OTOREVIEW.MY - "otomobil" review...: Autoworld.com.my 10th anniversary Carnival: Shah Alam Stadium
1 Utama (10) 10 Best Cars (3) 10.10.10 (1) 10/10 (1) 10000km report (1) 1000th post (1) 100th post (1) 10th anniversary (2) 11.11 (1) 11th birthday (1) 12.12.12 (1) 1438H (1) 15 Best New Cars (1) 1980s (4) 1990s (9) 1st time... (1) 2 Myvis (1) 2-million (1) 20000th (1) 200th post (1) 20112011 (1) 2012 (3) 2012 models (1) 2013 Accord (1) 2013 Forte (1) 2015 (3) 2016 (8) 2017 (1) 250th post (1) 300th post (1) 350th post (1) 36th birthday (1) 400th post (1) 450th post (1) 4th year (1) 4x4 (15) 500th post (1) 50th Anniversary (1) 550th post (1) 600th post (1) 660th post (1) 66th month Anniversary (1) 700th post (1) ...http://otoreview.blogspot.com/2009/11/autoworldcommy-10th-anniversary.html
Prostaglandin D2 Receptor 2 (Chemoattractant Receptor-Homologous Molecule Expressed On Th2 Cells or G-Protein Coupled Receptor...
[59 Pages Report] Check for Discount on Prostaglandin D2 Receptor 2 (Chemoattractant Receptor-Homologous Molecule Expressed On Th2 Cells or G-Protein Coupled Receptor 44 or CD294 or DP2 or PTGDR2) - Pipeline Review, H1 2016 report by Global Markets Direct. Global Markets Direct's, 'Prostaglandin D2 Receptor 2 (Chemoattractant Receptor-...http://www.reportsnreports.com/reports/640442-prostaglandin-d2-receptor-2-chemoattractant-receptor-homologous-molecule-expressed-on-th2-cells-or-g-protein-coupled-receptor-44-or-cd294-or-dp2-or-ptgdr2-pipeline-review-h1-2016.html
OTOREVIEW.MY - "otomobil" review...: MOST RECKLESS cars Count by make/model - 1st half Dec 09 + Hall of shame
1 Utama (10) 10 Best Cars (3) 10.10.10 (1) 10/10 (1) 10000km report (1) 1000th post (1) 100th post (1) 10th anniversary (2) 11.11 (1) 11th birthday (1) 12.12.12 (1) 1438H (1) 15 Best New Cars (1) 1980s (4) 1990s (9) 1st time... (1) 2 Myvis (1) 2-million (1) 20000th (1) 200th post (1) 20112011 (1) 2012 (3) 2012 models (1) 2013 Accord (1) 2013 Forte (1) 2015 (3) 2016 (8) 2017 (1) 250th post (1) 300th post (1) 350th post (1) 36th birthday (1) 400th post (1) 450th post (1) 4th year (1) 4x4 (15) 500th post (1) 50th Anniversary (1) 550th post (1) 600th post (1) 660th post (1) 66th month Anniversary (1) 700th post (1) ...http://otoreview.blogspot.com/2009/12/most-reckless-cars-count-by-makemodel.html
OTOREVIEW.MY - "otomobil" review...: COMPREHENSIVE REVIEW: Mercedes Benz W123 E-class
1 Utama (10) 10 Best Cars (3) 10.10.10 (1) 10/10 (1) 10000km report (1) 1000th post (1) 100th post (1) 10th anniversary (2) 11.11 (1) 11th birthday (1) 12.12.12 (1) 1438H (1) 15 Best New Cars (1) 1980s (4) 1990s (9) 1st time... (1) 2 Myvis (1) 2-million (1) 20000th (1) 200th post (1) 20112011 (1) 2012 (3) 2012 models (1) 2013 Accord (1) 2013 Forte (1) 2015 (3) 2016 (8) 2017 (1) 250th post (1) 300th post (1) 350th post (1) 36th birthday (1) 400th post (1) 450th post (1) 4th year (1) 4x4 (15) 500th post (1) 50th Anniversary (1) 550th post (1) 600th post (1) 660th post (1) 66th month Anniversary (1) 700th post (1) ...http://otoreview.blogspot.com/2010/07/comprehensive-review-mercedes-benz-w123.html
OTOREVIEW.MY - "otomobil" review...: CLOSE UP: Ford Lynx RS 2.0(A)
OTOREVIEW.MY - "otomobil" review...: Article: Hard lessons prepare Proton for downturn
OTOREVIEW.MY - "otomobil" review...: All Models from Honda Malaysia are RON95 compatible
OTOREVIEW.MY - "otomobil" review...: HAPPY NEW YEAR 2011...
