*  5-HT3 receptor - Wikipedia
... or serotonin) receptors which are G protein-coupled receptors. This ion channel is cation-selective and mediates neuronal ... On a cellular level, it has been shown that postsynaptic 5-HT3 receptors mediate fast excitatory synaptic transmission in rat ... sorted by their respective therapeutic application) include: Antiemetics AS-8112 Granisetron Ondansetron Tropisetron ... depolarization and excitation within the central and peripheral nervous systems. As with other ligand gated ion channels, the 5 ...
  https://en.wikipedia.org/wiki/5-HT3_receptor
*  Alpha-2 adrenergic receptor - Wikipedia
However, it is now known that clonidine binds to imidazoline receptors with a much greater affinity than α2 receptors, which ... Their pharmacology and therapeutic role". Anaesthesia. 54 (2): 146-65. doi:10.1046/j.1365-2044.1999.00659.x. PMID 10215710. ... The α2A adrenergic receptor is localised in the following central nervous system (CNS) structures: Brainstem (especially the ... α2C selective blockers include JP-1302 and spiroxatrine, the latter also being a serotonin 5-HT1A antagonist. Adrenergic ...
  https://en.wikipedia.org/wiki/Alpha-2_adrenergic_receptor
*  ενα πολυ ενδιαφερον αρθρο, αναφορικα με τις ουσιες
Similar therapeutic agents are in the pipeline. Of greater interest still are central-nervous-system-selective compounds, ... serotonin receptors implicated in dark moods and anxiety. By contrast, stimulation of the 5-HT2A receptors accounts for the ... The next few decades will take us much closer to the downstream intra-cellular action. For it is here that our minds will ... are the selective serotonin reuptake inhibitors [SSRIs]. Serotonin, "the civilising neurotransmitter", plays a vital role in ...
  http://brexmother1.blogspot.com/2007/12/blog-post_6438.html
*  Neurosteroids and cholinergic systems: implications for sleep and cognitive processes and potential role of age-related changes...
5α THPROG) have been implicated as powerful modulators of memory processes and sleep sta ... Steinbusch HW, Nieuwenhuys R (1981) Localization of serotonin-like immunoreactivity in the central nervous system and pituitary ... Datta S (1997) Cellular basis of pontine ponto-geniculo-occipital wave generation and modulation. Cell Mol Neurobiol 17:341-365 ... Lambert JJ, Belelli D, Peden DR, Vardy AW, Peters JA (2003) Neurosteroid modulation of GABAA receptors. Prog Neurobiol 71:67-80 ...
  https://link.springer.com/article/10.1007%2Fs00213-005-0254-6
*  Discovery Biology News
Serotonin 5-HT3 is part of the cys-loop receptor family, the mechanism of this family is not well understood due to ... Antibody therapeutic approach to combating Ebola virus. The current Ebola virus (EBOV) outbreak, taking its toll in Western ... Cellular structures, such as proteins, DNA, and lipids, are prone to these oxidation damages, which further contribute to the ... The mechanism of the blockade, targeting CTLA-4 and PD-1 receptors which act as on/off switches in T cell-mediated tumor ...
  https://www.genscript.com/DiscoveryBiology_news.html
*  Protocols and Video Articles Authored by Solomon H. Snyder
The ligand binding techniques that were used to identify opiate receptors were employed to characterize receptors for all of ... Serotonin, Cytokines, P11, and Depression Proceedings of the National Academy of Sciences of the United States of America. May ... We report a severe loss of IPMK in the striatum of HD patients and in several cellular and animal models of the disease. This ... This review focuses on the role of inter- and intracellular signaling systems in cell death, especially in the nervous system. ...
