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*  Engineering Polymer Systems for Improved Drug Delivery
Reviews new and emerging polymer systems that improve the accuracy of drug delivery High-throughput technology has dramatically ... High-throughput technology has dramatically increased the pace of new drug development; however, negative side effects remain a ... this text explains the role of polymers in the rational design and application of drug delivery systems that increase the ... 8 POLYMERIC DRUG DELIVERY SYSTEMS IN TISSUE ENGINEERING 227Matthew Skiles and James Blanchette ...
  https://www.researchandmarkets.com/reports/2561472/engineering_polymer_systems_for_improved_drug
*  Full text] The new era of nanotechnology, an alternative to change cancer treatme | DDDT
55 Liposomes have been clinically used to improve drug delivery to tumor sites and diminish the side effects of chemotherapy or ... improve therapeutic efficacy and decrease the intensity of side effects on the healthy tissues. Due to the intrinsic features ... drug adsorption study and statistical optimization of drug loading by factorial design methodology. J Braz Chem Soc. 2016;27(4 ... These carriers are attractive for drug designing due to their biodegradability, biocompatibility, low toxicity, ability to ...
  https://www.dovepress.com/the-new-era-of-nanotechnology-an-alternative-to-change-cancer-treatmen-peer-reviewed-fulltext-article-DDDT
*  Subcellular Behaviour Evaluation of Nanopharmaceuticals with Aggregation-Induced Emission Molecules
... which greatly mitigates the side effect of conventional pharmaceuticals on normal tissues. ... Deciphering these subcellular behaviours of nanopharmaceuticals can provide detailed information to guide drug design, drug ... polymers[13-15] and dendrimers[16, 17]. When precisely designed and engineered, nanopharmaceuticals show advanced ... Otherwise, PEI suffers from undesirable cytotoxicity, which greatly hinders its biological applications. To overcome these ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC4816494/
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
This underestimation could, in part, explain the low success rate of drug approval due to undesirable or toxic side effects. ... Drug Design, optimization (mathematics), Amino Acids, Peptides, and Proteins, De novo protein and peptide design, Drug design, ... In this study, a system for large-scale propagation of H. vitripennis cells via tissue culture was developed, providing a viral ... Using biodegradable polymers, clinical applications become a possibility. Furthermore, the last generation of micro- ...
  https://www.jove.com/visualize/abstract/24416193/predictors-grandparental-investment-decisions-contemporary-europe
*  A New Preparation Method for Ophthalmic Drug Nanoparticles | OMICS International
The most challenging task in ophthalmic therapy has long been the formulation of suitable ocular drug delivery systems due to ... However, the frequent administration of drugs can cause corneal damage as well as undesirable side effects resulting from the ... specific targeting and prolonged retention in the diseased tissues to improve therapeutic efficiency and mitigate side effects ... Design Considerations for Ocular Drug Nanomaterials. The size of a particle influences its functionality in terms of its uptake ...
  https://www.omicsonline.org/open-access/a-new-preparation-method-for-ophthalmic-drug-nanoparticles-2153-2435.1000305.php?aid=30058
*  US Patent # 6,530,958. Tissue regeneration matrices by solid free-form fabrication techniques - Patents.com
... medical devices for implantation and growth of cells from polymers or polymer/inorganic composites using computer aided design ... These effects of texture can be beneficial in designing devices to get optimal tissue regeneration rates. A single channel of ... These polymers have received a great deal of attention in the drug delivery and tissue regeneration areas for a number of ... For microstructures tailored to soft tissues it is undesirable to have an inorganic powder as a component of the final device. ...
  http://patents.com/us-6530958.html
*  Publications - Institute for Bioengineering of Catalonia (IBEC)
On the other hand, reduced specificity of toxic drugs demands low concentrations to minimize undesirable side-effects, thus ... The electrodes were designed in a needle shape instead of planar electrodes for a full contact with the tissue. The needle- ... which arises from a synergistic effect of the enhanced drug release and the ammonia produced at high concentrations of urea ... Keywords: antimalarial, heparin, magic bullet, malaria, nanomedicine, nanotechnology, nanovector, Plasmodium, polymers, ...
  http://www.ibecbarcelona.eu/for-researchers/publications/TOR/
*  Protocols and Video Articles Authored by Meital Reches
These new architectures may be useful as new vehicles for several applications including tissue regeneration and drug delivery. ... The first two designs-the "woven array" and the "branching design"-take advantage of the ease with which thread can be woven on ... To examine the effect of this group and its activity on the self-assembled structures, we irradiated the assemblies in solution ... Here we extend our research and explore the self-assembly of other homo-aromatic dipeptides in which their phenyl side-chains ...
  https://www.jove.com/author/Meital_Reches
*  Layered Nanoparticles for Sustained Release of Small Molecules - Patent application
The LbL nano-assemblies can specifically target cancers, metastases, or other diseased tissues, while minimizing side effects. ... The novel approach alternates layers of charged drug molecules with layers of oppositely charged polymers. This approach allows ... This effect can be avoided through the use of the present invention. Where some prior work has focused on designing more stable ... Design., vol. 11, pp. 1167-1180 (2005) [0013]Peptides are quickly degraded in biological environments, e.g., by proteolysis. ...