Organ-specific distribution of CD4(+) T1 /ST2(+) Th2 cells in Leishmania major infection - LSHTM Research Online | London...
Activated CD4(+) T helper cells (Th) comprise at least two functionally distinct subsets, Th1 and Th2, which mediate different immunological effector functions. Experimental leishmaniasis is widely used to study the effector function of Th cell subsets in vivo. Healing and nonhealing Leishmania major infections have been correlated with polarized Th1 and Th2 responses, respectively. In the study presented here, a stable cell surface marker expressed on Th2 cells, T1/ST2, has been used to assess the distribution of CD4(+)T1/ST2(+) T cells in different organs of healer and nonhealer strains of mice during the course of L. major infection. The frequency of CD4(+) T cells expressing the T1/ST2 cell surface ...http://researchonline.lshtm.ac.uk/16321/
Retnla (Relmα/Fizz1) Suppresses Helminth-Induced Th2-Type Immunity
Author Summary Retnla is a member of a family of cysteine-rich secreted proteins, referred to as 'resistin-like molecules' or 'found in inflammatory zone' that increase in expression during allergic reactions and following infection with a variety of metazoan parasites. Retnla was originally hypothesized to function as an effector molecule during helminth-induced Th2-type immune responses. Studies conducted here with Retnla-deficient mice, however, suggest that Retnla primarily functions as a regulatory molecule during helminth infection. Using three helminth model systems affecting three different organ systems, we show that Retlna is induced by IL-4 and IL-13 as a mechanism to suppress Th2-type immunity. Retnla deficiency increased inflammation in the lung ...http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1000393
Propionibacterium acnes promotes Th17 and Th17/Th1 responses in acne patients - Zurich Open Repository and Archive
Propionibacterium acnes is a Gram-positive commensal bacterium thought to be involved in the pathogenesis of acne vulgaris. Although the ability of P. acnes in the initiation of pro-inflammatory responses is well documented, little is known about adaptive immune responses to this bacterium. The observation that infiltrating immune cells consist mainly of CD4+ T cells in the perifollicular space of early acne lesions suggests that helper T cells may be involved in immune responses caused by the intra-follicular colonization of P. acnes. A recent report showing that P. acnes can induce IL-17 production by T cells suggests that acne might be a T helper type 17 (Th17)-mediated disease. In line ...http://www.zora.uzh.ch/id/eprint/115339/
Thymic Stromal Lymphopoietin (TSLP) and Receptor Research Areas: R&D Systems
Find Thymic Stromal Lymphopoietin (TSLP) and Receptor research area related information and Thymic Stromal Lymphopoietin (TSLP) and Receptor research products from R&D Systems. Learn more.https://www.rndsystems.com/research-area/thymic-stromal-lymphopoietin--tslp--and-receptor
Different populations of CD11b(+) dendritic cells drive Th2 responses in the small intestine and colon | Research Explorer |...
T-helper 2 (Th2) cell responses defend against parasites. Although dendritic cells (DCs) are vital for the induction of T-cell responses, the DC subpopulations that induce Th2 cells in the intestine are unidentified. Here we show that intestinal Th2 responses against Trichuris muris worms and Schistosoma mansoni eggs do not develop in mice with IRF-4-deficient DCs (IRF-4(f/f) CD11c-cre). Adoptive transfer of conventional DCs, in particular CD11b-expressing DCs from the intestine, is sufficient to prime S. mansoni-specific Th2 responses. Surprisingly, transferred IRF-4-deficient DCs also effectively prime S. mansoni-specific Th2 responses. Egg antigens do not induce the expression of IRF-4-related genes. Instead, IRF-4(f/f) CD11c-cre mice ...https://www.research.manchester.ac.uk/portal/en/publications/different-populations-of-cd11b-dendritic-cells-drive-th2-responses-in-the-small-intestine-and-colon
CD4+ effector cells default to the Th2 pathway in interferon gamma-deficient mice infected with Leishmania major. | JEM
Mice with homologous disruption of the interferon gamma (IFN-gamma) gene on the C57BL/6 background were infected with Leishmania major and the immune response assessed. In contrast to wild-type or heterozygous knockout mice, deficient animals were unable to restrict growth of the parasite and suffered lethal infection over 6-8 wk. Although wild-type and heterozygous littermates developed CD4+ cells that contained transcripts for IFN-gamma and lymphotoxin, typical of T helper type 1 (Th1) cells, the knockout mice developed CD4+ cells that contained transcripts for interleukin 4 (IL-4), IL-5, and IL-13, typical of Th2 cells. ELISPOT assays confirmed the reciprocal patterns of IFN-gamma or IL-4 ...http://jem.rupress.org/content/179/4/1367
Th17 Cell-associated Chemokine Receptor and Ligand Expression in Dry Eye Disease | IOVS | ARVO Journals
Purpose: : Th17 cells have been reported to be the predominate effector T cell in dry eye disease (DED). The purpose of this study was to investigate the chemokine receptor-ligand system in DED, which may be involved in Th17 cell homing to the ocular surface in this disorder. Methods: : 8-10 week old female C57BL/6 mice were housed in a low humidity controlled environment chamber for 12 days to induce DED. Expression of the Th17 associated chemokine receptors CCR2 and CCR6 was determined by flow cytometric analysis of Th17 (CD4+IL-17+) cells collected from the draining lymph nodes (LN). Conjunctival samples were analyzed via real time PCR to determine expression of the chemokines CCL2 and CCL20. Results: : Analysis of the ...http://iovs.arvojournals.org/article.aspx?articleid=2353035
Increased Th17 cells and IL-17A exist in patients with B cell acute lymphoblastic leukemia and promote proliferation and...
