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*  Placodes - Embryology
Renal-coloboma syndrome, resulting from mutations in Pax2, is characterized by kidney hypoplasia, optic nerve malformation, and ... Anos1 was identified as a target of Pax3 and Zic1, two transcription factors necessary and sufficient to generate neural crest ... Postotic Placode[9] "The (zebrafish) embryonic line originates from a postotic placode that produces both a migrating sensory ... Chick embryo rhombomere neural crest cells , Some derivatives of the pharyngeal arches , Tissue Architecture of the Central ...
  https://embryology.med.unsw.edu.au/embryology/index.php/Placodes
*  Retinal pigmented epithelium determination requires the redundant activities of Pax2 and Pax6 | Development
Interestingly, Pax2-/-; Pax6+/- mutants have reduced RPE differentiation as well as more severe optic-nerve defects than Pax2 ... The transcription factors Pax2 and Pax6 are co-expressed in the entire optic vesicle (OV) prior and concomitant with the ... Ectopic Pax-3 activates MyoD and Myf-5 expression in embryonic mesoderm and neural tissue. Cell 89,139 -148. ... but not to maintain the sharp border between optic cup and optic nerve after E12.5, and the differentiation of the optic nerve ...
  http://dev.biologists.org/content/130/13/2903
*  Prenatal ethanol exposure in mice phenocopies Cdon mutation by impeding Shh function in the etiology of optic nerve hypoplasia ...
2011). Septo-optic dysplasia and other midline defects: the role of transcription factors: HESX1 and beyond. Best Pract. Res. ... a transient embryonic tissue required for early aspects of forebrain development, including the specification of the ... The optic disc is not compromised in Cdon−/− or ethanol-treated embryos. (A-D) Immunostaining for Pax2 on transverse sections ... ONH can arise from defects in optic disc formation or from a deficit in the number of RGC axons that make up the optic nerve ( ...
  http://dmm.biologists.org/content/10/1/29?rss=1
*  Branching morphogenesis and kidney disease | Development
Mutation of the PAX2 gene in a family with optic nerve colobomas, renal anomalies and vesicoureteral reflux. Nat. Genet. 9,358 ... Whereas secreted peptides, ECM molecules, growth and transcription factors comprise the mainstay of signals operative during ... Overlapping expression domains of bone morphogenetic protein family members potentially account for limited tissue defects in ... TFCP2L1 represses multiple lineage commitment of mouse embryonic stem cells through MTA1 and LEF1. Kuisheng Liu, Yan Zhang, ...
  http://dev.biologists.org/content/131/7/1449
*  Cell Replacement Therapy for Optic Nerve Disorders
For better management of optic nerve disorders, the important role of tissues, genes, growth factors and proteins, nanomedicine ... instructing them to promote repair and regeneration in optic nerve cells and retina. ... photoreceptors and degeneration of optic neural network despite all ongoing challenges. Moreover, for solving visual disorders ... This review article explains major optic nerve disorders and cell replacement therapy. This article also signifies new ...
  https://www.ommegaonline.org/article-details/Cell-Replacement-Therapy-for-Optic-Nerve-Disorders/1541
*  PAX2-Related Disorder - GeneReviews® - NCBI Bookshelf
Ophthalmologic abnormalities are typically described as optic nerve coloboma or dysplasia. Iris colobomas have not been ... PAX2 pathogenic variants have been identified in multiple sporadic and familial cases of nonsyndromic renal disease including ... originally referred to as renal coloboma syndrome and characterized by renal hypodysplasia and abnormalities of the optic nerve ... a wider range of phenotypes has been recognized in association with pathogenic variants in PAX2. Abnormal renal structure or ...
  https://www.ncbi.nlm.nih.gov/books/NBK1451/
*  Purification and Characterization of Astrocyte Precursor Cells in the Developing Rat Optic Nerve | Journal of Neuroscience
The present studies show that in the developing optic nerve, the paired-box transcription factor Pax2 is a specific marker of ... The appearance of GFAP immunoreactivity in the developing rat optic nerve. Optic nerves from embryonic day 17 (A) and postnatal ... Immunofluorescence staining. The cryosections were baked at 50°C for 15 min to ensure the attachment of tissues to the slides. ... neural and metabolic defects and results in perinatal death. Development 121:1283-1299. ...
  http://www.jneurosci.org/content/19/3/1049
*  Congenital Anomalies of the Kidney and Urinary Tract: A Genetic Disorder?
