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*  Infantile Neuroaxonal Dystrophy 1 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials
... nerve or conjunctive tissue to confirm the presence of characteristic swellings (spheroid bodies) in the nerve axons. MalaCards ... cellular protein metabolic process. GO:0044267 9.46. APP CP PNPLA2 RPS27A 4. protein targeting to mitochondrion. GO:0006626 ... Affiliated tissues include brain, skin and eye. NIH Rare Diseases : 50 neuroaxonal dystrophy, infantile is a type of lipid ... MalaCards organs/tissues related to Infantile Neuroaxonal Dystrophy 1:. 39 Brain, Skin, Eye ...
  http://www.malacards.org/card/infantile_neuroaxonal_dystrophy_1
*  2009 Lecture 21 - CellBiology
spheroid cellular tissue culture structure. * mouse and human ES cells have the capacity to undergo controlled differentiation ... Tissue Stem Cells. * differentiated cells have short life spans continually replaced. * blood cells, epithelial cells of skin ... Chapter 19 Tissues p622-627. Molecular Biology of the Cell. Alberts, Bruce; Johnson, Alexander; Lewis, Julian; Raff, Martin; ... 1989 Pera et al., derive a clonal line of human embryonal carcinoma cells, which yields tissues from all three primary germ ...
  https://cellbiology.med.unsw.edu.au/cellbiology/index.php/2009_Lecture_21
*  TISuMR - Revolutionising Tissue Culture With NMR
Bishnubrata's main interests are designing microfluidic devices for tissue/ cellular spheroid. Read more ... We are delighted to announce the following have accepted an invitation to speak at TISuMR 1: Symposium On Tissue Culture and ... 24-27 September 2017 Please join us for the first TISuMR Symposium on Tissue Culture and Magnetic Resonance! If you are ... interested in attending please contact us at tisumr@soton.ac.uk The culture of tissue under controlled conditions holds great ...
  http://tisumr.soton.ac.uk
*  Bishnubrata Patra
Bishnubrata's main interests are designing microfluidic devices for tissue/ cellular spheroid culture and integrating them with ...
  http://tisumr.soton.ac.uk/2017/07/06/bishnubrata-patra/
*  Protocols and Video Articles Authored by Michael D. Menger (Translated to German)
Die Isolierung von murinen Fettgewebe stammenden mikrovaskuläre Fragmente als Vaskularisation Einheiten für Tissue Engineering ... Nov, 2017 , Pubmed ID: 28694177 Multi-cellular spheroids mimic the complex three-dimensional environment of natural tissues. ... Boosting Spheroid Function for Tissue Engineering Trends in Biotechnology. Sep, 2016 , Pubmed ID: 27634310 Spheroids provide a ... Spheroid sprouting assays are versatile in vitro models for the analysis of molecular and cellular determinants of blood vessel ...
  https://www.jove.com/author/Michael++D._Menger?language=German
*  Protocols and Video Articles Authored by Michael D. Menger (Translated to Japanese)
Nov, 2017 , Pubmed ID: 28694177 Multi-cellular spheroids mimic the complex three-dimensional environment of natural tissues. ... Boosting Spheroid Function for Tissue Engineering Trends in Biotechnology. Sep, 2016 , Pubmed ID: 27634310 Spheroids provide a ... Spheroid sprouting assays are versatile in vitro models for the analysis of molecular and cellular determinants of blood vessel ... In tissue engineering, spheroids serve in vivo as paracrine stimulators of angiogenesis and building blocks for the generation ...
  https://www.jove.com/author/Michael++D._Menger?language=Japanese
*  'spheroids cellular' Protocols and Video...