Th17 cells contribute to protection against fungal and parasitic infections and participate in various inflammatory and autoimmune diseases. Furthermore, Targeted IL-17 depletion has already been accepted as a therapeutic strategy and is now being tested in clinical trials for several human autoimmune diseases [26, 27]. Whether Th17 cells and IL-17 also play similar roles in tumor pathogenesis and progression deserves further study. Here we demonstrate that increased Th17 cells and decreased Th1 cells are presented in PB and BM from B-ALL patients. IL-17A or IL-21, two cytokines mainly produced by Th17 cells, can promote the proliferation of B-ALL cells.. The interplay between immune ...https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-016-0894-9
Small interfering RNA against CD86 during allergen challenge blocks experimental allergic asthma | Respiratory Research | Full...
The present study demonstrated that CD86 siRNA treatment attenuated the upregulation of CD86 on maturing BMDCs. CD86 siRNA-treated BMDCs were poor stimulators of effector Th2 cells, shown by reduced productions of IL-4, IL-5, and IL-13, but not of IFN-γ. In vivo, intratracheal administration of CD86 siRNA during OVA challenge reduced the production of IL-5, IL-13, and TARC release and ameliorated airway eosinophilia, airway hyperresponsiveness, and elevation of OVA-specific IgE. These results clearly show that CD86 has a pivotal role in the reactivation of Th2 cells in the effector phase of allergic reactions. In addition, CD86 siRNA treatment did not stimulate systemic production of IL-6 or IFN-β, suggesting that CD86 may become a promising target for the treatment of ...https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-014-0132-z
Acitretin exerted a greater influence on T-helper (Th)1 and Th17 than on Th2 cells in treatment of psoriasis vulgaris - NIU -...
NIU, X., CAO, W., MA, H., FENG, J., LI, X. and ZHANG, X. (2012), Acitretin exerted a greater influence on T-helper (Th)1 and Th17 than on Th2 cells in treatment of psoriasis vulgaris. The Journal of Dermatology, 39: 916-921. doi: 10.1111/j.1346-8138.2012.01637.x ...http://onlinelibrary.wiley.com/doi/10.1111/j.1346-8138.2012.01637.x/references?globalMessage=0&systemMessage=Wiley+Online+Library+usage+report+download+page+will+be+unavailable+on+Friday+24th+November+2017+at+21%3A00+EST+%2F+02.00+GMT+%2F+10%3A00+SGT+%28Saturday+25th+Nov+for+SGT+
B.Th. - definition of B.Th. by The Free Dictionary
Define B.Th.. B.Th. synonyms, B.Th. pronunciation, B.Th. translation, English dictionary definition of B.Th.. abbreviation for Bachelor of Theologyhttps://www.thefreedictionary.com/B.Th.
Expansion of Th17 Cells and Functional Defects in T Regulatory Cells Are Key Features of the Pancreatic Lymph Nodes in Patients...
To what extent proinflammatory Th17 cells and defects in Treg-mediated regulation contribute to the development of type 1 diabetes in humans is highly debated. Here we show that the PLNs of patients with type 1 diabetes, unlike their PB, have an altered immune status due to the expansion of Th17 cells and the presence of CD25bright T cells epigenetically imprinted to have a regulatory activity but which lack a proper function.. Increased Th17 cells in the PB of children with diabetes has been recently reported (8), and Tan and colleagues (9) have demonstrated that these circulating IL-17-producing T cells may reside mainly within the ...http://diabetes.diabetesjournals.org/content/60/11/2903.long
ERβ-Dependent Direct Suppression of Human and Murine Th17 Cells and Treatment of Established Central Nervous System...
