Reversal of Paralysis and Reduced Inflammation from Peripheral Administration of β-Amyloid in TH1 and TH17 Versions of...
... or TH17 cells. High-dimensional 14-parameter flow cytometry of peripheral immune cell populations after in vivo Aβ42 and Aβ40 ... Reversal of Paralysis and Reduced Inflammation from Peripheral Administration of β-Amyloid in TH1 and TH17 Versions of ...http://stm.sciencemag.org/content/4/145/145ra105
Proinflammatory cytokine production and cartilage damage due to rheumatoid synovial T helper-1 activation is inhibited by...
METHODS--SFMNC were stimulated with bacterial antigen (hsp60) to activate Th1 cells. Th1 and Th2 specific cytokine profiles ( ... OBJECTIVES--To investigate the role of T helper-1 cell (Th1) activation in the induction of proinflammatory cytokine production ... Th1 activation could be inhibited by IL-4 as shown by a reduction of IFN gamma. This was accompanied by a decrease in IL-1 and ... CONCLUSIONS--Th1 activation is a possible mechanism by which inflammation in RA joints is enhanced. The Th2 cytokine IL-4 ...http://ard.bmj.com/content/54/10/836
Colgate Virology (and Immunology) Blog: Mycobacterium tuberculosis and Immune Evasion
The most important Th1 interactions are with macrophages, while significant Th2 interactions are with B cells. Th1 cells ... Naïve CD4+ T cells are polarized to the Th1 effector subset by IL-12 and IFN-γ (Schluger & Rom 1998). Th2 cells produce IL-4, ... AIDS (3) Allergy (4) antibodies (17) autoimmune disease (9) cancer (10) CD4+ T cells (14) CD8+ T cells (10) DCs (5) HIV (18) ... Lutz, M.B. (2013). How quantitative differences in dendritic cell maturation can direct Th1/Th2-cell polarization. ...http://colgateimmunology.blogspot.com/2013/11/mycobacterium-tuberculosis-and-immune.html
The Presence of IL-17A and T Helper 17 Cells in Experimental Mouse Brain Tumors and Human Glioma
Interestingly, some Th17 cells present in mouse glioma co-expressed the Th1 and Th2 lineage markers, IFN-γ and IL-4, ... Methodology/Principal Findings In this report, we demonstrate that mRNA expression for the Th17 cell cytokine IL-17A, as well ... Conclusions These data confirm the presence of Th17 cells in glia-derived CNS tumors and provide the rationale for further ... Furthermore, the presence of Th17 cells was confirmed in both human and mouse glioma. ...http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0015390
T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis |...
... a profile distinct from Th1 or Th2 cells and similar to that of Th17 cells (Fig. 1 A; references 7-9). CD4+ T cells freshly ... and differentiate to Th17 cells (Fig. 1 A). Both SKG and BALB/c T cells can equally differentiate to Th17 as well as Th1 cells ... T cell self-reactivity and in vivo spontaneous differentiation of Th17 cells. (A) CD4-SP thymocytes and LN CD4+ T cells from 6- ... 2 B). Divided cells constituted 50% of SKG CD4+ T cells within 3 wk compared with 20% of BALB/c CD4+ T cells (Fig. 2 C). ...http://jem.rupress.org/content/204/1/41
Roles of repressive epigenetic machinery in lineage decision of T cells - Naito - 2013 - Immunology - Wiley Online Library
However, when Th2 cells were re-stimulated under Th1 conditions, substantial expression of Th1-associated molecules, IFN-γ and ... Conversely, Bmi1−/− CD4+ T cells were deficient in Th2 cytokine production with a concomitant increase in Th1 cells. Given a ... Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. Nature 2010; 466:1129- ... Sirtuin-1 targeting promotes Foxp3+ T-regulatory cell function and prolongs allograft survival. Mol Cell Biol 2011; 31:1022-9. ...http://onlinelibrary.wiley.com/doi/10.1111/imm.12058/full
JCI - Role of innate and adaptive immunity in obesity-associated metabolic disease
