*  Obatoclax Mesylate and Topotecan Hydrochloride in Treating Patients With Relapsed or Refractory Small Cell Lung Cancer or...
Topoisomerase I Inhibitors. Topoisomerase Inhibitors. Enzyme Inhibitors. Molecular Mechanisms of Pharmacological Action. ... Experimental: Treatment (enzyme inhibitor therapy and chemotherapy) Patients receive obatoclax mesylate IV over 3 hours on day ...
  https://clinicaltrials.gov/ct2/show/NCT00521144
*  Human Topoisomerase II Assay Kit, Topo II Assay, kDNA, Topoisomerase II, Measure Topo II Activity in a Crude Extract
Human Topoisomerase II Assay Kit available from TopoGEN - measure topo II activity in a crude extract. Highly specific and ... cell-permeable inhibitor of topoisomerase II. Cancer Research 2007, 67: 4451-4458. doi: 10.1158/0008-5472.CAN-07-0393 ... Human Topoisomerase II Assay Kit Contents (For 100 assay kit size):. -Kinetoplast DNA (kDNA) 20 ug. -Marker linear kDNA in gel ... Human Topoisomerase II Enzyme (TG2000H, sold separately) was incubated with kDNA for 15 min at 37° C using the assay buffer ...
  https://www.topogen.com/topo-assay-kits-drug-screening-and-ice-assay-kits/topoisomerase-assay-kits/human-topoisomerase-ii-assay-kit.html
*  Irinotecan Hydrochloride and Cetuximab With or Without Ramucirumab in Treating Patients With Advanced Colorectal Cancer With...
Topoisomerase I Inhibitors. Topoisomerase Inhibitors. Enzyme Inhibitors. Molecular Mechanisms of Pharmacological Action. ... Angiogenesis Inhibitors. Angiogenesis Modulating Agents. Growth Substances. Physiological Effects of Drugs. Growth Inhibitors. ...
  https://clinicaltrials.gov/ct2/show/study/NCT01079780?show_locs=Y
*  NK314 | CAS#208237-49-4 | Chk1 inhibitor | topoisomerase II inhibitor | MedKoo Biosciences
Pretreatment with topoisomerase II catalytic inhibitors, ICRF-193 and suramin, reduced both cleavable complex-mediated DNA ... It inhibited topoisomerase II activity and stabilized topoisomerase II-DNA cleavable complexes. The DNA breaks occurred within ... but protease inhibitors and nuclease inhibitors only decreased the latter. ... 1h after treatment with NK314 even without digestion of topoisomerase II by proteinase K, whereas etoposide required digestion ...
  http://www.medkoo.com/products/6224
*  Optical-Tweezers Study of Topoisomerase Inhibition
Topoisomerase inhibitors as therapeutic weapons. Cortés, Expert Opinion on Therapeutic Patents 17(5), 2007 ... Topoisomerase V relaxes supercoiled DNA by a constrained swiveling mechanism.. Taneja B, Schnurr B, Slesarev A, Marko JF, ... Optical-Tweezers Study of Topoisomerase Inhibition. Pla D, Sischka A, Albericio F, Alvarez M, Fernandez-Busquets X, Anselmetti ... Pla D, Sischka A, Albericio F, Alvarez M, Fernandez-Busquets X, Anselmetti D. Optical-Tweezers Study of Topoisomerase ...
  https://pub.uni-bielefeld.de/publication/1633270
*  Topotecan : usage, side effects, expert advice and topotecan based medicines | 1mg
It is an inhibitor of topoisomerase, an enzyme important for replication of genetic material (DNA) in the cancer cells. Thus it ...
  https://www.1mg.com/generics/topotecan-210843
*  Research Highlight - Programmed activation of cancer cell apoptosis: A tumor-targeted phototherapeutic topoisomerase I inhibitor
This system contains SN-38-a prodrug of the topoisomerase I inhibitor irinotecan. Topoisomerase I is a vital enzyme that ... Programmed activation of cancer cell apoptosis: A tumor-targeted phototherapeutic topoisomerase I inhibitor. ... An elevated level of topoisomerase I is found in many carcinomas, making it an attractive target for the development of ... diminishes the expression of topoisomerase I, and enhances the expression of inter alia mitochondrial apoptotic genes, death ...
