Reversal of Paralysis and Reduced Inflammation from Peripheral Administration of β-Amyloid in TH1 and TH17 Versions of...
... or TH17 cells. High-dimensional 14-parameter flow cytometry of peripheral immune cell populations after in vivo Aβ42 and Aβ40 ... Reversal of Paralysis and Reduced Inflammation from Peripheral Administration of β-Amyloid in TH1 and TH17 Versions of ...http://stm.sciencemag.org/content/4/145/145ra105
Increased Th17 cells and IL-17A exist in patients with B cell acute lymphoblastic leukemia and promote proliferation and...
B-cell acute lymphoblastic leukemiaTh17 cellsIL-17ATh1 cells. Background. B-cell acute lymphoblastic leukemia (B-ALL) ... Increased Th17 cells and decreased Th1 cells in B-ALL patients. Th17 cells have been reported to be enriched in hematological ... Th1 cells produce interferon-γ (IFN-γ) and predominantly promote cell-mediated immunity, whereas Th2 cells secrete IL-4, IL-5 ... We simultaneously analyzed the frequency of Th1 cells and found that the frequency of Th1 cells was significantly decreased in ...https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-016-0894-9
Proinflammatory cytokine production and cartilage damage due to rheumatoid synovial T helper-1 activation is inhibited by...
METHODS--SFMNC were stimulated with bacterial antigen (hsp60) to activate Th1 cells. Th1 and Th2 specific cytokine profiles ( ... OBJECTIVES--To investigate the role of T helper-1 cell (Th1) activation in the induction of proinflammatory cytokine production ... Th1 activation could be inhibited by IL-4 as shown by a reduction of IFN gamma. This was accompanied by a decrease in IL-1 and ... CONCLUSIONS--Th1 activation is a possible mechanism by which inflammation in RA joints is enhanced. The Th2 cytokine IL-4 ...http://ard.bmj.com/content/54/10/836
Colgate Virology (and Immunology) Blog: Mycobacterium tuberculosis and Immune Evasion
The most important Th1 interactions are with macrophages, while significant Th2 interactions are with B cells. Th1 cells ... Naïve CD4+ T cells are polarized to the Th1 effector subset by IL-12 and IFN-γ (Schluger & Rom 1998). Th2 cells produce IL-4, ... AIDS (3) Allergy (4) antibodies (17) autoimmune disease (9) cancer (10) CD4+ T cells (14) CD8+ T cells (10) DCs (5) HIV (18) ... Lutz, M.B. (2013). How quantitative differences in dendritic cell maturation can direct Th1/Th2-cell polarization. ...http://colgateimmunology.blogspot.com/2013/11/mycobacterium-tuberculosis-and-immune.html
Immune mechanisms of childhood asthma | Thorax
33 IL-12 induces dendritic cells, monocytes, and natural killer cells to produce IFN-γ, thus promoting a Th1 effector response ... 1995) Deficiency in T cell responses of human fetal lymph node cells: a lack of accessory cells. Immunol Cell Biol 73:353-361, ... 1996) T-cell cytokine profile evaluated at the single cell level in BAL and blood in allergic asthma. Am J Respir Cell Mol Biol ... 159Neonatal T cells produce less IFN-γ and IL-4 after polyclonal stimulation than adult T cells.160 161 IFN-γ producing T cell ...http://thorax.bmj.com/content/54/10/938
The Presence of IL-17A and T Helper 17 Cells in Experimental Mouse Brain Tumors and Human Glioma
Interestingly, some Th17 cells present in mouse glioma co-expressed the Th1 and Th2 lineage markers, IFN-γ and IL-4, ... Methodology/Principal Findings In this report, we demonstrate that mRNA expression for the Th17 cell cytokine IL-17A, as well ... Conclusions These data confirm the presence of Th17 cells in glia-derived CNS tumors and provide the rationale for further ... Furthermore, the presence of Th17 cells was confirmed in both human and mouse glioma. ...http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0015390
T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis |...
