Loading...
*  Primed to Understand Fibrinogen in Cardiovascular Disease | Arteriosclerosis, Thrombosis, and Vascular Biology
... fibrinogen to support high-affinity nonsubstrate binding of thrombin.22-24 Although fibrin-bound thrombin resists heparin- ... Inhibition of thrombin generation in plasma by fibrin formation (Antithrombin I). Thromb Haemost. 2002;88:253-258. ... Inhibition of thrombin-mediated factor V activation contributes to the anticoagulant activity of fibrinogen γ′. J Thromb ... Note on the adsorption of thrombin on fibrin. Science. 1945;101:520-521. doi: 10.1126/science.101.2629.520. ...
  http://atvb.ahajournals.org/content/36/1/4
*  Heparin cofactor II deficiency
Heparin cofactor II (HCII) is a serine proteinase inhibitor in human plasma that rapidly inhibits thrombin in the presence of ... Heparin cofactor II (HCF2; {142360}) rapidly inhibits thrombin in plasma in the presence of dermatan sulfate or heparin. ...
  http://diseaseinfosearch.org/Heparin+cofactor+II+deficiency/8506
*  Aniara: MEASUREMENT OF HEPARIN COFACTOR II
... and measurement of residual thrombin by its amidolytic activity on a thrombin specific chromogenic substrate (SIIa-01). pNA is ... The amount of pNA released is directly related to the residual thrombin activity. There is an inverse relationship between the ... TEST PRINCIPLE: Heparin Cofactor II is an anticoagulant protein which inhibits specifically thrombin. This inhibition is highly ... The BIOPHEN H-CoII assay is a chromogenic method based on the inhibition of a constant and in excess amount of thrombin, by the ...
  http://www.aniara.com/mm5/merchant.mvc?Store_Code=ANIA&Screen=CTGY&Category_Code=HEPARINCOFACTORII
*  Aggregated Low-Density Lipoprotein Uptake Induces Membrane Tissue Factor Procoagulant Activity and Microparticle Release in...
... initiating blood coagulation and leading to the focal production of thrombin via the successive activation of factor IX, factor ...
  http://circ.ahajournals.org/content/110/4/452
*  Factor xa inhibitors - Eliquis copay card
Direct Thrombin Inhibitors and Factor Xa Inhibitors in. Initial identification of fXa inhibitors relied on high-throughput ... bind directly to thrombin and do not require a cofactor such as antithrombin to exert their effect.. List of Factor Xa ... direct thrombin inhibitors and factor Xa inhibitors are likely to replace warfarin for long-term anticoagulation in selected ... a coagulation factor at a critical juncture in the blood coagulation pathway leading to thrombin generation. ...
  http://www.valleystamp.com/wepe/factor-xa-inhibitors-1598.php
*  Antifactor Xa Monitoring in Patients on IV Unfractionated Heparin
Of these, thrombin and factor Xa are most responsive, and thrombin's sensitivity to inhibition is approximately 10 times ... Heparin prohibits fibrin formation by inactivating thrombin and limits thrombin-induced activation of factors V and VIII. Once ... This leads to a conformational change that accelerates thrombin inhibition. The heparin-antithrombin complex binds to the ... Molecular weight dependency of the heparin potentiated inhibition of thrombin and activated factor X. Effect of heparin ...
  https://www.uspharmacist.com/article/antifactor-xa-monitoring-in-patients-on-iv-unfractionated-heparin
*  LDL Increases Inactive Tissue Factor on Vascular Smooth Muscle Cell Surfaces | Circulation
Thrombin stimulates proliferation of cultured rat aortic smooth muscle cells by a proteolytically activated receptor. J Clin ... Various agents, including serum, thrombin, angiotensin II, and platelet-derived growth factor have been shown to induce tissue ... In acute coronary syndrome, increased thrombin could promote coagulation after plaque rupture; in restenosis or atherosclerosis ... 1 3 4 5 and it has been proposed that the resulting increase in local thrombin production could play a pivotal role in the ...
  http://circ.ahajournals.org/content/99/13/1753
*  Heparin cofactor II - Wikipedia
2004). "Molecular mapping of the thrombin-heparin cofactor II complex". J. Biol. Chem. 279 (41): 43237-44. doi:10.1074/jbc. ... Heparin Cofactor II deficiency can lead to increased thrombin generation and a hypercoagulable state. GRCh38: Ensembl release ... 2003). "Plasma levels of heparin cofactor II (HCII) and thrombin-HCII complex in patients with disseminated intravascular ... 2002). "Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism". Proc ...
