Potential efficacy and toxicity of GM1 ganglioside against trimethyltin-induced brain lesions in rats: comparison with...
GM1 ganglioside (one week each at 10, 5, and 2.5 mg GM1/kg per day, ip) or gradual food restriction leading to a reduction in ... G(M1) Ganglioside / toxicity*. Hippocampus / pathology, physiology. Male. Motor Activity / drug effects. Rats. Reinforcement ... Potential efficacy and toxicity of GM1 ganglioside against trimethyltin-induced brain lesions in rats: comparison with ... GM1 ganglioside (one week each at 10, 5, and 2.5 mg GM1/kg per day, ip) or gradual food restriction leading to a reduction in ...http://www.biomedsearch.com/nih/Potential-efficacy-toxicity-GM1-ganglioside/7566684.html
Myelin-Associated Glycoprotein (MAG) Protects Neurons from Acute Toxicity Using a Ganglioside-Dependent Mechanism
Alterations on Na+,K+-ATPase and Acetylcholinesterase Activities Induced by Amyloid-β Peptide in Rat Brain and GM1 Ganglioside...
Aβ-induced toxicity is believed to involve alterations on as Na+,K+-ATPase and acetylcholinesterase (AChE) activities, prior to ... GM1 is a ganglioside proposed to have neuroprotective roles in AD models, through mechanisms not yet fully understood. ... Amyloid-β induced toxicity involves ganglioside expression and is sensitive to GM1 neuroprotective action. *Fernando Kreutz, ... GM1 Ganglioside: Past Studies and Future Potential. *Massimo Aureli, Laura Mauri, +4 authors Sandro Sonnino ...https://www.semanticscholar.org/paper/Alterations-on-Na%2B%2CK%2B-ATPase-and-Activities-Induced-Kreutz-Scherer/069e08152b7cce68fb27a18ddf237fa582ed3112
Binding to Gangliosides Containing N-Acetylneuraminic Acid Is Sufficient To Mediate the Immunomodulatory Properties of the...
Mutants of type II heat-labile enterotoxin LT-IIa with altered ganglioside-binding activities and diminished toxicity are ... Gangliosides. Purified gangliosides were obtained from Matreya, LLC (Pleasant Gap, PA) or were purified from mouse peritoneal ... Peritoneal macrophage ganglioside expression. Although LT-IIb(T13I) binds preferentially to NeuGc gangliosides, the mutant ... Purification of total gangliosides from murine peritoneal macrophages. Gangliosides were isolated from peritoneal macrophages ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2884423/?lang=en-ca
Targeting O-Acetyl-GD2 Ganglioside for Cancer Immunotherapy
M. L. Davila, I. Riviere, X. Wang et al., "Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute ... Repeated injection of gangliosides alone in human or in mouse is not enough for inducing the synthesis of anti-ganglioside ... Figure 2: Schematic representation of the main pathway of O-acetyl-GD2 ganglioside biosynthesis. GD2 ganglioside is synthesized ... 3. Metabolism of O-Acetyl-GD2 Ganglioside. The modification of ganglioside expression in oncogenesis is mainly associated with ...https://www.hindawi.com/journals/jir/2017/5604891/
Tay-Sachs disease - Wikipedia
The hydrolysis of GM2-ganglioside requires three proteins. Two of them are subunits of hexosaminidase A; the third is a small ... leading to toxicity. Diagnosis is by measuring the blood hexosaminidase A level or genetic testing. It is a type of ... This red spot is a retinal area that appears red because of gangliosides in the surrounding retinal ganglion cells. The ... Deficiency in any one of these proteins leads to ganglioside storage, primarily in the lysosomes of neurons. Tay-Sachs disease ...https://en.wikipedia.org/wiki/Tay%E2%80%93Sachs_disease
KAKEN - Research Projects | Action of nitric oxide on the mammalian ovary and molecular biological approach on its signal...
