*  MicroRNA-21 Limits In Vivo Immune Response-Mediated Activation of the IL-12/IFN-γ Pathway, Th1 Polarization, and the Severity...
IL-12 is a major cytokine that regulates Th1 versus Th2 decisions primarily by inducing T cells to produce the Th1 cytokine IFN ... Because NK cells and dendritic cells are also important IFN-γ-producing cells, we measured the levels of IFN-γ production by IL ... Because NK cells and dendritic cells are also important IFN-γ-producing cells, we measured the levels of IFN-γ production by NK ... Isolation and stimulation of NK cells. Splenic NK cells were isolated using NK Cell Isolation Kit (Miltenyi Biotec) according ...
  http://www.jimmunol.org/content/187/6/3362.long
*  'th1 cells' Protocols and Video...
... th1 cells' include 'Murine Lymphocyte Labeling by 64Cu-Antibody Receptor Targeting for In Vivo Cell Trafficking by PET/CT', ' ... Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets', 'Real-time Analysis of Transcription ... Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis', 'Experimental Infection with Listeria monocytogenes as a ... Application of Long-term cultured Interferon-γ Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell ...
  https://www.jove.com/keyword/th1+cells
*  Frontiers | Salmonella as a model for non-cognate Th1 cell stimulation | Immunology
... we address the issue of bystander activation of naïve T cells and non-cognate stimulation of activated and memory T cells. ... we address the issue of bystander activation of naïve T cells and non-cognate stimulation of activated and memory T cells. ... as a particularly appropriate model pathogen in the study of non-cognate CD4 T cell responses based on the strength of the Th1 ... as a particularly appropriate model pathogen in the study of non-cognate CD4 T cell responses based on the strength of the Th1 ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2014.00621/full
*  Th17 Cells Are More Protective Than Th1 Cells Against the Intracellular Parasite Trypanosoma cruzi. | Sigma-Aldrich
Th17 Cells Are More Protective Than Th1 Cells Against the Intracellular Parasite Trypanosoma cruzi.. [Catherine W Cai, Jennifer ... Th17 cells confer significantly stronger protection against T. cruzi-related mortality than even Th1 cells, traditionally ... Th17 cells are a subset of CD4+ T cells known to play a central role in the pathogenesis of many autoimmune diseases, as well ... Mechanistically, Th17 cells can directly protect infected cells through the IL-17A-dependent induction of NADPH oxidase, ...
  https://www.sigmaaldrich.com/catalog/papers/27695083
*  JCI - Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway...
Even on transfer of twice as many Th1 as Th2 cells (5 × 106 Th1 cells + 2.5 × 106 Th2 cells, Th1 + Th2 [2:1]), Th1 cells did ... antigen-specific Th3 cells (49), Tr1 cells (50), γδ cells (51), or CD8+ cells (52, 53) - may be more important than Th1 cells ... 106 cells per mouse), Th2 (2.5 × 106 cells per mouse), or Th1 plus Th2 (2.5 × 106 Th1 + 2.5 × 106 Th2 cells per mouse) cells in ... of total BAL cells (0.04 × 104 cells/ml) with Th1 cells. Transfer of a mixture of Th1 and Th2 cells in a ratio of 1:1 ...
  https://www.jci.org/articles/view/5155
*  Antagonizing Arachidonic Acid-Derived Eicosanoids Reduces Inflammatory Th17 and Th1 Cell-Mediated Inflammation and Colitis...
... biological response modifiers and the family of cell adhesion-promoting molecules. ... During colitis, activation of two inflammatory T cell subsets, Th17 and Th1 cells, promotes ongoing intestinal inflammatory ... Antagonizing Arachidonic Acid-Derived Eicosanoids Reduces Inflammatory Th17 and Th1 Cell-Mediated Inflammation and Colitis ... while n-3 PUFA antagonize both Th17 and Th1 cells and suppress PGE2 levels. We utilized two genetic mouse models, which ...
  https://www.hindawi.com/journals/mi/2014/917149/abs/
*  Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1...
Shown are cells gated on CD4+. C. Averages of the percentage of IL-17 or IFN-γ positive cells gated from the CD4+Tcr-β+ cells ( ... indicating conversion of donor cells into Th1 cells. Moreover, diabetes progression in NOD.scid recipients was dependent on IFN ... Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 ... Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 ...
  https://www.ncbi.nlm.nih.gov/pubmed/19130584?access_num=19130584&link_type=MED&dopt=Abstract
*  Demethylation of the RORC2 and IL17A in Human CD4+ T Lymphocytes Defines Th17 Origin of Nonclassic Th1 Cells | The Journal of...
