*  Foley - Use of single domain antibodies as therapeutics in fibrosis and other chronic diseases
Our group uses single domain antibodies that have been developed from sharks to identify novel therapeutics against a number of ... Foley - Use of single domain antibodies as therapeutics in fibrosis and other chronic diseases*Shark antibodies as therapeutic ... We have obtained high affinity, single domain antibodies to a variety of targets including ion channels as well as G-protein ... they may offer advantages over traditional antibodies.. Our group uses a library of shark antibodies and a library of the human ...
  http://www.latrobe.edu.au/biochemistry-and-genetics/research/foley
*  Anti-venom Antibody Discovery and Development Service - Creative Biolabs
Creative Biolabs can offer the custom anti-venom antibody discovery and development service to meet our clients' specific ... such as single domain antibodies (sdAbs) and single-chain antibodies (scFvs), with better properties in terms of homogeneity, ... Human Antibody Discovery Native™ Antibody Discovery Service Magic™ Membrane Protein Antibodies Membrane Protein Production ... At minimal expense or time, antibodies are easier to fit the criteria more readily than traditional hybridoma. ...
  https://www.creative-biolabs.com/anti-venom-antibody-discovery-and-development-service.html
*  La Trobe Institute for Molecular Science - Wikipedia
AdAlta develops single-domain antibodies for use as therapeutics and diagnostics. Hexima focusses on commercialising plant- ... Molecular Design; research includes protein-drug interaction, molecular synthesis, and surface and material science. Molecular ... Cancer; research includes metastasis, cell crosstalk, anti-tumour immunity, and therapeutic resistance and sensitivity. ... and painted with Rennie's traditional pattern. The research groups in LIMS teach undergraduate and graduate courses for La ...
  https://en.wikipedia.org/wiki/La_Trobe_Institute_for_Molecular_Science
*  Most recent papers in the journal Journal of Biomedical Nanotechnology | Read by QxMD
Natural Single-Domain Antibody-Nanobody: A Novel Concept in the Antibody Field. ... In comparison with traditional antibodies, VHHs performs equally high specificity and affinity and low toxicity to targets, and ... Cutting Edge Protein and Carbohydrate-Based Materials for Anticancer Drug Delivery.. Rasheed Ahmad, Yan Deng, Ravina Singh, ... Nano-Vesicles are a Potential Tool to Monitor Therapeutic Efficacy of Carbon Ion Radiotherapy in Prostate Cancer. ...
  https://www.readbyqxmd.com/journal/40815
*  Single-domain antibody - Wikipedia
... single-domain antibodies are much smaller than common antibodies (150-160 kDa) which are composed of two heavy protein chains ... Single-domain antibodies allow a broad range of applications in biotechnical as well as therapeutic use due to their small size ... As well, they are easily isolated using the same phage panning procedure used for traditional antibodies, allowing them to be ... Human single-domain VHs can be isolated from engineered antibody domain libraries by phage display. Human single-domain ...
  https://en.wikipedia.org/wiki/Single-domain_antibody
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Single-domain antibodies (sdAbs) derived from human V(H) are considered to be less soluble and prone to aggregate which makes ... Traditional methodologies applied to the study of integral membrane protein function can be hampered by the inherent ... of the interaction sites between two proteins as well as screening for peptides that bind the target protein for therapeutic ... small protein domain has been developed. The albumin-binding domain is derived from Streptococcal protein G and has a strong ...
  https://www.jove.com/visualize/abstract/22253912/crystal-structure-human-single-domain-antibody-dimer-formed-through-v
*  State of Research
... caplicizumab is the first therapeutic nano antibody. Nano antibodies are single-domain antibody fragments that bear full ... Because they are encoded by single genes, nano antibodies are easier and more cost-effective than traditional antibodies to ... generate a panel of antibodies that recognize this protein with the goal of employing one of these antibodies as a therapeutic ... which has generated multiple single-domain antibodies now in early development.. (1) Nakanishi N, Ryan SD, Zhang X, Khan A, ...
  http://blog.allelebiotech.com/category/state-of-research/
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
However, as another opportunity, these interesting and stable single-domain antibodies8 can be easily engineered with different ... transient protein production in plants is a promising approach to produce vaccine antigens and therapeutic proteins within a ... Our preliminary work suggested that a large portion of nuclear vRNPs were not extracted during traditional cell lysis, and ... protein crystallization, purification, protein production, X-ray crystallography, Gene Composer, Protein Maker, expression, E. ...
  https://www.jove.com/visualize/abstract/23226397/self-subunit-swapping-occurs-another-gene-type-cobalt-nitrile
*  Neurodegenerative Diseases | Leaders in Pharmaceutical Business Intelligence (LPBI) Group
Choosing the right antibody platform can speed the discovery of a new therapeutics against these new targets. Single domain ... Accordingly, for HIV-1 it is sufficient to express a single protein, the p55 GAG protein, for efficient production of virus- ... Therapeutic Clearance of Amyloid by Antibodies to Serum Amyloid P Component. N Engl J Med 2015;373:1106-14. ... Nanotechnology is not in itself a single emerging scientific discipline but rather a meeting of traditional sciences such as ...