Publications] M-A.Hattori,N.Nishida,M.Noda,N.Fjihara,R.Horiuchi: 'Ganglioside and nitric oxide function as local modulators in ... Reproductive Biology Update-novel tools for assessment of environmental toxicity. 43-57 (1998). *. Description. 「研究成果報告書概要(欧文)」 ... Publications] Hattori M-A,Nishida N,Noda N,Fujihara N&Horiuchi R: 'Ganglioside and nitric oxide function as local modulators in ... Publications] Hattori M-A, Nishida N, Noda N, Fujihara N & Horiuch R: 'Ganglioside and nitric oxide function as local ...https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09460139/
Alterations of membrane lipids and in gene expression of ganglioside metabolism in different brain structures in a mouse model...
Although GAG toxicity is not fully understood, previous works suggest a GAG-induced alteration in neuronal membrane composition ... These data suggest that the observed ganglioside changes result from a combined effect of GAGs on ganglioside biosynthesis and ... a total ganglioside increase in cortex and cerebellum, and a selective presence of GM3, GM2 and GD3 gangliosides in the ... Alterations of membrane lipids and in gene expression of ganglioside metabolism in different brain structures in a mouse model ...https://www.sigmaaldrich.com/catalog/papers/23774686
Frontiers | Metals and cholesterol: two sides of the same coin in Alzheimer's disease pathology | Frontiers in Aging...
... and Cell Toxicity"; Figure 2). The mechanism of aggregated Aβ toxicity is still a matter of debate. However, elevation of ROS ... Interactions of amyloid beta-protein with various gangliosides in raft-like membranes: importance of GM1 ganglioside-bound form ... The ganglioside GM1, which is predominantly found in the central nervous system, can bind Aβ peptides in lipid rafts to form a ... 2004). Enhanced toxicity and cellular binding of a modified amyloid beta peptide with a methionine to valine substitution. J. ...https://www.frontiersin.org/articles/10.3389/fnagi.2014.00091/full
Oncotarget | Targeting tumor-associated carbohydrate antigens: a phase I study of a carbohydrate mimetic-peptide vaccine in...
ANOVA, analysis of variance; CMP, carbohydrate mimicking peptide; DLT, dose-limiting toxicities; GD2, ganglioside disialic 2; ... Due to high background toxicity in preimmune plasma from this subject, no significant increase in plasma toxicity was observed ... No toxicities were observed. A summary of the subjects' status and response to the P10s-PADRE vaccination is listed in Tables ... This CMP was designed to mimic and induce responses to the ganglioside GD2  and the LeY antigen [12, 13]. In particular, LeY ...http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=21959&path%5B%5D=69621
Protocols and Video Articles Authored by Dae Hee Park
Sublimation of DAN Matrix for the Detection and Visualization of Gangliosides in Rat Brain Tissue for MALDI Imaging Mass ... of Simple Ganglioside Species GM2 and GM3 Detected by MALDI Imaging Mass Spectrometry in a Combined Rat Model of Aβ Toxicity ... Glutamate toxicity was induced for 1, 3, 6, and 24 h to injure and kill neurons. Immunofluorescence was used to stain for GM1 ... Gangliosides, a family of membrane lipids enriched in the central nervous system, may have a mechanistic role in mediating the ...https://www.jove.com/author/Dae++Hee_Park
Frontiers | Biophysical Insights into How Surfaces, Including Lipid Membranes, Modulate Protein Aggregation Related to...
