Colgate Virology (and Immunology) Blog: Ikaros Plays an Important Role in the Th17 Response
If you're interested in learning more about Th1 or Th2 responses check out this link) In order to become a Th17 cell, the ... AIDS (3) Allergy (4) antibodies (17) autoimmune disease (9) cancer (10) CD4+ T cells (14) CD8+ T cells (10) DCs (5) HIV (18) ... cells, Th17 cells, and a protein, Ikaros, that can lead the naïve Th cells towards a Th17 response. Before we jump into the ... influenza (6) innate immune system (10) interferon (15) multiple sclerosis (8) NK cells (8) regulatory T cell (4) Tregs (6) ...http://colgateimmunology.blogspot.com/2013/11/ikaros-plays-important-role-in-th17.html
Hierarchical IL-5 Expression Defines a Subpopulation of Highly Differentiated Human Th2 Cells | The Journal of Immunology
Th2 cells. IL-5+ Th2 cells expressed less CD27 and greater programmed cell death-1 than IL-5− Th2 cells, consistent with their ... cells were triple positive. In both allergen-specific Th2 cells and IL-4-sorted Th2 cell lines, 98-100% of IL-5+ Th2 cells had ... Th2 cells. First, IL-5+ Th2 cells were almost exclusively IL-4+IL-5+IL-13+ triple-positive cells within the larger Th2 ... Th2 cells are highly differentiated T cells. The delayed acquisition of the IL-5+ Th2 phenotype implies that IL-5+ Th2 cells ...http://www.jimmunol.org/content/187/6/3111
Th2 cells: help for helminths. | JEM
Pay Per Article - You may access this article (from the computer you are currently using) for 2 days for US$30.00. Regain Access - You can regain access to a recent Pay per Article purchase if your access period has not yet expired.. ...http://jem.rupress.org/content/179/5/1405
Interleukin-12 Receptor β2 Chain and TH2 Cells | Science Signaling
T cells differentiated into TH2 cells in the presence of IL-4, or IL-4 and IL-12. IL-12 treatment of TH2 cells expressing ... When naïve CD4+ T cells are treated simultaneously with both IL-4 and IL-12, the IL-4 effects predominate and TH2 cells develop ... Thus, TH2 cells are resistant to TH1 conversion, and decreased expression of IL-12Rβ2 is not necessary for the establishment of ... However, it is not known what effect constitutive expression of the IL-12Rβ2 chain has on the development of TH2 cells. ...http://stke.sciencemag.org/content/2000/23/tw2
Opinions on whether TH1 and TH2 cell types originate from TH0
... Thierry Sornasse tsornas at dbmdec5.ulb.ac.be Wed Mar 9 11:37:41 ... Thus, there could be some memory T cells that are already shifted to Th1 or to Th2. In conclusion, I could say that the ... Hi Immunonetters, The discrimination between Th1 and Th2 phenotypes was established from data about T cell clones derived from ... DC activate naive T cells but do not trigger the differentiation of Th1, while Mac do not activate naive T cells but trigger ...http://www.bio.net/bionet/mm/immuno/1994-March/001141.html
T follicular helper cells differentiate from Th2 cells in response to helminth antigens | JEM
TFH cells) PD-1− GFP+ CD4+ T cells (Th2 cells) and GFP− CD4+ T cells (Naive T cells) sorted from the same LNs. Real-time RT-PCR ... cells that have differentiated into TFH cells provide help to B cells, whereas "conventional" Th2 cells traffic to peripheral ... Data are from gated CD4+ T cells. Numbers are percentages of cells in each quadrant. (E) Th2 cells (CD4+/GFP+/PD-1−/CXCR5−) ... PD-1+ Th2 cells and germinal center B cells develop in response to helminth infections or immunization with Th2 response ...http://jem.rupress.org/content/206/5/991
JCI - Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway...
