*  Alternative Approaches for Acute Inhalation Toxicity Testing
Currently accepted guidelines for inhalation toxicity tests share core principles. These inform both essential testing needs to ... Additivity approaches may be useful for estimating toxicity of mixtures.. *A variety of available alternative test methods can ... Alternative approaches for acute inhalation toxicity testing to address global regulatory and non-regulatory data requirements ... Integrated approaches to testing and assessment will be needed to use these systems in ways that address the breadth of ...
  https://ntp.niehs.nih.gov/pubhealth/evalatm/3rs-meetings/past-meetings/inh-web-2016/index.html
*  Unilever's pathway-based, non-animal approaches to toxicity testing - Human Toxicology Project Consortium
... describes several areas of safety science in which they are using a pathway-based approach to replace traditional animal tests ... The article, 'Toxicity testing - non-animal approaches and safety science' (by… ... The article, "Toxicity testing - non-animal approaches and safety science" (by Fiona Reynolds, Carl Westmoreland and Julia ... describes several areas of safety science in which they are using a pathway-based approach to replace traditional animal tests ...
  https://humantoxicologyproject.org/2014/06/16/unilevers-pathway-based-non-animal-approaches-to-toxicity-testing/
*  MDMA Toxicity Workup: Approach Considerations, Imaging Studies, Other Tests
Send cultures of blood and urine for testing if signs of infection and fever are present. Consider lumbar puncture to exclude ... MDMA Toxicity Workup. Updated: Dec 20, 2017 * Author: In-Hei Hahn, MD, FACEP, FACMT; Chief Editor: Jeter (Jay) Pritchard Taylor ... Approach Considerations. If a patient gives a clear history of MDMA ingestion with mild symptoms and is hemodynamically stable ... Burgess C, O'Donohoe A, Gill M. Agony and ecstasy: a review of MDMA effects and toxicity. Eur Psychiatry. 2000 Aug. 15(5):287- ...
  https://emedicine.medscape.com/article/821572-workup
*  Salicylate Toxicity Workup: Approach Considerations, Toxicity Versus Serum Level, Bedside Ferric Chloride Testing
... making salicylate toxicity an important cause of morbidity and mortality. (See Epidemiology. ... Repeat these tests at least every 12 hours until the salicylate level falls and the acid-base disturbance improves. If ... Approach Considerations. Initial and serial salicylate levels are important in the evaluation of salicylate toxicity. The ... Toxicity Versus Serum Level. The toxicity of salicylates does not always correlate well with serum levels, and the levels are ...
  https://emedicine.medscape.com/article/1009987-workup
*  Applicability of ambient toxicity testing to national or regional water-quality assessment
Toxicity testing is one type of biological monitoring that can be used to identify possible effects of toxic contaminants. ... Toxicity-test results are most effective when used as a complement to chemical analyses, hydrologic measurements, and other ... However, all toxicity-testing procedures have certain limitations that must be considered in developing the methodology... ... Based on experimentation designed to monitor responses of organisms to environmental stresses, toxicity testing may have ...
  https://pubs.er.usgs.gov/publication/cir1049
*  African Journal of Biochemistry Research - protective effects of extract and fraction of root- bark of garcinia kola (heckel)...
Moreover, both the acute and sub-acute toxicities of ME and DCMF were determined in mice and albino rats with concentrations ... Lorke D (1983). A new approach to practical acute toxicity testing. Arch. Toxicol. 54:275-287.. Crossref ... Tietz NW (1995). Clinical guide to laboratory tests. 3rd edition. W.B Saunders company. Philadelphia, USA, pp. 518-519. ... Moreover, both the acute and sub-acute toxicities of ME and DCMF were determined in mice and albino rats with concentrations ...