P. Sanyanusin, L. A. Schimmenti, L. A. McNoe et al., "Mutation of the PAX2 gene in a family with optic nerve colobomas, renal ... Recent studies demonstrate that Pax2, a transcription factor critical for normal kidney development, is an important ... exhibit more severe defects, which include renal agenesis, hypodysplasia, and ureteral defects, whereas Tyr1015Ret mutans, ... S. J. M. Welham, P. R. Riley, A. Wade, M. Hubank, and A. S. Woolf, "Maternal diet programs embryonic kidney gene expression," ...
  https://www.hindawi.com/journals/ijn/2012/909083/
*  Kidney Tissue Engineering Using Decellularized Organs and Pluripotent Stem Cells
WT1 is a transcription factor found in glomerular podocytes; Pax 2 is a transcription factor primarily localized to cells in ... optic nerve, inner ear, and female genital organs. 67 211 Proving that the Pax 2 po sitive cells belong to the intermediate ... mutation is identical to a human PAX2 mutation in a family with renal coloboma syndrome and results in developmental defects of ... Influence of acellular natural lung matri x on murine embryonic stem cell differentiation and tissue formation. Tissue Eng Part ...
  http://ufdc.ufl.edu/UFE0045431/00001
*  Analysis of mouse models carrying the I26T and R160C substitutions in the transcriptional repressor HESX1 as models for septo...
1996)Pax2 contributes to inner ear patterning and optic nerve trajectory. Development 122, 3381-3391. ... 1995)Winged helix transcription factor BF-1 is essential for the development of the cerebral hemispheres. Neuron 14, 1141-1152. ... followed by optic nerve hypoplasia and midline commissural defects (Dattani et al., 1998; Thomas et al., 2001; Brickman et al ... 3H,K) (McMahon and Bradley, 1990; Lagutin et al., 2003; Andoniadou et al., 2007). The reduction of presumptive optic tissue was ...
  http://dmm.biologists.org/content/1/4-5/241
*  Protocols and Video Articles Authored by Bernd Fritzsch
2010 , Pubmed ID: 20727173 Pax2;5;8 transcription factors play diverse roles in vertebrate and invertebrate organogenesis, ... Past research has suggested various cochlear defects and some vestibular defects in Pax2 null mice but the details of the ... Nerve fiber guidance to specific vestibular end-organs is predominantly mediated by diffusible neurotrophic factors that work ... Dec, 2008 , Pubmed ID: 18985389 At embryonic day 8.5, the LIM-homeodomain factor Lmx1a is expressed throughout the otic placode ...
  https://www.jove.com/author/Bernd_Fritzsch
*  Identification and expression of the lamprey Pax6 gene: evolutionary origin of the segmented brain of vertebrates | Development
Steinberg, M. (1957). A nonnutrient culture medium for amphibian embryonic tissues. In Carnegie Institution of Washington Year ... Among these regulatory genes, the Pax gene family encodes transcription factors that are characterized by paired-type ... 3G), the optic stalk, and the ectoderm behind the optic vesicle (Fig. 3G). Later (stages 25-26), the basic brain segment was ... Immunohistochemical staining of nerve fibers. Several nerve tracts are observed including the habenular commissure (hc), the ...
  http://dev.biologists.org/content/128/18/3521
*  Philip Beachy | Stanford Medicine Profiles
Defects in all tissues extend beyond the normal sites of Shh transcription, confirming the proposed role of Shh proteins as an ... of the embryonic visceral mesoderm. Other factors are also required, including one that appears to act through homeodomain ... located between the sites of the future optic stalks. Using pax-2 and pax-6 as markers of proximo-distal fate within the ... for DM cells as cellular cues for axonal guidance during transverse nerve outgrowth and bifurcation of the median nerve. ...
  https://med.stanford.edu/profiles/philip-beachy
*  Interactive Fly, Drosophila
... pelvis occurred through regulatory mutations deleting a tissue-specific enhancer of the Pituitary homeobox transcription factor ... There is no invagination to form the characteristic double-layered optic cups, and the fused eye tissue at the midline forms a ... Cnidarians possess nerve nets and nerve rings but, so far, no evidence of a centralized nervous system has been found [Gaillot ... Pax-2 and c-ret expressions in the Wolffian duct and WT-1 and GDNF expressions in the metanephric blastema are initially normal ...
