains a JmjC domain recently defined as a histone demethylase signature motif. ... Combination of Rapamycin and Protein Tyrosine Kinase (PTK) Inhibitors for the Treatment of Leukemias Caused by Oncogenic PTKs ... Absence of the Transcription Factor CCAAT Enhancer Binding Protein Alpha Results in Loss of Myeloid Identity in Bcr/abl-induced ...
  https://www.jove.com/author/D.+Gary_Gilliland?language=Turkish
*  Demethylase - Wikipedia
KDM5 protein family appear to play key developmental functions. The deletion of the JmjC domain of retinoblastoma binding ... KDM2A has roles in either promoting or inhibiting tumor function, and KDM2B has roles in oncogenesis. In many eukaryotes, the ... thought that KDM2A proteins may bind to many gene regulatory elements without the aid of sequence specific transcription ... "Genomic amplification and oncogenic properties of the GASC1 histone demethylase gene in breast cancer". Oncogene. 28 (50): 4491 ...
  https://en.wikipedia.org/wiki/Demethylase
*  Publications - Orkin Lab
Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1. ... The transcription factor GATA2 regulates differentiation of brown adipocytes. Tsai J, Tong Q, Tan G, Chang AN, Orkin SH, ... Sox2 maintains self renewal of tumor-initiating cells in osteosarcomas. Basu-Roy U, Seo E, Ramanathapuram L, Rapp TB, Perry JA ... Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. Tuveson DA, Shaw ...
  http://research.danafarberbostonchildrens.org/orkin/publications/
*  E2F4 (E2F transcription factor 4, p107/p130-binding)
... p107/p130-binding), Authors: Marie-Christine Paquin, Nathalie Rivard. Published in: Atlas Genet Cytogenet Oncol Haematol. ... Mechanism of transcriptional repression of E2F by the retinoblastoma tumor suppressor protein.. ... thus suggesting an oncogenic rather than a tumor suppressor role for this factor in breast cancer. The same group (Rakha et al ... transcription factor binding transcription factor binding animal organ morphogenesis protein domain specific binding regulation ...
  http://atlasgeneticsoncology.org/Genes/GC_E2F4.html
*  Development of a novel mouse model of hepatocellular carcinoma with nonalcoholic steatohepatitis using a high-fat, choline...
Expression of Retinoblastoma binding protein 6 (Rbbp6) in HFCD + DEN presented a slight decrease, though it was a large ... FBS fasting blood sugar, CRP C-reactive protein, IL interleukin, TNF-alpha tumor necrosis factor-alpha ... It could therefore facilitate further studies of the development, oncogenic potential, diagnosis, and treatment of this ... Mitochondrial transcription termination factor 2 (Mterf2), ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 (Asap2), and ...
  https://bmcgastroenterol.biomedcentral.com/articles/10.1186/s12876-016-0477-5
*  Plus it
Bdp, a new member of a family of DNA-binding proteins, associates with the retinoblastoma gene product. Cancer Res 1999; 59: ... Tumor growth was monitored every 3 days.. RNA quantification. Northern blot analysis was done as described previously using a ... Oncogenic potential of ARID3B in primary MEFs. A, ARID3B overexpression can immortalize primary MEFs. MEF at passage 2 were ... BC041792) as the probe ( 4). Primers used for reverse transcription-PCR (RT-PCR) and quantitative PCR analyses are listed in ...
  http://cancerres.aacrjournals.org/content/66/17/8331
*  miR-212 promotes pancreatic cancer cell growth and invasion by targeting the hedgehog signaling pathway receptor patched-1 |...
Furthermore, the mRNA and protein levels of Patched-1(PTCH1) were measured. Meanwhile, luciferase assays were performed to ... a pro-oncogenic function of miR-212 was demonstrated in PDAC. Moreover, up-regulated of PTCH1 could attenuate the effect ... In the present study, we investigated the effect of miR-212 on pancreatic ductal adenocarcinoma (PDAC) and its target protein. ... Histone demethylase retinoblastoma binding protein 2 is overexpressed in hepatocellular carcinoma and negatively regulated by ...
  https://jeccr.biomedcentral.com/articles/10.1186/1756-9966-33-54
*  Anti-Histone H3 (mono methyl K4) 抗体 - ChIP Grade (ab8895) 使用論文
Tumor-specific retargeting of an oncogenic transcription factor chimera results in dysregulation of chromatin and transcription ... Klose RJ et al. The retinoblastoma binding protein RBP2 is an H3K4 demethylase. Cell 128:889-900 (2007). WB . PubMed: 17320163 ... Xu X et al. A signature motif in LIM proteins mediates binding to checkpoint proteins and increases tumour radiosensitivity. ... Niu X et al. The von Hippel-Lindau tumor suppressor protein regulates gene expression and tumor growth through histone ...
  http://www.abcam.co.jp/histone-h3-mono-methyl-k4-antibody-chip-grade-ab8895-references.html
*  Human Polyomaviruses in Skin Diseases
LT-ag retains the regions with predicted oncogenic potentials such as the DnaJ domain and the retinoblastoma binding pocket, ... and to enhance transcription of the cyclin-dependent kinase inhibitor p21Waf1/Cip1 gene [5]. The additional early proteins ... "Identification of structural elements involved in the interaction of simian virus 40 small tumor antigen with protein ... the retinoblastoma (pRb) binding domain, the p53 binding domain, a nuclear localization signal (NLS), a DNA binding domain, and ...
  https://www.hindawi.com/journals/pri/2011/123491/
*  Receptor tyrosine kinases (RTKs) in breast cancer: signaling, therapeutic implications and challenges | Molecular Cancer | Full...