Even on transfer of twice as many Th1 as Th2 cells (5 × 106 Th1 cells + 2.5 × 106 Th2 cells, Th1 + Th2 [2:1]), Th1 cells did ... B cells or γδ T cells are required for the development of Th2 effector cells from naive precursor cells but that once Th2 cells ... Th2 (2.5 × 106 cells per mouse), or Th1 plus Th2 (2.5 × 106 Th1 + 2.5 × 106 Th2 cells per mouse) cells in OVA-treated SCID mice ... Th2 and Th0 cells, but not Th1 cells, increase airway hyperreactivity. SCID mice received Th1, Th2, or Th0 cells (2.5 × 106 ...https://www.jci.org/articles/view/5155
IJMS | Free Full-Text | The Metalloporphyrin Antioxidant, MnTE-2-PyP, Inhibits Th2 Cell Immune Responses in an Asthma Model
... the addition of MnTE-2-PyP inhibited Th2 cell proliferation. MnTE-2-PyP suppressed CD25 expression on OVA-specific Th2 cells, ... MnTE-2-PyP-pretreated DC inhibited IL-4, IL-5 and IFNγ production and inhibited Th2 cell proliferation in the DC-Th2 co- ... Thus, we hypothesized that MnTE-2-PyP may alter dendritic cell-Th2 interactions. Bone marrow derived dendritic cells (DC) and ... which implied that MnTE-2-PyP can inhibit the activation of Th2 cells. MnTE-2-PyP also down-regulated co-stimulatory molecules ...http://www.mdpi.com/1422-0067/13/8/9785
Th2 cells become IL-12 responsive following adoptive tr | Open-i
... in vitro Th2 cells or naïve CD4 cells were transferred to Rag1-/-mice fo ... Th2 cells become IL-12 responsive following adoptive transfer.A and B). CD4+Il4gfp+ ... Th2 cells become IL-12 responsive following adoptive transfer.A and B). CD4+Il4gfp+in vitro Th2 cells or naïve CD4 cells were ... Th2 cells become IL-12 responsive following adoptive transfer.A and B). CD4+Il4gfp+in vitro Th2 cells or naïve CD4 cells were ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC4493106_ppat.1004994.g007&req=4
CD11b+ Myeloid Cells Are the Key Mediators of Th2 Cell Homing into the Airway in Allergic Inflammation | The Journal of...
... myeloid cells affects Ag presentation to Th2 cells; thus, the decreased accumulation of Th2 cells in the lung is secondary to a ... cell population in the lung is sufficient for Th2 cell recruitment, and also demonstrate that the Th2 cell recruitment defect ... The accumulation of Th2 cells in the airways in this model has been shown to be due to recruitment of Th2 cells that have ... After transfer of Th2 cells and Ag challenge, there was prominent recruitment of OVA-specific Th2 cells (identified by an Ab ...http://www.jimmunol.org/content/182/1/623.long
Functionally Defined T Cell Subsets in Transplantation Biology and Therapy: Regulatory T Cells and Th2 Cells | Springer for...
Functionally Defined T Cell Subsets in Transplantation Biology and Therapy: Regulatory T Cells and Th2 Cells. ... Regulatory T Cells and Th2 Cells. In: Bishop M. (eds) Hematopoietic Stem Cell Transplantation. Cancer Treatment and Research, ... Allospecific CD4+, Th1/Th2 and CD8+, Tc1/Tc2 populations in murine GVL: type I cells generate GVL and type II cells abrogate ... TH2.rapa cell treatment of established murine acute GvHD is abrogated by IL-2 therapy and T regulatory cells. Blood (ASH Annual ...https://rd.springer.com/chapter/10.1007/978-0-387-78580-6_7
TH2的功能(Functions of TH2 cells) - 小小整理網站 Smallcollation
2. 肥大細胞去顆粒化（Mast cell degranulation（４IL-4刺激B cell製造IgE３而IgE與mast cell結合可使mast cell去顆粒化３引發過敏反應. 3. 促進腸道黏膜分泌及蠕動（Intestinal mucus ... 當寄生蟲或蛋白質抗https://smallcollation.blogspot.com/2013/10/th2functions-of-th2-cells.html
The autophagy gene Atg16l1 differentially regulates Treg and TH2 cells to control intestinal inflammation. - The Kennedy...