  http://academicjournals.org/journal/AJBR/article-abstract/3FDBB7760578
*  Silbergeld, Ellen K.. Papers of Ellen K. Silbergeld, 1968-1994: A Finding Aid
Neurochemical Approaches to Toxicity Testing: [Artificial Food Dyes] Monte Carlo 1979 *445. "Probs in Exper[imental] studies of ... Organisation for Economic Co-operation and Development: Updating Panel/Ad Hoc Review and Editing Panel: Mutagen tests [draft ... Toxic Substances Control Act Section 4 (rules, guidance, Interagency Testing Committee (ITC) reports): Test rules, 1979-1980 [ ... "Structure, Mechanism & Toxicity," Changing Metal Cycles & Human Health, ed. Nriagu, pp. 391-404, 1984 ...
  http://oasis.lib.harvard.edu/oasis/deliver/~sch00906
*  Potentials of leaves of Aspilia africana (Compositae) in wound care: an experimental evaluation | BMC Complementary and...
Acute toxicity and lethality (LD50) test in mice established an i.p LD50 of 894 mg/kg for the methanol extract (ME). ... wound contaminants and rate of healing of experimentally-induced wounds in rats were studied as well as the acute toxicity and ... Lorke D: A new approach to practical acute toxicity testing. Arch Toxicol. 1983, 54: 251-187. 10.1007/BF01234480.View Article ... sodium chloride and mannitol fermentation tests [18]. Antimicrobial activity test was performed using the agar well diffusion ...
  https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/1472-6882-7-24
*  Items where Division is "Colleges (2008 onwards) | College of Life & Environmental Sciences" - eTheses Repository
Taylor, Nadine Suzanne (2010) Novel approaches to toxicity testing in Daphnia magna. Ph.D. thesis, University of Birmingham. ... Lieb, Ralf (2011) Horizontal and vertical transport in a multilayered aquifer of the Triassic sandstone, UK - tracer tests and ... Gavin, Alex (2016) Investigating the mechanisms of silver nanoparticle toxicity in Daphnia magna: a multi-omics approach. Ph.D ... White, Thomas Andrew (2014) Assessing toxicity in Daphnia magna: an oxidative lipidomic approach. Ph.D. thesis, University of ...
  http://etheses.bham.ac.uk/view/divisions/10col=5Flife.default.html
*  Nanotoxicology: Health & Environmental Impacts | Event Details | powered by RegOnline
2007). "A new approach to the toxicity testing of carbon-based nanomaterials--the clonogenic assay." Toxicol Lett 174(1-3): 49- ... Nanotest: development of in vitro tests to measure potential toxicity of nanoparticles to placental function ... 15:50 - 16:25 Toxic Effects of Nanomaterials to Trout: Implications for Fish Toxicity Testing, Characterisation of Test Media ... NanoTEST will develop alternative testing strategies and high-throughput toxicity-testing protocols using in vitro and in ...
  https://www.regonline.co.uk/builder/site/Default.aspx?eventid=161852
*  ALKBH7 drives a tissue and sex-specific necrotic cell death response following alkylation-induced damage
Alternative approaches in median lethality (LD50) and acute toxicity testing. Toxicol Lett 1989; 49: 159-170. [PubMed] ... ANOVA was performed with follow-up Tukey's tests. ... In addition, we tested whether WT or Alkbh7−/− mice exhibit any ... mice display increased resistance to MMS-induced toxicity without changes in bone marrow toxicity, we focused on additional ... To support this finding, we tested the response of WT and Alkbh7−/− MEF cells after treatment with TNF-α and z-vad-fmk, which ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC5550884/
*  Ocular Toxicity Test Method Evaluations
Pyrogen Tests Ocular Toxicity Test Method Evaluations. Ocular toxicity testing, one of the four most commonly conducted product ... The workshop identified best practices for chemical and product ocular toxicity testing using methods and approaches that ... OptiSafe Test Method. OptiSafe is an in vitro test method in which a test substance is applied to a semipermeable membrane. ... Short Time Exposure Test The short time exposure (STE) test is an in vitro test proposed for identifying ocular irritants. ...