These pathways are also imperative for a reciprocal interaction of tumor and stromal cells. Multi-faceted role of RTKs renders ... structural and biological features which respond to environmental cues by initiating appropriate signaling cascades in tumor ... Retinoblastoma binding protein 2 (RBP2), an ER co-regulator is overexpressed in tamoxifen-resistant breast cancer patients and ... have observed the interaction of FGFR2 with progesterone and STAT5 in breast tumor resulted in increased transcription of PR/ ...
  https://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-018-0797-x
*  Comprehensive predictions of target proteins based on protein-chemical interaction using virtual screening and experimental...
Here, N is the number of human proteins, M is the number of proteins potentially binding to the incednine, t is the number of ... essential role for stress proteins in oncogenic transformation. Proc Natl Acad Sci U S A. 1994, 91: 8324-8328. 10.1073/pnas. ... Flanagan WM, Corthesy B, Bram RJ, Crabtree GR: Nuclear association of a T-cell transcription factor blocked by FK-506 and ... ACACA may also contribute to cell survival in Bcl-xL-overexpressing tumor cells. Indeed, our preliminary experiments suggested ...
  https://bmcchembiol.biomedcentral.com/articles/10.1186/1472-6769-12-2
*  Gentaur Molecular :Brady \ 1534 E \ 015354
Retinoblastoma-binding protein 3) (RBBP-3) (pRB-binding protein E2F-1). [UBE3A E6AP EPVE6AP HPVE6A] Ubiquitin-protein ligase ... Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54). ... Transcription factor phi AP3) (p120E4F). [TRIM27 RFP RNF76] Zinc finger protein RFP (EC 2.3.2.27) (RING finger protein 76) ( ... Tumor necrosis factor type 2 receptor-associated protein 3). [MDM2] E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double ...
  http://www.antibody-antibodies.com/product_det.php?id=1359680&supplier=search&name=1534_E
*  Gentaur Molecular :Sceti K.K. \ E.coli RuvA Protein \ 01-007
E.coli RuvA Protein \ 01-007 for more molecular products just contact us ... Retinoblastoma-binding protein 3) (RBBP-3) (pRB-binding protein E2F-1). [UBE3A E6AP EPVE6AP HPVE6A] Ubiquitin-protein ligase ... Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54). ... Transcription factor E4F) (p120E4F) (p50E4F). [hns bglY cur drdX hnsA msyA osmZ pilG topS b1237 JW1225] DNA-binding protein H- ...
  http://www.antibody-antibodies.com/product_det.php?id=333721&supplier=search&name=E.coli%20RuvA%20Protein
*  Gentaur Molecular :Sceti K.K. \ E.coli LexA repressor \ 01-006
Retinoblastoma-binding protein 3) (RBBP-3) (pRB-binding protein E2F-1). [APC2 APCL] Adenomatous polyposis coli protein 2 ( ... Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54). [E2F1 RBBP3] Transcription factor E2F1 (E2F-1 ... Tumor necrosis factor type 2 receptor-associated protein 3). [rseP ecfE yaeL b0176 JW0171] Regulator of sigma-E protease RseP ( ... DNA-binding protein H-NS (Heat-stable nucleoid-structuring protein) (Histone-like protein HLP-II) (Protein B1) (Protein H1). [ ...
  http://www.antibody-antibodies.com/product_det.php?id=333720&supplier=search&name=E.coli%20LexA%20repressor
*  Gentaur Molecular :Alpha Dia \ Anti E coli IgG, aff pure \ ECO11-A
Retinoblastoma-binding protein 3) (RBBP-3) (pRB-binding protein E2F-1). [APC2 APCL] Adenomatous polyposis coli protein 2 ( ... Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54). [E2F1 RBBP3] Transcription factor E2F1 (E2F-1 ... TP53 P53] Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53). [BRCA1 RNF53] Breast ... DNA-binding protein H-NS (Heat-stable nucleoid-structuring protein) (Histone-like protein HLP-II) (Protein B1) (Protein H1). [ ...
  http://www.antibody-antibodies.com/product_det.php?id=58396&supplier=search&name=Anti_E_coli%20IgG,%20aff%20pure
*  INDIVIDUALIZED CANCER TREATMENTS - Patent application
... at tumor protein p53 binding protein, 1 TP53BP1 15q15-q21 1881_at 31321_at 31725_s_at ATP-binding cassette, sub-family A (ABC1 ... at nuclear transcription factor Y, beta NFYB 84928 AU151875 218134_s_at RNA binding motif protein 22 RBM22 202023 NM_018047 218 ... at retinoblastoma binding protein 4 RBBP4 1p35.1 1518_at v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) ETS1 ... Predictions of the relative oncogenic pathway status and chemosensitivity of the validation cell lines or tumor samples are ...
  http://www.patentsencyclopedia.com/app/20100305058