Moreover, we also identify an unexpected role for autophagy in directly limiting mucosal TH2 cell expansion. These findings ... Treg cells. Specific ablation of Atg16l1 in Foxp3(+) Treg cells in mice demonstrated that autophagy directly promotes their ... Here, we demonstrate that autophagy is essential for maintenance of balanced CD4(+) T cell responses in the intestine. ... Selective deletion of Atg16l1 in T cells in mice resulted in spontaneous intestinal inflammation that was characterized by ...https://www.kennedy.ox.ac.uk/publications/607153
Organ-specific distribution of CD4(+) T1 /ST2(+) Th2 cells in Leishmania major infection - LSHTM Research Online | London...
The frequency of CD4(+) T cells expressing the T1/ST2 cell surface marker and Th2 cytokines in the lymphoid organs was low in ... In the study presented here, a stable cell surface marker expressed on Th2 cells, T1/ST2, has been used to assess the ... Kropf, P; Bickle, Q; Herath, S; Klemenz, R; Muller, I; (2002) Organ-specific distribution of CD4(+) T1 /ST2(+) Th2 cells in ... Leishmania, Th2 cell, T1/ST2, cytokine, local immune response, Interleukin-1 receptor, selective expression, protective, ...http://researchonline.lshtm.ac.uk/16321/
Progesterone favors the development of human T helper cells producing Th2-type cytokines and promotes both IL-4 production and...
These results indicate that P can favor the development of Th cells producing Th2-type cytokines and is an inducer of both ... Progesterone favors the development of human T helper cells producing Th2-type cytokines and promotes both IL-4 production and ... Progesterone favors the development of human T helper cells producing Th2-type cytokines and promotes both IL-4 production and ... Progesterone favors the development of human T helper cells producing Th2-type cytokines and promotes both IL-4 production and ...http://www.jimmunol.org/content/155/1/128.long
NAVER Academic | Differential effects of myelin basic protein-activated Th1 and Th2 cells on the local immune microenvironment...
Th2 cells, regulatory T cells, and M2 macrophages) and cytokines (IL-4, -10, and -13) were found in MBP-Th2 cell transferred ... In this study, the Th1 and Th2 type MBP-T cells (MBP-Th1 and -Th2) were polarized in vitro, and their effects on the local ... In MBP-Th1 cell transferred rats, the high levels of pro-inflammatory cells (Th1 cells and M1 macrophages) and cytokines (IFN-γ ... of Th2 cells may alter the local microenvironment from one primarily populated by Th1 and M1 cells to another dominated by Th2 ...https://academic.naver.com/article.naver?doc_id=177595806
JCI - Airway epithelial SPDEF integrates goblet cell differentiation and pulmonary Th2 inflammation
SPDEF was required for goblet cell differentiation and pulmonary Th2 inflammation in response to house dust mite (HDM) extract ... expression was accompanied by recruitment of Th2 lymphocytes, group 2 innate lymphoid cells, and eosinophils to the lung. ... Together, our results indicate that SPDEF causes goblet cell differentiation and Th2 inflammation during postnatal development ... Here, we show that expression of SPDEF or FOXA3 in airway epithelial cells in neonatal mice caused goblet cell differentiation ...https://www.jci.org/articles/view/79422/pdf
Interferons direct Th2 cell reprogramming to generate a stable GATA-3(+)T-bet(+) cell subset with combined Th2 and Th1 cell...
Th2+1' phenotype that was maintained in vivo for months. Th2 cell reprogramming required T cell receptor stimulation, concerted ... However, knowledge on the plasticity of Th2 cell lineage commitment is limited. Here we show that infection with Th1 cell- ... Stable coexpression of GATA-3 and T-bet provides a molecular concept for the long-term coexistence of Th2 and Th1 cell lineage ... LCMV-triggered T-bet induction in adoptively transferred virus-specific Th2 cells was crucial to prevent viral persistence and ...https://www.ndorms.ox.ac.uk/publications/553317
Differential Contribution of Adhesion Molecules to Th1 and Th2 Cell-Mediated Lung and Bowel Inflammation. | Biol Pharm Bull;40...
