Frontiers | Effect of murine exposure to gamma rays on the interplay between Th1 and Th2 lymphocytes | Pharmacology
Exposure to gamma radiation could cause a state of immune stimulation or suppression via controlling Th1/Th2 cell ... Exposure to 5 or 10 gray of γ-rays resulted in a state of immune stimulation (Th1 bias), but exposure to 20 gray showed a ... Aim: This study is carried out to show the effect of gamma rays on the interplay between Th1/Th2 response, splenocyte ... Th1 bias). While exposure of splenocytes suspension to different doses of γ-rays (5, 10, 20 gray) showed activation in ...https://www.frontiersin.org/articles/10.3389/fphar.2015.00074/full
Th1/Th2 cytokine profiles characterize CD as a preferentially Th1 cell-mediated disease initiated by DC-derived IL-12 and/or IL ... Then, in turn, Tregs are also able to suppress Th1 cells as well as Th17 cells (Bettelli et al., 2006, 2007). ... Th1 cell-driven IBD is more severe, and Th2 cell-driven asthma does not develop (Cantorna et al., 2004). The VDR gene maps to a ... TGFβ has been implicated in the conversion of naive CD4+CD25- T cells into CD4+CD25+ T cells via the induction of FoxP3 ( ...http://jpet.aspetjournals.org/content/324/1/23
Enhancement of Th2-Dependent and Inflammatory Response - Patent application
A Th1 response is typically promoted by CD4 "Th1" T-helper cells however a Th1 response can include CD8 Tc1 T cytotoxic cells. ... Cultured cells include "cell lines" and "primary cultured cells." As used herein, the term "cell line," refers to cells ... killer T cells (e.g. natural killer T cells (NKT cells), cytotoxic T cells, and the like), naive T cells and the like. As ... Examples of T cells include but are not limited to T helper cells (e.g. Th0, Th1 and Th2 and the like) and cytotoxic T cells (e ...http://www.patentsencyclopedia.com/app/20080213817
CXCL13, CCL4, and sTNFR as circulating inflammatory cytokine markers in primary and SLE-related autoimmune hemolytic anemia |...
... and suggested potential role of Treg and Th1 cells in AIHA [4-6]. However, the exact dominating Th functional population is yet ... Clonal regulatory T cells specific for a red blood cell autoantigen in human autoimmune hemolytic anemia. Blood. 2008;111:680-7 ... Human TNFRII expressed restrictively upon certain T cell populations and a few other cell types, while TNFRI was found on ... Perforin-low memory CD8+ cells are the predominant T cells in normal humans that synthesize the β-chemokine macrophage ...https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-015-0474-4
Innate lymphoid cell - Wikipedia
ILC1s are analogous to Th1 cells, and share the common transcription factor of T-bet. Natural killer ('NK') cells are cytotoxic ... ILC1 cells comprise NK cells, CD127low CD103+ intraepithelial ILC1s and CD127high ILC1s. ILC1s are weakly cytotoxic cells ... 2016). "Cancer immunosurveillance by tissue-resident innate lymphoid cells and innate-like T cells". Cell. 164 (3): 365-377. ... NK cells express a number of cell surface activating NK cell receptors with specificity for stress induced ligands ...https://en.wikipedia.org/wiki/Innate_lymphoid_cell
"Th1 genetic adjuvants modulate immune responses in neonates" by Tamera Marie Pertmer, Alp E. Oran et al.
In contrast, the Th1 genetic adjuvants had no effect on IgG subtype patterns in adults. In neonatal mice, the Th1 genetic ... Thus, coinoculation of Th1 genetic adjuvants had greater effects on the nature of the immune response in the neonate than in ... we address the ability of DNA encoding Th1 cytokines to bias the isotype of antibody raised by neonatal or adult immunization ... Th1 Cells; Vaccination; Vaccines, DNA ... In contrast, the Th1 genetic adjuvants had no effect on IgG ...https://escholarship.umassmed.edu/gsbs_sp/980/
Dendritic Cells in Irradiated Mice Trigger the Functional Plasticity and Antitumor Activity of Adoptively Transferred Tc17...