CCR6+CD161+CXCR3− CD4+ T cells were defined as Th17 cells, CCR6+CXCR3+ cells as Th17/Th1 cells, and CCR6−CXCR3+ as Th1 cells ( ... Th17/Th1 cells as CD4+CD161+CCR6+IL-17A+IFN-γ+, nonclassic Th1 cells as CD4+CD161+CCR6+IL-17A−IFN-γ+, and classic Th1 cells as ... Th17/Th1) cells, CD4+CCR6+CD161+IL-17A−IFN-γ+ (nonclassic Th1) cells, and CD4+CCR6−CD161−IL-17A−IFN-γ+ (classic Th1) cells; and ... Th17/Th1, and nonclassic Th1 cells had a marked demethylation, naive CD4+ Th cells and classic Th1 cells were characterized by ...
  http://www.jimmunol.org/content/194/7/3116
*  C-Reactive Protein Directly Suppresses Th1 Cell Differentiation and Alleviates Experimental Autoimmune Encephalomyelitis | The...
... native CRP binds specifically to human Jurkat T cells and to mouse naive CD4+ T cells and modulates their Th1 and Th2 responses ... a lesser proportion of the T cells recovered from the spleens of healthy animals were Th1 cells. Moreover, in both CRP ... C-Reactive Protein Directly Suppresses Th1 Cell Differentiation and Alleviates Experimental Autoimmune Encephalomyelitis. Lin ... C-Reactive Protein Directly Suppresses Th1 Cell Differentiation and Alleviates Experimental Autoimmune Encephalomyelitis ...
  http://www.jimmunol.org/content/early/2015/04/25/jimmunol.1402909
*  Colitogenic Th1 Cells Are Present in the Antigen-Experienced T Cell Pool in Normal Mice: Control by CD4+ Regulatory T Cells and...
Colitogenic Th1 Cells Are Present in the Antigen-Experienced T Cell Pool in Normal Mice: Control by CD4+ Regulatory T Cells and ... Colitogenic Th1 Cells Are Present in the Antigen-Experienced T Cell Pool in Normal Mice: Control by CD4+ Regulatory T Cells and ... Colitogenic Th1 Cells Are Present in the Antigen-Experienced T Cell Pool in Normal Mice: Control by CD4+ Regulatory T Cells and ... Colitogenic Th1 Cells Are Present in the Antigen-Experienced T Cell Pool in Normal Mice: Control by CD4+ Regulatory T Cells and ...
  http://www.jimmunol.org/content/171/2/971
*  Cathepsin H deficiency in mice induces excess Th1 cell activation and early-onset of EAE though impairment of toll-like...
Cathepsin H Cathepsin S Dendritic cell Microglia Experimental autoimmune encephalomyelitis Th1 cell ... Cathepsin H deficiency in mice induces excess Th1 cell activation and early-onset of EAE though impairment of toll-like ... CatH−/− showed a significantly earlier disease onset of EAE and increased Th1 cell differentiation in splenocytes. Splenocytes ... leading to the enhancement of Th1 cell differentiation and consequent early disease onset of EAE. ...
  https://link.springer.com/article/10.1007/s00011-018-1136-9
*  A3.7 Comparison of the Effects of Th17 and Th1 Cells on Endothelial Cells and Synoviocytes | Annals of the Rheumatic Diseases
Methods To assess the interaction of T cells with stromal cells, the effects of Th1 or Th17 cytokines, Th1 or Th17 clone ... Activated Th1 and Th17 supernatants had the same effect on synoviocytes (254 and 754 fold compared to control). Th1 cells were ... Conclusions While Th1 cells were able to induce inflammatory cytokine expression in EC and synoviocytes, Th17 cells were only ... CD4+ T cells, derived from PBMCs of healthy donors, were used to obtain T-cell clones. CD4+ T-cell clones were classified on ...