  https://www.jove.com/author/Solomon+H._Snyder
*  heart rate
sympathetic nervous system*cardiovascular physiologic phenomena*autonomic nervous system*electrocardiography*heart*hypertension ... serotonin transporter products*Agtr1a products*Nos3 products*Nos1 products*GNB3 products*IL-6 products*Adra2c products*ADRA2C ... show dysregulation of these receptors in CFS after 25 min of moderate exercise (at 70% of age-predicted maximum heart rate). ... Targeting thermoreceptors for therapeutic hypothermia. Sean P Marrelli; Fiscal Year: 2012. ..Multiple physiologic variables ( ...
  https://www.labome.org/topics/physical/natural/biological/circulatory/cardiovascular/cardiovascular/hemodynamic/heart-rate-20007.html
*  5-HT6 receptor - Wikipedia
IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. serotonin 6 receptor at ... Yun HM, Kim S, Kim HJ, Kostenis E, Kim JI, Seong JY, Baik JH, Rhim H (Feb 2007). "The novel cellular mechanism of human 5-HT6 ... 5HT6 activation may play a role in the therapeutic benefits of serotonergic antidepressants like the selective serotonin ... serotonin) receptor 6". Woolley ML, Marsden CA, Fone KC (Feb 2004). "5HT6 receptors". Current Drug Targets. CNS and ...
  https://en.wikipedia.org/wiki/5-HT6_receptor
*  Serotonin - Wikipedia
Serotonin present in the blood then stimulates cellular growth to repair liver damage. 5HT2B receptors also activate osteocytes ... Serotonin taken orally does not pass into the serotonergic pathways of the central nervous system, because it does not cross ... At present, no known pharmaceuticals are known to appreciably inhibit PMAT at normal therapeutic doses. The PMAT also ... There are various serotonin receptors. Serotonin is metabolized mainly to 5-HIAA, chiefly by the liver. Metabolism involves ...
  https://en.wikipedia.org/wiki/Serotonin
*  Cannabis and Cannabinoids (PDQ®): Integrative, alternative, and complementary therapies - Health Professional Information [NCI]...
... cannabinoid receptors are present in other tissues throughout the body, not just in the central nervous system, and adverse ... Report on therapeutic outcome or outcomes, such as tumor response, improvement in survival, or measured improvement in quality ... A comprehensive Health Canada monograph on marijuana concluded that while there are many cellular and molecular studies that ... a serotonin 5-hydroxytryptamine 3 (5-HT3) receptor antagonist, is one of the mainstay agents in the current antiemetic ...
  https://www.uwhealth.org/health/topic/nci/cannabis-and-cannabinoids-pdq-integrative-alternative-and-complementary-therapies-health-professional-information-nci/ncicdr0000683767.html
*  Frontiers | Drug Development for the Irritable Bowel Syndrome: Current Challenges and Future Perspectives | Pharmacology
Holzer, P. (2004b). Opioids and opioid receptors in the enteric nervous system: from a problem in opioid analgesia to a ... 2011). Intestinal serotonin release, sensory neuron activation, and abdominal pain in irritable bowel syndrome. Am. J. ... To provide a more complete picture, a therapeutic target can coincide with the biomarker (e.g., TNFα) or, as a component of the ... Contrasting effects of linaclotide and lubiprostone on restitution of epithelial cell barrier properties and cellular ...
  https://www.frontiersin.org/articles/10.3389/fphar.2013.00007/full
*  David C. Yeomans | Stanford Medicine Profiles
... peptide release from trigeminal dural afferents suggests that activation of these receptors may provide therapeutic benefit in ... Assessment of cellular localization of the thromboxane A2 receptor by immunocytochemistry. Methods in molecular biology ( ... The central nervous system undergoes dynamic changes as it matures. However, until recently, very little was known about the ... The omenta were removed and standard immunohistochemistry was performed for gamma-amino-butyric acid (GABA), serotonin, ...