... a profile distinct from Th1 or Th2 cells and similar to that of Th17 cells (Fig. 1 A; references 7-9). CD4+ T cells freshly ... and differentiate to Th17 cells (Fig. 1 A). Both SKG and BALB/c T cells can equally differentiate to Th17 as well as Th1 cells ... T cell self-reactivity and in vivo spontaneous differentiation of Th17 cells. (A) CD4-SP thymocytes and LN CD4+ T cells from 6- ... 2 B). Divided cells constituted 50% of SKG CD4+ T cells within 3 wk compared with 20% of BALB/c CD4+ T cells (Fig. 2 C). ...http://jem.rupress.org/content/204/1/41
Anti-IL-16 treatment enhances Th1-type cytokine secretion and apoptosis of spleen T-cells. Spleen T-cells (A) or PLN-derived T- ... T-cells, B220+ B-cells, CD4+ and CD8+ T-cells, p46+ NK-cells, and CD11c+ dendritic cells (Fig. 2 and supplementary Fig. 1, ... IL-16 immunoreactivity was found in islet infiltrating T-cells, B-cells, NK-cells, and dendritic cells, and within an insulitic ... The latter finding is consistent with reports that IFN-γ induces the apoptosis of effector Th1 cells (42), triggers CD4+ T-cell ...http://diabetes.diabetesjournals.org/content/59/11/2862
Anti-beta Actin antibody [mAbcam 8226] - Loading Control (ab8226) References
Ettle B et al. a-Synuclein deficiency promotes neuroinflammation by increasing Th1 cell-mediated immune responses. J ... Caì Y et al. CD26/DPP4 cell-surface expression in bat cells correlates with bat cell susceptibility to Middle East respiratory ... Pewsey E et al. Proteomics analysis of epithelial cells reprogrammed in cell-free extract. Mol Cell Proteomics 8:1401-12 (2009 ... Mast cell chymase induces smooth muscle cell apoptosis by disrupting NF-kappaB-mediated survival signaling. Exp Cell Res 312: ...http://www.abcam.com/beta-actin-antibody-mabcam-8226-loading-control-ab8226-references.html
Patents filed at Feb 07 2017 | Medical devices | Patents.com
KIF20A epitope peptides for TH1 cells and vaccines containing the same. Isolated KIF20A-derived epitope peptides having Th1 ... Methods of targeting T-cells to tumors. The invention provides a method of targeting T-cells to tumor cells using a tumor- ... Compositions and methods for rendering tumor cells susceptible to CD8+ T cell-mediated killing. The present invention provides ... The nanostars can be used for treating and imaging cells in in vivo or ex... ...http://www.patents.com/isd-20170207-p90.html
Hosken NA[au] - PubMed - NCBI
Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells. ... The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model. ... Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations. ... Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects. ...https://www.ncbi.nlm.nih.gov/pubmed?access_num=Hosken+NA&link_type=AUTHORSEARCH&cmd=search&term=Hosken+NA%5Bau%5D&dispmax=50
Synovial and Mucosal Immunopathology in Spondyloarthritis | SpringerLink
The proportion of Th1 cells, which prevail in gut mucosa, is decreased in inflammatory bowel syndrome. Clin Exp Immunol 2001; ... Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells. Nat Immunol 2005; 6: ... Impaired Th1 cytokine production in spondyloarthropathy is restored by anti-TNFalpha. Ann Rheum Dis 2001; 60:750-5.PubMedGoogle ... Low T-cell production of TNFalpha and IFN gamma in ankylosing spondylitis: its relation to HLA-B27 and influence of the TNF-308 ...https://link.springer.com/chapter/10.1007/978-1-4419-0298-6_5
CCR5 Plays a Critical Role in Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance by Regulating Both Macrophage...