For example, Th17 cells can be converted to Th1 cells or Tregs under distinct polarizing conditions (15). Likewise, Th2 cells ... IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-gamma production ... B, relative infiltration of donor pmel-1 Tc17 cells compared with host CD8+ T cells, host CD4+ T cells, or host NK cells within ... Th1 cells are considered functionally less plastic. As Tc17 cells represent a recently described IL17-producing CD8+ T-cell ...http://clincancerres.aacrjournals.org/content/21/11/2546
Accelerated Pathological and Clinical Nephritis in Systemic Lupus Erythematosus-Prone New Zealand Mixed 2328 Mice Doubly...
Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17. J. Leukocyte ... 7⇓, a, c, and e). No statistically significant differences in total B cells (Fig. 7⇓b) or in follicular B cells, B1a cells, or ... CD4-positive T cells; f, CD4+CD44highCD62Llow/neg activated memory T cells; g, CD4+CD69+ recently activated T cells. Value of p ... for naive T cells) or CD4+CD44highCD62Llow (for activated memory T cells). A, Naive and activated memory cells isolated from 5 ...http://www.jimmunol.org/content/182/4/2532
T helper cell - Wikipedia
The main effector cells of Th1 immunity are macrophages as well as CD8 T cells, IgG B cells, and IFN-γ CD4 T cells. The key Th1 ... IFN-γ drives Th1 cell production while IL-10 and IL-4 inhibit Th1 cell production. Conversely, IL-4 drives Th2 cell production ... Their main effector cells are NK cells as well as CD8 T cells, IgG B cells, and IL-10 CD4 T cells. The key THαβ transcription ... Proliferating helper T cells that develop into effector T cells differentiate into two major subtypes of cells known as Th1 and ...https://en.wikipedia.org/wiki/T_helper_cell
Immunotherapeutic agent and its use - Patent # 6056964 - PatentGenius
... killed cells of Mycobacterium vaccae in an amount sufficient at least to delay or prevent the growth or spread of the neoplasm. ... It is known that there are at least 2 patterns of maturation of helper T cells, called TH1 and TH2. The former is associated ... The Koch phenomenon, probably induced by Coley's toxin, is thought to be the result of a mixture of TH1+TH2matured cells.. It ... The latter produce IL4, IL5, enhance antibody production and down-regulate TH1 cells. ...http://www.patentgenius.com/patent/6056964.html
How chronic infections can outsmart the immune system | EurekAlert! Science News
The findings published in Cell Reports have the potential to lead to treatment and bring to light a phenomenon that may be ... Simona Stäger and her team at INRS have shown that damage from chronic inflammation induces the death of white blood cells ... In the case of visceral leishmaniasis, CD4 T cells expressing IFN-γ (Th1 cells) appear later than expected during infection and ... Professor Stäger's new findings show that IRF-5 leads Th1 cells to self-destruct. Tracing the thread of molecular events, the ...https://www.eurekalert.org/pub_releases/2018-07/indl-hci073118.php
IJMS | Free Full-Text | Melatonin: Buffering the Immune System | HTML
Likewise, the absence of melatonin due to pinealectomy polarized rat thymic Th1/Th2 cells towards a Th1 response by increasing ... cells, which control excessive responses of the effector lineages. Th1 cells play a key role in the development of inflammatory ... High doses of melatonin reduced the proportion of Th1 cells and elevated the percentage of IL-10-producing cells, significantly ... mast cells, natural killer cells and eosinophils ; and in several immune cell lines [36,39,44,45]. ...http://www.mdpi.com/1422-0067/14/4/8638/htm
Patent and Trademark Office Notices
435/007, Title: METHODS FOR DETECTING TH1 CELLS, Inventor: Keiko Yamaguchi et al., Owners of Record: Eisai R&D Management Co., ... 30, 2012 Philip Soletsky 13/464,383 May 4, 2012 Chunfu Zhou Solar Cell Connection Module 13/464,591 May 4, 2012 Heather Rupp ...https://www.uspto.gov/web/offices/com/sol/og/2013/week08/TOC.htm
Frontiers | Transient Receptor Potential Ankyrin 1 Channel Expression on Peripheral Blood Leukocytes from Rheumatoid Arthritic...