Cells from normal tissues can also form spheroids. They represent an in-vitro model for studies of the biology of both normal ... Spheroids, Cellular: Spherical, heterogeneous aggregates of proliferating, quiescent, and necrotic cells in culture that retain ... The ability to form spheroids is a characteristic trait of Cultured tumor cells derived from solid Tumors. ... three-dimensional architecture and tissue-specific functions. ... From Bjerkvig, Spheroid Culture in Cancer Research, 1992, p4) ...
  https://www.jove.com/keyword/spheroids+cellular
*  Alignment of cellular motility forces with tissue flow as a mechanism for efficient wound healing | PNAS
2011) Stress clamp experiments on multicellular tumor spheroids. Phys Rev Lett 107(18):188102-188106. ... Alignment of cellular motility forces with tissue flow as a mechanism for efficient wound healing. Markus Basan, Jens Elgeti, ... Both tissues have identical parameters except that the adhesion force is set to zero in the tissue on the right-hand side, . ... Alignment of cellular motility forces with tissue flow as a mechanism for efficient wound healing ...
  http://www.pnas.org/content/110/7/2452
*  Hallmarks in prostate cancer imaging with Ga68-PSMA-11-PET/CT with reference to detection limits and quantitative properties |...
Three-dimensional cellular spheroid formation provides human prostate tumor cells with tissue-like features. Anticancer Res. ... The MDC for LNCaP cells incubated as spheroids (Fig. 2b), is reached at higher cellular number 1.52 × 103, 3.2 × 104, 5 × 104, ... Although spheroids mimic some of the biological characteristics of tumors cells in tissues, the radioligand binding affinity ... Time course for LNCaP spheroid formation from seeding (a) and at 24 h (b), 48 h (c), 72 h (d), and at 168 h (e). Final spheroid ...
  https://link.springer.com/article/10.1186/s13550-018-0378-4
*  3D cell culture - Wikipedia
3D spheroids more closely resemble in vivo tissue in terms of cellular communication and the development of extracellular ... There are also problems using spheroids as a model for cancerous tissue. Although beneficial for 3D tissue culture, tumor ... spheroids are 3-6 times softer than MCF 10A (normal epithelial) spheroids. Spheroids co-cultured with tumor and healthy cells ... "Spheroid Culture as a Tool for Creating 3D Complex Tissues." Trends in Biotechnology, vol. 31, ser. 02, Feb. 2013. 02. doi: ...
  https://en.wikipedia.org/wiki/3D_cell_culture
*  KAKEN - Research Projects | Clarification of bone mineralization process and hard tissue construction (KAKENHI-PLANNED-23106010)
Presentation] Incorporation of calcium phosphate microparticles into cellular aggregates using an oxygen-permeable spheroid ... and that the tissue formation, including the formation of the mineralized tissue and the bone-related non-mineralized tissue, ... Chapter 16: Bone related cell-stimulating scaffold materials and a 3D cellular construct for hard tissue regeneration.2015. *. ... Journal Article] An oxygen-permeable spheroid culture system for the prevention of central hypoxia and necrosis of spheroids. ...
  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-23106010/
*  Scientists grow human liver tissue to be used for transplantation | NextBigFuture.com
... liver cells formed tightly packed cellular aggregates, called spheroids, and took on a liver-like appearance. Human liver cells ... In applying their tissue engineering approach, the German researchers were able to successfully create new liver tissue ... Scientists grow human liver tissue to be used for transplantation. brian wang , January 22, 2011 , ... From day two to four, the average number of spheroids more than doubled from 18 to 41 per visual field. … Our experimental ...
  https://www.nextbigfuture.com/2011/01/scientists-grow-human-liver-tissue-to.html
*  Leading malignant cells initiate collective epithelial cell invasion in a three-dimensional heterotypic tumor spheroid model |...
... we developed a tissue-engineered multicellular spheroid (MCS) co-culture model that recapitulates the cellular diversity and ... Burdett E, Kasper FK, Mikos AG, Ludwig JA (2010) Engineering tumors: a tissue engineering perspective in cancer biology. Tissue ... Mapping the cellular and molecular heterogeneity of normal and malignant breast tissues and cultured cell lines. Breast Cancer ... Yamada KM, Cukierman E (2007) Modeling tissue morphogenesis and cancer in 3D. Cell 130:601-610PubMedCrossRefGoogle Scholar ...
