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*  MyD88-dependent toll-like receptor signalling is not a requirement for fetal islet xenograft rejection in mice
Receptors; Cell Surface/*metabolism, Receptors; Immunologic/deficiency/genetics/*metabolism, Signal Transduction, Swine, Toll- ... MyD88-dependent toll-like receptor signalling is not a requirement for fetal islet xenograft rejection in mice. Schmidt, Peter ... mechanism of acute cellular xenograft rejection in a strain of mice with a targeted gene disruption of the toll-like receptor ( ... Like Receptors, Transplantation; Heterologous/*immunology National Category Medical and Health Sciences Identifiers. URN: urn: ...
  http://uu.diva-portal.org/smash/record.jsf?pid=diva2:53488
*  The impact of single and pairwise Toll-like receptor activation on neuroinflammation and neurodegeneration | Journal of...
The family of Toll-like receptors (TLRs) comprises germ-line encoded pathogen recognition receptors that allow the innate ... Kawai T, Akira S: The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol. ... Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor ... Owens T: Toll-like receptors in neurodegeneration. Curr Top Microbiol Immunol. 2009, 336: 105-120.PubMedGoogle Scholar. ...
  https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-014-0166-7
*  Signatures of selection acting on the innate immunity gene Toll-like receptor 2 (TLR2) during the evolutionary history of...
Signatures of selection acting on the innate immunity gene Toll-like receptor 2 (TLR2) during the evolutionary history of ... the Toll-like receptor 2 (TLR2), across 17 rodent species. Although purifying selection was the prevalent evolutionary force ... the Toll-like receptor 2 (TLR2), across 17 rodent species. Although purifying selection was the prevalent evolutionary force ... Signatures of selection acting on the innate immunity gene Toll-like receptor 2 (TLR2) during the evolutionary history of ...
  http://www.zora.uzh.ch/id/eprint/73244/
*  Toll-like receptor-2 mediates inflammation and matrix degradation in human atherosclerosis. - The Kennedy Institute of...
Toll-like receptors (TLRs), key players in innate immunity, are upregulated in atherosclerotic lesions, but their functional ... a signaling adaptor shared by most TLRs and interleukin-1 receptor (IL-1R), in an in vitro model of human atherosclerosis. ... Toll-like receptors (TLRs), key players in innate immunity, are upregulated in atherosclerotic lesions, but their functional ... Toll-like receptor-2 mediates inflammation and matrix degradation in human atherosclerosis. ...
  https://www.kennedy.ox.ac.uk/publications/224454
*  Human Neuronal Cells Possess Functional Cytoplasmic and TLR-Mediated Innate Immune Pathways Influenced by Phosphatidylinositol...
... a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-β promoter in the Toll-like receptor ... IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors. Nat. Rev. Immunol. 6 ... Toll-like receptor 3 (TLR3) plays a major role in the formation of rabies virus Negri Bodies. PLoS Pathog. 5: e1000315. ... Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis. Nat. Med. 10: 1366-1373. ...
  http://www.jimmunol.org/content/184/12/7010
*  Frontiers | Specific Pathogen Recognition by Multiple Innate Immune Sensors in an Invertebrate | Immunology
... pattern recognition receptors) to trigger immune signaling pathways. In most invertebrates, their roles have been inferred by ... pattern recognition receptors) to trigger immune signaling pathways. In most invertebrates, their roles have been inferred by ... This implies a mediation by different soluble and/or membrane-anchored proteins related to innate immune receptors called PRRs ... This implies a mediation by different soluble and/or membrane-anchored proteins related to innate immune receptors called PRRs ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2017.01249/full
*  Catching the adaptor-WDFY1, a new player in the TLR-TRIF pathway | EMBO Reports
Kawai T, Akira S (2011) Toll‐like receptors and their crosstalk with other innate receptors in infection and immunity Immunity ... The Toll‐like receptors (TLRs) are the best‐described set of PRRs. TLRs are membrane‐bound receptors localized on the plasma ... 1 receptor domain‐containing adapter that preferentially activates the IFN‐beta promoter in the Toll‐like receptor signaling J ... Yamamoto M, Sato S, Hemmi H et al (2003) TRAM is specifically involved in the Toll‐like receptor 4‐mediated MyD88‐independent ...
  http://embor.embopress.org/content/early/2015/03/03/embr.201540145
*  IRAK4 - Wikipedia
Members of interleukin-1 receptor (Il-1R) and the Toll-like receptor superfamily share an intracytoplasmic Toll-IL-1 receptor ( ... or Toll-like receptor-mediated immune responses (TLR), but was not essential to T-cell Receptor (TCR) signalling as was ... "Interactions of sequence variants in interleukin-1 receptor-associated kinase4 and the toll-like receptor 6-1-10 gene cluster ... The Toll-Like Receptors (TLRs) are stimulated by recognition of pathogen-associated molecular patterns (PAMPS), whereas members ...