  https://med.stanford.edu/profiles/david-yeomans
*  Myenteric plexus - Wikipedia
These receptors sense "sweetness" on the tongue and sense glucose in the enteric nervous system. These receptors help regulate ... and serotonin. More than 90% of the body's serotonin lies in the gut; as well as about 50% of the body's dopamine, which is ... One receptor that has been targeted for therapeutic reasons has been the 5-hydroxytryptamine (5-HT4) receptor. Activating this ... Cellular and molecular biology (Noisy-le-Grand, France). 41 (8): 1033-8. PMID 8747084. Shprecher, D. R.; Derkinderen, P. (2012 ...
  https://en.wikipedia.org/wiki/Myenteric_plexus
*  Schizophrenia: Current Therapies | CNS Diseases
Indeed, the blocking of the serotonin receptors may be a requirement for the reduction in extrapyramidal symptoms that is ... traditionally centered on the role of D2 receptors because partial blockade of these receptors correlates with the therapeutic ... Other data indicate that people who had a childhood viral infection of the central nervous system are approximately five times ... such as cellular proliferation and differentiation, axonal outgrowth, and synaptic regression. ...
  http://cnsdiseases.com/schizophrenia-current-therapies
*  Neurodegenerative Diseases | Leaders in Pharmaceutical Business Intelligence (LPBI) Group
The number of receptors for serotonin in the brain amounts to 14, occurring in different cell types. Consequently, determining ... potentially translate into targeted cellular and tissue-specific clinical applications designed to achieve maximal therapeutic ... Drug delivery to the target site in the central nervous system (CNS) is one of the most difficult steps in neuroscience ... She has analyzed several light-sensitive varieties of the serotonin receptors 5-HT1A and 5-HT2C in great detail. Together with ...
  https://pharmaceuticalintelligence.com/category/neurodegenerative-diseases/
*  May 30. Registration Opening Session. Prémio Janssen Neurociências Reception. 13h45 14h45-15h00 - PDF
Chapter 7: The Nervous System Chapter 7: The Nervous System Objectives Discuss the general organization of the nervous system ... Neurotrophic factors and Their receptors Neurotrophic factors and Their receptors Huang Shu-Hong Institute of neurobiology 1 ... Study of the cellular properties of nerve cells and how these properties give rise to behaviors from simple to complex ... THERAPEUTIC ROLE OF IL-37 IN SPINAL CORD INJURY. Rubén López Vales Faculty of Medicine, UAB (Universitat Autònoma de Barcelona) ...
  http://docplayer.net/1315969-May-30-registration-opening-session-premio-janssen-neurociencias-reception-13h45-14h45-15h00.html
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... complex and centralised nervous system, tractability for studies of learning and cellular mechanisms of memory (e.g. long-term ... A number of these agents are currently being developed as anti-cancer agents designed to improve the therapeutic index of the ... Increased central serotonin sensitivity is hypothesized to contribute toward the development of cancer-related fatigue syndrome ... The hypothesis is supported by evidence from many levels-genes, neurotransmitters and their receptors, neurophysiology, ...
  https://www.jove.com/visualize?author=Paul%20S%20Andrews%20
*  diltiazem
of serotonin in 22 consecutive patients 1 year after the operation, subsequently evaluating the effect of diltiazem in 9 ... the mechanism(s) of EICA at the cellular and subcellular levels, and (3) to evaluate the effects of ATP-MgCl2, Diltiazem (DTZM ... RECEPTORS FOR CALCIUM CHANNEL INHIBITORS. PAL VAGHY; Fiscal Year: 1992. ..subunit. This is a 1,4- dihydropyridine and ... Statement: L-type Ca2+ channels are important therapeutic targets of a class of drugs that include verapamil and diltiazem, ...
  https://www.labome.org/topics/chemicals/heterocyclic/2/benzazepines/diltiazem-11350.html
*  Dopamine receptor D4 - Wikipedia
"Dopamine Receptors: D4". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. ... Cellular component. • integral component of membrane. • integral component of plasma membrane. • membrane. • plasma membrane. • ... Roxindole - D4 selective but also D2 and D3 autoreceptor agonist, 5HT1A receptor agonist, serotonin reuptake inhibitor) ... Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction ...