  https://link.springer.com/article/10.1007/s10585-013-9565-x
*  Differentiation of human mesenchymal stem cell spheroids under microgravity conditions | Cell Regeneration | Full Text
The use of gelatin scaffolds holds promise to design implantable stem cell tissue of various sizes and shapes for future ... 3 × 106 cells generated homogeneous spheroids and maximum spheroid loading was accomplished after 3 days of culture. Spheroids ... Spheroids cultured in adipogenic and osteogenic differentiation media exhibited oil red O staining and von Kossa staining, ... Further characterization of osteogenic lineage, showed that 10 day spheroids exhibited stronger calcification than any other ...
  https://cellregenerationjournal.biomedcentral.com/articles/10.1186/2045-9769-1-2
*  Scientists grow human liver tissue to be used for transplantation - Healthcanal.com : Healthcanal.com
... liver cells formed tightly packed cellular aggregates, called spheroids, and took on a liver-like appearance. Human liver cells ... In applying their tissue engineering approach, the German researchers were able to successfully create new liver tissue ... From day two to four, the average number of spheroids more than doubled from 18 to 41 per visual field. "Our experimental model ... Researchers suggest that this liver tissue could be used in place of donor organs during liver transplantation or during the ...
  https://www.healthcanal.com/medical-breakthroughs/13962-scientists-grow-human-liver-tissue-to-be-used-for-transplantation.html
*  WO2018165565 SYNTHETIC HYDROGEL CARRIERS FOR CELLULAR STRUCTURES, GENERATION OF ORGANOIDS, AND TREATMENT OF TISSUE INJURY
... storage and administration of cellular structures such as spheroids and organoids. ... storage and administration of cellular structures such as spheroids and organoids.. (FR) La présente invention concerne un ... EN) SYNTHETIC HYDROGEL CARRIERS FOR CELLULAR STRUCTURES, GENERATION OF ORGANOIDS, AND TREATMENT OF TISSUE INJURY. (FR) SUPPORTS ... 1. (WO2018165565) SYNTHETIC HYDROGEL CARRIERS FOR CELLULAR STRUCTURES, GENERATION OF ORGANOIDS, AND TREATMENT OF TISSUE INJURY ...
  https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2018165565
*  Stromal Vascular Fraction From Adipose Tissue Forms Profound Vascular Network Through the Dynamic Reassembly of Blood...
... of the cellular components.32 We found that most of the vasculatures in the adipose tissue are disassembled during the ... Spheroids formed with ,5 passages of SVF failed to effectively create a vascular network. Previous studies using ADSCs16,17 ... Adipose tissue engineering for soft tissue regeneration. Tissue Eng Part B Rev. 2010; 16: 413-426. ... Isolation of SVF From Adipose Tissue. Because epididymal adipose tissue (EAT) has no adjacent tissues, we isolated the SVF from ...
  http://atvb.ahajournals.org/content/31/5/1141
*  Development of tissue-engineered models of oral dysplasia and early invasive oral squamous cell carcinoma.
... lack the complexity that mimics in vivo tissue. Here we describe a three-dimensional in vitro model of the oral epithelium that ... FaDu spheroids produced a histological picture mimicking carcinoma in situ with severe cellular atypia juxtaposed to normal ... Paraffin-embedded tissue sections (5 μm) were prepared from tissue-engineered mucosal models and for comparative purposes from ... Multicellular tumour spheroid (MCTS) production Multicellular tumour spheroid were generated from FaDu cells using the liquid ...
  http://www.biomedsearch.com/nih/Development-tissue-engineered-models-oral/21989184.html
*  Björn Nitzsche | DVM, PhD | University of Leipzig, Leipzig | Department für Nuklearmedizin | ResearchGate
... labeling of neurofilament proteins revealed spheroid and bead-like structural alterations in human and rodent tissue, ... Histological investigations were performed to reveal (1) the impact of different MCAO modalities on a cellular level and (2) ... We analyzed brain tissues obtained 1 day after ischemia onset from: (a) mice after filament-based permanent middle cerebral ... Absolute tissue volume differences were not detected, indeed ewes showed significantly more GM per bodyweight as compared to ...