CCR5 is preferentially expressed on Th1 cells (36). Recent studies show that infiltration of CD8+ T cells into adipose tissue, ... myeloid cells or Kupffer cells in liver may play a role in obesity-induced hepatic steatosis similar to CCR2+ myeloid cells ... B: The ratio of F4/80-stained cells to total cells counted in the fields of WAT from mice on an HF diet (n = 6). *P , 0.05 vs. ... To detect Ccr5−/− cells in the blood of chimeric mice lacking CCR5 only in myeloid cells (Ccr5−/− to WT), we performed PCR on ...http://diabetes.diabetesjournals.org/content/61/7/1680?cited-by=yes&legid=diabetes%3B61%2F7%2F1680
Frontiers | Leishmania infantum Parasites Subvert the Host Inflammatory Response through the Adenosine A2A Receptor to Promote...
These cells were characterized by high expression of CXCR2 and CD69 on their cell surfaces and increased cxcl1 expression. ... In conclusion, we demonstrated that the A2AR-signalling pathway is detrimental to development of Th1-type adaptive immunity and ... These cells were characterized by high expression of CXCR2 and CD69 on their cell surfaces and increased cxcl1 expression. ... During ex vivo cell culture, A2AR-/- splenocytes produced smaller amounts of IL-10. In conclusion, we demonstrated that the ...https://www.frontiersin.org/articles/10.3389/fimmu.2017.00815/full
Most cited article(s) | The Journal of Immunology
IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells. D F Fiorentino, A Zlotnik, P Vieira, T R ... Cutting Edge: Naive T Cells Masquerading as Memory Cells Kaja Murali-Krishna and Rafi Ahmed ... Subsets of Myeloid-Derived Suppressor Cells in Tumor-Bearing Mice Je-In Youn, Srinivas Nagaraj, Michelle Collazo and Dmitry I. ... BDCA-2, BDCA-3, and BDCA-4: Three Markers for Distinct Subsets of Dendritic Cells in Human Peripheral Blood Andrzej Dzionek, ...http://www.jimmunol.org/articles/most-cited?page=3
Induction of Potent CD8 T Cell Cytotoxicity by Specific Targeting of Antigen to Cross-Presenting Dendritic Cells In Vivo via...
MARX10-OVA and XCL1-OVA induce proliferation of CD4+ T cells, their differentiation to Th1 cells, and the generation of isotype ... Cells and cell isolation. Murine splenocytes were obtained by mashing spleens through 70-μm cell sieves into PBS, followed by ... T cells in an inflammatory context is required. Only dendritic cells (DC) as professional APCs can prime naive CD8+ T cells to ... dendritic cells, but cross-presented to CD8 T cells by CD8+ dendritic cells. J. Immunol. 166: 5327-5330. ...http://www.jimmunol.org/content/194/3/1069
Genetics of rheumatoid arthritis: is there a scientific explanation for the human leukocyte antigen association? - Semantic...
Autoreactive Th1 cells activate monocytes to support regional Th17 responses in inflammatory arthritis.. *Donald M Simons, ...https://www.semanticscholar.org/paper/Genetics-of-rheumatoid-arthritis%3A-is-there-a-scien-Buckner-Nepom/ce4fcbe6ce52b86751bf8f56395870e2f6fd7230
Characterization of cis-regulatory elements and nuclear factors conferring Th2-specific expression of the IL-5 gene: a role for...