  https://ntp.niehs.nih.gov/pubhealth/evalatm/test-method-evaluations/ocular/index.html
*  Toxicity Testing in the 21st Century: Using the New Toxicity Testing Paradigm to Create a Taxonomy of Adverse Effects
The ongoing refinement of the Ames test approach presages the future of toxicity testing and illustrates the need for time, ... The Ames test and its derivatives are great mutagenicity tests, but as carcinogenicity tests, they are often derided because of ... Toxicity Testing in the 21st Century: Using the New Toxicity Testing Paradigm to Create a Taxonomy of Adverse Effects. Kim ... the approaches proposed for toxicity testing in the 21st century are nonapical, focused on human cells, in vitro approaches, ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2902917/?lang=en-ca
*  Physicians Committee Awarded Prize for Work to End Animal Testing | The Physicians Committee
This report called for modernizing the toxicity testing and assessment of chemicals using nonanimal, human-relevant approaches. ... The EPA is also required to create a strategic plan to replace and reduce animal tests, provide incentives to use non-animal ... when the National Academies of Sciences released the groundbreaking report Toxicity Testing in the 21st Century: A Vision and a ... The Lush Prize acknowledges efforts to end or replace animal testing, with up to 350,000 British pounds awarded across multiple ...
  http://www.pcrm.org/media/news/physicians-committee-awarded-prize-for-work-to-end-animal-testing
*  prof. dr. A.H. (Aldert) Piersma - Veterinary Medicine - Utrecht University
Zebrafish embryotoxicity test for developmental (neuro)toxicity - Demo case of an integrated screening approach system using ... Complementary detection of embryotoxic properties of substances in the neural and cardiac embryonic stem cell tests. ... the rat Whole Embryo Culture and the Zebrafish Embryotoxicity Test as alternative methods for developmental toxicity testing of ... Toxicogenomic Approaches in Developmental Toxicology Testing. Chapter 31. In P.C. Barrow (Eds.), Teratogenicity Testing, ...
  https://www.uu.nl/staff/AHPiersma/0
*  Streamlining the preparation of annual toxic release inventory program reports, presented at EUEC 2010 on Environmental XPRT
This paper describes the approach used and results from sediment toxicity tests, discussing any causal relationships between ... Evaluation of Metals, Metalloids, and Ash Mixture Toxicity Using Sediment Toxicity Testing. Aug. 14, 2014. In December 2008, a ... Solving Toxicity Issue with Leachate - Case Study. Dec. 13, 2016. Toxicity of lanfills leachate is a big environmental concern ...
  https://www.environmental-expert.com/articles/streamlining-the-preparation-of-annual-toxic-release-inventory-program-reports-presented-at-euec-201-271482
*  Tissue residue - Wikipedia
... or tissue residue-based toxicity tests. Historically, aquatic toxicology toxicity tests have focused on water-based approaches ... A Tissue residue approach to toxicity testing is considered a more direct and less variable measure of chemical exposure and is ... The water-based approach has been re-evaluated due to challenges in assessing the toxicity of bioaccumulating chemicals. Water- ... Tissue residue is the only approach that inherently accounts for toxicity due to multiple exposure pathways. There is also a ...
  https://en.wikipedia.org/wiki/Tissue_residue
*  Alternatives to animal testing - Wikipedia
The low-throughput of current toxicity testing approaches (which are largely the same for industrial chemicals, pesticides and ... including more than 200 human tissue culture tests to replace toxicity and other testing on animals ... Today, AFAAR funds a ... Committee on Toxicity Testing and Assessment of Environmental Agents, National Research Council (2007). "Toxicity testing in ... to evaluate perturbations in key toxicity pathways, and to conduct targeted testing against those pathways. This approach will ...