... vascular cell adhesion molecule (VCAM)-1; and αL, ß2, and ß7 integrins participate in the accumulation of Th2 cells and ... Differential Contribution of Adhesion Molecules to Th1 and Th2 Cell-Mediated Lung and Bowel Inflammation.. Kaminuma, Osamu; ... We investigated the differential contribution of adhesion molecules to T helper 1 (Th1) and Th2 cell-mediated allergic lung and ... BALB/c mice transferred with in vitro-differentiated antigen-specific Th1 and Th2 cells were intratracheally or intrarectally ...http://pesquisa.bvsalud.org/portal/resource/pt/mdl-28966255
Adoptive Transfer of Paternal Antigen-Hyporesponsive T Cells Facilitates a Th2 Bias in Peripheral Lymphocytes and at Materno...
Adoptive Transfer of Paternal Antigen-Hyporesponsive T Cells Facilitates a Th2 Bias in Peripheral Lymphocytes and at Materno- ... Adoptive Transfer of Paternal Antigen-Hyporesponsive T Cells Facilitates a Th2 Bias in Peripheral Lymphocytes and at Materno- ...http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0897.2006.00425.x/references?globalMessage=0
Follicular Homing T Helper (Th) Cells and the Th1/Th2 Paradigm | JEM
For CD4+ cells, at least three effector subsets may arise: Th1 cells, Th2 cells, or TFH cells. TFH cells can be distinguished ... Relationship of TFH to Th1 and Th2 Cells.. The discovery of a non-Th1, non-Th2 effector T cell for B cell help poses an ... B cells localize in the B cell follicles, whereas T cells colocalize with dendritic cells in the T cell areas. This segregation ... which keeps Th1 cells closer to the T cell area, whereas its absence allows Th2 cells to drift closer to the B cell follicles ( ...http://jem.rupress.org/content/192/11/F31
Dendritic Cells and B Cells: Unexpected Partners in Th2 Development | The Journal of Immunology
TFH cells, Tregs (reviewed in Ref. 53), Th17 cells (73) and, as discussed in this article, Th2 cells. In the case of Th2 cell ... Tuning the Th2-priming capacity of DCs by B cells. *B cell-dependent remodeling of LN architecture facilitates DC-dependent Th2 ... Th2 development is regulated by multiple cell types, including DCs and B cells. Effective priming of naive CD4 T cells is ... Role of B cells as antigen-presenting cells in vivo revisited: antigen-specific B cells are essential for T cell expansion in ...http://www.jimmunol.org/content/193/4/1531
A central role for Type I IFN in the induction of Th2 responses by dendritic cells | The Journal of Immunology
A central role for Type I IFN in the induction of Th2 responses by dendritic cells. Lauren M Webb, Rachel J Lundie, Jessica G ... Although dendritic cells (DCs) are critical for induction of Th2 immunity against helminths or allergens, relatively little is ... Together, our data suggest a key role for IFN-I to enable Th2 induction by DCs against Th2 Ag in vivo. Future work will address ... A central role for Type I IFN in the induction of Th2 responses by dendritic cells ...http://www.jimmunol.org/content/196/1_Supplement/46.13
The transcription factor lymphoid enhancer factor 1 controls invariant natural killer T cell expansion and Th2-type effector...
Thymic iNKT cells can be identified as Th1-like PLZFloTBET+ iNKT1 cells, which are largely found among ST3 cells, Th2-like PLZF ... iNKT cells (Fig. 5 C). A majority of CD4+ iNKT cells are iNKT2 cells, but a small subset of iNKT1 and iNKT17 cells also express ... plays multiple roles in T cell development and is critical for the development of CD4 Th2 cells, Th2-like ILCs (ILC2), and a ... iNKT1 cells, whereas ST2 cells are a mixture of RORγt+ iNKT17 cells and GATA3hi iNKT2 cells, which are also found among ST1 ...http://jem.rupress.org/content/early/2015/04/14/jem.20141849
"Subcutaneous Late Phase Responses are Augmented During Local Inhalatio" by Anurag Singh, Roger S. Thrall et al.
... characterized by Th2 cytokine-dependent pulmonary eosinophilia, methacholine hyperresponsiveness and antigen-specific IgE ... Immunol Cell Biol. Author manuscript; available in PMC 2008 October 31. Published in final edited form as: Immunol Cell Biol. ... Acute exposure of sensitized mice to antigen elicits allergic airway disease (AAD) characterized by Th2 cytokine-dependent ...http://opencommons.uconn.edu/uchcres_articles/50/