  http://ard.bmj.com/content/72/Suppl_1/A15.3
*  CD152 enhances chemotaxis of Th1 cells.(A) Migration of | Open-i
Migration of unpolarized T cells. Recall response of CD4+ OVA-specific TCRtg T cells from CD152−/− or CD152+/+ mi ... CD152 enhances chemotaxis of Th1 cells.(A) Migration of unpolarized T cells. Recall response of CD4+ OVA-specific TCRtg T cells ... CD152 enhances chemotaxis of Th1 cells.(A) Migration of unpolarized T cells. Recall response of CD4+ OVA-specific TCRtg T cells ... Bars show the chemotactic index of CD4+ cells. (C) Specific migration of antigen-specific stimulated Th1 cells in a recall ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC2682661_pone.0005702.g001&req=4
*  P-Selectin and P-Selectin Glycoprotein Ligand 1 Are Major Determinants for Th1 Cell Recruitment to Nonlymphoid Effector Sites...
P-Selectin and P-Selectin Glycoprotein Ligand 1 Are Major Determinants for Th1 Cell Recruitment to Nonlymphoid Effector Sites ... P-Selectin and P-Selectin Glycoprotein Ligand 1 Are Major Determinants for Th1 Cell Recruitment to Nonlymphoid Effector Sites ...
  http://jem.rupress.org/content/early/2003/07/28/jem.20020691
*  Cell mediated immunity to Bordetella pertussis: role of Th1 cells in bacterial clearance in a murine respiratory infection model
Mills, K.H.G., Barnard, A.L., Watkins, J. and Redhead, K. `Cell mediated immunity to Bordetella pertussis: role of Th1 cells in ... Cell mediated immunity to Bordetella pertussis: role of Th1 cells in bacterial clearance in a murine respiratory infection ... Cell-mediated immunity to Bordetella pertussis - role of Th1 cells in bacterial clearance in a murine respiratory infection ... Furthermore, transfer of enriched T cells or purified CD4+ T cells but not CD8+ T cells from immune mice conferred a high level ...
  http://www.tara.tcd.ie/handle/2262/33382
*  T Follicular Helper, but Not Th1, Cell Differentiation in the Absence of Conventional Dendritic Cells | The Journal of...
T Follicular Helper, but Not Th1, Cell Differentiation in the Absence of Conventional Dendritic Cells. Madelene W. Dahlgren, ... T Follicular Helper, but Not Th1, Cell Differentiation in the Absence of Conventional Dendritic Cells ... T Follicular Helper, but Not Th1, Cell Differentiation in the Absence of Conventional Dendritic Cells ... T Follicular Helper, but Not Th1, Cell Differentiation in the Absence of Conventional Dendritic Cells ...
  http://www.jimmunol.org/content/early/2015/04/25/jimmunol.1401938
*  Ex-Th17 (Nonclassical Th1) Cells Are Functionally Distinct from Classical Th1 and Th17 Cells and Are Not Constrained by...
These ex-Th17 cells are also called nonclassical Th1 cells because of their ability to produce IFN-γ, similar to Th1 cells; ... Ex-Th17 (Nonclassical Th1) Cells Are Functionally Distinct from Classical Th1 and Th17 Cells and Are Not Constrained by ... Ex-Th17 (Nonclassical Th1) Cells Are Functionally Distinct from Classical Th1 and Th17 Cells and Are Not Constrained by ... Ex-Th17 (Nonclassical Th1) Cells Are Functionally Distinct from Classical Th1 and Th17 Cells and Are Not Constrained by ...
  http://www.jimmunol.org/content/early/2017/02/04/jimmunol.1600737
*  Correlation of Local FOXP3-Expressing T Cells and Th1-Th2 Balance in Perennial Allergic Nasal Mucosa
... Hideaki Shirasaki, Etsuko ... Hideaki Shirasaki, Etsuko Kanaizumi, Nobuhiko Seki, and Tetsuo Himi, "Correlation of Local FOXP3-Expressing T Cells and Th1-Th2 ...
  https://www.hindawi.com/journals/ijoto/2011/259867/cta/
*  Opinions on whether TH1 and TH2 cell types originate from TH0
DC activate naive T cells but do not trigger the differentiation of Th1, while Mac do not activate naive T cells but trigger ... Opinions on whether TH1 and TH2 cell types originate from TH0. Thierry Sornasse tsornas at dbmdec5.ulb.ac.be Wed Mar 9 11:37:41 ... O'Garra about the role of macrophages and dendritic cells in the differentiation of Th1 clones from naive T cells confirms this ... Thus, there could be some memory T cells that are already shifted to Th1 or to Th2. In conclusion, I could say that the ...