  http://chem.korea.ac.kr/index.php?mid=Research_Highlight&page=2&document_srl=2470
*  Recombinant human Topoisomerase I protein (ab3808) Protocols
There are no specific protocols for Recombinant human Topoisomerase I protein (ab3808). Please download our general protocols ... Agonists, activators, antagonists and inhibitors. Lysates. Multiplex miRNA assays. By research area. Cancer. Cardiovascular. ...
  http://www.abcam.com/recombinant-human-topoisomerase-i-protein-ab3808-protocols.html
*  Teniposide - DrugBank
This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA ... Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. ... Non-inhibitor. 0.8415. ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 ... Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segr.... Gene Name. TOP2A. Uniprot ...
  https://www.drugbank.ca/drugs/DB00444
*  IDENTIFICATION OF NOVEL TOPOISOMERASE INHIBITORS | SBIR.gov
THE ABILITY OF LEAD COMPOUNDS TO INHIBIT TOPOISOMERASE ACTIVITY IN VITRO USING PURIFIED TOPOISOMERASE I AND II, AS WELL AS ... BECAUSE TOPOISOMERASES HAVE BEEN IDENTIFIED AS THE PRIMARY TARGET OF SOME OF THE MOST POPULAR ANTINEOPLASTIC DRUGS CURRENTLY IN ... AND TRADITIONAL MEDICINES WILL BE ANALYZED IN A HIGH-THROUGHPUT BIOCHEMICAL ASSAY FOR THEIR ABILITY TO INHIBIT TOPOISOMERASE ...
  https://www.sbir.gov/sbirsearch/detail/245542
*  Beta-Lapachone | Topoisomerase inhibitor | Read Reviews & Product Use Citations
Beta-Lapachone is a selective DNA topoisomerase I inhibitor, exhibiting no inhibitory activities against DNA topoisomerase II ... Beta-Lapachone is a selective DNA topoisomerase I inhibitor, exhibiting no inhibitory activities against DNA topoisomerase II ... Related Topoisomerase Products. * SCR7 New SCR7 is a specific DNA Ligase IV inhibitor, which blocks nonhomologous end-joining ( ... Camptothecin is a specific inhibitor of DNA topoisomerase I (Topo I) with IC50 of 0.68 μM in a cell-free assay. Phase 2. ...
  http://www.selleckchem.com/products/beta-lapachone.html
*  Topoisomerase inhibitor - Wikipedia
Topoisomerase inhibitors are chemical compounds that block the action of topoisomerase (topoisomerase I and II), which are ... Topoisomerase inhibitors are often divided according to which type of enzyme it inhibits. Topoisomerase I inhibitors: ... "Definition of topoisomerase inhibitor - NCI Dictionary of Cancer Terms". "Dorlands Medical Dictionary:topoisomerase inhibitor ... topoisomerase poisons, which target the topoisomerase-DNA complex, and topoisomerase inhibitors, which disrupt catalytic ...
  https://en.wikipedia.org/wiki/Topoisomerase_inhibitor
*  Human Topoisomerase I Inhibitors
Topoisomerases are ubiquitous enzymes that solvetopological problems due to DNA (deoxyribonucleic acid) supercoiling occurring ... 2012) Topoisemerase I inhibitors In: Pommier Y (ed.) DNA Topoisomerases and Cancer. New York: Springer, pp. 245-277. ... Human Topoisomerase I Inhibitors. Alessandro Desideri, University of Roma Tor Vergata, Roma, Italy ... Pommier Y (2006) Topoisomerase I inhibitors: camptothecins and beyond. Nature Review Cancer 6 (10): 789-802. ...
  http://www.els.net/WileyCDA/ElsArticle/refId-a0026795.html
*  KAKEN - Research Projects | TOPOISOMERASE INHIBITORS ENHANCE THE CYTOCIDAL EFFECT OF AAV-HSVTK/GANCICLOVIR ON CANCER CELLS ...
