Thromboxane A2 receptor antagonism and synthase inhibition in essential hypertension. | Hypertension
Thromboxane A2 receptor antagonism and synthase inhibition in essential hypertension.. J M Ritter, S E Barrow, H S Doktor, P D ... Thromboxane A2 receptor antagonism and synthase inhibition in essential hypertension.. J M Ritter, S E Barrow, H S Doktor, P D ... Thromboxane A2 receptor antagonism and synthase inhibition in essential hypertension.. J M Ritter, S E Barrow, H S Doktor, P D ... Short-term effects of ridogrel, a combined thromboxane synthase inhibitor and receptor antagonist, were investigated in 16 ...http://hyper.ahajournals.org/content/22/2/197
Differential effects of thromboxane A2 synthase inhibition, singly or combined with thromboxane A2/prostaglandin endoperoxide...
... singly or combined with thromboxane A2/prostaglandin endoperoxide receptor antagonism, on occlusive thrombosis elicited by ... Differential effects of thromboxane A2 synthase inhibition, singly or combined with thromboxane A2/prostaglandin endoperoxide ... Differential effects of thromboxane A2 synthase inhibition, singly or combined with thromboxane A2/prostaglandin endoperoxide ... Differential effects of thromboxane A2 synthase inhibition, singly or combined with thromboxane A2/prostaglandin endoperoxide ...http://circres.ahajournals.org/content/69/2/313
1997) Alterations in thromboxane synthase and thromboxane A2 receptors in experimental alcoholic liver disease. J Pharmacol Exp ... 1995) Differential activation of peroxisome proliferator-activated receptor by eicosanoids. J Biol Chem 270:23975-23983. ... and in TNF receptor-1 knockout mice (Yin et al., 1999). However, activation of nuclear factor-κB (NF-κB), which regulates ... alcohol-induced liver injury in wild-type mice fed ethanol is prevented in TNF receptor-1 knockout mice (Yin et al., 1999). TNF ...http://jpet.aspetjournals.org/content/293/1/296
Terbogrel - Wikipedia
Terbogrel is an orally available thromboxane A2 receptor antagonist and a thromboxane A synthase inhibitor. The drug was ... a Combined Thromboxane A2 Receptor and Synthase Inhibitor, in Healthy Subjects". British Journal of Clinical Pharmacology. 58 ( ... a Dual-Acting Agent for Thromboxane Receptor Antagonism and Thromboxane Synthase Inhibition". Acta Crystallographica. 56 (Pt 10 ... Capra V, Bäck M, Angiolillo DJ, Cattaneo M, Sakariassen KS (2014). "Impact of vascular thromboxane prostanoid receptor ...https://en.wikipedia.org/wiki/Terbogrel
Kudos - helping increase the reach and impact of research
Design of new potential 5-lipoxygenase inhibitors, dual thromboxane synthase inhibitors, and thromboxane a2 receptor ... Receptor-Dependent 4D-QSAR Analysis of Peptidemimetic Inhibitors of Trypanosoma cruzi Trypanothione Reductase with Receptor- ... Receptor-dependent (RD) 3D-QSAR approach of a series of benzylpiperidine inhibitors of human acetylcholinesterase (HuAChE). ... Residue-Ligand Interaction Energy (ReLIE) on a Receptor-Dependent 3D-QSAR Analysis of S- and NH-DABOs as Non-Nucleoside Reverse ...https://www.growkudos.com/profiles/12124
PTGS2 prostaglandin-endoperoxide synthase 2 [Homo sapiens (human)] - Gene - NCBI
... and thromboxane A2 receptor (TBXA2R) compared to clade C gp120. PubMed env HIV-1 gp120 increases the intracellular ... prostaglandin G/H synthase 2. Names. PGH synthase 2. PHS II. cyclooxygenase 2. cyclooxygenase 2b. prostaglandin H2 synthase 2. ... prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase). NP_000954.1. *EC 188.8.131.52 ... Nuclear Receptor Signaling Atlas (NURSA). * Transcriptomine: regulation of the PTGS2 gene by nuclear receptor signaling ...https://www.ncbi.nlm.nih.gov/gene?LinkName=pubmed_gene_rif&from_uid=17214885