  http://www.bio.net/bionet/mm/immuno/1994-March/001141.html
*  Vaccines | Free Full-Text | Dendritic Cell-Induced Th1 and Th17 Cell Differentiation for Cancer Therapy
While Th1/Tc1 cells are traditionally used for their potent anti-tumor responses, mounting evidence suggests Th17/Tc17 cells ... The type of T-cell response generated (e.g., Th1 or Th2) will determine the efficacy of the therapy, and it is generally ... The induction of polarized T-cell responses can be regulated by dendritic cells (DCs). DCs are key regulators of the immune ... It is therefore important to understand the factors involved in the induction of both type-1 and type-17 T-cell responses by ...
  http://www.mdpi.com/2076-393X/1/4/527
*  Amplification of Th17 and Th1 cell activity in p55 TNFR | Open-i
LN cells from WT, p55 TNFR−/−, and p75 TNFR−/− mice were taken 14 d after immunizat ... Amplification of Th17 and Th1 cell activity in p55 TNFR−/− mice. ... expanded populations of Th1 and Th17 cells, which were shown by adoptive transfer to be pathogenic. Th1 and Th17 cell ... expanded populations of Th1 and Th17 cells, which were shown by adoptive transfer to be pathogenic. Th1 and Th17 cell ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC2571924_jem2052491f02&req=4
*  Pathogenic conversion of Foxp3+ T cells into Th1 and Th17 cells in Stromal Keratitis | The Journal of Immunology
Pathogenic conversion of Foxp3+ T cells into Th1 and Th17 cells in Stromal Keratitis. Siva Karthik Varanasi, Siddheshvar Bhela ... Pathogenic conversion of Foxp3+ T cells into Th1 and Th17 cells in Stromal Keratitis ... Pathogenic conversion of Foxp3+ T cells into Th1 and Th17 cells in Stromal Keratitis ... Pathogenic conversion of Foxp3+ T cells into Th1 and Th17 cells in Stromal Keratitis ...
  http://www.jimmunol.org/content/196/1_Supplement/147.8
*  The ICE inhibitor pralnacasan reduces dextran sulfate sodium-induced murine colitis and Th1 T-cell activation | Journal of...
The ICE inhibitor pralnacasan reduces dextran sulfate sodium-induced murine colitis and Th1 T-cell activation. Florian Loher, ... The ICE inhibitor pralnacasan reduces dextran sulfate sodium-induced murine colitis and Th1 T-cell activation. Florian Loher, ... The ICE inhibitor pralnacasan reduces dextran sulfate sodium-induced murine colitis and Th1 T-cell activation. Florian Loher, ... The ICE inhibitor pralnacasan reduces dextran sulfate sodium-induced murine colitis and Th1 T-cell activation ...
  http://jpet.aspetjournals.org/content/early/2003/11/10/jpet.103.057059
*  Follicular Homing T Helper (Th) Cells and the Th1/Th2 Paradigm | JEM
For CD4+ cells, at least three effector subsets may arise: Th1 cells, Th2 cells, or TFH cells. TFH cells can be distinguished ... Relationship of TFH to Th1 and Th2 Cells.. The discovery of a non-Th1, non-Th2 effector T cell for B cell help poses an ... B cells localize in the B cell follicles, whereas T cells colocalize with dendritic cells in the T cell areas. This segregation ... which keeps Th1 cells closer to the T cell area, whereas its absence allows Th2 cells to drift closer to the B cell follicles ( ...
  http://jem.rupress.org/content/192/11/F31
*  Absence of Vasoactive Intestinal Peptide Expression in Hematopoietic Cells Enhances Th1 Polarization and Antiviral Immunity in...
... with more Th1/Tc1-polarized T cells, fewer IL-10+ T cells, and more mCMV-M45 epitope peptide MHC class I tetramer+ CD8+ T cells ... and by B cells, T cells, accessory cells, and other nonlymphoid cells (3-6). VIP and the closely related neuropeptide pituitary ... with coordinated activities of innate and adaptive immune cells, including DC, macrophages, NK cells, T cells, and B cells (27- ... The generation of Ag-specific antiviral T cells and Th1 polarization was increased in cultures of DC and T cells from VIP-KO ...
  http://www.jimmunol.org/content/187/2/1057.long