Journal Article] Topoisomerase inhibitors enhance the cytocidal effect of AAV-HSVth/ganciclovir on head and neck cancer cells. ... TOPOISOMERASE INHIBITORS ENHANCE THE CYTOCIDAL EFFECT OF AAV-HSVTK/GANCICLOVIR ON CANCER CELLS. Research Project ... These findings suggest that the combination of AAV-mediated suicide gene therapy and treatment with topoisomerase inhibitors ... In the present study, we investigated whether topoisomerase inhibitors (etoposide and camptothecin) enhance the AAV vector- ...
  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14571627/
*  JAIRO | DNA-PK inhibition by NU7441 enhances chemosensitivity to topoisomerase inhibitor in non-small cell lung carcinoma cells...
DNA-PK inhibition by NU7441 enhances chemosensitivity to topoisomerase inhibitor in non-small cell lung carcinoma cells by ... blocking DNA damage repairDNA-PK inhibition by NU7441 enhances chemosensitivity to topoisomerase inhibitor in non-small cell ...
  http://jairo.nii.ac.jp/0112/00004898/en
*  Trisbenzimidazoles useful as topoisomerase I inhibitors - Rutgers, The State University of New Jersey
The present invention provides anti-neoplastic topoisomerase I inhibitors of the formula: ##STR1## wherein Ar is (C,sub,6,/sub ... In comparison to topoisomerase II inhibitors, there are relatively few known topoisomerase I inhibitors. Camptothecin ... or 13 as an inhibitor of topoisomerase I. Its weak activity as a topoisomerase I inhibitor correlated with its weak ... are inhibitors of topoisomerase I, as demonstrated by their ability to promote DNA cleavage in the presence of topoisomerase I ...
  http://www.freepatentsonline.com/5767142.html
*  Substituted Purine Analogues Define a Novel Structural Class of Catalytic Topoisomerase II Inhibitors | Cancer Research
Catalytic topoisomerase II inhibitors have the potential to protect cultured cells from topoisomerase II poison-induced ... serving as proof of principle that topoisomerase catalytic inhibitors can modulate the activity of topoisomerase poisons by ... Maleimide is a potent inhibitor of topoisomerase II in vitro and in vivo: a new mode of catalytic inhibition. Mol Pharmacol ... Substituted Purine Analogues Define a Novel Structural Class of Catalytic Topoisomerase II Inhibitors. Lars H. Jensen, ...
  http://cancerres.aacrjournals.org/content/65/16/7470
*  Complex response of breast epithelial cell lines to topoisomerase inhibitors. | Scholars@Duke
Complex response of breast epithelial cell lines to topoisomerase inhibitors.'s profile, publications, research topics, and co- ... The topoisomerase inhibitors, camptothecin and etoposide target the activity of topoisomerase I and II respectively. These ... Complex response of breast epithelial cell lines to topoisomerase inhibitors. Journal Article ... expression and activity of topoisomerase I and II, expression of mdr-1, p53 status, cell cycle arrest, level of apoptosis, and ...
  https://scholars.duke.edu/display/pub681456
*  Marine Drugs | Free Full-Text | Discovery of DNA Topoisomerase I Inhibitors with Low-Cytotoxicity Based on Virtual Screening...
Therefore, it is urgent to find and develop novel low toxic Topo I inhibitors. In recent years, during our ongoing research on ... In total, eight potent Topo I inhibitors were found from 138 low cytotoxic or non-cytotoxic compounds from coral-derived fungi ... In the present study, new Topo I inhibitors were discovered from low cytotoxic and non-cytotoxic natural products by virtual ... These newly discovered Topo I inhibitors exhibited structurally diverse and could be considered as a good starting point for ...