CD4+ T cells are classified according to their signature cytokines as follows: Th1 cells by IFN-γ; Th17 cells by IL-17; Th2 ... of non-adipocyte cells in human AT and include T cells, B cells, NK cells, NKT cells, and ILC2s (67). T and B lymphocytes, ... Thus, M1 macrophages, IFN-γ-secreting Th1 cells, CD8+ T cells, and B cells promote IR, in part through secretion of ... In particular, they play a role in inducing differentiation of naive CD4+ T cells into Th1, Th2, or Th17 cells or Tregs. ...https://www.jci.org/articles/view/88876
Table of Contents - June 15, 2006, 176 (12) | The Journal of Immunology
Regulatory T Cells Control Uveoretinitis Induced by Pathogenic Th1 Cells Reacting to a Specific Retinal Neoantigen Céline ... A Membrane Form of TNF-α Presented by Exosomes Delays T Cell Activation-Induced Cell Death Huang-Ge Zhang, Cunren Liu, Kaihun ... NK Cells and γδ+ T Cells Are Phenotypically and Functionally Defective due to Preferential Apoptosis in Patients with Atopic ... CD4 T Cells Play Major Effector Role and CD8 T Cells Initiating Role in Spontaneous Autoimmune Myocarditis of HLA-DQ8 ...http://www.jimmunol.org/content/176/12
Induction and Maintenance of IL-4 Expression Are Regulated Differently by the 3′ Enhancer in CD4 T Cells | The Journal of...
Th1 cells from [Δ5a+Tg→Aβ−/−] mice that generate T-CD4 T cells produced IL-4 under the Th1 condition (Fig. 5A). Together, cells ... Unlike CD4 T cells that are developed by thymic epithelial cells (TECs; epithelial cell-selected CD4 T cell [E-CD4 T cells ... we compared GFP expression of Δ5a cells after differentiated to Th1 or Th2 cells. The Th1 culture had few GFP+ cells, whereas ... 3B), a majority of cells lost GFP expression when cells were differentiated to Th1 cells. ...http://www.jimmunol.org/content/186/5/2792.long
Non-coding RNA in T cell activation and function
The TH1 cell subtype is generally pro-inflammatory and IFNγ-secreting. There are regulatory T (Treg) cells that are involved in ... Upon isolation of IFNγ-secreting TH1 cells and Treg-like IL10-secreting cells, it was found that the ncRNA 886 (nc886) was ... In the IL10-secreting Treg-like cells the microRNA 150 (miR-150) was found upregulated compared to IFNγ-secreting TH1 cells. ... T cells are important mediators of immune responses, for example upon viral infections. The T helper cells (TH or CD4+ cells) ...http://liu.diva-portal.org/smash/record.jsf?pid=diva2:644795
BrainMeta.com Forum ->...
O those of Th1 cells is elevated in blood samples from 0 Weinreich. 199. 17th August 2017 - 05:57 AM. Last post by: Weinreich. ... Within the immune cells. Taking a look at the top network 1, some important ...http://brainmeta.com/forum/index.php?showforum=54
004101 - B6;129P-Ccr4|tm1Pwr|/J
in vitro, homozygotes display normal Th2 and Th1 cell differentiation relative to wild-type mice ... Lung dendritic cells imprint T cell lung homing and promote lung immunity through the chemokine receptor CCR4. J Exp Med 210(9 ... CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice. J Clin Invest 121( ... The construct was electroporated into 129P2/OlaHsd-derived HM-1 embryonic stem cells and selected cells were injected into ...https://www.jax.org/strain/004101
Table of Contents - July 01, 2013, 191 (1) | The Journal of Immunology
Nitric Oxide-Induced Regulatory T Cells Inhibit Th17 but Not Th1 Cell Differentiation and Function Wanda Niedbala, Anne-Gaelle ... Cutting Edge: CD1d Restriction and Th1/Th2/Th17 Cytokine Secretion by Human Vδ3 T Cells Bozgana A. Mangan, Margaret R. Dunne, ... Dendritic Cell-Dependent In Vivo Generation of Autoregulatory T Cells by Antidiabetogenic MHC Class II Sue Tsai, Pau Serra, ... Leishmania-Infected MHC Class IIhigh Dendritic Cells Polarize CD4+ T Cells toward a Nonprotective T-bet+ IFN-γ+ IL-10+ ...http://www.jimmunol.org/content/191/1
Arachidonate 15-lipoxygenase type B knockdown leads to reduced lipid accumulation and inflammation in atherosclerosis.
