*  Effect of eltrombopag on platelet counts and bleeding during treatment of chronic idiopathic thrombocytopenic purpura: a...
INTERPRETATION: Eltrombopag is an effective treatment for managment of thrombocytopenia in chronic ITP. ... and splenectomy status) or by the number of previous ITP treatments. Of the 34 patients in the efficacy analysis who increased ... and splenectomy status) or by the number of previous ITP treatments. Of the 34 patients in the efficacy analysis who increased ... INTERPRETATION: Eltrombopag is an effective treatment for managment of thrombocytopenia in chronic ITP. ...
  https://www.rdm.ox.ac.uk/publications/620137
*  Hypersplenism, Information about Hypersplenism
Splenectomy will correctthe effects of low blood cell concentrations in the blood. ... or thrombocytopenia, a deficiency of circulating platelets in the blood. Other symptomsmay be present. ...
  http://www.faqs.org/health/topics/46/Hypersplenism.html
*  Splenectomy and the Thrombocytopenia of Systemic Lupus Erythematosus | Annals of Internal Medicine | American College of...
Splenectomy and the Thrombocytopenia of Systemic Lupus Erythematosus. Ann Intern Med. 1986;105:971-972. doi: 10.7326/0003-4819- ... Splenectomy and the Thrombocytopenia of Systemic Lupus Erythematosus PETER JACOBS; LUCILLE WOOD; DAVID M. DENT ... To the editor: In 1985, Hall and colleagues (1) reported on 14 patients in whom platelet counts after splenectomy followed a ... In an analysis of 148 adults with immune thrombocytopenia (2), a subgroup of 8 patients with systemic lupus erythematosus ...
  http://annals.org/aim/article-abstract/700992/splenectomy-thrombocytopenia-systemic-lupus-erythematosus
*  Temporal trends of splenectomy in pediatric hospitalizations with immune thrombocytopenia | Lurie Children's
Temporal trends of splenectomy in pediatric hospitalizations with immune thrombocytopenia. Bhatt, N. S.; Bhatt, P.; Donda, K.; ... BACKGROUND: Splenectomy is considered an effective treatment for immune thrombocytopenia (ITP) with 70-80% response rate. ... Research InnovationPublications Temporal trends of splenectomy in pediatric hospitalizations with immune thrombocytopenia ... Splenectomy rate declined over time (3.4% [2005-2006] to 1.6% [2013-2014], P < 0.001) with the younger age (  https://www.luriechildrens.org/en/research/publications/temporal-trends-of-splenectomy-in-pediatric-hospitalizations-with-immune-thrombocytopenia/
*  Splenectomy in the management of the thrombocytopenia of the Wiskott-Aldrich syndrome. - Semantic Scholar
... and profound thrombocytopenia. We evaluated the effects of splenectomy on hemostatic improvement and subsequent clinical course ... with six of these patients still alive an average of 11.0 years or more after splenectomy. Thus, splenectomy is a useful ... Survival after splenectomy correlated with the prophylactic use of antibiotics. Five of seven patients not taking prophylactic ... All 16 had an increase in platelet counts to at least 100,000 per cubic millimeter after splenectomy, with the mean increasing ...
  https://www.semanticscholar.org/paper/Splenectomy-in-the-management-of-the-thrombocytope-Lum-Tubergen/29586ccc4c09aa9e15a59672e1a63bfec19e45a2
*  Should medical treatment options be exhausted before splenectomy is performed in adult ITP patients? A debate | SpringerLink
Patients with primary immune thrombocytopenia (ITP) may require treatment to reduce the risk of serious bleeding if platelets ... The course of severe autoimmune thrombocytopenia in patients not undergoing splenectomy. Haematologica 91(8):1041-1045PubMed ... Bell WR Jr (2002) Role of splenectomy in immune (idiopathic) thrombocytopenic purpura. Blood Rev 16(1):39-41CrossRefPubMed ... Schilling RF (1997) Spherocytosis, splenectomy, strokes, and heat attacks. Lancet 350(9092):1677-1678CrossRefPubMedGoogle ...