ORBi: Browsing ORBi
Effects of thromboxane A2 receptor antagonists and thromboxane synthase inhibitors on osteogenic sarcoma cell induced platelet ... BM-613, a new thromboxane A2 antagonist, is characterized by a preferential activity on platelet thromboxane A2 receptors. ... on both thromboxane A(2) (TXA(2)) receptors (TP) and thromboxane synthase of human platelets. The drug affinity for TP ... BM-573, a dual thromboxane synthase inhibitor and thromboxane receptor antagonist, prevents pig myocardial infarction induced ...https://orbi.uliege.be/browse?type=author&sort_by=1&order=DESC&rpp=20&etal=3&value=Masereel%2C+B.&offset=20
H oxidases by thromboxane A2 receptor uncouples endothelial nitric oxide synthase. Thromb. Vasc. Biol. 31(1):125-32, 2011. ... Liver kinase B1 is required for thromboxane receptor-dependent NF-κB activation and inflammatory responses. Thromb. Vasc. Biol ... Zou, M.H, Li, H., He, C., Lyons, T., Xie, Z. Tyrosine Nitration of Prostacyclin Synthase Is Associated with Enhanced Retinal ... Endothelial nitric oxide synthase-derived nitric oxide prevents dihydrofolate reductase degradation via promoting S- ...http://medicine.gsu.edu/work/
IFETROBAN TREATMENT FOR SYSTEMIC SCLEROSIS - CUMBERLAND PHARMACEUTICALS, INC.
Thromboxane A2 receptor antagonists also include thromboxane synthase inhibitors, as well as compounds that have both ... a thromboxane A2 receptor antagonist inhibits binding of thromboxane A 2 to the receptor. Thromboxane A2 receptor antagonists ... amount of a thromboxane A2 receptor antagonist to provide a desired plasma concentration of the thromboxane A2 receptor ... thromboxane A2 receptor antagonist activity and thromboxane synthase inhibitor activity.  As used herein, the term "unit ...http://www.sumobrain.com/patents/wipo/Ifetroban-treatment-systemic-sclerosis/WO2017189885A1.html
PHENYL DERIVATIVE - Patent application
... leukotriene receptor antagonists, thromboxane synthase inhibitors, thromboxane A2 receptor antagonists, mediator release ... PGD receptors (DP and CRTH2), a PGF receptor (FP), a PGI receptor (IP), a thromboxane receptor (TP) and the like.  The ... 0125] The thromboxane A2 receptor antagonists may include, for example, seratrodast, ramatroban, domitroban calcium hydrate and ... PG receptor antagonists and the like.  The PG receptor may include, for example, PGE receptors (EP1, EP2, EP3 and EP4), ...http://www.patentsencyclopedia.com/app/20140235611
Medical Advisor Journals, Kyle J. Norton Site, Health Tips for Better Living and Living Health: The Effects of...
Expression of thromboxane synthase, TBXAS1 and the thromboxane A2 receptor, TBXA2R, in human breast cancer. Thromboxane ... In the study to investigate the expression of thromboxane synthases, TBXAS1 and the thromboxane A2 receptor, TBXA2R in a cohort ... Thromboxane A2, a potent stimulator of platelet aggregation, and thromboxane B2, a metabolite of thromboxane A2 which is known ... 7. Prostacyclin synthase and thromboxane synthase signaling in the development and progression of cancer. Prostacyclin synthase ...https://kylejnorton.blogspot.ca/2013/12/the-effects-of-hormonethromboxane-2.html
Protocols and Video Articles Authored by Zsolt Bagi (Translated to Japanese)