Multiple sclerosis (MS), an autoimmune disease of the CNS, is mediated by autoreactive Th cells. A previous study showed that the neurosteroid dehydroepiandrosterone (DHEA), when administered preclinically, could suppress progression of relapsing-remitting experimental autoimmune encephalomyelitis (EAE). However, the effects of DHEA on human or murine pathogenic immune cells, such as Th17, were unknown. In addition, effects of this neurosteroid on symptomatic disease, as well as the receptors involved, had not been investigated. In this study, we show that DHEA suppressed peripheral responses from patients with MS and reversed established paralysis and CNS inflammation in four different EAE models, including the 2D2 TCR-transgenic mouse model. DHEA directly ...http://www.jimmunol.org/content/early/2016/08/20/jimmunol.1601038
A polymorphism in the interleukin-4 receptor affects the ability of interleukin-4 to regulate Th17 cells: a possible...
Several earlier studies supported a key role for IL-17 in the pathogenesis of RA . Determining the regulatory mechanisms that could suppress Th17 cells might lead to novel approaches to the treatment of RA. In this study, we have examined the role of a single nucleotide polymorphism in the IL-4R in the control of IL-17 production.. The results indicate that a polymorphism in IL-4R in part controls production of IL-17 by Th17 cells cultured from healthy individuals. Specifically, IL-4 significantly inhibited IL-17 production by cells from subjects with the I/I genotype (P = 0.0079) and the I/V genotype (P = 0.013), but not the V/V genotype. An earlier ...https://arthritis-research.biomedcentral.com/articles/10.1186/ar3239
Enhancement of Th2-Dependent and Inflammatory Response - Patent application
0018]In one embodiment, the present invention provides a method for reducing inflammation and disease associated with Th1 cell abundance by increasing the in vivo production of Th2 cells comprising reducing one or more of MEKK1-MEKK4/MEKK7-JNK-ITCH cascade pathway activity and direct MEKK1-ITCH protein to protein interactions. In another embodiment, the present invention provides a method to reduce inflammation and disease associated with Th1 cell abundance wherein said reducing is comprises using one or more MEKK1 enzyme inhibitors. In another embodiment, the present invention provides a method to reduce inflammation and disease associated with Th1 cell abundance wherein said enzyme inhibitors comprises ...http://www.patentsencyclopedia.com/app/20080213817
Computational-biology] CFP: 10th Int. Conf. on Artificial Immune Systems - July 18-21, 2011 University of Cambridge, UK
CFP: 10th Int. Conf. on Artificial Immune Systems - July 18-21, 2011 University of Cambridge, UK CALL FOR PAPERS The 10th International Conference on Artificial Immune Systems July 18-21, 2011 University of Cambridge, UK http://www.artificial-immune-systems.org/icaris/2011/index.html http://www.easychair.org/conferences/?conf=icaris2011 The proceedings will be published in Lecture Notes in Computer Science, Springer. Best Papers will be published in Evolutionary Computation Journal MIT Press and BMC Bioinformatics. Important Dates: Paper submission: 28th February 2011 Author notification: 30th April 2011 Paper final version: 15th May 2011 KEYNOTES: Arup Chakraborty, MIT, USA Rob J. de Boer, Utrecht University, The Netherlands Jonathan Jones, Sainsbury Laboratory, UK Rino Rappuoli, Novartis, Italy (TBC) Jon Timmis, University ...http://www.bio.net/bionet/mm/comp-bio/2011-February/004094.html
Synovial Fibroblasts Directly Induce Th17 Pathogenicity via the Cyclooxygenase/Prostaglandin E2 Pathway, Independent of IL-23 |...
Th17 cells are critically involved in autoimmune disease induction and severity. Recently, we showed that Th17 cells from patients with rheumatoid arthritis (RA) directly induced a proinflammatory loop upon interaction with RA synovial fibroblasts (RASF), including increased autocrine IL-17A production. To unravel the mechanism driving this IL-17A production, we obtained primary CD4+CD45RO+CCR6+ (Th17) cells and CD4+CD45RO+CCR6− (CCR6−) T cells from RA patients or healthy individuals and cocultured these with RASF. IL-1β, IL-6, IL-23p19, and cyclooxygenase (COX)-2 expression and PGE2 production in Th17-RASF cultures were higher than in CCR6− T cell-RASF cultures. Cytokine neutralization showed ...http://www.jimmunol.org/content/early/2013/06/27/jimmunol.1300274