  https://en.wikipedia.org/wiki/IRAK4
*  Molecular mechanism of activation of the Drosophila Toll receptor - AFMB UMR 7257
Genetic analysis has delineated two major regulatory pathways, the Toll and Imd pathways, that control the expression of AMP ... Toll, the founding member of the Toll-like receptor family, is not itself a PRR. Rather, it is activated by a ligand of the ... To bind to the Toll receptor, Pro-Spz needs to be proteolytically processed by a protease, the Spz-processing enzyme (SPE) [ ... Molecular mechanism of activation of the Drosophila Toll receptor. Heads Alain ROUSSEL ...
  http://www.afmb.univ-mrs.fr/molecular-mechanism-of-activation
*  Toll-like receptors definition | Drugs.com
Definition of toll-like receptors. Provided by Stedman's medical dictionary and Drugs.com. Includes medical terms and ... toll-like receptors. Definition: a family of pattern-recognition receptors in mammals that can discriminate between chemically ...
  https://www.drugs.com/dict/toll-like-receptors.html
*  Toll-Like Receptors: Role in Dermatological Disease
S. Garantziotis, J. W. Hollingsworth, A. K. Zaas, and D. A. Schwartz, "The effect of toll-like receptors and toll-like receptor ... S. Weidinger, N. Novak, N. Klopp et al., "Lack of association between Toll-like receptor 2 and Toll-like receptor 4 ... activation by Staphylococcus aureus is Toll-like receptor 2 but not Toll-like receptor 4 or platelet activating factor receptor ... role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling," Journal of ...
  https://www.hindawi.com/journals/mi/2010/437246/
*  Toll-Like Receptors in Secondary Obstructive Cholangiopathy
... role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling," Journal of ... Toll-Like Receptor-1, -2, and -6. TLR-1 is a member of the innate immune system family receptors [11]. It recognizes PAMP ... Toll-Like Receptor-7. TLR-7 is involved in recognition of imidazoquinolines. These receptors induce type I IFN production ... Toll-Like Receptor-10. TLR-10 is an orphan members of human TLRs. It shares a common locus on chromosome 4p14 [27]. In ...
  https://www.hindawi.com/journals/grp/2011/265093/
*  Toll-like receptor 4 (IPR027168) | InterPro | EMBL-EBI
Toll-like receptor 4 (TLR4) is a member of the Toll-like receptor (TLR) family, which plays a role in activation of innate ... GO:0034142 toll-like receptor 4 signaling pathway Molecular Function. GO:0001875 lipopolysaccharide receptor activity GO: ... Toll-like receptors: cellular signal transducers for exogenous molecular patterns causing immune responses.. Int. J. Med. ... Murine TOLL-like receptor 4 confers lipopolysaccharide responsiveness as determined by activation of NF kappa B and expression ...
  http://www.ebi.ac.uk/interpro/entry/IPR027168
*  Toll-like receptor 5 (IPR027176) | InterPro | EMBL-EBI
Toll-like receptor 5 (TLR5) participates in the innate immune response to microbial agents. Toll-like receptors are classified ... GO:0002755 MyD88-dependent toll-like receptor signaling pathway GO:0042742 defense response to bacterium GO:0045087 innate ... A stop codon polymorphism of Toll-like receptor 5 is associated with resistance to systemic lupus erythematosus.. Proc. Natl. ... The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5.. Nature 410 1099-103 2001 ...
  http://www.ebi.ac.uk/interpro/entry/IPR027176
*  Toll-Like Receptor 3 in Liver Diseases
Shi Yin and Bin Gao, "Toll-Like Receptor 3 in Liver Diseases," Gastroenterology Research and Practice, vol. 2010, Article ID ... Toll-Like Receptor 3 in Liver Diseases. Shi Yin1,2 and Bin Gao1 ...
  https://www.hindawi.com/journals/grp/2010/750904/cta/
*  Toll-Like Receptors in Hepatic Ischemia/Reperfusion and Transplantation
... John Evankovich, Timothy Billiar, and Allan Tsung ... John Evankovich, Timothy Billiar, and Allan Tsung, "Toll-Like Receptors in Hepatic Ischemia/Reperfusion and Transplantation," ...
  https://www.hindawi.com/journals/grp/2010/537263/cta/
*  Toll-Like Receptors in Leishmania Infections: Guardians or Promoters?