Reactive Oxygen Species and Cyclooxygenase 2-derived Thromboxane A2 Reduce Angiotensin II Type 2 Receptor Vasorelaxation in ... receptor antagonist SQ-29548. Dilations due to H2O2 were significantly reduced by inhibition of nitric oxide synthase (to 38 ... Constrictions due to H2O2 were completely abolished by indomethacin and the prostaglandin H2/thromboxane A2 (PGH2/TxA2) ... Plasma thromboxane B(2) (thromboxane A(2) metabolite), initially high in ZDF rats, was decreased by chronic Tempol and by ...https://www.jove.com/author/Zsolt_Bagi?language=Japanese
thromboxane A Synthase 1 (Platelet) (TBXAS1) ELISA Kits
Thromboxane A2 Receptor ELISA Kits * Thymic Stromal Lymphopoietin ELISA Kits * Thymidine Kinase 1, Soluble ELISA Kits ... thromboxane-A synthase , Thromboxane-A synthase , thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A ... thromboxane synthase, prostacyclin synthase (zeige PTGIS ELISA Kits) and thromboxane receptor (zeige TBXA2R ELISA Kits) have ... thromboxane A synthase 1 (platelet) , thromboxane-A synthase-like , TXA synthase , cytochrome P450 5A1 , cytochrome P450, ...http://www.antikoerper-online.de/abstract/thromboxane+A+Synthase+1+
Coagulation Factors and the Risk of Ischemic Heart Disease | Circulation: Genomic and Precision Medicine
... a combined thromboxane a2 synthase inhibitor and thromboxane a2/prostaglandin endoperoxide receptor antagonist, versus aspirin ... but suggest that ETP and thromboxane A synthase might potentially play a role in IHD and MI. Whether vWF and FVIII affect IHD ... but suggest that ETP and thromboxane A synthase might potentially play a role in IHD and MI. Whether vWF and FVIII affect IHD ... and TBXAS1 for thromboxane A synthase) were associated with IHD and MI, as potential targets of intervention. For each gene, we ...http://circgenetics.ahajournals.org/content/11/1/e001956
Seratrodast - Wikipedia
Seratrodast (development name, AA-2414; marketed originally as Bronica) is a thromboxane A2 (TXA2) receptor (TP receptor) ... Unlike thromboxane synthase inhibitors such as ozagrel, seratrodast does not affect thrombus formation, time to occlusion and ... It was the first TP receptor antagonist that was developed as an anti-asthmatic drug and received marketing approval in Japan ...https://en.wikipedia.org/wiki/Seratrodast
Cardiac thromboxane A2 receptor activation does not directly induce cardiomyocyte hypertrophy but does cause cell death that is...
We found that TXA2 receptors were expressed in ventricular cardiomyocytes and were functional via calcium imaging. U46619 ... receptor agonist, U46619, can directly induce ventricular arrhythmias that were associated with increases in intracellular ... Treatment of cells with the TXA2 receptor antagonist SQ29548 and inhibitors of the IP3 pathway, gentamicin and 2-APB, ... We have previously shown that the thromboxane (TXA2) ... is produced from prostaglandin H2 via thromboxane-A synthase ...https://bmcpharmacoltoxicol.biomedcentral.com/articles/10.1186/2050-6511-15-73
12-Hydroxyheptadecatrienoic acid - Wikipedia
Thromboxane synthase further metabolizes PGH2 to the 20 carbon product, Thromboxane A2, the 17 carbon product, 12-HHT, and the ... thromboxane synthase knockout, and BLT2 receptor knockout but not TXA2 receptor knockout impair keratinocyte-based re- ... "Characterization of the thromboxane synthase pathway product 12-oxoheptadeca-5(Z)-8(E)-10(E)-trienoic acid as a thromboxane A2 ... BLT1 receptor) and its low affinity BLT2 receptor (Kd=23 nM); both receptors are G protein coupled receptors that, when ligand- ...https://en.wikipedia.org/wiki/12-Hydroxyheptadecatrienoic_acid
Vascular wall-produced prostaglandin E2 exacerbates arterial thrombosis and atherothrombosis through platelet EP3 receptors |...