  https://en.wikipedia.org/wiki/Heparin_cofactor_II
*  Thrombin - Wikipedia
E thrombin, beta-thrombin, gamma-thrombin) is a serine protease, an enzyme that, in humans, is encoded by the F2 gene. ... Thrombin is sold under the brand name Fibrimex for use as a binding agent for meat. The thrombin in Fibrimex derives from ... Thrombin interacts with thrombomodulin. As part of its activity in the coagulation cascade, thrombin also promotes platelet ... Due to its high proteolytic specificity, thrombin is a valuable biochemical tool. The thrombin cleavage site (Leu-Val-Pro-Arg- ...
  https://en.wikipedia.org/wiki/Thrombin
*  Willems1991 - Simulating thrombin generation
Simulations of the effect of hirudin indicate that factor V is predominantly activated by thrombin and not by factor Xa. The ... A simulation model for the production of thrombin in plasma is presented. Values of the reaction rate constants as determined ... The dependence of this threshold value on different negative feedback reactions, e.g. the inactivation of thrombin and factor ... in purified systems are used and the model is tested by comparison of simulations of factor Xa, factor Va and thrombin ...
  http://www.ebi.ac.uk/biomodels/MODEL1807240002
*  THROMBIN TIME
Home : For health professionals : Refer a patient : Laboratory Services : Test Table : THROMBIN TIME ... Heparin, Direct Thrombin Inhibitors (Lepirudin, Argatroban, Dabigatran, etc.), Fibrin/fibrinogen degradation products may cause ... prolongation of the Thrombin Time. Other interferences include: Hemoglobin (,500 mg/dL), Triglycerides (1,000 mg/dL), Bilirubin ...
  http://www.legacyhealth.org/for-health-professionals/refer-a-patient/laboratory-services/test-table/thrombin-time.aspx
*  thrombin cleavage
... stephen goodwin goodwin at BINAH.CC.BRANDEIS.EDU Thu Oct 10 06:42:16 EST 1996 *Previous message: Looking for ... Hi folks Does anyone know of any bead technology that exists that allows efficient removal of thrombin protease after cleavage ...
  http://www.bio.net/bionet/mm/dros/1996-October/002429.html
*  thrombin antibodies?
... Ding Ming ming at mbcrr.harvard.edu Fri Mar 24 12:35:13 EST 1995 *Previous message: MW of IgG? ... I would appreciate if you can tell me who produce the thrombin antibodies and what their telephone numbers. Thanks in advance. ...
  http://www.bio.net/bionet/mm/methods/1995-March/026418.html
*  Thrombin time - Wikipedia
Batroxobin has a similar action to thrombin but unlike thrombin it is not inhibited by heparin. Normal values for thrombin time ... The thrombin time (TT), also known as the thrombin clotting time (TCT) is a blood test that measures the time it takes for a ... The thrombin time compares the rate of clot formation to that of a sample of normal pooled plasma. Thrombin is added to the ... The time between the addition of the thrombin and the clot formation is recorded as the thrombin clotting time. Whole blood is ...
  https://en.wikipedia.org/wiki/Thrombin_time
*  Thrombin receptor - Wikipedia
Thrombin, a serine protease, binds to and cleaves the extracellular N-terminal domain of the receptor. A tethered ligand ... "Thrombin receptors and their antagonists: an update on the patent literature". Expert Opin Ther Pat. 20 (7): 875-84. Jul 2010. ... There are three known thrombin receptors termed PAR1, PAR3 and PAR4 (PAR for protease-activated receptor). These receptors are ...
  https://en.wikipedia.org/wiki/Thrombin_receptor
*  Thrombin Sawai - Drugs.com
A list of US medications equivalent to Thrombin Sawai is available on the Drugs.com website. ... Thrombin Sawai is a medicine available in a number of countries worldwide. ... Thrombin Sawai may be available in the countries listed below.. Ingredient matches for Thrombin Sawai. Thrombin. Thrombin is ...
  https://www.drugs.com/international/thrombin-sawai.html
*  STA THROMBIN 10
Determination of the Thrombin Time by STA Analyzers. Freeze-dried human thrombin (1.5NIH units/mL) with calcium.,medicine, ... Determination of the Thrombin Time by STA Analyzers. Freeze-dried human thrombin (1.5NIH units/mL) with calcium. ...
  http://www.bio-medicine.org/medicine-products/STA-THROMBIN-10-20319-1/