2. Toll-Like Receptors (TLRs) and Leishmania. Toll-like receptors (TLRs) are hallmarks of cellular receptors that recognize ... T. Kawai and S. Akira, "Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity," ... Toll-Like Receptors in Leishmania Infections: Guardians or Promoters?. Marilia S. Faria, Flavia C. G. Reis, and Ana Paula C. A ... key roles for interleukin-1-receptor-associated kinase-4 and phosphatidylinositol 3-kinase but not Toll/IL-1 receptor (TIR) ...
  https://www.hindawi.com/journals/jpr/2012/930257/
*  Toll-Like Receptor Signaling - QIAGEN
Toll-Like Receptor Signaling Pathway RT2 Profiler PCR Array The Rat Toll-Like Receptor (TLR) Signaling Pathway RT² Profiler PCR ... Toll-Like Receptor Signaling Pathway RT2 Profiler PCR Array The Human Toll-Like Receptor (TLR) Signaling Pathway RT² Profiler ... Toll-Like Receptor Signaling Pathway RT2 Profiler PCR Array The Mouse Toll-Like Receptor (TLR) Signaling Pathway RT² Profiler ... Toll-Like Receptor (TLR) Signaling EpiTect Methyl II PCR Array The Human Toll-Like Receptor Signaling Pathway EpiTect Methyl II ...
  https://www.qiagen.com/lb/shop/genes-and-pathways/complete-biology-list/toll-like-receptor-signaling/
*  Microbial Signaling through Toll-like receptors | Frontiers Research Topic
... and their mammalian homologues Toll-like receptors (TLRs), discoveries for which Jules Hoffman and Bruce Beutler were awarded ... are innate immune receptors localized on the cell surface or endosomal compartments where microorganisms are first encountered ... their cognate ligands through leucine-rich repeat ectodomains and activate downstream signalling cascades via the Toll/IL-1R ( ... The discovery of Toll, (in fruit fly) and their mammalian homologues Toll-like receptors (TLRs), discoveries for which Jules ...
  https://www.frontiersin.org/research-topics/766/microbial-signaling-through-toll-like-receptors
*  Interaction between Cannabinoid System and Toll-Like Receptors Controls Inflammation
Kathleen L. McCoy, "Interaction between Cannabinoid System and Toll-Like Receptors Controls Inflammation," Mediators of ... Interaction between Cannabinoid System and Toll-Like Receptors Controls Inflammation. Kathleen L. McCoy ...
  https://www.hindawi.com/journals/mi/2016/5831315/cta/
*  Sulfated polysaccharides of brown seaweeds are ligands of toll-like receptors | SpringerLink
... and Fucus evanescenswith Toll-like receptors (TLRs) expressed on membranes of... ... toll-like receptors transcription nuclear factor NF-κB fucoidan lipopolysaccharide gas-liquid chromatography ... and Fucus evanescens with Toll-like receptors (TLRs) expressed on membranes of human embryonic kidney epithelial cells (HEK293- ...
  https://link.springer.com/article/10.1134/S1990750812010118
*  Natural Products with Toll-Like Receptor 4 Antagonist Activity
Toll-Like Receptor 4 (TLR4) belongs to the family of pattern recognition receptors (PRRs), conserved receptors of innate ... Toll-Like Receptors (TLRs) are the innate immunity receptors that play an activating role when interacting with molecules ... T. Kawai and S. Akira, "The role of pattern-recognition receptors in innate immunity: update on toll-like receptors," Nature ... E. M. Palsson-McDermott and L. A. J. O'Neill, "Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4," ...
  https://www.hindawi.com/journals/iji/2018/2859135/
*  Small Molecules Target Toll-Like Receptors | Chemical & Engineering News
Small Molecules Target Toll-Like Receptors. ACS Meeting News: New small-molecule screens tackle protein-protein interactions ... Aided by high-throughput screening, chemists have found new ways to target Toll-like receptors (TLRs), membrane-spanning ... an indicator of receptor activity. In Philadelphia, Yin explained how optimizing hits from that assay and others led to ...
  https://cen.acs.org/articles/90/web/2012/08/Small-Molecules-Target-Toll-Like.html
*  Toll-like Receptors - Immunology & Inflammation
Toll-like receptor modulator - Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune ... Toll-Like Receptor 7 Ligand II TLR7 Ligand Toll-Like Receptor 7 Ligand II is a cell-permeable hydroxyadenine compound which ... Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic ... TAK-242 (Resatorvid), a small-molecule inhibitor of Toll-like receptor (TLR) 4 signaling. TAK-242 is in treatment of sepsis and ...
  https://www.adooq.com/toll-like-receptors.html
*  Genistein modulates the expression of Toll-like receptors in experimental autoimmune encephalomyelitis | SpringerLink
Role of toll-like receptors in multiple sclerosis. Am J Clin Exp Immunol. 2013;2:75-93.PubMedPubMedCentralGoogle Scholar ... Toll-like receptor-2, CD14 and heat-shock protein 70 in inflammatory lesions of rat experimental autoimmune neuritis. ... Gooshe M, Abdolghaffari AH, Gambuzza ME, Rezaei N. The role of Toll-like receptors in multiple sclerosis and possible targeting ... Reynolds JM, Martinez GJ, Chung Y, Dong C. Toll-like receptor 4 signaling in T cells promotes autoimmune inflammation. Proc ...
  https://link.springer.com/article/10.1007/s00011-018-1146-7