  http://www.patentsencyclopedia.com/app/20090061006
*  Protease-Activated Drug Development
Maeda H, Matsumura Y. Epr effect based drug design and clinical outlook for enhanced cancer chemotherapy. Adv Drug Deliv Rev. ... reduce undesirable irritation, pain or non-specific toxicity to normal tissues [12-13]. ... a major side effect of anthracycline derivatives. Similarly, Leu-DOX prodrugs were also developed to lower the cardiotoxicity ... Furthermore, function of the protease in the type and stage of tumors is significant when designing PAPs. Most enzymes are ...
  http://thno.org/v02p0156.htm
*  Protocols and Video Articles Authored by Juan Yao
Protective Effect and Action Mechanism of Petroleum Ether Extracts from Saussurea Involucrate on Brain Tissues of Hypoxia Rats] ... May, 2015 , Pubmed ID: 26178509 To explore the efficacies and side effects of neoadjuvant chemotherapy with DN (docetaxel plus ... From the results of the pharmacokinetics study, the VCR-SANs remarkably held the amount of drug removed from the whole body per ... We reported herein the design, synthesis, and biological evaluations of a series of potential Sec probes based on the mechanism ...
  https://www.jove.com/author/Juan_Yao
*  3D Printing in Pharmaceutical and Medical Applications - Recent Achievements and Challenges
Assessment of different polymers and drug loads for fused deposition modeling of drug loaded implants. Eur J Pharm Biopharm. ... This process is designed to result in filaments with higher drug content and mechanical properties suitable for 3DP (46,48). Li ... Goyanes A, Robles Martinez P, Buanz A, Basit AW, Gaisford S. Effect of geometry on drug release from 3D printed tablets. Int J ... A hydrogel bioink toolkit for mimicking native tissue biochemical and mechanical properties in bioprinted tissue constructs. ...
  https://www.drugpatentwatch.com/blog/3d-printing-in-pharmaceutical-and-medical-applications-recent-achievements-and-challenges/
*  Frontiers | Peptides with Dual Antimicrobial and Anticancer Activities | Chemistry
... with the number of nature-driven or synthetically designed peptides increasing year by year. With similar properties, AMPs that ... with the number of nature-driven or synthetically designed peptides increasing year by year. With similar properties, AMPs that ... It is urgent to develop new therapeutic methods, with higher efficiency and lower side effects. Antimicrobial peptides (AMPs) ... It is urgent to develop new therapeutic methods, with higher efficiency and lower side effects. Antimicrobial peptides (AMPs) ...
  https://www.frontiersin.org/articles/10.3389/fchem.2017.00005/full
*  Methods and compositions related to wrapping of dehydrons - The Board of Regents of the University of Texas System
This application describes a novel technology in drug discovery and drug-based imaging/detection: the wrapping technology. This ... The wrapping technology described herein is a novel form of rational drug design for avoiding side effects in drug therapy and ... In epithelial tissue, 1 micron resolution has been achieved with a 200-400 micron field of view and penetration depth up to 500 ... The goal is to reduce and control cross reactivity by re-designing the inhibitor according to the data gathered, turning it ...
  http://www.freepatentsonline.com/8466154.html
*  Novel Poly (glycerol-adipate) Polymers Used for Nanoparticle Making: A Study of Surface Free Energy
New glycerol adipate polymers with hydroxyl group substituted with different percent of acyl group, sited as figures within the ... In conclusion, it seems that this method could be used to predict characteristics of polymers used for the selection of the ... The results were then incorporated into the Fowkes equation, toobtion the surface energy of the polymers. Also, different ... of the polymers, using the Zizman's method. The results of surface characteristics indicated that the 40% C8 polymer was ...
  http://ijpr.sbmu.ac.ir/article_739.html
*  Protocols and Video Articles Authored by Balamurali K. Ambati (Translated to Arabic)
... may induce retinal neuronal toxicity and risk other side effects. We developed a novel strategy which inhibits retinal pigment ... The Capsule Drug Device: Novel Approach for Drug Delivery to the Eye Vision Research. Mar, 2010 , Pubmed ID: 19854210 Treatment ... the identified interactions will be used for designing mutagenesis studies to investigate their effect on binding activity. ... Tissue-specific loss of sVegfr-2 in mice induced, at birth, spontaneous lymphatic invasion of the normally alymphatic cornea ...
  https://www.jove.com/author/Balamurali+K._Ambati?language=Arabic
*  Patent US7813806 - Current producing surface for treating biologic tissue - Google Patents
... between the first design and the second design maintains a relatively consistent distance between adjacent sides of the designs ... Electrochemical controlled release drug delivery system. US4619252 *. 16 Apr 1984. 28 Oct 1986. Ibbott Jack Kenneth. ... The effect of this binding interaction between silver and bacterial proteins is that the proteins' intrinsic chemical bonds are ... Medical uses of styrene sulfonate polymers. US6333093. 17 Mar 1997. 25 Dec 2001. Westaim Biomedical Corp.. Anti-microbial ...