  https://www.researchgate.net/profile/Bjoern_Nitzsche
*  Cellular Metabolism, O2 consumption and glycolysis | amsbio
Browse our cellular metabolism assays. Use MitoXpress® Xtra to measure O2 consumption or pH-Xtra™ glycolysis assay for kinetic ... tissues, small organisms, spheroids, scaffolds and matrixes. The assay is also suitable for measurement of isolated enzymes, ... of cellular ATP while in cardiac tissue it can be responsible for up to 90% of cellular energy requirements FAO is also now ... Cellular Metabolism, O2 consumption and toxicity. MitoXpress® Xtra - Oxygen Consumption Assay [HS Method]. MitoXpress® Xtra - ...
  http://www.amsbio.com/metabolism-oxygen-consumption-and-glycolysis-assays.aspx
*  Customized Ca-P/PHBV nanocomposite scaffolds for bone tissue engineering: design, fabrication, surface modification and...
... are then injected in single cell suspensions or can be further manipulated by cellular assembly into multi-cellular spheroid or ... 2009 Organ printing: tissue spheroids as building blocks. Biomaterials 30, 2164-2174. (doi:10.1016/j.biomaterials.2008.12.084) ... 2009 Biopolymer-based growth factor delivery for tissue repair: from natural concepts to engineered systems. Tissue Eng. Part B ... 2010 Development and characterization of a novel hybrid tissue engineering-based scaffold for spinal cord injury repair. Tissue ...
  http://rsif.royalsocietypublishing.org/content/early/2010/05/20/rsif.2010.0127.focus
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
The blood brain barrier (BBB) specifically regulates molecular and cellular flux between the blood and the nervous tissue. Our ... Spheroid Assay to Measure TGF-β-induced Invasion. Authors: Hildegonda P.H. Naber, Eliza Wiercinska, Peter ten Dijke, Theo van ... Thereafter, the tissue homogenate was centrifuged in bovine serum albumin to separate vessel fragments from nervous tissue. The ... Biomedical Engineering, Issue 70, Bioengineering, Tissue Engineering, Cellular Biology, Molecular Biology, Biomaterials, beta ...
  https://www.jove.com/visualize/abstract/19956728/perk-regulates-proliferation-development-insulin-secreting-beta-cell
*  Plus it
In this study, we systematically investigated the expression of 588 known cellular genes in primary tissue samples from ... IGF also enhances three-dimensional growth of glioblastoma spheroids in vitro (9) . The effect of IGFs on cells is regulated by ... cDNA array images of normal brain tissues and tissues from GBM, AA, AO, and O. mRNAs were isolated from these tissues, reverse- ... H&E-stained frozen tissue sections are routinely prepared from all tissue bank specimens for screening purposes. All tissue ...
  http://cancerres.aacrjournals.org/content/59/17/4228
*  Microfluidic device for primary tumor spheroid isolation
... multi-cellular spheroids in 3-D formation preserve cells' in vivo physiological condition, and primary cells from fresh tissue ... thus resulting in altered cellular function. Three-dimensional multi-cellular spheroids, on the other hand, are a better ... Primary spheroids freshly isolated from tissue samples are especially ideal for cell-based assays by avoiding the two problems ... Cellular capsules as a tool for multicellular spheroid production and for investigating the mechanics of tumor progression in ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC5545869/
*  Protocols and Video Articles Authored by Narutoshi Hibino
Creation of Cardiac Tissue Exhibiting Mechanical Integration of Spheroids Using 3D Bioprinting' ... We use cellular magnetic resonance imaging (MRI) to track the fate of cells seeded onto functional tissue-engineered vascular ... Creation of Cardiac Tissue Exhibiting Mechanical Integration of Spheroids Using 3D Bioprinting Chin Siang Ong1,2, Takuma ... Principles of the Kenzan Method for Robotic Cell Spheroid-Based Three-Dimensional Bioprinting() Tissue Engineering. Part B, ...
  https://www.jove.com/author/Narutoshi_Hibino