Th2 specificity of NFIL-5C was also confirmed using in vitro-differentiated Th1 and Th2 cells derived from TCR-transgenic mice ... We now report that the 1.2-kb region of the IL-5 promoter directs expression of the IL-5 gene in a Th2 clone but not a Th1 ... We have previously defined four cis-regulatory elements of the IL-5 promoter responding to PMA and cAMP in EL-4 cells. ... We showed preferential expression of GATA-3 in Th2 cells. Finally, we demonstrated that in vitro-translated GATA-3 bound to IL- ...https://www.semanticscholar.org/paper/Characterization-of-cis-regulatory-elements-and-of-Lee-O%27Garra/73209494ddef5ff167d8990582557aa7bbf7ae3b
JEM | The Journal of Experimental Medicine
demonstrate that eosinophils suppress mucosal inflammation by directly interacting with pro-inflammatory Th1 cells. This ... BCAP modulates CD8+ T cell responses Singh et al. show that expression of B cell adaptor for PI3-kinase (BCAP) is induced upon ... Lysosomal metabolic control of T reg cell identity Metabolic programs are crucial for T reg cell stability and function. Yu et ... Etv6 facilitates cross-priming by dendritic cells Transcriptional control of dendritic cell (DC) functions is poorly understood ...http://jem.rupress.org
Table of Contents - August 06, 2018, 215 (8) | JEM
Eosinophils control Th1 cells in acute and chronic infection and in the steady state and possess bactericidal properties. ... Ca2+-mitochondria axis drives cell division in hematopoietic stem cells The activation of Ca2+-mitochondria pathway drives cell ... T cell response. The absence of T reg cells led to exacerbated inflammation, infiltration of CD8+ T cells to the epidermis, and ... Foxp3+ T reg cells control psoriasiform inflammation by restraining an IFN-I-driven CD8+ T cell response Stockenhuber et al. ...http://jem.rupress.org/content/215/8
The failed HIV Merck vaccine study: a step back or a launching point for future vaccine development? | JEM
Th1 and Th2), B cells, and other innate immune cells, including dendritic cells and natural killer (NK) cells. Our current ... The DNA/NYVAC vaccine elicited a greater frequency of CD8 cells and Th1 cells secreting IL-2, TNF, and IFN-γ, whereas the rAD- ... Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major. Nat. Med. 13:843-850. ... The T cell responses were also polyfunctional; nearly 50% of the HIV-specific CD4+ and CD8+ T cells induced in vaccinated ...http://jem.rupress.org/content/205/1/7
PRIMA-1 cytotoxicity correlates with nucleolar localization and degradation of mutant p53 in breast cancer cells.
... has been identified as a compound that restores the transactivation function to mutant p53 and induces apoptosis in cells ... Next Document: Th1 cells promote neurite outgrowth from cortical neurons via a mechanism dependent on semaphorins.. ... Cell Line, Tumor. Cell Nucleus / metabolism*. Drug Resistance, Neoplasm*. Female. Humans. Mutation. Tumor Suppressor Protein ... Interestingly, cells where p53-R280K was silenced were more sensitive to PRIMA-1 than the parental ones. These results indicate ...http://www.biomedsearch.com/nih/PRIMA-1-cytotoxicity-correlates-with/20946886.html
miR-148a is upregulated by Twist1 and T-bet and promotes Th1-cell survival by regulating the proapoptotic gene Bim European ... Selective targeting of pro-inflammatory Th1 cells by microRNA-148a-specific antagomirs in vivo Journal of Autoimmunity : (2017- ... microRNAs regulate cell-to-cell variability of endogenous target gene expression in developing mouse thymocytes PLoS Genetics ... Cell fixation and preservation for droplet-based single-cell transcriptomics BMC Biology 15 (1): 44 (2017-05-19) ...https://www.mdc-berlin.de/1151070/en/research/research_teams/systems_biology_of_gene_regulatory_elements/publications
Lecture 16 Thrush Flashcards by Kristen Phifer | Brainscape
due to autoantibodies and Th1 cells. inflammation/ cytotoxicity damage to thyroid gland. genetic component middle aged japanese ... B cells or T cells. failure of central or peripheral tolerance apoptosis (lack of Fas). some MHC (HLA-B27; HLA-DQ6) ... T cells on myelin sheaths. highest incidents- living more northern autoreactive cells and vitamin D ... self-reactive cells are destroyed in the primary lymphoid organs (bone marrow or thymus) ...https://www.brainscape.com/flashcards/lecture-16-thrush-3347441/packs/5238945
NAVER Academic | Two-sided roles of IL-27: induction of Th1 differentiation on naive CD4+ T cells versus suppression of...
Two-sided roles of IL-27: induction of Th1 differentiation on naive CD4+ T cells versus suppression of proinflammatory cytokine ... Animals, CD4-Positive T-Lymphocytes, immunology, Cell Differentiation, Cell Line, Cytokines, biosynthesis, Humans, Interleukin- ... production including IL-23-induced IL-17 on activated CD4+ T cells partially through STAT3-dependent mechanism.. Author. Takeru ...http://academic.naver.com/article.naver?doc_id=147095510