  http://www.google.com.au/patents/US7813806
*  Frontiers | Therapeutic Antibodies against Intracellular Tumor Antigens | Immunology
Dendrimers and dendritic polymers in drug delivery. Drug Discov Today (2005) 10:35-43. doi:10.1016/S1359-6446(04)03276-3 ... They can exhibit unpredictable off-target activities, which consequently lead to adverse side effects and may require a more ... The first is designing an antibody format that will retain its stability and antibody binding capacity within the cell and the ... By comparing the MHC-I bound peptides in normal and diseased tissues, it is possible to prioritize those epitopes that are most ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2017.01001/full
*  Protocols and Video Articles Authored by Vojtech Adam
Current drug design strategies are focused on drug bioavailability and their tissue targeting, whereas drug delivery to ... DNA-damaging effects and adverse side-effects. We also summarize ways to enhance the therapeutic effects of these drugs ... Moreover, surface layers of polymers, silica, biomolecules, etc. can be designed to obtain affinity to target molecules. The ... represents an important risk to human health due to its undesirable effects (oxidative stress, changes in activities of many ...
  https://www.jove.com/author/Vojtech_Adam
*  Patent US7718400 - Methods of increasing lean tissue mass using OB protein compositions - Google Patents
... increasing lean tissue mass, increasing overall body strength, or regulating bone resorption, or effecting any combination of ... These are noted to have undesirable side effects however. (The summary below is fully explained in Remington's Pharmaceutical ... the drug is enclosed in a semipermeable membrane which allows water to enter and push drug out through a single small opening ... liposuction or laser surgeries designed to reduce body mass, or implant surgeries designed to increase the appearance of body ...
  http://www.google.com/patents/US7718400?dq=3657699
*  Drug delivery systems: An updated review :Gaurav Tiwari, Ruchi Tiwari, Birendra Sriwastawa, L Bhati, S Pandey, P Pandey,...
... and unwanted delivery of anticancer agents to normal brain tissues are the undesired side-effects of this approach in humans. [ ... The design modifications that protect liposomes from undesirable interactions with plasma proteins and cell membranes, and ... Nanopartiacles are polymeric particles made of natural or artificial polymers ranging in size between about 10 and 1000 nm (1 ... efforts have been focused on designing colon-specific delivery systems with improved site specificity and versatile drug ...
  http://www.jpionline.org/printarticle.asp?issn=2230-973X
*  protein facts, information, pictures | Encyclopedia.com articles about protein
For example, some proteins can be used as medicines, though they may also have undesirable side effects. By making small ... protein All living tissues contain proteins; they are polymers of amino acids, joined by peptide bonds. The name was coined by ... Many such designs involve making small changes in already existing proteins: for example, by changing three amino acids in an ... One of the challenges facing such a development, however, is the problem of designing a protein that attacks only cancer cells ...
  https://www.encyclopedia.com/science-and-technology/biochemistry/biochemistry/protein
*  Patent US5331573 - Method of design of compounds that mimic conformational features of selected ... - Google Patents
The rational design of novel compounds, useful as drugs, e.g., bioactive peptidomimetic compounds, and constrained analogs ... A method of rational drug design includes simulating polypeptides in a way that predicts the most probable secondary and/or ... 3C is thus illustrative of the "lock-and-key" analogy associated with drug design. Only by designing the conformation of one ... it is desired that the peptide drug survive in its active form until it reaches the site where it exerts its biological effect. ...
  http://www.google.com/patents/US5331573?dq=inventor:%22Arthur+R.+Hair%22&ei=VAy0Tsa4NYTl0QGQiqWiBA
*  Application # 2005/0002865. Diagnostic/therapeutic agents - Patents.com
To reduce the effects of movement, successive images of tissues such as the heart or kidney may be collected with the aid of ... Drug Res. (1977) 27, 1158-1162); [0091] vii) polymers and copolymers of short-chain aliphatic hydroxyacids such as glycolic, ... "Designing Therapies That Target Tumor Blood Vessels". Science 275 (January 24): 482-484. [0156] C. Folkman, J., P. B. Weisz, M ... The simultaneous removal of peptide from the resin and side-chain protecting groups was carried out in TFA containing 5% EDT, ...
  http://www.patents.com/us-20050002865.html
*  Genetic Algorithms and Evolutionary Computation
In designing libraries of reactants for this technique, there are two main approaches: reactant-based design, which chooses ... If the aim is to find molecules similar to an existing molecule of known function (a common method of new drug design), ... "Designing conducting polymers using genetic algorithms." Chemical Physics Letters. , vol.366, no.1-2, p.170-175 (November 25, ... There are 12 pieces on each side arranged in a specific manner to begin play. You are told the rules of how the pieces move (i. ...
  http://talkorigins.org/faqs/genalg/genalg.html