  https://link.springer.com/article/10.1007%2Fs00277-010-1066-2
*  Milz | Springer for Research & Development
Schwartz SI (1985) Splenectomy for thrombocytopenia. World J Surg 9: 416-421PubMedCrossRefGoogle Scholar ... Schwartz SI (1981) Splenectomy for hematologic disease. Surg Clin North Am 61: 117-125PubMedGoogle Scholar ... 1987) The value of splenectomy in chronic lymphocytic leukemia. Cancer 59: 340-345PubMedCrossRefGoogle Scholar ... Dawson AA, Jones PF, King DJ (1987) Splenectomy in the management of haematological disease. Br J Surg 74: 353-357PubMed ...
  https://rd.springer.com/chapter/10.1007/978-3-662-21701-6_10
*  Hairy Cell Leukemia Treatment (PDQ )
8] [10] [14] For a few patients, such as those with severe thrombocytopenia, splenectomy might be considered. [15] After ... Splenectomy will partially or completely normalize the peripheral blood in the vast majority of patients with hairy cell ... 14] [15] [16] Interferon-alpha and splenectomy are therapeutic options that can be considered when other options have been ... Added text to state that interferon-alpha and splenectomy are therapeutic options that can be considered when other options ...
  https://www.meb.uni-bonn.de/cancer.gov/CDR0000062926.html
*  Learning About Wiskott-Aldrich Syndrome: An Immune Deficiency Disorder that Primarily Affects Males
To help control thrombocytopenia, a splenectomy may be beneficial for some patients. This may also help to normalize platelet ... Thrombocytopenia may be treated with corticosteroids and/or intravenous immunoglobulin. If the patient has bleeding, red blood ... impairment of cell-mediated immunity and thrombocytopenia. ...
  http://www.brighthub.com/science/genetics/articles/120552.aspx
*  Balancing Therapy with Thrombopoietin Receptor Agonists and Splenectomy in Refractory Immune Thrombocytopenic Purpura: A Case...
W. Ghanima, B. Godeau, D. B. Cines, and J. B. Bussel, "How I treat immune thrombocytopenia: the choice between splenectomy or a ... M. J. Choe and C. D. Packer, "Severe romiplostim-induced rebound thrombocytopenia after splenectomy for refractory ITP," Annals ... "Usage of eltrombopag for chronic immune thrombocytopenia as a pretreatment for splenectomy," Acta Haematologica, vol. 129, no. ... Another case report describes recurrent thrombocytopenia after splenectomy after romiplostim dose was held in preparation for ...
  https://www.hindawi.com/journals/crihem/2016/5403612/
*  George P. Canellos, MD - Dana-Farber Cancer Institute | Boston, MA
Splenectomy for thrombocytopenia in chronic granulocytic leukemia. Cancer. 1972 Mar; 29(3):660-5.. View in: PubMed. Bagley CM, ... Splenectomy in the chronic phase of chronic granulocytic leukemia. Effects in 32 patients. Ann Intern Med. 1976 Jan; 84(1):17- ... Effect of splenectomy on tolerance to combination chemotherapy in patients with lymphoma. Blood. 1976 Feb; 47(2):211-22.. View ... Splenic enlargement and hyperfunction as indications for splenectomy in chronic leukemia. Ann Surg. 1987 Jan; 205(1):13-7. ...
  https://www.dana-farber.org/find-a-doctor/george-p-canellos/
*  Table of Contents | Blood Journal
Role of splenectomy in inherited thrombocytopenias Carlo L. Balduini. Blood 2004 104:1227; doi: https://doi.org/10.1182/blood- ... Long-term outcomes in adults with chronic ITP after splenectomy failure Robert McMillan and Carol Durette ...