Atherosclerosis is a Th1-cell-driven disease and Th1 cytokines stimulate plaque formation . Furthermore IL-2 promotes ... Lesional T cells mainly have properties of the proinflammatory Th1 subtype and secrete the cytokines IL-2, IFN-γ, and tumor ... Knockdown of mouse Alox15b reduces T cell number and IL-2 levels in vivo The number of T cells was significantly reduced in ... IFN-γ is known to promote foam cell formation  suggesting that the anti-foam cell formation effect of ALOX15B knockdown ...http://www.biomedsearch.com/nih/Arachidonate-15-lipoxygenase-type-B/22912809.html
Comparisons of Therapeutic effects of Mesenchymal Stem Cells and Dexamethasone on Recurrent Experimental Autoimmune Uveitis |...
Th1 cells in draining lymph nodes of MSC-treated group were also reduced. Moreover, MSCs suppressed the proliferation of R16 ... Functions of T cells and antigen presenting cells (APCs) in spleens were determined by - proliferation assays. ... subsets of T cells in the eyes, cervical draining lymph nodes and spleens were analyzed by flow cyctometry at day 10 post ... MSCs significantly decreased the frequency of Th17 cells in the eyes, draining lymph nodes and spleen, and had a tendency to up ...http://iovs.arvojournals.org/article.aspx?articleid=2272447
Interleukin-12 family members and type I interferons in Th17-mediated inflammatory disorders - Goriely - 2009 - Allergy - Wiley...
Th1 cells facilitate the entry of Th17 cells to the central nervous system during experimental autoimmune encephalomyelitis. J ... Oral dendritic cells mediate antigen-specific tolerance by stimulating TH1 and regulatory CD4+ T cells. J Allergy Clin Immunol ... Plasmacytoid dendritic cell precursors/type I interferon-producing cells sense viral infection by toll-like receptor (TLR) 7 ... A pivotal role for the natural interferon alpha-producing cells (plasmacytoid dendritic cells) in the pathogenesis of lupus. J ...http://onlinelibrary.wiley.com/doi/10.1111/j.1398-9995.2009.02039.x/references
Adenovirus Infection in Allogeneic Stem Cell Transplantation | SpringerLink
Adoptive T-cell therapy with hexon-specific Th1 cells as a treatment of refractory adenovirus infection after HSCT. Blood. 2015 ... Adenovirus-pulsed dendritic cells stimulate human virus-specific T-cell responses in vitro. J Virol. 1996;70(10): 6733-40. ... T-cell lines specific for peptides of adenovirus hexon protein and devoid of alloreactivity against recipient cells can be ... Biron CA, Brossay L. NK cells and NKT cells in innate defense against viral infections. Curr Opin Immunol. 2001;13(4):458-64. ...https://link.springer.com/chapter/10.1007/978-3-319-28797-3_33
JCI - Skeletal muscle inflammation and insulin resistance in obesity
T cells are increased in SM of obese mice. While the proportion of IFN-γ-expressing Th1 cells is increased, the proportion of ... Changes in other immune cells including neutrophils, B cells, NK cells, and invariant NKT (iNKT) cells, which are found in ... IL-12 is critical for T cell polarization to Th1, whereas IL-4 is critical for T cell polarization to Th2 phenotypes. TNF-α, ... ablation of Th1 cells in αβT cell-deficient mice blunts this effect (35). ...https://www.jci.org/articles/view/88880
Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. |...