2010). EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity. Proc. Natl. Acad. Sci. U.S.A. 107 ... Lin, M.-S., Chen, L.-Y., Wang, S. S. S., Chang, Y., and Chen, W.-Y. (2008). Examining the levels of ganglioside and cholesterol ... Toxicity in cell models is usually displayed without fibrillar or protofibrillar species, but rather a 54-83 kDa aggregate, ... It has been hypothesized that a potential pathway for Aβ toxicity may lie in its ability to modulate lipid membrane function. ...https://www.frontiersin.org/articles/10.3389/fneur.2013.00017/full
Most recent papers with the keyword toxic white matter | Read by QxMD
... and gangliosides with longer long-chain bases (d20:1) have been linked to toxicity and the pathogenesis of Alzheimer's disease ... Altered Insulin/Insulin-Like Growth Factor Signaling in a Comorbid Rat model of Ischemia and β-Amyloid Toxicity. ... Toxicity and Applications of Internalised Magnetite Nanoparticles Within Live Paramecium caudatum Cells. ... Membrane-lipid homeostasis in a prodromal rat model of Alzheimer's disease: Characteristic profiles in ganglioside ...https://www.readbyqxmd.com/keyword/61426
Monosialoganglioside‐Containing Nanoliposomes Restore Endothelial Function Impaired by AL Amyloidosis Light Chain Proteins |...
Ganglioside‐dependent factor, inhibiting lipid peroxidation in rat brain synaptosomes. Neurochem Int. 1992;20:401-407. ... It is caused by toxicity of misfolded light chain proteins (LC) in vascular, cardiac, and other tissues. There is no treatment ... GM1 ganglioside prevents seizures, Na+, K+‐ATPase activity inhibition and oxidative stress induced by glutaric acid and ... Oxidative stress alters the morphology and toxicity of aortic medial amyloid. Biophys J. 2015;109:2363-2370. ...http://jaha.ahajournals.org/content/5/6/e003318
"Examining the role of Ganglioside dysregulation in neurodegeneration and aging" by Sarah Caughlin
A comorbid rat model of stroke and Aβ toxicity, using an endothelin-1 (ET-1) induced unilateral striatal stroke together with ... Finally, chloroquine (CQ), a pharmacological inhibitor of ganglioside catabolism, was used as a treatment for ganglioside ... Ganglioside dysregulation has been implicated as an important mechanisms driving pathology in the aging brain, yet there is ... Results indicated that ganglioside dysregulation was correlated with the severity of the neurodegenerative injury and showed a ...https://ir.lib.uwo.ca/etd/5236/
Preparation of affinity-purified, biotiny... & related info | Mendeley
Biotinylated derivatives of tetanus toxin were prepared and isolated by chromatofocusing and ganglioside-affinity ... At molar biotin:toxin ratios from 1:1 to 20:1 only biotinylated derivatives with low toxicity were obtained; these derivatives ... A biotinylated tetanus toxin derivative purified by ganglioside-affinity chromatography was used to identify and localize ... Biotinylated derivatives of tetanus toxin were prepared and isolated by chromatofocusing and ganglioside-affinity ...https://www.mendeley.com/research-papers/preparation-affinitypurified-biotinylated-tetanus-toxin-characterization-localization-cell-surface-b/
Toxins and Toxicity Archives - Perfect Health Diet | Perfect Health Diet
One of the sialic acid-containing molecules gliadin binds to is called GM1 ganglioside. This molecule is found on the ... Category Archives: Toxins and Toxicity. Do the Elderly Need Paleo More than the Young?. Posted by Paul Jaminet on September 15 ... When wheat binds to GM1 ganglioside on the intestinal surface, it induces the formation of auto-antibodies that attack the ... It's possible, by the way, that differing toxicities among grains could be responsible for epidemiological evidence favoring " ...http://perfecthealthdiet.com/category/toxins-and-toxicity/
Microsoft powerpoint - the genus vibrio web [režim kompatibility]
toxicity. l The B unit mediates tight binding to a cell wall ganglioside of enterocytes in the small intestine. It means ... toxicity. l V. cholerae is pathogenic only for humans. Cholera is not an invasive infection. The microorganism do not reach the ... toxicity. - it has only a negligible significance as a virulence factor.. - it is a main factor of pathogenity,- it is heat- ...http://onlinepdfcatalog.com/l/lf.upol.cz1.html