  https://en.wikipedia.org/wiki/Alternatives_to_animal_testing
*  Joseph F. Holson - Wikipedia
"Nonclinical Juvenile Toxicity Testing". In Hood, R.D. Developmental and Reproductive Toxicology: A Practical Approach, Second ... FDA include a similar approach to standardize the statistical resolving power of tests relative to known interlaboratory and ... Early in Holson's career, while at NCTR, he led studies that assessed the developmental toxicity of FD&C Red No. 2, an amaranth ... Holson, J. F.; Stump, D. G.; Pearce, L. B.; Watson, R. E.; DeSesso, J. M. (2015-04-01). "Absence of developmental toxicity in a ...
  https://en.wikipedia.org/wiki/Joseph_F._Holson
*  Evidence-based toxicology - Wikipedia
Toxicity Testing in the 21st Century, has also been an impetus for EBT. EBT provides new tools for assessing test method ... This approach is similar to legal arguments Some experts warn that this approach could increase the evidence burden for proving ... Research in the 1970s and 1980s showed that different physicians regularly recommended different treatments and tests for ... National Research Council (2007). Toxicity Testing in the 21st Century: A Vision and a Strategy. Washington, DC: The National ...
  https://en.wikipedia.org/wiki/Evidence-based_toxicology
*  Lord Dowding Fund for Humane Research - Wikipedia
... toxicity testing of dental fillings, breast and lung cancer, product safety testing, Parkinson's disease, schizophrenia, cot ... These cells may play a crucial role in neurodegenerative disease but there has been no model on which to perform tests - but ... To date, the Fund has awarded grants approaching £2 million to researchers working in a wide range of research fields including ... Neurotoxicity, or nerve toxicity, is a potential side-effect of new drugs. By studying which substances cause neurotoxicity and ...
  https://en.wikipedia.org/wiki/Lord_Dowding_Fund_for_Humane_Research
*  Production of antibiotics - Wikipedia
The remainder must be tested for their selective toxicities and therapeutic activities, and the best candidates can be examined ... One such infection is Osteomyelitis which can offer a unique challenges in treatment efforts, one novel approach has been the ... rather than tests to show general inhibition of a culture. Research into antibiotic identification has shown the opportunity ... To conduct such a screen, isolates of many different microorganisms are cultured and then tested for production of diffusible ...
  https://en.wikipedia.org/wiki/Production_of_antibiotics
*  Sediment quality triad (SQT) - Wikipedia
... in community structure that directly relate to the test species used during the sediment toxicity portion of the triad approach ... Toxicity LOE are determined by the mean of toxicity category score from all relevant tests. Development of LOE for benthic ... Sediment toxicity is evaluated based on bioassay analysis. Standard bioassay toxicity tests are utilized and are not organism ... These bioassay tests evaluate effects based on different toxicological endpoints. The toxicity tests are conducted with respect ...
  https://en.wikipedia.org/wiki/Sediment_quality_triad_(SQT)
*  Evidence-based Toxicology Collaboration - Wikipedia
... of evidence-based approaches for helping researchers evaluate new laboratory tools and tests for assessing chemical toxicity. ... The need to improve how the performance of toxicological test methods is assessed was the main impetus for translating these ... speakers presented the concept of EBT as it pertains to decision-making about the utility of new toxicity tests and their ... The evidence-based approach that the collaboration is championing have been used in medicine for decades. Evidence-based ...
  https://en.wikipedia.org/wiki/Evidence-based_Toxicology_Collaboration
*  Draize test - Wikipedia
Maurice D: Direct toxicity to the cornea: a nonspecific process? In: Goldberg AM (Ed): In vivo Toxicology: Approaches to ... The FDA supports the test, stating that "to date, no single test, or battery of tests, has been accepted by the scientific ... uTH BADDIS The Draize Test is an acute toxicity test devised in 1944 by Food and Drug Administration (FDA) toxicologists John H ... Swanston DW: Eye irritancy testing. In: Balls M, Riddell RJ, Warden AN (Eds). Animals and Alternatives in Toxicity Testing. ...
  https://en.wikipedia.org/wiki/Draize_test