  https://en.wikipedia.org/wiki/Dopamine_D4_receptor
*  Cannabis
... receptors without diminishing nervous system function or chemotherapy efficacy. Br J Pharmacol 171 (3): 636-45, 2014. [PUBMED ... Baker D, Pryce G, Giovannoni G, et al.: The therapeutic potential of cannabis. Lancet Neurol 2 (5): 291-8, 2003. [PUBMED ... A comprehensive Health Canada monograph on marijuana concluded that while there are many cellular and molecular studies that ... such ashistamine and serotonin, and on keratinocytes to enhance the release of analgesic opioids has been described.[44-46] One ...
  http://www.fitnessblenders.com/cannabis.html
*  06th week of 2011 patent applcation highlights part 44
The therapeutic agent is released in a biologically active form, for example, the therapeutic agent may retain its three ... a selective serotonin reuptake inhibitor; a serotonin-norepinephrine reuptake inhibitor; a cholinesterase inhibitor; a dopamine ... abnormal cellular proliferation, angiogenesis, Alzheimer's disease and osteoarthritis), the modulation of cellular events ... FARNESOID X RECEPTOR AGONISTS - The present invention relates to farnesoid X receptors (FXR, NR1H4). FXR is a member of the ...
  http://www.patentsencyclopedia.com/hgl/02-10-11/02-10-11_44
*  https://www.cancer.gov/about-cancer/treatment/cam/hp/cannabis-pdq
... cannabinoid receptors are present in other tissues throughout the body, not just in the central nervous system, and adverse ... Report on therapeutic outcome or outcomes, such as tumor response, improvement in survival, or measured improvement in quality ... A comprehensive Health Canada monograph on marijuana concluded that while there are many cellular and molecular studies that ... such as histamine and serotonin, and on keratinocytes to enhance the release of analgesic opioids has been described.[44-46] ...
  https://www.cancer.gov/about-cancer/treatment/cam/hp/cannabis-pdq
*  Frontiers | Cannabinoids Modulate Neuronal Activity and Cancer by CB1 and CB2 Receptor-Independent Mechanisms | Pharmacology
... action may lead to the design and development of therapeutic agents with greater efficacy and specificity for their cellular ... it has become clear that not all effects of cannabinoid drugs are attributable to their interaction with CB1 and CB2 receptors ... This review summarizes evidence for these interactions in the CNS and in cancer, and is organized according to the cellular ... This review summarizes evidence for these interactions in the CNS and in cancer, and is organized according to the cellular ...
  https://www.frontiersin.org/articles/10.3389/fphar.2017.00720/full
*  Apitherapy News: 2014
Serotonin was depleted by a daily injection of DL-p-chlorophenylalanine (PCPA, 150 mg/kg, i.p.) for 3 days. The amount of ... Objective: To evaluate the immunological and clinical therapeutic effect of using Apitherapy in the treatment of RLPP.. Methods ... Both of these cellular effects were suppressed by addition of theophylline. These data indicate that BPE induced both cell ... At very low doses, these systemic pesticides negatively impact the immune system of the bee, interfere with their nervous ...
  http://apitherapy.blogspot.com/2014/
*  No Liquor
An example is buspirone, an antianxiety medication that activates certain serotonin receptors. Seroton in, a neurotransmitter ... Pharmacological Effects of Ethanol on the Nervous System. Boca Raton, FL: CRC Press, 1996. (12) Grant, K.A. Emerging ... 2) Koob, G.F., and Bloom, F.E. Cellular and molecular mechanisms of drug dependence. Science 242(4879):715-723, 1988. (3) Di ... the potential therapeutic value of using pharmacotherapy over a longer period of time, and which subsets of patients are most ...
  http://noliquor.us/liquor/faq/aa33.html