Identification of a Novel Cancer-Testis Antigen CRT2 Frequently Expressed in Various Cancers Using Representational...
The CTLs lysed CRT2+ HLA-A24+ 501mel (filled circles) and DC201MEL (filled squares) but did not lyse HLA-A24−, CRT2+ 397mel ( ... Cancer-testis antigens are preferentially expressed in various cancers and in some normal tissues including testis, ovary, and ... Melanoma and colon cell lines expressing HLA-A24/02 (501mel and DC201 MEL), HLA-A01/10 (397mel), and HLA-A01/02 (Colo205) were ... expressing both HLA-A24 and CRT2, but did not lyse cell lines (397mel or Colo205) with no expression of HLA-A24 or CRT2 (Fig. ...http://clincancerres.aacrjournals.org/content/13/21/6267
Phase I/II clinical trial using HLA-A24-restricted peptide vaccine derived from KIF20A for patients with advanced pancreatic...
... we established an epitope peptide that were likely to be presented as an antigen in a HLA-A*2402- or HLA-A*0201-restricted ... Boon T: Tumor antigens recognized by cytolytic T lymphocytes: present perspectives for specific immunotherapy. Int J Cancer. ... we identified dozens of cancer-testis or oncofetal proteins from more than 1,000 clinical cancer tissues using cDNA microarray ... KIF20A-66 is HLA-A24-restricted epitope peptide derived from KIF20A, a member of kinesin super family protein 20A that is ...https://translational-medicine.biomedcentral.com/articles/10.1186/1479-5876-11-291
HLA-Cw7 - Wikipedia
"The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 ... The class I region of these supertype is HLA A1-B8 haplotype, HLA A3-B7, HLA-A2-B7 and HLA A24-B7. Arce-Gomez B, Jones EA, ... HLA-Cw7 (Cw7) is a human leukocyte antigen serotype within HLA-C serotype group. (For more general information on HLA serotypes ... Tissue Antigens. 61 (5): 403-7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660. ...https://en.wikipedia.org/wiki/HLA-Cw7
HLA-A24 - Wikipedia
"The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 ... A24 is a split antigen of the broad antigen HLA-A9 and it is a sister serotype of HLA-A23. A*2402 has one of the highest "A" ... HLA-A24 (A24) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody ... A24-Cw7-B39 A24-Cw10-B60 A24-Cw10-B61 A24-B48 This particular haplotype is common across a fairly wide region, possibly the ...https://en.wikipedia.org/wiki/HLA-A24
KAKEN - Research Projects | Immunotherapy of leukemias by targeting hematopoietic lineage-specific minor histocompatibility...
We successfully generated 4 distinct HLA-A24-restricted CTL clones. By using LCL from members of large CEPH families whose ... Cytotoxic T lymphocytes (CTL) specific for minor histocompatibility antigens (mHAgs) whose tissue expression is limited to ... Minor histocompatibility antigen / Cytotoxic T lymphocyte / Adoptive immunotherapy / Leukemia / 細胞障害性T細胞 / マイナー組織適合性抗原. ... Efficient cloning and expression of HLA class I cDNA in human B-lymphoblastoid cell lines'Tissue Antigens. (in press). (2002). ...https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13671092/
Primary Raynaud's phenomenon in monozygotic twins | Annals of the Rheumatic Diseases
Identical HLA antigens were HLA-A2, A24, B17, B57, Cw3, Cw6, DR4, and DR11. Medical evaluation subsequently disclosed no ... The suggested criteria for primary RP are symmetric attacks; the absence of tissue necrosis, ulceration or gangrene; the ... and Smith antigen were negative. The twins were diagnosed as monozygotic with almost complete certainty by examining the ABO ... Association with HLA antigens, parental consanguinity, and development in identical twins may indicate that genetic factors ...http://ard.bmj.com/content/63/2/219
Expression of Classic and Nonclassic HLA Class I Antigens in Uveal Melanoma | IOVS | ARVO Journals
A23 and A24) in immunoprecipitation experiments (data not shown). HLA-G antigens were detected in paraffin-embedded tissue ... Molecular and functional phenotypes of melanoma cells with abnormalities in HLA class I antigen expression Tissue Antigens ... HLA-A. HLA-A. HLA-B. HLA-B. HLA-C. HLA-C. HLA-A2. ... HLA-A. HLA-A. HLA-B. HLA-B. HLA-C. HLA-C. HLA-A2. ... tissue specimens, which three affected the HLA-A locus (HLA-A2, A28, and A29) and three the HLA-B locus (HLA-B18, B35, B55). In ...http://iovs.arvojournals.org/article.aspx?articleid=2163235
The Assessment of Mesothelin Antigen Specific Immunologic Assays in Ovarian Cancer Patients - Full Text View - ClinicalTrials...