  http://www.bloodjournal.org/content/104/4?sso-checked=true
*  Clinical updates in adult immune thrombocytopenia | Blood Journal
Long-term results of splenectomy in adult chronic immune thrombocytopenia. Eur J Haematol. 2017;98(3):235-241. ... Long-term complications of splenectomy in adult immune thrombocytopenia. Medicine (Baltimore). 2016;95(48):e5098. ... Long-term outcome following splenectomy for chronic and persistent immune thrombocytopenia (ITP) in adults and children : ... Immune thrombocytopenia (ITP) is an acquired thrombocytopenia, defined as a platelet count ,100 × 109/L, and caused by immune ...
  http://www.bloodjournal.org/content/129/21/2829?sso-checked=true
*  Selected transjugular intrahepatic portosystemic shunt versus laparoscopic splenectomy plus endoscopic varices ligation in the...
Splenectomy could effectively improve thrombocytopenia caused by hypersplenism and the long-term liver function. The present ... Selected transjugular intrahepatic portosystemic shunt versus laparoscopic splenectomy plus endoscopic varices ligation in the ... study was to compare elective TIPS and laparoscopic splenectomy (LS) plus EVL in their efficacy in preventing recurrent ...
  https://www.sages.org/meetings/annual-meeting/abstracts-archive/selected-transjugular-intrahepatic-portosystemic-shunt-versus-laparoscopic-splenectomy-plus-endoscopic-varices-ligation-in-the-treatment-of-portal-hypertension/
*  The spleen in liver cirrhosis: revisiting an old enemy with novel targets | Journal of Translational Medicine | Full Text
Splenectomy is contraindicated for thrombocytopenia secondary to portal hypertension. Surg Gynecol Obstet. 1985;160(3):233-8. ... An alternative to splenectomy, however, is required for many patients with precluding conditions such as thrombocytopenia. ... Efficacy and safety of splenectomy in telaprevir-based triple therapy for chronic hepatitis C patients with thrombocytopenia ... Splenectomy. Splenectomy has been traditionally performed to treat liver cirrhosis for the alleviation of portal hypertension. ...
  https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-017-1214-8
*  Most recent papers with the keyword Lifestyle medicine | Read by QxMD
Splenectomy is an effective therapy for steroid-refractory or dependent immune thrombocytopenia (ITP). With the advent of ... www.readbyqxmd.com/read/29295846/splenectomy-for-immune-thrombocytopenia-down-but-not-out ... Splenectomy removes the primary site of platelet clearance and autoantibody production, and offers the highest rate of durable ... However, there are no reliable predictors of splenectomy response, and long-term risks of infection and cardiovascular ...
  https://www.readbyqxmd.com/keyword/61708
*  Protocols and Video Articles Authored by Kenji Saito (Translated to German)
Development of Overt Hemolytic Anemia After Splenectomy for Thrombocytopenia in Evans Syndrome with Negative Coombs Test] [ ... Splenectomy performed in June 2000 had only a transient and marginal influence on his platelet count. Two months later, he ... Although the mechanism responsible for development of AIHA after splenectomy in this patient with ITP remains unknown, close ...
  https://www.jove.com/author/Kenji_Saito?language=German
*  Wiskott-Aldrich Syndrome: Background, Pathophysiology, Epidemiology
WAS always causes persistent thrombocytopenia and, in its complete form, also causes small platelets, atopy, cellular and ... Splenectomy in the management of the thrombocytopenia of the Wiskott-Aldrich syndrome. N Engl J Med. 1980 Apr 17. 302(16):892-6 ... Prolonged survival after splenectomy in Wiskott-Aldrich syndrome: a case report. Ital J Pediatr. 2011 Sep 10. 37:42. [Medline] ... With aggressive care (eg, splenectomy), longer survival is possible. [26, 27] Bone marrow transplant can be curative. [26] ...