TRPA1 levels on these cells were associated with the numbers of polymorphonuclear and the activation of CD14+ cells. No ... TRPA1 levels on these cells were associated with the numbers of polymorphonuclear and the activation of CD14+ cells. No ... We suggest that the activation levels of CD14+ cells, the numbers of PMNs in the peripheral blood and the expression of TRPA1 ... We suggest that the activation levels of CD14+ cells, the numbers of PMNs in the peripheral blood and the expression of TRPA1 ...https://www.frontiersin.org/articles/10.3389/fphar.2017.00053/full
Chemokine Receptor 7 Knockout Attenuates Atherosclerotic Plaque DevelopmentClinical Perspective | Circulation
To investigate T helper cell responses in ccr7−/−/ldlr−/− mice, T-cell cytokine analyses were performed. Although Th1 cells ... Equal numbers of cell tracker orange (CTO) -labeled WT T cells and cell tracker green (CTG) -labeled ccr7−/−-derived T cells ... Ccr7−/−/ldlr−/− mice showed ≈25% more CD3+ cells (87.42±7.60 cells per section in ccr7−/−/ldlr−/− mice versus 65.71±4.89 cells ... Both T-cell activation and differentiation have been associated with atherogenesis. In particular, Th1 cells, characterized by ...http://circ.ahajournals.org/content/122/16/1621
Characterization of cis-regulatory elements and nuclear factors conferring Th2-specific expression of the IL-5 gene: a role for...
Th2 specificity of NFIL-5C was also confirmed using in vitro-differentiated Th1 and Th2 cells derived from TCR-transgenic mice ... We now report that the 1.2-kb region of the IL-5 promoter directs expression of the IL-5 gene in a Th2 clone but not a Th1 ... We have previously defined four cis-regulatory elements of the IL-5 promoter responding to PMA and cAMP in EL-4 cells. ... We showed preferential expression of GATA-3 in Th2 cells. Finally, we demonstrated that in vitro-translated GATA-3 bound to IL- ...https://www.semanticscholar.org/paper/Characterization-of-cis-regulatory-elements-and-of-Lee-O%27Garra/73209494ddef5ff167d8990582557aa7bbf7ae3b
Anti-beta Actin antibody [mAbcam 8226] - Loading Control (ab8226) References
Ettle B et al. a-Synuclein deficiency promotes neuroinflammation by increasing Th1 cell-mediated immune responses. J ... Caì Y et al. CD26/DPP4 cell-surface expression in bat cells correlates with bat cell susceptibility to Middle East respiratory ... Pewsey E et al. Proteomics analysis of epithelial cells reprogrammed in cell-free extract. Mol Cell Proteomics 8:1401-12 (2009 ... Mast cell chymase induces smooth muscle cell apoptosis by disrupting NF-kappaB-mediated survival signaling. Exp Cell Res 312: ...http://www.abcam.com/beta-actin-antibody-mabcam-8226-loading-control-ab8226-references.html
Protocols and Video Articles Authored by Raymond A. Sobel
Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4' ... Th1) T cells, histamine receptor 1 and 2 (H1R and H2R) are present on inflammatory cells in brain lesions. Th1 cells reactive ... T cell counts, and increased myelin-reactive Th1 and Th17 cells, with reduced numbers of regulatory T cells. Reconstitution of ... Th1 and Th2 cells. Th1 cells produce cytokines (interferon (IFN)-gamma, interleukin (IL)-2, tumour-necrosis factor (TNF)-alpha ...https://www.jove.com/author/Raymond++A._Sobel
Respiratory - Stuff Missed Flashcards by A Fleary | Brainscape
genetic predisposition to have more Th2 cells than Th1 cells. - environmental irritants (e.g. smoking) triffer bronchospasm ... to replicate in host cell, an RNA-dependent RNA polymerase within intact virion mus also gain entry into the host cell. ... stimulates natural killer cells and is responsible for T helper cell secretion of IFN-gamma ... lack cell wall, capsule, or cell envelope so require cholesterol in rowth medium ...https://www.brainscape.com/flashcards/respiratory-stuff-missed-851098/packs/1473017