The incidence of HLA-A2 haplotype is over 50% in the Western countries. The incidence of HLA-A2 and A24 haplotype is around 30 ... In normal tissues, the expression of mesothelin has subsequently been shown to be largely restricted to mesothelial cells, ... identification and characterization of tumor antigens, and determination of the microenvironment factors that could impact on ... In addition, the specific epitopes of mesothelin in the HLA-A2 and A24 haplotype have been identified. It seems that mesothelin ...https://clinicaltrials.gov/ct2/show/study/NCT00173394?show_desc=Y
Determination of Cellularly Processed HLA-A2402-Restricted Novel CTL Epitopes Derived from Two Cancer Germ Line Genes, MAGE-A4...
HLA class I allele distributions in six Pacific/Asian populations: evidence of selection at the HLA-A locus. Tissue Antigens ... Yamaguchi H, Tanaka F, Ohta M, Inoue H, Mori M. Identification of HLA-A24-restricted CTL epitope from cancer-testis antigen, NY ... HLA-A24 expression was detected with anti-HLA-A23/-A24 mAb 0041HA (One Lambda) at 4°C for 20 minutes, followed by incubation ... New MAGE-4 antigenic peptide recognized by cytolytic T lymphocytes on HLA-A1 tumor cells. Tissue Antigens 2003;62:426-32. ...http://clincancerres.aacrjournals.org/content/11/15/5581
Frontiers | Immune Responses to Epidermal Growth Factor Receptor (EGFR) and Their Application for Cancer Treatment |...
Chimeric antigen receptor is a synthetic molecule designed to redirect T cells to specific antigens expressed on surface of ... We have used one of the HLA-A24-restricted epitopes, EGFR800-809, as a candidate peptide for personalized peptide vaccination, ... Based on these reported studies, the relationship between mutant EGFR status and PD-L1 expression in tumor tissues is ... including HLA-DR4, HLA-DR15, and HLA-DR53. EGFR875-889-specific CD4 T cells can be detected in the peripheral blood of HNSCC ...https://www.frontiersin.org/articles/10.3389/fphar.2016.00405/full
KAKEN - Research Projects | BASIC RESEARCH FOR TUMOR SPECIFIC IMMUNOTHERAPY USING TUMOR REJECTED ANTIGEN GENES (KAKENHI-PROJECT...
Because HLA-A24 is the most common allele in Japanese, MAGE-3 encoded synthetic peptides with binding affinity for HLA-A24 were ... For the development of immunotherapy using MAGE peptides, the identification of additional tumor antigens is required. ... Immunopositive cells of MAGE-3 protein showed cytoplasmic staining and nonmalignant cells within stomach tissues were ... of HLA-A24 healthy donors. The induced CTLs coud lyseHLA-A24 carcinoma cells expressing MAGE-3, as well as the peptidepulsed ...https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09470253/
HLA-A23 - Wikipedia
A23 is a split antigen of the broad antigen HLA-A9 and it is a sister serotype of HLA-A24. A23 is common in Africa and regions ... "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 ... HLA-A23 (A23) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody ... Tissue Antigens. 61 (5): 403-7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660. Tang J, Tang S, Lobashevsky E, Myracle A, ...https://en.wikipedia.org/wiki/HLA-A23
The Assessment of Mesothelin Antigen Specific Immunologic Assays in Ovarian Cancer Patients
The incidence of HLA-A2 haplotype is over 50% in the Western countries. The incidence of. HLA-A2 and A24 haplotype is around 30 ... normal tissues, the expression of mesothelin has subsequently been shown to be largely. restricted to mesothelial cells, ... characterization of tumor antigens, and determination of the microenvironment factors that. could impact on the different ... are the epitopes of HLA-A24 haplotype.. Our research team has focused on the development of cancer vaccine and immunotherapy ...http://www.knowcancer.com/cancer-trials/NCT00173394/
Most recent papers with the keyword Neoepitope and cancer | Read by QxMD