  https://pharmaceuticalintelligence.com/category/neurodegenerative-diseases/
*  Application # 2016/0194410. BINDING AGENT - Patents.com
... an antibody. In certain embodiments, a single-domain antibody is a human single-domain antibody (Domantis, Inc., Waltham, Mass ... By way of example, "an antibody" means one antibody or more than one antibody. [0043] The terms "polypeptide" and "protein" are ... 0054] Antibody fragments may be generated by traditional means, such as enzymatic digestion or by recombinant techniques. For a ... 0036] Bispecific monoclonal antibodies also represent quite interesting novel therapeutic modalities. A broad spectrum of ...
  http://patents.com/us-20160194410.html
*  Discovery Biology News
... or as a new bi-specific antibody therapeutic.. Camelid single domain antibodies are a novel bi-specific antibody platform that ... via traditional hybridoma, phage and yeast display, or single-domain antibody approaches. GenScript is your ideal partner for ... Protein engineering enhancement of crystal packing and X-ray phasing capabilities of camelid single-domain antibody (VHH) ... GenScript has over 5 years' experience in developing novel single domain antibodies as therapeutic agents or tool reagents for ...
  https://www.genscript.com/DiscoveryBiology_news.html
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
However, as another opportunity, these interesting and stable single-domain antibodies8 can be easily engineered with different ... transient protein production in plants is a promising approach to produce vaccine antigens and therapeutic proteins within a ... as a late-acting mediator has initiated a new field of investigation for the development of sepsis therapies using Traditional ... Provided that one protein can be tagged and another protein labeled, this method can be implemented for the investigation of ...
  https://www.jove.com/visualize/abstract/25347556/protective-effect-different-anti-rabies-virus-vhh-constructs-against
*  Most recent papers with the keyword Camelid* | Read by QxMD
Camelid single-domain antibodies (sdAbs, VHHs, or Nanobodies®) are types of antibody fragments that are composed of the heavy- ... As a novel class of antibody, they show many advantages compared with traditional antibodies such as smaller size, higher ... Protein function is typically studied and engineered by modulating protein levels within the complex cellular environment. To ... The development of innovative targeted therapeutic approaches are expected to surpass the efficacy of current forms of ...
  https://www.readbyqxmd.com/keyword/173
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
However, as another opportunity, these interesting and stable single-domain antibodies8 can be easily engineered with different ... transient protein production in plants is a promising approach to produce vaccine antigens and therapeutic proteins within a ... can pose challenges for traditional methods of cell isolation such as laser microdissection and fluorescence-activated cell ... After successful expression of DENV type 2 NS1 protein, the genes of VHH antibodies against NS1 protein were biopanned from a ...
  https://www.jove.com/visualize/abstract/24751715/development-vhh-antibodies-against-dengue-virus-type-2-ns1-comparison
*  NICBR Forum - Biostabilization - Abstracts
Ellen Goldman and Scott Walper will present a brief introduction to the intrinsically stabile single-domain antibodies (sdAb) ... Although Xoma does not work on biostabilizers per say, they do develop therapeutic antibody formulations that could benefit ... Insights gathered from this and other studies offer an opportunity for ATCC to step out from traditional biological sample ... Specimens collected in PBS were used for protein extraction and activities of β-glucuronidase and β-glucosidase were measured ...
  https://ncifrederick.cancer.gov/events/Biostabilization/abstracts.asp
*  Yale receives $8.4 million to study DNA repair in ca... ( New Haven Conn.Yale School of Medic...)
We have put together a program to target protein and DNA repair enzym... Cancer therapies such as radiation and chemotherapy ... 0] Singh Biotechnology Receives Second FDA Orphan Drug Designation for its Novel Single Domain Antibody for the Treatment of ... and how their repair pathways are regulated at the level of protein-protein interactions. ... We feel this could create an Achilles heel for cancer cells that would make them more vulnerable to traditional cancer ...
  http://www.bio-medicine.org/biology-news-1/Yale-receives--248-4-million-to-study-DNA-repair-in-cancer-cells-967-1/
*  Most recent papers with the keyword Infectious modification | Read by QxMD
Next-Generation DNA Sequencing of VH/VL Repertoires: A Primer and Guide to Applications in Single-Domain Antibody Discovery. ... Small modifications to multiple antibody biophysical features induced by vaccines and other therapeutic regimens can ... These post-translational modifications may assist in protein folding and play important roles in the functionality of S protein ... BACKGROUND: Traditional paramedian forehead flap reconstruction exploits the aesthetic subunit principle. Refinements and ...