Coagulation defects and altered hemodynamic response in mice lacking receptors for thromboxane A2. J. Clin. Invest. 102:1994- ... Balance between PGD synthase and PGE synthase is a major determinant of atherosclerotic plaque instability in humans. ... Role of prostacyclin in the cardiovascular response to thromboxane A2. Science. 296:539-541. ... Inhibiting the EP3 receptor instead might be safer, especially considering that the EP3 receptor has multiple isoforms (35). ...http://jem.rupress.org/content/204/2/311.full
Thromboxane receptor - Wikipedia
TBXA2R thromboxane A2 receptor (Homo sapiens) Abe T, Takeuchi K, Takahashi N, Tsutsumi E, Taniyama Y, Abe K (1995). "Rat kidney ... Ekambaram P, Lambiv W, Cazzolli R, Ashton AW, Honn KV (2011). "The thromboxane synthase and receptor signaling pathway in ... The thromboxane receptor is one among the five classes of prostanoid receptors and was the first eicosanoid receptor cloned. ... The TP receptor derives its name from its preferred endogenous ligand thromboxane A2. The gene responsible for directing the ...https://en.wikipedia.org/wiki/Thromboxane_receptor
Thromboxane A2 - Wikipedia
Receptors that mediate TXA2 actions are thromboxane A2 receptors. The human TXA2 receptor (TP) is a typical G protein-coupled ... TXA2 is generated from prostaglandin H2 by thromboxane-A synthase in a metabolic reaction which generates approximately equal ... Circulating fibrinogen binds these receptors on adjacent platelets, further strengthening the clot. Thromboxane A2 is also a ... Yamamoto, K.; Ebina, S.; Nakanishi, H.; Nakahata, N. (November 1995). "Thromboxane A2 receptor-mediated signal transduction in ...https://en.wikipedia.org/wiki/Thromboxane_A2
Neuropeptide Y-induced potentiation of noradrenergic vasoconstriction in the human saphenous vein: involvement of endothelium...
... the selective thromboxane A2 (TxA2) receptor antagonists Bay u3405 and ifetroban, and (vi) the TxA2 synthase inhibitor, UK ... Accordingly, both TNS- and NA-induced contractions were not potentiated by NPY in the presence of the TxA2 synthase inhibitor, ... 4. When the TxA2 receptor antagonists, Bay u 3405 (1 microM) and ifetroban (1 microM) were added to the superfusing medium, NPY ... endothelin receptor antagonist, Ro 47-0203 (10 microM). These data indicate that the NPY-induced effect does not involve either ...https://www.semanticscholar.org/paper/Neuropeptide-Y-induced-potentiation-of-noradrenerg-Fabi-Argiolas/df9e56d4ecb2f8649562ae450b8dbf78ab329527
DSpace at EWHA: Search
... is mediated by thromboxane (TX) A2 receptor blockade with TXA2 synthase inhibition and suppression of cytosolic Ca2+ ...http://dspace.ewha.ac.kr/handle/2015.oak/171622/simple-search?query=&sort_by=dc.date.issued_dt&order=desc&rpp=10&filter_field_1=dateIssued&filter_type_1=equals&filter_value_1=%5B2000+TO+2009%5D&etal=0&filtername=dateIssued&filterquery=2005&filtertype=equals
Platelet - Wikipedia
... and thromboxane-A synthase. Platelets secrete thromboxane A2, which acts on the platelet's own thromboxane receptors on the ... Collagen-mediated GPVI signalling increases the platelet production of thromboxane A2 (TXA2) and decreases the production of ... This dense tubular system is connected to the surface platelet membrane to aid thromboxane A2 release. ... These receptors trigger intraplatelet signaling, which converts GPIIb/IIIa receptors to their active form to initiate ...https://en.m.wikipedia.org/wiki/Platelet
Conceptus elongation in ruminants: roles of progesterone, prostaglandin, interferon tau and cortisol | Journal of Animal...
... thromboxane A2 receptor. ... synthase (PTGIS), PGI2 receptors (PTGIR), PPARs and RXRs in ... receptor; DP, prostaglandin D receptor (PTGDR); EP, prostaglandin E receptor (PTGER); FP, prostaglandin F receptor (PTGFR); IP ... prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase); PG Synthases, prostaglandin synthases ( ... prostaglandin I receptor (PTGIR); PLA2, phospholipase A2; PPARD, peroxisome proliferator-activated receptor delta; PPARG, ...https://jasbsci.biomedcentral.com/articles/10.1186/2049-1891-5-53
Human Metabolome Database: Showing metabocard for Thromboxane (HMDB0003208)
2. Thromboxane A2 receptor. General function:. Involved in G-protein coupled receptor protein signaling pathway. Specific ... 1. Thromboxane-A synthase. General function:. Involved in monooxygenase activity. Specific function:. Not Available. Gene Name: ... Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a ... Wacker MJ, Tyburski JB, Ammar CP, Adams MC, Orr JA: Detection of thromboxane A(2) receptor mRNA in rabbit nodose ganglion ...http://www.hmdb.ca/metabolites/HMDB03208