  http://www.sdbonline.org/sites/fly/segment/emptysp2.htm
*  ojoplano-mediated basal constriction is essential for optic cup morphogenesis | Development
Torres, M., Gómez-Pardo, E. and Gruss, P. (1996). Pax2 contributes to inner ear patterning and optic nerve trajectory. ... under the control of the transcription factor Rx3 (Loosli et al., 2001). In a second series of morphogenetic events, the optic ... mYFP impaired optic cup folding in 27% of the treated embryos (n=102). The optic cup morphogenetic defects observed in these ... Furthermore, tissue-specific interference with integrin-adhesive function impairs optic cup folding, resembling the ocular ...
  http://dev.biologists.org/content/136/13/2165
*  Distinct developmental programs require different levels of Bmp signaling during mouse retinal development | Development
Ectopic expression of Bmp4 in the embryonic chick retina leads to the upregulation of the dorsal transcription factor, Tbx5, ... optic nerve head axonal guidance may require only Bmpr1b function (Liu et al., 2003). Dorsoventral patterning defects are ... Tissue preparations for marker analyses. Embryonic tissue explant culture using filters and BMP4-soaked beads was performed ... throughout the optic cup, and downregulation of the ventral markers, Vax and Pax2 (Koshiba-Takeuchi et al., 2000). Bmp4 ...
  http://dev.biologists.org/content/132/5/913
*  Browse by Academic Unit (A-Z) - White Rose Research Online
6 more authors) (2009) Genomic analysis of the function of the transcription factor gata3 during development of the Mammalian ... 6 more authors) (2015) Intrinsic factors and the embryonic environment influence the formation of extragonadal teratomas during ... 5 more authors) (2010) Genetic defects of GDF6 in the zebrafish out of sight mutant and in human eye developmental anomalies. ... 4 more authors) (2018) Imaging Neuronal Activity in the Optic Tectum of Late Stage Larval Zebrafish. Journal of Developmental ...
  http://eprints.whiterose.ac.uk/view/iau/Sheffield=2EBMS.html
*  Interactive Fly, Drosophila
... and Engrailed transcription factors. Gel shift and Western blot experiments document the presence of these transcription ... extracts containing Engrailed and Foxa2 and has regulatory functions in primary cultures of embryonic mesmetencephalic nerve ... Thus Wnts and FGF can both pattern neural tissues but these factors exhibit differences in their neural patterning activities. ... The chick optic tectum consists of 16 laminae. This study reports contribution of En2 to laminar formation in chick optic tecta ...
  http://www.sdbonline.org/sites/fly/segment/engral2b.htm
*  Neural Development - ISSN: 1749-8104
Selective regulation of nerve growth factor expression in developing cutaneous tissue by early sensory innervation Author(s): ... Runx transcription factors in neuronal development Author(s): Inoue Ken-ichi , Shiga Takashi , Ito Yoshiaki. Volume: 3. Issue: ... Neuronal migration defects in the Loa dynein mutant mouse Author(s): Ori-McKenney Kassandra , Vallee Richard. Volume: 6. Issue ... Promotion of embryonic cortico-cerebral neuronogenesis by miR-124 Author(s): Maiorano Nicola , Mallamaci Antonello. Volume: 4. ...
  http://journaldatabase.info/journal/issn1749-8104
*  Peptides and Proteins: Novus Biologicals
Nerve Degeneration (10). *. Nerve Transections, Optic (3). *. Nervous System Disorder (2). *. Nervousness (54) ... Transcription Factors and Regulators (8). *. Tumor Suppressors (3). *. Vision (21). *. Wnt Signaling Pathway (1) ... They are low cost, easy to use, and tissue culture friendly making them ideal for stem cell research. ... Congenital Heart Defects (18). *. Congenital Keratoglobus (3). *. Congenital Lamellar Cataract (9). *. Congenital Muscular ...
  https://www.novusbio.com/product-type/peptides-and-proteins?related_diseases=Eye%20Abnormalities