HLA-A24 ligandome analysis of colon and lung cancer cells identifies a novel cancer-testis antigen and a neoantigen that ... Harnessing the immune system to attack tumor cells by targeting tumor-associated or -preferably- tumor-specific antigens has ... a gene found to be expressed in a variety of cancers but not in normal tissues (except for the testis)... ... readbyqxmd.com/read/28533942/hla-a24-ligandome-analysis-of-colon-and-lung-cancer-cells-identifies-a-novel-cancer-testis-antigen ...https://www.readbyqxmd.com/keyword/79738
MAGEA3 - Wikipedia
2006). "A newly identified MAGE-3-derived, HLA-A24-restricted peptide is naturally processed and presented as a CTL epitope on ... 2001). "Activation of melanoma antigen tumor antigens occurs early in lung carcinogenesis". Cancer Res. 61 (21): 7959-63. PMID ... and NY-ESO-1 in cancerous and benign prostatic tissue". Prostate. 66 (1): 13-8. doi:10.1002/pros.20312. PMID 16114059. Miyagawa ... 2003). "Identification of immunodominant regions among promiscuous HLA-DR-restricted CD4+ T-cell epitopes on the tumor antigen ...https://en.wikipedia.org/wiki/MAGEA3
Potential immunogenic CT antigens expressed in synovial sarcoma but not normal tissues have been identified, including NY-ESO-1 ... depending on the use of agretope-modified peptide with increased affinity for HLA-A24, and on the addition of Freund's ... Chimeric antigen receptor T cells represent another promising approach, in which T cells are engineered to express a chimeric T ... Tissue microarray validation of epidermal growth factor receptor and SALL2 in synovial sarcoma with comparison to tumors of ...http://cancerdiscovery.aacrjournals.org/content/5/2/124
Immunoselective Pressure and Human Leukocyte Antigen Class I Antigen Machinery Defects in Microsatellite Unstable Colorectal...
... the mAb HC-A2 which recognizes a determinant expressed on β2m-free HLA-A (excluding HLA-A24), HLA-B7301, and HLA-G heavy chains ... van Kaer L. Major histocompatibility complex class I-restricted antigen processing and presentation. Tissue Antigens 2002; 60: ... HLA-A28, HLA-A29, HLA-A30, HLA-A31, HLA-A32, and HLA-A33 heavy chains and on all β2m-free HLA-B and HLA-C heavy chains ( 22, 23 ... In particular, total HLA class I and selective HLA-A antigen loss on tumor cell surface was closely linked to the MSI-H ...http://cancerres.aacrjournals.org/content/65/14/6418
Cancers | Free Full-Text | Sarcoma Immunotherapy | HTML
Thomas, L. Reactions to homologous tissue antigens in relation to hypersensitivity [discussion]. In Cellular and Humoral ... Detection and induction of CTLs specific for SYT-SSX-derived peptides in HLA-A24(+) patients with synovial sarcoma. J. Immunol. ... Immunohistochemical analysis of NY-ESO-1 antigen expression in normal and malignant human tissues. Int. J. Cancer 2001, 92, 856 ... immunotherapeutic process is ex vivo expansion and maturation of antigen-presenting DCs pulsed with antigen, reintroducing ...http://mdpi.com/2072-6694/3/4/4139/htm
HLA-A9 - Wikipedia
HLA-A9 (A9) is a broad antigen HLA-A serotype that recognized the HLA-A23 and HLA-A24 serotypes. A*2402 appears to have evolved ... 1992). "HLA antigens in Tlingit Indians with rheumatoid arthritis". Tissue Antigens. 40 (2): 57-63. doi:10.1111/j.1399- ... Fussell H, Thomas M, Street J, Darke C (1996). "HLA-A9 antibodies and epitopes". Tissue Antigens. 47 (4): 307-12. doi:10.1111/j ... high allelic diversity and frequency of heterozygotes at the HLA-B locus". Tissue Antigens. 53 (6): 519-26. doi:10.1034/j.1399- ...https://en.wikipedia.org/wiki/HLA-A9
The peptide-binding specificity of HLA-A*3001 demonstrates membership of the HLA-A3 supertype - Semantic Scholar