"Overcoming Toxicity from Transgene Overexpression Through Vector Desig" by Diane L. Golebiowski
GM2 ganglioside, in cells resulting in cellular dysfunction and death. There is currently no treatment for GM2 gangliosidoses. ... We hypothesized that toxicity was due to high overexpression of HexA, which dose reduction of vector could not compensate for. ... The top three vectors that showed reduction of HexA expression with low toxicity were chosen and tested for safety in non-human ... A final formulation was chosen from the primate screen that showed overexpression of HexA with minimal to no toxicity. ...https://escholarship.umassmed.edu/gsbs_diss/895/
JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
The chimeric peptide also interacted with several other gangliosides, including major brain gangliosides (GM4, GD1a, GD1b, and ... It could inhibit the binding of A?1-42 onto neural SH-SY5Y cells and did not induce toxicity in these cells. In conclusion, ... Deciphering the glycolipid code of Alzheimer's and Parkinson's amyloid proteins allowed the creation of a universal ganglioside ... of toxicity are still unclear. Aβ is also deposited intramuscularly in Inclusion Body Myositis, a severe human myopathy. The ...https://www.jove.com/visualize/abstract/25140899/deciphering-glycolipid-code-alzheimer-s-parkinson-s-amyloid-proteins
Tetanus Toxin: Structure and Purification
It also inhibits the action of synaptic nerves and thus exhibits an important role in the toxicity of the toxin. On the other ... This fragment is seen to bind with gangliosides, motor endplates and synaptic membranes. It also helps in transportation of the ...https://www.ukessays.com/essays/sciences/tetanus-toxin-structure-purification-2135.php
Defective FA2H leads to a novel form of neurodegeneration with brain iron accumulation (NBIA).
Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity. Nat ... Protective role of endogenous gangliosides for lysosomal pathology in a cellular model of synucleinopathies. Am J Pathol 2009; ... Cd2þ, Mn2þ, Ni2þ and Se2þ toxicity to Saccharomyces cerevisiae lacking YPK9p the orthologue of human ATP13A2. Biochem Biophys ... has been implicated as a lysosomal divalent cation transporter.30 Impaired ganglioside signaling may impair normal lysosomal ...https://www.docme.ru/doc/1922125/defective-fa2h-leads-to-a-novel-form-of-neurodegeneration..
Expression and functional validation of heat-labile enterotoxin B (LTB) and cholera toxin B (CTB) subunits in transgenic rice ...
GM1-ganglioside receptor binding assay of LTB and CTB proteins. Expression levels of LTB and CTB protein in seeds from the T5 ... to endocytose and cause toxicity (Mason et al. 1998). ... GM1-ganglioside binding assay. Transgenic and wild-type rice ... a) GM1-ganglioside receptor binding assay of LTB and CTB protein expression in transgenic rice. The relative amount of LTB and ... 1991). LTB forms a 60-kDa pentamer that facilitates binding to the GM1-ganglioside receptors on host epithelial cells, allowing ...https://springerplus.springeropen.com/articles/10.1186/s40064-015-0847-4
Monoclonal Antibody A1G4 Plus BCG in Treating Patients With Cancer - Full Text View - ClinicalTrials.gov
Assess the toxicity and feasibility of immunizing patients with anti-idiotypic rat monoclonal antibody A1G4 combined with ... Determine whether immunization with A1G4 combined with BCG results in an immune response directed against GD2 ganglioside in ... If 0-1 patient experiences dose limiting toxicity (DLT) at a given dose level, then patients are accrued to the next higher ... have been followed for at least 8 weeks after the first immunization without encountering grade 3 or worse non-skin toxicity. ...https://www.clinicaltrials.gov/ct2/show/NCT00003023
B-Raf specific antibody responses in melanoma patients
Induction of antibodies against GD3 ganglioside in melanoma patients by vaccination with GD3-lactone-KLH conjugate plus ... and the protective effect was attributed to antibody dependent cellular toxicity . Therefore, the induction of Raf ... For different extracellular tumor antigens, including gangliosides, in melanoma, positive associations between the induction of ...http://pubmedcentralcanada.ca/pmcc/articles/PMC518968/?lang=en-ca