  https://www.readbyqxmd.com/keyword/87637
*  Nanotechnology | Britannica.com
At very small sizes (a few nanometres), magnetic nanoclusters have a single magnetic domain, and the strongly coupled magnetic ... Furthermore, antibodies may be attached to the outer gold surface of the shells to cause them to bind specifically to certain ... While such traditional applications for physical sensing generally rely on microscale sensing devices, the advent of nanoscale ... These spherical "fuzz balls" are about the size of a typical protein but cannot unfold like proteins. Interest in dendrimers ...
  https://www.britannica.com/technology/nanotechnology
*  RECOMBINANT RENEWABLE POLYCLONAL ANTIBODIES - Patent application
... the antibody display library is a single domain VH, VHH, VL, scFv or Fab library. In some examples, the antibody display ... These recombinant molecules are recognized by protein A, as well as traditional rabbit secondary reagents, allowing their ... For instance, the described antibodies (and polyclonal pools of antibodies) can be used in research, in therapeutic ... 0070] Single-scaffold library: A synthetic antibody library based on a single antibody framework. [0071] Specific for a target ...
  http://www.patentsencyclopedia.com/app/20130085072
*  IJMS | Free Full-Text | Bispecific Antibodies as a Development Platform for New Concepts and Treatment Strategies | HTML
The single-chain-based bispecific antibodies usually bridge tumor cells with immune cells and form an immunological synapse ... antibodies that can simultaneously bind to cell surface antigens and payloads are a very ideal delivery system for therapeutic ... Bispecific antibodies in the IgG format include asymmetric bispecific antibodies and homodimerized bispecific antibodies, all ... Bispecific antibodies can also be used to treat hemophilia A by mimicking the function of factor VIII. Bispecific antibodies ...
  http://www.mdpi.com/1422-0067/18/1/48/htm
*  Protocols and Video Articles Authored by Peter Nagy (Translated to Norwegian)
This is accomplished by the viral p33 replication protein, which interacts with Opi1p FFAT domain protein and Scs2p VAP protein ... Since the therapeutic effects of the administration of a single type of polyphenol might be limited because of the reduced ... Recently, a new antibody against protein-kinase Cγ (PKCγ) was detected in a patient with paraneoplastic cerebellar degeneration ... We have demonstrated that sustainable milk production is possible from a traditional species, the dromedary camel, under an ...
  https://www.jove.com/author/Peter_Nagy?language=Norwegian
*  William Weis | Stanford Medicine Profiles
Here we report stabilization of two distinct β2AR conformations using single domain camelid antibodies (nanobodies)-a ... Drugging a Stem Cell Compartment Using Wnt3a Protein as a Therapeutic PLOS ONE Dhamdhere, G. R., Fang, M. Y., Jiang, J., Lee, K ... An epithelial tissue in Dictyostelium challenges the traditional origin of metazoan multicellularity BIOESSAYS Dickinson, D. J ... binding EGF-like domain, a second CUB domain, two complement control protein modules and a C-terminal serine protease domain. ...
  https://med.stanford.edu/profiles/william-weis
*  Diagnostics and Treatment of Metastatic Cancers with Magnetic Nanoparticles | OMICS International
c) relaxation losses in 'superparamagnetic' single-domain magnetic particles. d) frictional losses in viscous suspensions. ... The capture antibody-bound magnetic beads can lead to rapid immunoassay as they can be instantaneously bound to the substrate ... Therapeutic Applications. Hyperthermic therapy. Magnetic induced thermal therapy also known as Magnetic Fluid Hyperthermia (MFH ... In a study, Green Fluorescent Protein (GFP) gene were introduced into a mouse embryonic carcinoma cell line, P19CL6 using PEI ...
  https://www.omicsonline.org/diagnostics-and-treatment-of-metastatic-cancers-with-magnetic-nanoparticles-2155-983X.1000115.php?aid=17991
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... single domain group displayed normal performance across all semantic tasks, whereas the non-a-MCI-multiple domain group ... We expressed enhanced green fluorescent protein-tagged to ribosomal protein L10a in podocytes under the control of the collagen ... Gentianaceae) is more commonly known as "Ganyan-cao" and used mainly as a traditional Chinese folk medicine for the treatment ... To observe therapeutic efficacy of osteoarthritis treated by electroacupuncture, and explore its function of promoting ...
  https://www.jove.com/visualize?author=Hua%20Sun%20
*  DiVA - Search result
Single domain affinity proteins for the detection of the genome organizer protein SATB1Manuscript (preprint) (Other academic). ... investigated affibody variants could be completely blocked by premixing the target with the therapeutic monoclonal antibody ... corresponding to regions of the protein domain not addressed by traditional affibody molecule affinity maturation strategies. ... protein A (SPA)-IgG interaction was designed, in which a single domain was engineered to facilitate site-specific incorporation ...
  http://kth.diva-portal.org/smash/resultList.jsf?af=%5B%5D&aq=%5B%5B%7B%22personId%22%3A%22authority-person%3A31099+OR+0000-0003-4214-6991%22%7D%5D%5D&aqe=%5B%5D&aq2=%5B%5B%5D%5D&language=en&query=