TH1 cells were found among examples of T cell clones specific for chicken RBC and mouse alloantigens. TH2 cells were found ... Type 1 T helper cells (TH1) produced IL 2, interferon-gamma, GM-CSF, and IL 3 in response to antigen + presenting cells or to ... The relationship between these two types of T cells and previously described subsets of T helper cells is discussed. ... a mast cell growth factor distinct from IL 3 and a T cell growth factor distinct from IL 2. Clones representing each type of T ...http://www.jimmunol.org/content/136/7/2348.long
Tbet is a critical modulator of FoxP3 expression in autoimmune graft versus host disease | Haematologica
Th1 cells are one of the major disease mediating T cell subsets and require IFNγ signaling and Tbet expression for their ... Regulatory T cells on the other hand can inhibit Th1 cell mediated responses. Using an established murine model that isolates ... we hypothesized that Th1 cells would restrict FoxP3-driven regulatory T cells. Upon transfer into immune-deficient syngeneic ... Cell Therapy & Immunotherapy. *. In vivo IL-12/IL-23p40 neutralization blocks Th1/Th17 response after allogeneic hematopoietic ...http://www.haematologica.org/content/early/2017/05/02/haematol.2016.155879
Displaying Fel d1 on virus-like particles prevents reactogenicity despite greatly enhanced immunogenicity: a novel therapy for...
This suggests that the reduced Th2 response is not caused by a shift to Th1 cells. The mechanism of this inhibition will need ... Depletion of these cell populations was confirmed by FACS (Figs. S4 and S5). As shown in Fig. 5 (B and C), T reg cells and CD4+ ... T reg cells and CD4+ effector T cells are dispensable for Qβ-Fel d1 desensitization. (A) Schematic outline of the experiment. ... Numbers of IL-4 producing cells per 2 × 105 spleen cells ± SD (n = 4) are shown (Qβ-Fel d1-PBS vs. Qβ-Fel d1-Fel d1 challenge, ...http://jem.rupress.org/content/206/9/1941
It is believed that MHC alleles susceptible to autoantigen specific T cells, particularly Th1 cells specific for B cell islet ... These susceptible cells bind antigens that elicit a primarily Th1 cell response. The resistant alleles, like those of the DR ... Though the specific interaction between CD8 and CD4 T cells is unknown, the interaction between Th1 and Th2 cells is more clear ... The antigen then reacts with antigen-specific Th2 cells that release IL-4, IL-10, and TGFbeta that suppress Th1 cell production ...http://www.bio.davidson.edu/courses/immunology/Students/spring2000/hutchins/restricted/diabetes.html
From Individuals to Populations: Immunological and Epidemiological Significance of Co-infection in the Dynamics of HIV | Open...
Differentiation of Th1 cells from naïve Th cells is promoted by gamma interferon (IFN-γ). These cells are able to produce ... Th2 cells and B cells, that inhibits cytokine production in Th1 and CD8+ T cells .. ... cytotoxic T cells, suppressor T cells and helper T cells (Th). The presence of specialized receptors on the surface of T cells ... The type of Th they become (Th0, Th1, Th2 or Th3) will depend on the type of cytokines these cells will produce [50,51] and ...https://www.omicsonline.org/from-individuals-to-populations-immunological-epidemiological-significance-of-co-infection-in-the-dynamics-of-hiv-2155-9899.S7-003.php?aid=8363
Adipose Tissue-Derived Stem Cells From Obese Subjects Contribute to Inflammation and Reduced Insulin Response in Adipocytes...
Fetal BM-derived mesenchymal stem cells promote the expansion of human Th17 cells, but inhibit the production of Th1 cells. Eur ... Th17 cells, but not Th1 cells, from patients with early rheumatoid arthritis are potent inducers of matrix metalloproteinases ... ASCs From Obese Donors Polarize T Cells Toward the Th17 Inflammatory Subset, Negatively Modulate Th1 Cell Responses, and ... Human ASCs from obese subjects polarize T cells toward the Th17 inflammatory subset, negatively modulate Th1 cell responses, ...http://diabetes.diabetesjournals.org/content/64/7/2477
Progesterone favors the development of human T helper cells producing Th2-type cytokines and promotes both IL-4 production and...
... instead of Th1-like, cytokine profile. Furthermore, SK-specific T cell clones with an established Th1 profile of cytokine ... In addition, SK-specific T cell lines generated in the presence of P developed into T cell clones showing a Th0-, ... cells producing Th2-type cytokines and promotes both IL-4 production and membrane CD30 expression in established Th1 cell ... cells producing Th2-type cytokines and promotes both IL-4 production and membrane CD30 expression in established Th1 cell ...http://www.jimmunol.org/content/155/1/128.long
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