  http://www.mdpi.com/1660-3397/15/7/217
*  Etoposide (VP-16) | Topoisomerase II inhibitor | Buy Etoposide (VP-16) from Supplier AdooQ®
Etoposide forms a ternary complex with DNA and the topoisomerase II enzyme (which aids in DNA unwinding), prevents re-ligation ... Etoposide (VP-16) Topoisomerase II inhibitor Etoposide forms a ternary complex with DNA and the topoisomerase II enzyme (which ... Etoposide forms a ternary complex with DNA and the topoisomerase II enzyme (which aids in DNA unwinding), prevents re-ligation ... Etoposide forms a ternary complex with DNA and the topoisomerase II enzyme (which aids in DNA unwinding), prevents re-ligation ...
  http://www.adooq.com/etoposide-vp-16.html
*  Abstract 5370: Potentiation of the novel topoisomerase I inhibitor indenoisoquinoline NSC743400 by Chk1/2 inhibitors in p53...
Abstract 5370: Potentiation of the novel topoisomerase I inhibitor indenoisoquinoline NSC743400 by Chk1/2 inhibitors in p53- ... Abstract 5370: Potentiation of the novel topoisomerase I inhibitor indenoisoquinoline NSC743400 by Chk1/2 inhibitors in p53- ... Abstract 5370: Potentiation of the novel topoisomerase I inhibitor indenoisoquinoline NSC743400 by Chk1/2 inhibitors in p53- ... Abstract 5370: Potentiation of the novel topoisomerase I inhibitor indenoisoquinoline NSC743400 by Chk1/2 inhibitors in p53- ...
  http://cancerres.aacrjournals.org/content/70/8_Supplement/5370
*  Correction: Potentiation of the Novel Topoisomerase I Inhibitor Indenoisoquinoline LMP-400 by the Cell Checkpoint and Chk1-Chk2...
Potentiation of the novel topoisomerase I inhibitor indenoisoquinoline LMP-400 by the cell checkpoint and Chk1-Chk2 inhibitor ... Potentiation of the Novel Topoisomerase I Inhibitor Indenoisoquinoline LMP-400 by the Cell Checkpoint and Chk1-Chk2 Inhibitor ... Potentiation of the Novel Topoisomerase I Inhibitor Indenoisoquinoline LMP-400 by the Cell Checkpoint and Chk1-Chk2 Inhibitor ... Potentiation of the Novel Topoisomerase I Inhibitor Indenoisoquinoline LMP-400 by the Cell Checkpoint and Chk1-Chk2 Inhibitor ...
  http://cancerres.aacrjournals.org/content/early/2014/07/17/0008-5472.CAN-14-1770
*  DS-8201a, A Novel HER2-Targeting ADC with a Novel DNA Topoisomerase I Inhibitor, Demonstrates a Promising Antitumor Efficacy...
... and a novel topoisomerase I inhibitor. Topoisomerase I inhibitors such as irinotecan (CPT-11) bind to topoisomerase I-DNA ... Topoisomerase I inhibitors: camptothecins and beyond. Nat Rev Cancer 2006;6:789-802. ... Purpose: An anti-HER2 antibody-drug conjugate with a novel topoisomerase I inhibitor, DS-8201a, was generated as a new ... 13). We synthesized a novel ADC with a topoisomerase I inhibitor, which has a different mechanism of action from tubulin ...
  http://clincancerres.aacrjournals.org/content/22/20/5097
*  Kinase-dead ATM protein is highly oncogenic and can be preferentially targeted by Topo-isomerase I inhibitors. | Sigma-Aldrich
... leading to severe genomic instability and hypersensitivity to Topo-isomerase I inhibitors. Correspondingly, Topo-isomerase I ... Kinase-dead ATM protein is highly oncogenic and can be preferentially targeted by Topo-isomerase I inhibitors.. [Kenta Yamamoto ... identify ATM kinase-domain missense mutations as a potent oncogenic event and a biomarker for Topo-isomerase I inhibitor based ... Kinase-dead ATM protein (Atm-KD), but not loss of ATM (Atm-null), prevents replication-dependent removal of Topo-isomerase I- ...
  https://www.sigmaaldrich.com/catalog/papers/27304073