  https://emedicine.medscape.com/article/137015-overview
*  IAC Express: Issue 1175
How long after a splenectomy should a person wait before they get an MMR vaccination? A history of thrombocytopenia is a ... I have a female patient who has a history of immune thrombocytopenia and had a splenectomy as treatment. This patient responded ... Ask the Experts-Question of the Week: I have a female patient who has a history of immune thrombocytopenia and had a…read more ... particularly since the thrombocytopenia has been treated. For more information on vaccination of persons with asplenia, see the ...
  http://www.immunize.org/express/issue1175.asp
*  Immunosuppressive Therapy in the Treatment of Immune-mediated Disease - Miller - 2008 - Journal of Veterinary Internal Medicine...
Feldman BF, Handagama P., Lubberink AAME. Splenectomy as adjunctive therapy for immune-mediated thrombocytopenia and hemolytic ... Marino C., Cook P. Danazol for lupus thrombocytopenia. Arch Intern Med 1985; 145:2251-2252. *CrossRef, ... Jans HE, Armstrong J., Price GS. Therapy of immune mediated thrombocytopenia: A retrospective study of I5 dogs. J Vet Intern ... Bloom JC, Meunier LD, Thiem PA, et al. Use ofdanazol for treatment of corticosteroid-resistant immune-mediated thrombocytopenia ...
  http://onlinelibrary.wiley.com/doi/10.1111/j.1939-1676.1992.tb00340.x/references
*  Protocols and Video Articles Authored by Sung-Hyun Park (Translated to Hebrew)
... with a known diagnosis of autoimmune thrombocytopenic purpura who had a worsening thrombocytopenia 11 years after splenectomy. ... Accessory splenectomy was performed with only a transient elevation of the platelets. We report here on this case with a review ... Splenectomy is the major treatment modality after the failure of more conservative medical therapy. Approximately 15% of the ... Postsplenectomy Recurrence of Thrombocytopenia with an Accessory Spleen The Korean Journal of Internal Medicine. Sep, 2004 , ...
  https://www.jove.com/author/Sung-Hyun_Park?language=Hebrew
*  Thrombocytopenia and Platelet problems
Splenectomy is another option. There are dogs who respond really well to splenectomy to control thrombocytopenia (just in case ... Thrombocytopenia in Springer Spaniel Question: Dear Dr. Mike, My 6 year old female Springer Spaniel has had thrombocytopenia ... A decrease in platelet numbers is referred to as thrombocytopenia. Immune mediated thrombocytopenia (ITP) can occur due to drug ... we would probably consider doing a splenectomy to see if that would provide additional relief from the thrombocytopenia but I ...
  https://www.vetinfo.com/dthrombo.html
*  Purpura, thrombocytopenic | definition of Purpura, thrombocytopenic by Medical dictionary
Splenectomy may be considered for severe unresponsive thrombocytopenia. Immune globulin is given to prepare severely ... Splenectomy is indicated when other, more conservative measures fail and is successful in a majority of cases. In some ... thrombotic thrombocytopenic purpura a form of thrombotic microangiopathy characterized by thrombocytopenia, hemolytic anemia, ... The lower the platelet count falls, the more precautions the patient will need to take; in severe thrombocytopenia, even minor ...
  http://medical-dictionary.thefreedictionary.com/Purpura%2C+thrombocytopenic
*  Thrombocytopenia | National Heart, Lung, and Blood Institute (NHLBI)
Splenectomy. A splenectomy is surgery to remove the spleen. This surgery may be used if treatment with medicines doesn't work. ... Severe Thrombocytopenia. If your thrombocytopenia is severe, your doctor may prescribe treatments such as medicines, blood or ... Thrombocytopenia (THROM-bo-si-to-PE-ne-ah) is a condition in which your blood has a lower than normal number of blood cell ... Severe thrombocytopenia can cause bleeding in almost any part of the body. Bleeding can lead to a medical emergency and should ...
  https://www.nhlbi.nih.gov/health-topics/thrombocytopenia