... the international HLA registry holds ,1,650 unique HLA-I protein entries). In an attempt to reduce this complexity, it has been ... Unfortunately, the large and rapidly increasing number of known HLA-I molecules seriously complicates a comprehensive analysis ... HLA-I) molecules are highly polymorphic peptide receptors, which select and present endogenously derived peptide epitopes to ... CD8+ cytotoxic T cells (CTL). The specificity of the HLA-I system is an important component of the overall specificity of the ...https://www.semanticscholar.org/paper/The-peptide-binding-specificity-of-HLA-A
HLA-A2-Restricted T-Cell Epitopes Specific for Prostatic Acid Phosphatase
PSA and prostate-specific membrane antigen (PSMA) are two other proteins being investigated as prostate tumor antigens. However ... To date, there have been several reports seeking to identify either HLA-A2 or HLA-A24 restricted CD8+ T cell epitopes for PAP [ ... Briefly, PBMC from HLA-A2-expressing individuals were plated at 108 cells/flask in T150 tissue culture flasks for 2 hours at 37 ... T2 in vitro HLA-A2 binding assay. The HLA-A2 expressing, TAP-1 deficient human T-cell line T2 was used as an assay of HLA-A2 ...http://pubmedcentralcanada.ca/pmcc/articles/PMC3038205/?lang=en-ca
Identification of Peptide Vaccine Candidates Sharing among HLA-A3+, -A11+, -A31+, and -A33+ Cancer Patients | Clinical Cancer...
Analysis of three HLA-A*3303 binding peptide anchors using an HLA-A*3303 stabilization assay. Tissue Antigens, 55: 296-302, ... A24+ cancer patients (2 , 9) . This limitation is largely due to the relative infrequency of HLA-A alleles other than HLA-A2 ... derived from viral protein and melanoma antigen, were recognized by different HLA-A3 supertype alleles (3 , 12) . Subsequently ... B, targets cells were HLA-A33+ LC1, HLA-A33+ cervical cancer cells RKN, HLA-A33− lung cancer cells 1-87, and HLA-A33+ PHA- ...http://clincancerres.aacrjournals.org/content/10/3/1112
Exploring dendritic cell based vaccines targeting survivin for the treatment of head and neck cancer patients | Journal of...
We therefore conclude that survivin, although it is a universal tumor antigen, might not be the ideal target for ... most tumor antigens are also expressed in normal tissues albeit often at lower levels. In a number of cases tumor antigens are ... Tanaka M, Butler MO, Ansen S: Induction of HLA-DP4-restricted anti-survivin Th1 and Th2 responses using an artificial antigen- ... In a phase I trial the splice variant survivin 2B peptide has been used in HLA-A24 positive patients with oral cancer. Although ...https://translational-medicine.biomedcentral.com/articles/10.1186/1479-5876-11-152
WT1 PEPTIDE VACCINATION IN COMBINATION WITH IMATINIB THERAPY FOR A PATIENT WITH CML IN THE CHRONIC PHASE
Two distinct HLA-A0201-presented epitopes of the Wilms tumor antigen 1 can function as targets for leukemia-reactive CTL. Blood ... WT1 peptides have already been used in clinical trials for specific immunotherapy of HLA-A24+ patients with brain tumor, breast ... bone/soft tissue sarcoma and head/neck squamous cell carcinoma 3. WT1-specific CTLs with HLA-A*0201 or A*2402 could be ... vaccines of these leukemia-associated antigens have shown that the clinical response is associated with generation of antigen- ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2860640/
HLA-A*24 Is an Independent Predictor of 5-Year Progression to Diabetes in Autoantibody-Positive First-Degree Relatives of Type...
Tissue Antigens 2003;61:146-153 [PubMed]. 20. Nakanishi K, Inoko H. Combination of HLA-A24, -DQA1*03, and -DR9 contributes to ... and cytotoxic T-lymphocyte antigen-4-immunoglobulin fusion protein (5) transiently preserved β-cell function, preferentially in ... in carriers of HLA-DQ2/DQ8 (P = 0.062 vs. absence of HLA-DQ2/DQ8) or HLA-A*24 (P = 0.077 vs. absence of HLA-A*24), Ab frequency ... HLA-A*24 interacts with HLA-DQ and/or auto-Ab-inferred risk of diabetes; and 3) HLA-A*24 typing can refine the sensitivity or ...http://pubmedcentralcanada.ca/pmcc/articles/PMC3609594/?lang=en-ca