CD133 - Wikipedia
... melanoma induces specific Th17 and Th1 cell-mediated antitumor reactivity against parental tumor". Cancer Immunol. Immunother. ... CD133 is expressed in hematopoietic stem cells, endothelial progenitor cells, glioblastoma, neuronal and glial stem cells, ... CD133+ melanoma cells are considered a subpopulation of CSC a critical role in recurrence. Moreover, CD133+ melanoma cells are ... Wang Q, Chen ZG, Du CZ, Wang HW, Yan L, Gu J (2009). "Cancer stem cell marker CD133+ tumour cells and clinical outcome in ...https://en.wikipedia.org/wiki/CD133
JCI - Inflammatory osteolysis: a conspiracy against bone
Activated Th1 cells were originally considered pro-osteoclastogenic, as they express RANKL (95). Th1 cells, however, actually ... Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. J Exp Med. 2006; ... Understanding the role of Th1 cells in the skeleton has been more complex than exploring Tregs. ... While resident mesenchymal and immune cells participate in inflammatory bone destruction, the effector cell of focal osteolysis ...https://www.jci.org/articles/view/93356
Liver infiltrating T lymphocytes express interferon γ and inducible nitric oxide synthase in chronic hepatitis C virus...
1997) Inhibition of IL-2 production by nitric oxide: a novel self-regulatory mechanism for Th1 cell proliferation. Immunol Cell ... inhibit Th1 cell proliferation29; suppress interleukin 2 secretion30; and switch Th1 to Th2 type lymphocytes.31 These findings ... mononuclear cells and in those from patients with PBC in 58 mononuclear cells, whereas 3.5 (0.5) mononuclear cells in cases of ... 1996) The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol Today 17:138-146. ...http://gut.bmj.com/content/46/2/255
Butyrate inhibits inflammatory responses through NFκB inhibition: implications for Crohn's disease | Gut
1993) Th1 cell anergy and blockade in G1a phase of the cell cycle. J Immunol 151:1245-1254. ... for example downregulation of T cell responses, induction of Th1 cell anergy, and modulation of antigen presentation associated ... peripheral blood mononuclear cells. LPMC. lamina propria mononuclear cells. NFκB. nuclear factor kappa B. IκB. inhibitor ... THP-1 cells were stimulated for various periods of time with 2.5 μg/ml LPS in the presence or absence of 2 mM butyrate. Cells ...http://gut.bmj.com/content/47/3/397
CD25+ regulatory T cells suppress both Th1 and Th2 cells and that these regulatory T cells have a profound therapeutic ... 2 is required for langerhans cell migration and localization of T helper cell type 1 (Th1)-inducing dendritic cells. Absence of ... These data suggest that CD4+ T cells that normally respond to antigens by differentiation to Th1 cells default to the Th2 ... CD4+CD25+ regulatory T cells suppress differentiation and functions of Th1 and Th2 cells, Leishmania major infection, and ...http://www.labome.org/topics/diseases/parasitic/parasitic/leishmaniasis/cutaneous-leishmaniasis-5398.html
Interleukin-12 family members and type I interferons in Th17-mediated inflammatory disorders - Goriely - 2009 - Allergy - Wiley...
Th1 cells facilitate the entry of Th17 cells to the central nervous system during experimental autoimmune encephalomyelitis. J ... Oral dendritic cells mediate antigen-specific tolerance by stimulating TH1 and regulatory CD4+ T cells. J Allergy Clin Immunol ... Plasmacytoid dendritic cell precursors/type I interferon-producing cells sense viral infection by toll-like receptor (TLR) 7 ... A pivotal role for the natural interferon alpha-producing cells (plasmacytoid dendritic cells) in the pathogenesis of lupus. J ...http://onlinelibrary.wiley.com/doi/10.1111/j.1398-9995.2009.02039.x/references